Published in Ann N Y Acad Sci on June 01, 2004
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat. Proc Natl Acad Sci U S A (2009) 2.14
DNA damage, cellular senescence and organismal ageing: causal or correlative? Nucleic Acids Res (2007) 2.09
DNA replication stress is a determinant of chronological lifespan in budding yeast. PLoS One (2007) 1.46
Nuclear-mitochondrial epistasis and drosophila aging: introgression of Drosophila simulans mtDNA modifies longevity in D. melanogaster nuclear backgrounds. Genetics (2005) 1.31
Mitochondrial uncoupling and lifespan. Mech Ageing Dev (2010) 1.24
The oxidative stress theory of aging: embattled or invincible? Insights from non-traditional model organisms. Age (Dordr) (2008) 1.20
Mitochondrial ROS production correlates with, but does not directly regulate lifespan in Drosophila. Aging (Albany NY) (2010) 1.19
Mitochondria and PGC-1α in Aging and Age-Associated Diseases. J Aging Res (2011) 1.04
Replicative senescence induced by Romo1-derived reactive oxygen species. J Biol Chem (2008) 0.93
The free radical theory of aging revisited: the cell signaling disruption theory of aging. Antioxid Redox Signal (2013) 0.92
An in silico model of the ubiquitin-proteasome system that incorporates normal homeostasis and age-related decline. BMC Syst Biol (2007) 0.91
Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent. Curr Pharm Des (2011) 0.88
Caloric restriction and its mimetics. BMB Rep (2013) 0.85
Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants. Biogerontology (2009) 0.84
Expression of human uncoupling protein-3 in Drosophila insulin-producing cells increases insulin-like peptide (DILP) levels and shortens lifespan. Exp Gerontol (2009) 0.84
Aging and the Mammalian regulatory triumvirate. Aging Dis (2010) 0.80
Oxidative damage, aging and anti-aging strategies. Age (Dordr) (2005) 0.78
Life-history Constraints on the Mechanisms that Control the Rate of ROS Production. Curr Genomics (2014) 0.77
Sympatric Drosophila simulans flies with distinct mtDNA show age related differences in mitochondrial metabolism. Insect Biochem Mol Biol (2007) 0.77
Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan. Front Genet (2016) 0.75
The hallmarks of aging. Cell (2013) 14.29
Extending healthy life span--from yeast to humans. Science (2010) 12.12
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science (2009) 7.80
Genome-wide transcript profiles in aging and calorically restricted Drosophila melanogaster. Curr Biol (2002) 5.58
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A (2005) 5.34
Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31
Demography of dietary restriction and death in Drosophila. Science (2003) 4.82
Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science (2004) 4.70
Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature (2011) 4.48
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
Calories do not explain extension of life span by dietary restriction in Drosophila. PLoS Biol (2005) 4.30
Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila. Nature (2009) 4.22
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J (2007) 3.83
Dietary restriction in long-lived dwarf flies. Science (2002) 3.71
The sex peptide of Drosophila melanogaster: female post-mating responses analyzed by using RNA interference. Proc Natl Acad Sci U S A (2003) 3.25
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Optimization of dietary restriction protocols in Drosophila. J Gerontol A Biol Sci Med Sci (2007) 3.00
Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem (2009) 2.86
High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One (2011) 2.82
Molecular evolution and functional characterization of Drosophila insulin-like peptides. PLoS Genet (2010) 2.80
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev (2007) 2.75
Stress-response hormesis and aging: "that which does not kill us makes us stronger". Cell Metab (2008) 2.71
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell (2004) 2.60
Dietary restriction in Drosophila: delayed aging or experimental artefact? PLoS Genet (2007) 2.51
Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem J (2004) 2.49
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J (2003) 2.43
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem (2004) 2.42
The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol (2004) 2.33
Genetics of longevity in model organisms: debates and paradigm shifts. Annu Rev Physiol (2012) 2.25
Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol (2007) 2.19
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Quantification of food intake in Drosophila. PLoS One (2009) 1.98
Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs. PLoS One (2008) 1.95
Role of dFOXO in lifespan extension by dietary restriction in Drosophila melanogaster: not required, but its activity modulates the response. Aging Cell (2008) 1.93
A Drosophila insulin-like peptide promotes growth during nonfeeding states. Dev Cell (2009) 1.90
Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell (2002) 1.89
Insulin/IGF-like signalling, the central nervous system and aging. Biochem J (2009) 1.89
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radic Biol Med (2003) 1.87
No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects. PLoS Genet (2007) 1.82
Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J (2003) 1.79
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem (2012) 1.76
Ageing as a risk factor for disease. Curr Biol (2012) 1.71
Role of insulin-like signalling in Drosophila lifespan. Trends Biochem Sci (2007) 1.70
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell (2007) 1.69
The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda) (2011) 1.69
Reactive oxygen species production by mitochondria. Methods Mol Biol (2009) 1.69
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem (2001) 1.69
Sex differences in the effect of dietary restriction on life span and mortality rates in female and male Drosophila melanogaster. J Gerontol A Biol Sci Med Sci (2004) 1.67
Dietary restriction and aging: a unifying perspective. Cell Metab (2011) 1.67
The endosymbiont Wolbachia increases insulin/IGF-like signalling in Drosophila. Proc Biol Sci (2009) 1.63
dFOXO-independent effects of reduced insulin-like signaling in Drosophila. Aging Cell (2011) 1.62
Mitochondrial proton and electron leaks. Essays Biochem (2010) 1.62
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J Biol Chem (2003) 1.62
Genome-wide gene expression in response to parasitoid attack in Drosophila. Genome Biol (2005) 1.57
Lifespan extension by dietary restriction in female Drosophila melanogaster is not caused by a reduction in vitellogenesis or ovarian activity. Exp Gerontol (2004) 1.54
Effect of a standardised dietary restriction protocol on multiple laboratory strains of Drosophila melanogaster. PLoS One (2009) 1.53
New model of health promotion and disease prevention for the 21st century. BMJ (2008) 1.53
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci (2011) 1.50
Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice. Physiol Genomics (2006) 1.47
Insulin signaling is necessary for vitellogenesis in Drosophila melanogaster independent of the roles of juvenile hormone and ecdysteroids: female sterility of the chico1 insulin signaling mutation is autonomous to the ovary. J Insect Physiol (2005) 1.46
Dynamics of the action of dFOXO on adult mortality in Drosophila. Aging Cell (2007) 1.44
Endocrine regulation of aging and reproduction in Drosophila. Mol Cell Endocrinol (2008) 1.44
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol (2013) 1.44
DILP-producing median neurosecretory cells in the Drosophila brain mediate the response of lifespan to nutrition. Aging Cell (2010) 1.42
Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster. Exp Gerontol (2004) 1.39
Counting the calories: the role of specific nutrients in extension of life span by food restriction. J Gerontol A Biol Sci Med Sci (2005) 1.38
A longer and healthier life with TOR down-regulation: genetics and drugs. Biochem Soc Trans (2011) 1.38
The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem Sci (2009) 1.37
Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling. Mol Syst Biol (2011) 1.32
Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I). J Biol Chem (2011) 1.30
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem (2014) 1.29
Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci (2010) 1.29
QTL mapping reveals a striking coincidence in the positions of genomic regions associated with adaptive variation in body size in parallel clines of Drosophila melanogaster on different continents. Evolution (2003) 1.27
The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim Biophys Acta (2005) 1.27
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J (2008) 1.26
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene (2008) 1.26
Interpreting interactions between treatments that slow aging. Aging Cell (2002) 1.25
The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle. J Biol Chem (2011) 1.25
Mitochondrial uncoupling and lifespan. Mech Ageing Dev (2010) 1.24
Feeding, fecundity and lifespan in female Drosophila melanogaster. Proc Biol Sci (2008) 1.23
Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease. PLoS Genet (2010) 1.23
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J (2008) 1.23
Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production--a correction using glutathione depletion. FEBS J (2010) 1.21
Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria. Free Radic Biol Med (2010) 1.21
On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta (2008) 1.20
Patterns of diversity and linkage disequilibrium within the cosmopolitan inversion In(3R)Payne in Drosophila melanogaster are indicative of coadaptation. Genetics (2005) 1.20
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J (2002) 1.19
Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila. PLoS One (2012) 1.19
Diet, metabolism and lifespan in Drosophila. Exp Gerontol (2005) 1.17
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport. Biochim Biophys Acta (2008) 1.17
The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta (2010) 1.17
Science fact and the SENS agenda. What can we reasonably expect from ageing research? EMBO Rep (2005) 1.16
Mitochondrial uncouplers with an extraordinary dynamic range. Biochem J (2007) 1.16
No extension of lifespan by ablation of germ line in Drosophila. Proc Biol Sci (2006) 1.16
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Biochem J (2007) 1.15