Published in Biochim Biophys Acta on March 06, 2010
Redox regulation of mitochondrial function. Antioxid Redox Signal (2012) 1.34
Oxidative stress induces mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines in a well-matched case control cohort. PLoS One (2014) 1.20
Cellular model of Warburg effect identifies tumor promoting function of UCP2 in breast cancer and its suppression by genipin. PLoS One (2011) 1.16
Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines. Transl Psychiatry (2014) 1.11
Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. PLoS One (2010) 1.09
The mitochondrial component of intracrine action. Am J Physiol Heart Circ Physiol (2010) 1.03
Insulin resistance improves metabolic and contractile efficiency in stressed rat heart. FASEB J (2012) 0.94
Mitochondrial reprogramming induced by CaMKIIδ mediates hypertrophy decompensation. Circ Res (2015) 0.89
Mitochondrial oxidative metabolism and uncoupling proteins in the failing heart. Heart Fail Rev (2015) 0.86
Long-term treatment with the pan-PPAR agonist tetradecylthioacetic acid or fish oil is associated with increased cardiac content of n-3 fatty acids in rat. Lipids Health Dis (2012) 0.84
Gene Polymorphisms of ADIPOQ +45T>G, UCP2 -866G>A, and FABP2 Ala54Thr on the Risk of Colorectal Cancer: A Matched Case-Control Study. PLoS One (2013) 0.84
Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K. PLoS One (2012) 0.84
Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart. Cardiovasc Diabetol (2013) 0.83
Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2. Sci Signal (2015) 0.83
Complex formation and turnover of mitochondrial transporters and ion channels. J Bioenerg Biomembr (2016) 0.82
Accumulation of newly synthesized F1 in vivo in arabidopsis mitochondria provides evidence for modular assembly of the plant F1Fo ATP synthase. J Biol Chem (2012) 0.82
Therapeutic phytogenic compounds for obesity and diabetes. Int J Mol Sci (2014) 0.79
Arabidopsis thaliana uncoupling proteins (AtUCPs): insights into gene expression during development and stress response and epigenetic regulation. J Bioenerg Biomembr (2011) 0.79
Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study. FASEB J (2016) 0.78
A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. PLoS One (2012) 0.77
Control mechanisms in mitochondrial oxidative phosphorylation. Neural Regen Res (2013) 0.76
In utero exposure to benzo[a]pyrene increases adiposity and causes hepatic steatosis in female mice, and glutathione deficiency is protective. Toxicol Lett (2013) 0.76
Isoproterenol Increases Uncoupling, Glycolysis, and Markers of Beiging in Mature 3T3-L1 Adipocytes. PLoS One (2015) 0.75
Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes. Biomed Res Int (2016) 0.75
Mitochondrial Gene Expression Profiles Are Associated with Maternal Psychosocial Stress in Pregnancy and Infant Temperament. PLoS One (2015) 0.75
Tempol protects cardiomyocytes from nucleoside reverse transcriptase inhibitor-induced mitochondrial toxicity. Toxicol Sci (2014) 0.75
MSL1 is a mechanosensitive ion channel that dissipates mitochondrial membrane potential and maintains redox homeostasis in mitochondria during abiotic stress. Plant J (2016) 0.75
Common UCP2 variants contribute to serum urate concentrations and the risk of hyperuricemia. Sci Rep (2016) 0.75
Increased susceptibility to ethylmercury-induced mitochondrial dysfunction in a subset of autism lymphoblastoid cell lines. J Toxicol (2015) 0.75
Cytoprotective Effect of the UCP2-SIRT3 Signaling Pathway by Decreasing Mitochondrial Oxidative Stress on Cerebral Ischemia-Reperfusion Injury. Int J Mol Sci (2017) 0.75
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality. Cell Metab (2009) 8.16
Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese. Nature (1997) 6.73
Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet (1997) 5.54
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells. PLoS Biol (2005) 5.54
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet (2000) 5.42
Thermogenic mechanisms in brown fat. Physiol Rev (1984) 5.34
High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett (1997) 5.21
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell (2001) 5.13
Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature (2007) 4.20
Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med (2004) 3.85
Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab (2005) 3.49
Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett (1997) 3.11
A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J (1997) 2.56
Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem J (2004) 2.49
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J (2003) 2.43
Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem (2000) 2.36
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest (2003) 2.35
Only UCP1 can mediate adaptive nonshivering thermogenesis in the cold. FASEB J (2001) 2.34
Proteolytic and lipolytic responses to starvation. Nutrition (2006) 2.33
Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab (2006) 2.25
Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem (1997) 2.06
The basal proton conductance of mitochondria depends on adenine nucleotide translocase content. Biochem J (2005) 2.05
Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance. J Clin Invest (2007) 1.91
Learning new tricks from old dogs: beta-adrenergic receptors teach new lessons on firing up adipose tissue metabolism. Mol Endocrinol (2004) 1.88
Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3. J Biol Chem (2000) 1.86
Brown-adipose-tissue mitochondria: photoaffinity labelling of the regulatory site of energy dissipation. Eur J Biochem (1978) 1.80
Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes (2008) 1.78
Characterization of a novel metabolic strategy used by drug-resistant tumor cells. FASEB J (2002) 1.76
UCP1 is essential for adaptive adrenergic nonshivering thermogenesis. Am J Physiol Endocrinol Metab (2006) 1.76
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action. Diabetes (2001) 1.74
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology (2009) 1.71
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem (2001) 1.69
Uncoupling proteins 2 and 3 are highly active H(+) transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone). Proc Natl Acad Sci U S A (2001) 1.67
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J Biol Chem (2003) 1.62
Reduced skeletal muscle uncoupling protein-3 content in prediabetic subjects and type 2 diabetic patients: restoration by rosiglitazone treatment. J Clin Endocrinol Metab (2005) 1.58
Generating, partitioning, targeting and functioning of superoxide in mitochondria. Biosci Rep (1997) 1.57
Regulation of UCP1 and UCP3 in arctic ground squirrels and relation with mitochondrial proton leak. J Appl Physiol (1985) (2006) 1.56
A significant portion of mitochondrial proton leak in intact thymocytes depends on expression of UCP2. Proc Natl Acad Sci U S A (2001) 1.55
Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3. Diabetes (2008) 1.55
Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J Biol Chem (2004) 1.53
Protective role of uncoupling protein 2 in atherosclerosis. Circulation (2003) 1.48
No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem (2002) 1.40
Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation. FASEB J (2005) 1.39
UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett (1999) 1.38
The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem Sci (2009) 1.37
Physiological role of UCP3 may be export of fatty acids from mitochondria when fatty acid oxidation predominates: an hypothesis. Exp Biol Med (Maywood) (2001) 1.36
On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J Biol Chem (1996) 1.35
The physiological regulation of uncoupling proteins. Biochim Biophys Acta (2006) 1.33
Physiological increases in uncoupling protein 3 augment fatty acid oxidation and decrease reactive oxygen species production without uncoupling respiration in muscle cells. Diabetes (2005) 1.31
UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing. Biochim Biophys Acta (2009) 1.30
Mitochondrial reactive oxygen species are required for hypothalamic glucose sensing. Diabetes (2006) 1.30
Uncoupling proteins: a role in protection against reactive oxygen species--or not? Biochim Biophys Acta (2006) 1.30
Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci (2010) 1.29
The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim Biophys Acta (2005) 1.27
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J (2008) 1.26
Amino acid metabolism, insulin secretion and diabetes. Biochem Soc Trans (2007) 1.25
The physiological significance of mitochondrial proton leak in animal cells and tissues. Biosci Rep (1997) 1.24
Uncoupling protein-2 participates in cellular defense against oxidative stress in clonal beta-cells. Biochem Biophys Res Commun (2001) 1.24
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J (2008) 1.23
Uncoupling protein 1 in fish uncovers an ancient evolutionary history of mammalian nonshivering thermogenesis. Physiol Genomics (2005) 1.20
On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta (2008) 1.20
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J (2002) 1.19
The uncoupling protein 2 modulates the cytokine balance in innate immunity. Cytokine (2006) 1.19
Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export. J Biol Chem (2008) 1.19
The reconstituted isolated uncoupling protein is a membrane potential driven H+ translocator. EMBO J (1985) 1.18
Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3. Biochem J (2002) 1.18
Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool. Biochem J (1992) 1.17
Inhibition of UCP2 expression reverses diet-induced diabetes mellitus by effects on both insulin secretion and action. FASEB J (2007) 1.17
Pharmacology: uncoupling the agony from ecstasy. Nature (2003) 1.17
Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria. Eur J Biochem (1982) 1.13
Reduced antioxidant capacity and diet-induced atherosclerosis in uncoupling protein-2-deficient mice. J Lipid Res (2008) 1.11
UCP2 is a mitochondrial transporter with an unusual very short half-life. FEBS Lett (2007) 1.11
Stronger control of ATP/ADP by proton leak in pancreatic beta-cells than skeletal muscle mitochondria. Biochem J (2006) 1.10
UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci U S A (2008) 1.09
Functional relationship between MyoD and peroxisome proliferator-activated receptor-dependent regulatory pathways in the control of the human uncoupling protein-3 gene transcription. Mol Endocrinol (2003) 1.08
Role of ubiquitin-proteasome degradation pathway in biogenesis efficiency of {beta}-cell ATP-sensitive potassium channels. Am J Physiol Cell Physiol (2005) 1.08
Role of uncoupling protein UCP2 in cell-mediated immunity: how macrophage-mediated insulitis is accelerated in a model of autoimmune diabetes. Proc Natl Acad Sci U S A (2007) 1.07
Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism? Prog Lipid Res (2005) 1.06
Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion. J Biol Chem (2006) 1.05
A history of UCP1. Biochem Soc Trans (2001) 1.05
Regulation of the third member of the uncoupling protein family, UCP3, by cold and thyroid hormone. Biochem Biophys Res Commun (1997) 1.03
Proteasome inhibition alters glucose-stimulated (pro)insulin secretion and turnover in pancreatic {beta}-cells. J Biol Chem (2005) 1.03
A 211-bp enhancer of the rat uncoupling protein-1 (UCP-1) gene controls specific and regulated expression in brown adipose tissue. Biochem J (1998) 1.02
Glutamine stimulates translation of uncoupling protein 2mRNA. Cell Mol Life Sci (2007) 1.02
Mitochondrial uncoupling protein 3 and its role in cardiac- and skeletal muscle metabolism. Physiol Behav (2007) 1.01
Uncoupling protein-2 accumulates rapidly in the inner mitochondrial membrane during mitochondrial reactive oxygen stress in macrophages. Biochim Biophys Acta (2007) 1.00
Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochim Biophys Acta (2008) 0.99
Participation of ATP/ADP antiporter in oleate- and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate. Biochim Biophys Acta (2006) 0.99
Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle. Diabetologia (2003) 0.98
Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J Biol Chem (2001) 0.97
Uncoupling protein-3 expression in rodent skeletal muscle is modulated by food intake but not by changes in environmental temperature. J Biol Chem (1998) 0.96
Rapid turnover of mitochondrial uncoupling protein 3. Biochem J (2010) 0.96
Novel uncoupling proteins. Novartis Found Symp (2007) 0.96
Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J Comp Physiol B (2007) 0.95
Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Biochem J (2006) 0.95
Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria. J Bioenerg Biomembr (2009) 0.95
Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis. BMC Evol Biol (2009) 0.95
Enhanced colon tumor induction in uncoupling protein-2 deficient mice is associated with NF-kappaB activation and oxidative stress. Carcinogenesis (2006) 0.94
Superoxide activates mitochondrial uncoupling proteins. Nature (2002) 5.43
Topology of superoxide production from different sites in the mitochondrial electron transport chain. J Biol Chem (2002) 5.31
Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem (2009) 2.86
High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria. PLoS One (2011) 2.82
Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer. Aging Cell (2004) 2.60
Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane. Biochem J (2004) 2.49
A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J (2003) 2.43
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem (2004) 2.42
Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes. Diabetes (2004) 2.08
Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J Biol Chem (2002) 2.04
Superoxide and hydrogen peroxide production by Drosophila mitochondria. Free Radic Biol Med (2003) 1.87
Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J (2003) 1.79
Mitochondrial complex II can generate reactive oxygen species at high rates in both the forward and reverse reactions. J Biol Chem (2012) 1.76
Identification of proliferative and mature β-cells in the islets of Langerhans. Nature (2016) 1.71
Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell (2007) 1.69
The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda) (2011) 1.69
Reactive oxygen species production by mitochondria. Methods Mol Biol (2009) 1.69
The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3. J Biol Chem (2001) 1.69
Mitochondrial proton and electron leaks. Essays Biochem (2010) 1.62
Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J Biol Chem (2003) 1.62
A reduction in ATP demand and mitochondrial activity with neural differentiation of human embryonic stem cells. J Cell Sci (2011) 1.50
Sites of reactive oxygen species generation by mitochondria oxidizing different substrates. Redox Biol (2013) 1.44
The on-off switches of the mitochondrial uncoupling proteins. Trends Biochem Sci (2009) 1.37
Evidence for two sites of superoxide production by mitochondrial NADH-ubiquinone oxidoreductase (complex I). J Biol Chem (2011) 1.30
The 2-oxoacid dehydrogenase complexes in mitochondria can produce superoxide/hydrogen peroxide at much higher rates than complex I. J Biol Chem (2014) 1.29
Degradation of an intramitochondrial protein by the cytosolic proteasome. J Cell Sci (2010) 1.29
The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim Biophys Acta (2005) 1.27
Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion. Biochem J (2008) 1.26
Experimental assessment of bioenergetic differences caused by the common European mitochondrial DNA haplogroups H and T. Gene (2008) 1.26
The mechanism of superoxide production by the antimycin-inhibited mitochondrial Q-cycle. J Biol Chem (2011) 1.25
Mitochondrial uncoupling and lifespan. Mech Ageing Dev (2010) 1.24
Energization-dependent endogenous activation of proton conductance in skeletal muscle mitochondria. Biochem J (2008) 1.23
Hydrogen peroxide efflux from muscle mitochondria underestimates matrix superoxide production--a correction using glutathione depletion. FEBS J (2010) 1.21
Skeletal muscle mitochondrial uncoupling drives endocrine cross-talk through the induction of FGF21 as a myokine. Am J Physiol Endocrinol Metab (2013) 1.21
Uncoupling protein-3 lowers reactive oxygen species production in isolated mitochondria. Free Radic Biol Med (2010) 1.21
Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins. PLoS One (2013) 1.21
On the role of uncoupling protein-2 in pancreatic beta cells. Biochim Biophys Acta (2008) 1.20
Artifactual uncoupling by uncoupling protein 3 in yeast mitochondria at the concentrations found in mouse and rat skeletal-muscle mitochondria. Biochem J (2002) 1.19
Adaptive thermogenesis and thermal conductance in wild-type and UCP1-KO mice. Am J Physiol Regul Integr Comp Physiol (2010) 1.18
UCPs--unlikely calcium porters. Nat Cell Biol (2008) 1.17
Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport. Biochim Biophys Acta (2008) 1.17
Mitochondrial uncouplers with an extraordinary dynamic range. Biochem J (2007) 1.16
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines. Biochem J (2007) 1.15
The topology of superoxide production by complex III and glycerol 3-phosphate dehydrogenase in Drosophila mitochondria. Biochim Biophys Acta (2005) 1.15
Uncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins. J Physiol (2004) 1.14
The efficiency of cellular energy transduction and its implications for obesity. Annu Rev Nutr (2008) 1.14
A refined analysis of superoxide production by mitochondrial sn-glycerol 3-phosphate dehydrogenase. J Biol Chem (2012) 1.12
Native rates of superoxide production from multiple sites in isolated mitochondria measured using endogenous reporters. Free Radic Biol Med (2012) 1.12
Measurement of proton leak and electron leak in isolated mitochondria. Methods Mol Biol (2012) 1.11
Stronger control of ATP/ADP by proton leak in pancreatic beta-cells than skeletal muscle mitochondria. Biochem J (2006) 1.10
Stimulation of mitochondrial proton conductance by hydroxynonenal requires a high membrane potential. Biosci Rep (2008) 1.09
Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium-induced de- and hyperpolarization of neuronal mitochondria. J Physiol (2012) 1.07
Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med (2010) 1.07
p62 links β-adrenergic input to mitochondrial function and thermogenesis. J Clin Invest (2012) 1.07
Measuring mitochondrial bioenergetics in INS-1E insulinoma cells. Methods Enzymol (2009) 1.06
Hydroxynonenal and uncoupling proteins: a model for protection against oxidative damage. Biofactors (2005) 1.06
Transcript and metabolite analysis of the effects of tamoxifen in rat liver reveals inhibition of fatty acid synthesis in the presence of hepatic steatosis. FASEB J (2005) 1.06
Dissociation of superoxide production by mitochondrial complex I from NAD(P)H redox state. FEBS Lett (2008) 1.04
Wolfram Syndrome protein, Miner1, regulates sulphydryl redox status, the unfolded protein response, and Ca2+ homeostasis. EMBO Mol Med (2013) 1.04
Flight activity, mortality rates, and lipoxidative damage in Drosophila. J Gerontol A Biol Sci Med Sci (2006) 1.03
Uncoupling protein 1 decreases superoxide production in brown adipose tissue mitochondria. J Biol Chem (2010) 1.02
The effect of dietary restriction on mitochondrial protein density and flight muscle mitochondrial morphology in Drosophila. J Gerontol A Biol Sci Med Sci (2006) 1.02
Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann N Y Acad Sci (2004) 1.02
High membrane potential promotes alkenal-induced mitochondrial uncoupling and influences adenine nucleotide translocase conformation. Biochem J (2008) 1.02
Superoxide stimulates a proton leak in potato mitochondria that is related to the activity of uncoupling protein. J Biol Chem (2003) 1.01
Compromised mitochondrial fatty acid synthesis in transgenic mice results in defective protein lipoylation and energy disequilibrium. PLoS One (2012) 1.00
Real-time visualization of cytoplasmic calpain activation and calcium deregulation in acute glutamate excitotoxicity. J Neurochem (2009) 1.00
Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells. Biochim Biophys Acta (2008) 0.99
Brown fat in a protoendothermic mammal fuels eutherian evolution. Nat Commun (2013) 0.98
Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3. FEBS Lett (2004) 0.97
Novel uncoupling proteins. Novartis Found Symp (2007) 0.96
Rapid turnover of mitochondrial uncoupling protein 3. Biochem J (2010) 0.96
4-hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production. Redox Rep (2007) 0.96
Research on mitochondria and aging, 2006-2007. Aging Cell (2007) 0.95
Leptin-mediated changes in hepatic mitochondrial metabolism, structure, and protein levels. Proc Natl Acad Sci U S A (2009) 0.95
Uncoupling protein-1 (UCP1) contributes to the basal proton conductance of brown adipose tissue mitochondria. J Bioenerg Biomembr (2009) 0.95
Functional characterisation of UCP1 in the common carp: uncoupling activity in liver mitochondria and cold-induced expression in the brain. J Comp Physiol B (2007) 0.95
Synergy of fatty acid and reactive alkenal activation of proton conductance through uncoupling protein 1 in mitochondria. Biochem J (2006) 0.95
Low complex I content explains the low hydrogen peroxide production rate of heart mitochondria from the long-lived pigeon, Columba livia. Aging Cell (2009) 0.95
Molecular evolution of UCP1 and the evolutionary history of mammalian non-shivering thermogenesis. BMC Evol Biol (2009) 0.95
Spare mitochondrial respiratory capacity permits human adipocytes to maintain ATP homeostasis under hypoglycemic conditions. FASEB J (2013) 0.94
Intrinsic bioenergetic properties and stress sensitivity of dopaminergic synaptosomes. J Neurosci (2011) 0.94
Uncoupling protein 3 protects aconitase against inactivation in isolated skeletal muscle mitochondria. Biochim Biophys Acta (2005) 0.93
A model of the proton translocation mechanism of complex I. J Biol Chem (2011) 0.93
Plasticity of oxidative metabolism in variable climates: molecular mechanisms. Physiol Biochem Zool (2010) 0.93
Tissue-specific depression of mitochondrial proton leak and substrate oxidation in hibernating arctic ground squirrels. Am J Physiol Regul Integr Comp Physiol (2003) 0.92
Plasma membrane potential oscillations in insulin secreting Ins-1 832/13 cells do not require glycolysis and are not initiated by fluctuations in mitochondrial bioenergetics. J Biol Chem (2012) 0.91
UCP1 ectopically expressed in murine muscle displays native function and mitigates mitochondrial superoxide production. Biochim Biophys Acta (2009) 0.91
Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening. Free Radic Biol Med (2013) 0.91
Targeting dinitrophenol to mitochondria: limitations to the development of a self-limiting mitochondrial protonophore. Biosci Rep (2006) 0.90
The molecular and biochemical basis of nonshivering thermogenesis in an African endemic mammal, Elephantulus myurus. Am J Physiol Regul Integr Comp Physiol (2007) 0.89
The determination and analysis of site-specific rates of mitochondrial reactive oxygen species production. Methods Enzymol (2013) 0.89
Superoxide activates a GDP-sensitive proton conductance in skeletal muscle mitochondria from king penguin (Aptenodytes patagonicus). Biochem Biophys Res Commun (2003) 0.88
Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis Rheum (2003) 0.88
Walking the oxidative stress tightrope: a perspective from the naked mole-rat, the longest-living rodent. Curr Pharm Des (2011) 0.88