Spatiotemporal dynamics of RhoA activity in migrating cells.

Cell adhesion: integrating cytoskeletal dynamics and cellular tension. Nat Rev Mol Cell Biol (2010) 7.27

A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25

Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature (2010) 6.25

Random versus directionally persistent cell migration. Nat Rev Mol Cell Biol (2009) 4.99

The PAR proteins: fundamental players in animal cell polarization. Dev Cell (2007) 4.92

Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76

Rapid signal transduction in living cells is a unique feature of mechanotransduction. Proc Natl Acad Sci U S A (2008) 3.04

Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol (2012) 2.76

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol (2010) 2.72

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol (2010) 2.65

RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol (2011) 2.59

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52

Proneural transcription factors regulate different steps of cortical neuron migration through Rnd-mediated inhibition of RhoA signaling. Neuron (2011) 2.42

A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol (2011) 2.34

Caveolin-1 regulates cell polarization and directional migration through Src kinase and Rho GTPases. J Cell Biol (2007) 2.31

Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens. Nat Cell Biol (2012) 2.23

Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20

Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19

Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12

Biosensors for characterizing the dynamics of rho family GTPases in living cells. Curr Protoc Cell Biol (2010) 2.11

The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10

A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol (2009) 2.05

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99

Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97

Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89

Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88

Wave-pinning and cell polarity from a bistable reaction-diffusion system. Biophys J (2008) 1.86

Keeping in touch with contact inhibition of locomotion. Trends Cell Biol (2010) 1.85

Rho GTPase activity zones and transient contractile arrays. Bioessays (2006) 1.79

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. J Cell Sci (2009) 1.78

Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes. Dev Cell (2012) 1.76

Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72

Antagonistic regulation of actin dynamics and cell motility by TRPC5 and TRPC6 channels. Sci Signal (2010) 1.70

Myosin-IXA regulates collective epithelial cell migration by targeting RhoGAP activity to cell-cell junctions. Curr Biol (2012) 1.70

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67

Scaffold mediated regulation of MAPK signaling and cytoskeletal dynamics: a perspective. Cell Signal (2007) 1.65

Localized RhoA GTPase activity regulates dynamics of endothelial monolayer integrity. Cardiovasc Res (2013) 1.63

Lipoprotein accumulation in macrophages via toll-like receptor-4-dependent fluid phase uptake. Circ Res (2009) 1.63

Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol (2015) 1.62

Dynamics of the Rho-family small GTPases in actin regulation and motility. Cell Adh Migr (2011) 1.60

Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells. Am J Physiol Cell Physiol (2011) 1.57

A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci (2009) 1.55

Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge. Mol Biol Cell (2009) 1.55

Spatial organization of intracellular communication: insights from imaging. Nat Rev Mol Cell Biol (2010) 1.55

Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell (2006) 1.54

Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc (2009) 1.53

Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells. Nat Cell Biol (2011) 1.51

Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotype. J Biol Chem (2010) 1.51

Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol (2011) 1.47

Regulation of RhoGEF proteins by G12/13-coupled receptors. Br J Pharmacol (2009) 1.45

Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity. J Biol Chem (2010) 1.44

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44

Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression. Dev Cell (2012) 1.43

p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J Cell Biol (2008) 1.41

The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell (2007) 1.39

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility. Cancer Metastasis Rev (2009) 1.36

The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood (2008) 1.36

Coordinated RhoA signaling at the leading edge and uropod is required for T cell transendothelial migration. J Cell Biol (2010) 1.35

Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Mol Biol Cell (2008) 1.32

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation. Oncogene (2013) 1.32

Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29

A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29

Memo-RhoA-mDia1 signaling controls microtubules, the actin network, and adhesion site formation in migrating cells. J Cell Biol (2008) 1.25

From mechanical force to RhoA activation. Biochemistry (2012) 1.23

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22

The on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migration. Small GTPases (2014) 1.21

Localized tensional forces on PECAM-1 elicit a global mechanotransduction response via the integrin-RhoA pathway. Curr Biol (2012) 1.20

PDZRhoGEF and myosin II localize RhoA activity to the back of polarizing neutrophil-like cells. J Cell Biol (2007) 1.20

Rapid activation of Rac GTPase in living cells by force is independent of Src. PLoS One (2009) 1.20

Rac1 activation in podocytes induces rapid foot process effacement and proteinuria. Mol Cell Biol (2013) 1.19

Rho activation regulates CXCL12 chemokine stimulated actin rearrangement and restitution in model intestinal epithelia. Lab Invest (2007) 1.18

Directed migration of mesenchymal cells: where signaling and the cytoskeleton meet. Curr Opin Cell Biol (2014) 1.17

Imaging protein activity in live embryos using fluorescence resonance energy transfer biosensors. Nat Protoc (2011) 1.16

Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech (2011) 1.15

A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol (2014) 1.15

Synthetic spatially graded Rac activation drives cell polarization and movement. Proc Natl Acad Sci U S A (2012) 1.14

Rho GTPases: masters of cell migration. Small GTPases (2014) 1.14

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer. Cancer Res (2010) 1.14

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation. J Biol Chem (2011) 1.13

Fluorescence applications in molecular neurobiology. Neuron (2010) 1.13

Induction of entosis by epithelial cadherin expression. Cell Res (2014) 1.13

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13

Integrin regulation of caveolin function. J Cell Mol Med (2007) 1.10

Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability. J Cell Biol (2011) 1.10

A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nat Chem Biol (2011) 1.09

Regulation of RhoA-dependent ROCKII activation by Shp2. J Cell Biol (2008) 1.08

Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring? Biophys J (2012) 1.08

Visualizing dynamic activities of signaling enzymes using genetically encodable FRET-based biosensors from designs to applications. Methods Enzymol (2012) 1.07

Myosin-interacting guanine exchange factor (MyoGEF) regulates the invasion activity of MDA-MB-231 breast cancer cells through activation of RhoA and RhoC. Oncogene (2009) 1.07

Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proc Natl Acad Sci U S A (2013) 1.06

Dynamic functions of RhoA in tumor cell migration and invasion. Small GTPases (2013) 1.06

Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer. Philos Trans R Soc Lond B Biol Sci (2008) 1.05

Phosphorylation of a novel site on the {beta}4 integrin at the trailing edge of migrating cells promotes hemidesmosome disassembly. Mol Biol Cell (2008) 1.05

Motorized RhoGAP myosin IXb (Myo9b) controls cell shape and motility. Proc Natl Acad Sci U S A (2010) 1.05

Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts. PLoS One (2008) 1.05

CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. J Cell Biol (2014) 1.04

Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction. J Cell Biol (2015) 1.04

Plakophilin 2 couples actomyosin remodeling to desmosomal plaque assembly via RhoA. Mol Biol Cell (2010) 1.04

A genetically encoded photoactivatable Rac controls the motility of living cells. Nature (2009) 7.25

Coordination of Rho GTPase activities during cell protrusion. Nature (2009) 6.54

Activation of endogenous Cdc42 visualized in living cells. Science (2004) 3.57

Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI. Nat Cell Biol (2002) 3.50

Differential regulation of protrusion and polarity by PI3K during neutrophil motility in live zebrafish. Dev Cell (2010) 3.19

Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol (2010) 2.65

GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. Dev Cell (2007) 2.52

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo. Nat Cell Biol (2010) 2.45

Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells. Proteomics (2011) 2.44

Engineered allosteric activation of kinases in living cells. Nat Biotechnol (2010) 2.44

A novel spatiotemporal RhoC activation pathway locally regulates cofilin activity at invadopodia. Curr Biol (2011) 2.34

Effects of cell tension on the small GTPase Rac. J Cell Biol (2002) 2.24

Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools. J Cell Biochem Suppl (2002) 2.14

Directed cell invasion and migration during metastasis. Curr Opin Cell Biol (2011) 2.12

To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front. J Cell Biol (2006) 2.10

Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis. Curr Biol (2002) 2.01

Designing photoswitchable peptides using the AsLOV2 domain. Chem Biol (2012) 1.99

Functions of cofilin in cell locomotion and invasion. Nat Rev Mol Cell Biol (2013) 1.95

Vascular lipid accumulation, lipoprotein oxidation, and macrophage lipid uptake in hypercholesterolemic zebrafish. Circ Res (2009) 1.89

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol (2013) 1.89

Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold. J Cell Biol (2002) 1.87

Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. Biochim Biophys Acta (2004) 1.84

Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. J Cell Biol (2004) 1.83

Spatial and temporal regulation of focal adhesion kinase activity in living cells. Mol Cell Biol (2007) 1.72

Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One (2009) 1.68

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms. Mol Carcinog (2008) 1.67

Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRbeta/B-RAF. Proc Natl Acad Sci U S A (2010) 1.67

High-resolution quantification of focal adhesion spatiotemporal dynamics in living cells. PLoS One (2011) 1.63

Vimentin organization modulates the formation of lamellipodia. Mol Biol Cell (2011) 1.60

Dynamics of the Rho-family small GTPases in actin regulation and motility. Cell Adh Migr (2011) 1.60

Designing biosensors for Rho family proteins--deciphering the dynamics of Rho family GTPase activation in living cells. J Cell Sci (2004) 1.58

Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci (2012) 1.50

Imaging the coordination of multiple signalling activities in living cells. Nat Rev Mol Cell Biol (2011) 1.47

Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A (2007) 1.40

Regulation of cell migration and survival by focal adhesion targeting of Lasp-1. J Cell Biol (2004) 1.38

Merocyanine dyes with improved photostability. Org Lett (2007) 1.37

R-Ras controls membrane protrusion and cell migration through the spatial regulation of Rac and Rho. Mol Biol Cell (2004) 1.28

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression [corrected]. Proc Natl Acad Sci U S A (2010) 1.27

Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J Cell Biol (2007) 1.25

ERK and RhoA differentially regulate pseudopodia growth and retraction during chemotaxis. J Biol Chem (2003) 1.24

Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP. J Am Chem Soc (2010) 1.23

RhoA/ROCK-mediated switching between Cdc42- and Rac1-dependent protrusion in MTLn3 carcinoma cells. Exp Cell Res (2008) 1.22

KRas induces a Src/PEAK1/ErbB2 kinase amplification loop that drives metastatic growth and therapy resistance in pancreatic cancer. Cancer Res (2012) 1.22

Vinculin controls PTEN protein level by maintaining the interaction of the adherens junction protein beta-catenin with the scaffolding protein MAGI-2. J Biol Chem (2004) 1.20

Spatial mapping of the neurite and soma proteomes reveals a functional Cdc42/Rac regulatory network. Proc Natl Acad Sci U S A (2008) 1.20

Design and optimization of genetically encoded fluorescent biosensors: GTPase biosensors. Methods Cell Biol (2008) 1.20

Spatiotemporal control of small GTPases with light using the LOV domain. Methods Enzymol (2011) 1.18

Biosensor Förster resonance energy transfer detection by the phasor approach to fluorescence lifetime imaging microscopy. Microsc Res Tech (2011) 1.15

Role of connexins in metastatic breast cancer and melanoma brain colonization. J Cell Sci (2013) 1.11

A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry (2007) 1.10

A biosensor generated via high-throughput screening quantifies cell edge Src dynamics. Nat Chem Biol (2011) 1.09

Endogenous RhoG is rapidly activated after epidermal growth factor stimulation through multiple guanine-nucleotide exchange factors. Mol Biol Cell (2010) 1.08

Rational design of a ligand-controlled protein conformational switch. Proc Natl Acad Sci U S A (2013) 1.08

Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07

PB1 domain-dependent signaling complex is required for extracellular signal-regulated kinase 5 activation. Mol Cell Biol (2006) 1.07

The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8. Proc Natl Acad Sci U S A (2008) 1.05

CellGeo: a computational platform for the analysis of shape changes in cells with complex geometries. J Cell Biol (2014) 1.04

Guiding cell migration through directed extension and stabilization of pseudopodia. Exp Cell Res (2004) 1.03

Cytoplasmic c-Abl provides a molecular 'Rheostat' controlling carcinoma cell survival and invasion. Oncogene (2003) 1.02

Multiplex imaging of Rho family GTPase activities in living cells. Methods Mol Biol (2012) 1.02

Digital autofocus methods for automated microscopy. Methods Enzymol (2006) 1.01

From imaging to understanding: Frontiers in Live Cell Imaging, Bethesda, MD, April 19-21, 2006. J Cell Biol (2006) 1.01

Deregulation of proteasome function induces Abl-mediated cell death by uncoupling p130CAS and c-CrkII. J Biol Chem (2005) 1.01

External push and internal pull forces recruit curvature-sensing N-BAR domain proteins to the plasma membrane. Nat Cell Biol (2012) 1.00

Simple one-pot preparation of water-soluble, cysteine-reactive cyanine and merocyanine dyes for biological imaging. Bioconjug Chem (2007) 1.00

Millisecond spatiotemporal dynamics of FRET biosensors by the pair correlation function and the phasor approach to FLIM. Proc Natl Acad Sci U S A (2012) 1.00

Functional proteometrics for cell migration. Cytometry A (2006) 0.99

Laser-scanning velocimetry: a confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnol (2007) 0.98

Rho GTPase isoforms in cell motility: Don't fret, we have FRET. Cell Adh Migr (2014) 0.98

Quantitative ratiometric imaging of FRET-biosensors in living cells. Methods Cell Biol (2013) 0.95

RhoA GTPase activation by TLR2 and TLR3 ligands: connecting via Src to NF-kappa B. J Immunol (2009) 0.94

Knowledge-based design of a biosensor to quantify localized ERK activation in living cells. Chem Biol (2013) 0.93

Manipulation of endogenous kinase activity in living cells using photoswitchable inhibitory peptides. ACS Synth Biol (2014) 0.93

Assay for neurite outgrowth quantification. Biotechniques (2003) 0.93

Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy. Cytometry A (2008) 0.93

A theoretical study of the UV/visible absorption and emission solvatochromic properties of solvent-sensitive dyes. Chemphyschem (2003) 0.93

A RhoC biosensor reveals differences in the activation kinetics of RhoA and RhoC in migrating cells. PLoS One (2013) 0.92

Methods for pseudopodia purification and proteomic analysis. Sci STKE (2007) 0.92

Involvement of phospholipase C signaling in melanoma cell-induced endothelial junction disassembly. Front Biosci (2005) 0.91

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials (2012) 0.91

A PKA-Csk-pp60Src signaling pathway regulates the switch between endothelial cell invasion and cell-cell adhesion during vascular sprouting. Blood (2010) 0.91

Spatial regulation of RhoC activity defines protrusion formation in migrating cells. J Cell Sci (2013) 0.90

Environment-sensing merocyanine dyes for live cell imaging applications. Bioconjug Chem (2013) 0.90

PEAK1, a novel kinase target in the fight against cancer. Oncotarget (2010) 0.88

Intracellular calcium changes in rat aortic smooth muscle cells in response to fluid flow. Ann Biomed Eng (2002) 0.88

Hold me tightly LOV. Nat Methods (2010) 0.88

PhosphoBlast, a computational tool for comparing phosphoprotein signatures among large datasets. Mol Cell Proteomics (2007) 0.88

Dynamic phosphorylation of tyrosine 665 in pseudopodium-enriched atypical kinase 1 (PEAK1) is essential for the regulation of cell migration and focal adhesion turnover. J Biol Chem (2012) 0.86

Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes. J Cell Biol (2013) 0.85

Biochemical purification of pseudopodia from migratory cells. Methods Mol Biol (2007) 0.85

Facile synthesis of thiol-reactive Cy3 and Cy5 derivatives with enhanced water solubility. Bioconjug Chem (2002) 0.84

Redesign of the PAK1 autoinhibitory domain for enhanced stability and affinity in biosensor applications. J Mol Biol (2011) 0.84

Computational methods for comparison of large genomic and proteomic datasets reveal protein markers of metastatic cancer. J Proteome Res (2006) 0.83

Experimental and DFT studies: novel structural modifications greatly enhance the solvent sensitivity of live cell imaging dyes. J Phys Chem A (2007) 0.83