Published in J Biol Chem on September 12, 2003
Effects of tempol and redox-cycling nitroxides in models of oxidative stress. Pharmacol Ther (2010) 1.66
Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res (2013) 1.48
Mitochondrial dysfunction and β-cell failure in type 2 diabetes mellitus. Exp Diabetes Res (2011) 1.25
Mitochondrial uncoupling and lifespan. Mech Ageing Dev (2010) 1.24
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J (2008) 1.23
Use of electron paramagnetic resonance spectroscopy to evaluate the redox state in vivo. Antioxid Redox Signal (2007) 1.22
Mitochondrial medicine for aging and neurodegenerative diseases. Neuromolecular Med (2008) 1.22
The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta (2010) 1.17
Mitochondrial longevity pathways. Biochim Biophys Acta (2011) 1.11
Mitochondrial targets for volatile anesthetics against cardiac ischemia-reperfusion injury. Front Physiol (2014) 1.10
Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study. J Gerontol A Biol Sci Med Sci (2007) 1.09
Mitochondrial oxidative damage in aging and Alzheimer's disease: implications for mitochondrially targeted antioxidant therapeutics. J Biomed Biotechnol (2006) 1.07
Mitochondria-targeted antioxidants for treatment of Parkinson's disease: preclinical and clinical outcomes. Biochim Biophys Acta (2013) 1.04
Accumulation of lipophilic dications by mitochondria and cells. Biochem J (2006) 1.04
Reduced coupling of oxidative phosphorylation in vivo precedes electron transport chain defects due to mild oxidative stress in mice. PLoS One (2011) 0.99
Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose. Biochem J (2006) 0.98
Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity. Endocrinology (2012) 0.97
Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Biochem J (2006) 0.95
Uncoupling proteins: role in insulin resistance and insulin insufficiency. Curr Diabetes Rev (2006) 0.93
The role of mitochondrial uncoupling proteins in lifespan. Pflugers Arch (2009) 0.93
Brain mitochondrial dysfunction in aging, neurodegeneration, and Parkinson's disease. Front Aging Neurosci (2010) 0.93
Mitochondria as a target in treatment. Environ Mol Mutagen (2010) 0.92
TGF-β1 stimulates mitochondrial oxidative phosphorylation and generation of reactive oxygen species in cultured mouse podocytes, mediated in part by the mTOR pathway. Am J Physiol Renal Physiol (2013) 0.92
Lipophilic triphenylphosphonium cations inhibit mitochondrial electron transport chain and induce mitochondrial proton leak. PLoS One (2015) 0.90
Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal (2015) 0.89
Metabolic depression and increased reactive oxygen species production by isolated mitochondria at moderately lower temperatures. J Biol Chem (2010) 0.89
P-glycoprotein (Mdr1a/1b) and breast cancer resistance protein (Bcrp) decrease the uptake of hydrophobic alkyl triphenylphosphonium cations by the brain. Biochim Biophys Acta (2013) 0.89
Calcium and reactive oxygen species in acute pancreatitis: friend or foe? Antioxid Redox Signal (2011) 0.87
Potential implication of the chemical properties and bioactivity of nitrone spin traps for therapeutics. Future Med Chem (2012) 0.86
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev (2015) 0.86
Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection. J Bioenerg Biomembr (2014) 0.85
Ubiquinone is not required for proton conductance by uncoupling protein 1 in yeast mitochondria. Biochem J (2004) 0.85
Cardiac metabolism in hypertrophy and heart failure: implications for therapy. Heart Fail Rev (2013) 0.85
Reactive oxygen and nitrogen species in steatotic hepatocytes: a molecular perspective on the pathophysiology of ischemia-reperfusion injury in the fatty liver. Antioxid Redox Signal (2014) 0.84
An Intimate Relationship between ROS and Insulin Signalling: Implications for Antioxidant Treatment of Fatty Liver Disease. Int J Cell Biol (2014) 0.84
Nitrones for understanding and ameliorating the oxidative stress associated with aging. Age (Dordr) (2009) 0.84
Making heads or tails of mitochondrial membranes in longevity and aging: a role for comparative studies. Longev Healthspan (2014) 0.83
Synthesis of a mitochondria-targeted spin trap using a novel Parham-type cyclization. Tetrahedron (2009) 0.83
Mitochondrial function in hypoxic ischemic injury and influence of aging. Prog Neurobiol (2016) 0.83
Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation. Am J Physiol Gastrointest Liver Physiol (2011) 0.82
A transient increase in lipid peroxidation primes preadipocytes for delayed mitochondrial inner membrane permeabilization and ATP depletion during prolonged exposure to fatty acids. Free Radic Biol Med (2013) 0.81
Targeted nanoparticles in mitochondrial medicine. Wiley Interdiscip Rev Nanomed Nanobiotechnol (2014) 0.81
Mitochondrial Dysfunction in Alzheimer's Disease and the Rationale for Bioenergetics Based Therapies. Aging Dis (2016) 0.81
Synthesis of N-arylpyridinium salts bearing a nitrone spin trap as potential mitochondria-targeted antioxidants. Tetrahedron (2009) 0.81
Targeted delivery of radioprotective agents to mitochondria. Mol Interv (2008) 0.81
The role of peroxidation of mitochondrial membrane phospholipids in pancreatic β -cell failure. Curr Diabetes Rev (2012) 0.80
Molecular design of new inhibitors of peroxidase activity of cytochrome c/cardiolipin complexes: fluorescent oxadiazole-derivatized cardiolipin. Biochemistry (2008) 0.80
Channel character of uncoupling protein-mediated transport. FEBS Lett (2010) 0.79
Loss of Intralipid®- but not sevoflurane-mediated cardioprotection in early type-2 diabetic hearts of fructose-fed rats: importance of ROS signaling. PLoS One (2014) 0.79
UCP2 and ANT differently modulate proton-leak in brain mitochondria of long-term hyperglycemic and recurrent hypoglycemic rats. J Bioenerg Biomembr (2013) 0.78
Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak. PLoS One (2014) 0.77
Delphinidin-3-glucoside protects against oxidized low-density lipoprotein-induced mitochondrial dysfunction in vascular endothelial cells via the sodium-dependent glucose transporter SGLT1. PLoS One (2013) 0.77
Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. Chem Rev (2017) 0.76
Transport pathways--proton motive force interrelationship in durum wheat mitochondria. Int J Mol Sci (2014) 0.76
Metabolic manipulators: a well founded strategy to combat mitochondrial dysfunction. J Inherit Metab Dis (2010) 0.76
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells. Sci Rep (2016) 0.76
Hydroxynonenal, a lipid peroxidation end product, stimulates uncoupling protein activity in Acanthamoeba castellanii mitochondria; the sensitivity of the inducible activity to purine nucleotides depends on the membranous ubiquinone redox state. J Bioenerg Biomembr (2012) 0.76
Uncoupling Protein, UCP-4 May Be Involved in Neuronal Defects During Aging and Resistance to Pathogens in Caenorhabditis elegans. Mol Cells (2016) 0.75
N-[2-(2-Methoxyphenyl)benzylidene]-tert-butyl-amine N-oxide. Acta Crystallogr Sect E Struct Rep Online (2008) 0.75
Oleate induces KATP channel-dependent hyperpolarisation in mouse hypothalamic glucose-excited neurones without altering cellular energy charge. Neuroscience (2017) 0.75
Reactivities of substituted α-phenyl-N-tert-butyl nitrones. J Org Chem (2014) 0.75
The role of UCP2 and ADP/ATP antiporter in superoxide radical-induced uncoupling in kidney mitochondria. Dokl Biochem Biophys (2009) 0.75
Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. Alcohol Clin Exp Res (2017) 0.75
trans,trans-2,4-decadienal induces mitochondrial dysfunction and oxidative stress. J Bioenerg Biomembr (2008) 0.75
Functional impact of global rare copy number variation in autism spectrum disorders. Nature (2010) 14.66
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31
Targeting antioxidants to mitochondria by conjugation to lipophilic cations. Annu Rev Pharmacol Toxicol (2007) 4.16
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med (2004) 3.85
A genome-wide scan for common alleles affecting risk for autism. Hum Mol Genet (2010) 3.42
Global iron-dependent gene regulation in Escherichia coli. A new mechanism for iron homeostasis. J Biol Chem (2003) 3.39
Feedback between p21 and reactive oxygen production is necessary for cell senescence. Mol Syst Biol (2010) 3.27
Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I. Nat Med (2013) 3.10
Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem (2009) 2.86
High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One (2011) 2.82
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell (2004) 2.60
Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem J (2004) 2.49
Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Hum Mol Genet (2012) 2.46
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J (2003) 2.43
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem (2004) 2.42
Targeting an antioxidant to mitochondria decreases cardiac ischemia-reperfusion injury. FASEB J (2005) 2.33
Mitochondria-targeted antioxidant MitoQ10 improves endothelial function and attenuates cardiac hypertrophy. Hypertension (2009) 2.28
Reversible glutathionylation of complex I increases mitochondrial superoxide formation. J Biol Chem (2003) 2.28
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Glutaredoxin 2 catalyzes the reversible oxidation and glutathionylation of mitochondrial membrane thiol proteins: implications for mitochondrial redox regulation and antioxidant DEFENSE. J Biol Chem (2004) 1.99
A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia. Nat Genet (2008) 1.97
Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radic Biol Med (2003) 1.87
Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production. Biochem Soc Symp (2004) 1.82
Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J (2003) 1.79
A mitochondria-targeted S-nitrosothiol modulates respiration, nitrosates thiols, and protects against ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2009) 1.78
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem (2012) 1.76
A double-blind, placebo-controlled study to assess the mitochondria-targeted antioxidant MitoQ as a disease-modifying therapy in Parkinson's disease. Mov Disord (2010) 1.72
Mitochondria-targeted antioxidants protect Friedreich Ataxia fibroblasts from endogenous oxidative stress more effectively than untargeted antioxidants. FASEB J (2003) 1.70
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell (2007) 1.69
The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda) (2011) 1.69
Reactive oxygen species production by mitochondria. Methods Mol Biol (2009) 1.69
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem (2001) 1.69
Mitochondrial proton and electron leaks. Essays Biochem (2010) 1.62
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes. Proc Natl Acad Sci U S A (2003) 1.56
A mitochondria-targeted macrocyclic Mn(II) superoxide dismutase mimetic. Chem Biol (2012) 1.55
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients. Liver Int (2010) 1.54
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci (2011) 1.50
Adult-onset, short-term dietary restriction reduces cell senescence in mice. Aging (Albany NY) (2010) 1.45
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol (2013) 1.44
A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Hum Genet (2011) 1.43
Nitric oxide inhibition of respiration involves both competitive (heme) and noncompetitive (copper) binding to cytochrome c oxidase. Proc Natl Acad Sci U S A (2006) 1.42
Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant. FEBS Lett (2004) 1.38
Mutations in FBXL4 cause mitochondrial encephalopathy and a disorder of mitochondrial DNA maintenance. Am J Hum Genet (2013) 1.37
The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem Sci (2009) 1.37
Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response. Aging Cell (2012) 1.35
A family of putative transcription termination factors shared amongst metazoans and plants. Curr Genet (2005) 1.33
Antioxidant properties of MitoTEMPOL and its hydroxylamine. Free Radic Res (2009) 1.31
Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I). J Biol Chem (2011) 1.30
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem (2014) 1.29
Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci (2010) 1.29
Rapid and extensive uptake and activation of hydrophobic triphenylphosphonium cations within cells. Biochem J (2008) 1.28
The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim Biophys Acta (2005) 1.27
The radical and redox chemistry of myoglobin and hemoglobin: from in vitro studies to human pathology. Antioxid Redox Signal (2004) 1.27
Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice. Free Radic Biol Med (2009) 1.26
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene (2008) 1.26
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J (2008) 1.26
The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle. J Biol Chem (2011) 1.25
A mitochondria-targeted nitroxide is reduced to its hydroxylamine by ubiquinol in mitochondria. Free Radic Biol Med (2008) 1.24
Mitochondrial uncoupling and lifespan. Mech Ageing Dev (2010) 1.24
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J (2008) 1.23
Relationship between brain tissue haemodynamics, oxygenation and metabolism in the healthy human adult brain during hyperoxia and hypercapnea. Adv Exp Med Biol (2009) 1.21
Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production--a correction using glutathione depletion. FEBS J (2010) 1.21
Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G. Basic Res Cardiol (2013) 1.21
Antioxidant and prooxidant properties of mitochondrial Coenzyme Q. Arch Biochem Biophys (2004) 1.21
Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria. Free Radic Biol Med (2010) 1.21
On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta (2008) 1.20
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J (2002) 1.19
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem J (2002) 1.18
Specific modification of mitochondrial protein thiols in response to oxidative stress: a proteomics approach. J Biol Chem (2002) 1.18
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport. Biochim Biophys Acta (2008) 1.17
The regulation and turnover of mitochondrial uncoupling proteins. Biochim Biophys Acta (2010) 1.17
Interaction of the mitochondria-targeted antioxidant MitoQ with phospholipid bilayers and ubiquinone oxidoreductases. J Biol Chem (2007) 1.16
Mitochondrial uncouplers with an extraordinary dynamic range. Biochem J (2007) 1.16
Mitochondrial targeting of vitamin E succinate enhances its pro-apoptotic and anti-cancer activity via mitochondrial complex II. J Biol Chem (2010) 1.16
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Biochem J (2007) 1.15
The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria. Biochim Biophys Acta (2005) 1.15
Singlet Oxygen Sensor Green®: photochemical behavior in solution and in a mammalian cell. Photochem Photobiol (2011) 1.15