Published in Proc Natl Acad Sci U S A on July 09, 2004
PPAR delta: a dagger in the heart of the metabolic syndrome. J Clin Invest (2006) 3.17
PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proc Natl Acad Sci U S A (2010) 1.71
Regulation of exercise-induced fiber type transformation, mitochondrial biogenesis, and angiogenesis in skeletal muscle. J Appl Physiol (1985) (2010) 1.67
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab (2010) 1.56
The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle. Cell Metab (2007) 1.54
Mechanisms of specificity in neuronal activity-regulated gene transcription. Prog Neurobiol (2011) 1.49
Functional overload in ground squirrel plantaris muscle fails to induce myosin isoform shifts. Am J Physiol Regul Integr Comp Physiol (2009) 1.45
p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice. PLoS One (2009) 1.41
Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics. Physiol Rep (2016) 1.40
NFAT isoforms control activity-dependent muscle fiber type specification. Proc Natl Acad Sci U S A (2009) 1.33
Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise. Biol Rev Camb Philos Soc (2010) 1.23
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev (2005) 1.13
Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle. J Physiol (2009) 1.11
Increased fatigue resistance linked to Ca2+-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice. J Physiol (2010) 1.10
Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn (2013) 1.09
Genome-wide DNA methylation changes with age in disease-free human skeletal muscle. Aging Cell (2013) 1.08
Toll-like receptors differentially regulate CC and CXC chemokines in skeletal muscle via NF-kappaB and calcineurin. Infect Immun (2006) 1.07
Differential integration of Ca2+-calmodulin signal in intact ventricular myocytes at low and high affinity Ca2+-calmodulin targets. J Biol Chem (2008) 1.06
Pharmacological activation of PPARbeta promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2008) 1.06
The denervated muscle: facts and hypotheses. A historical review. Eur J Appl Physiol (2006) 1.04
Cooperative synergy between NFAT and MyoD regulates myogenin expression and myogenesis. J Biol Chem (2008) 1.01
Activity-dependent repression of muscle genes by NFAT. Proc Natl Acad Sci U S A (2008) 1.00
Genetic disruption of calcineurin improves skeletal muscle pathology and cardiac disease in a mouse model of limb-girdle muscular dystrophy. J Biol Chem (2007) 1.00
A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. J Cell Biol (2007) 0.99
Restoration versus reconstruction: cellular mechanisms of skin, nerve and muscle regeneration compared. Regen Med Res (2013) 0.97
Overexpression of SERCA1a in the mdx diaphragm reduces susceptibility to contraction-induced damage. Hum Gene Ther (2010) 0.96
Extracellular signal-regulated kinase 1/2-mediated phosphorylation of p300 enhances myosin heavy chain I/beta gene expression via acetylation of nuclear factor of activated T cells c1. Nucleic Acids Res (2011) 0.92
Arpp/Ankrd2, a member of the muscle ankyrin repeat proteins (MARPs), translocates from the I-band to the nucleus after muscle injury. Histochem Cell Biol (2007) 0.90
A role for Insulin-like growth factor 2 in specification of the fast skeletal muscle fibre. BMC Dev Biol (2007) 0.89
Mycobacterium bovis bacillus Calmette-Guerin induces CCL5 secretion via the Toll-like receptor 2-NF-kappaB and -Jun N-terminal kinase signaling pathways. Clin Vaccine Immunol (2007) 0.88
Imaging transcription in vivo: distinct regulatory effects of fast and slow activity patterns on promoter elements from vertebrate troponin I isoform genes. J Physiol (2004) 0.88
Calcineurin inhibition and new-onset diabetes mellitus after transplantation. Transplantation (2013) 0.87
Transcription factors in muscle atrophy caused by blocked neuromuscular transmission and muscle unloading in rats. Mol Med (2007) 0.87
DNA binding sites target nuclear NFATc1 to heterochromatin regions in adult skeletal muscle fibers. Histochem Cell Biol (2010) 0.86
The calcineurin-NFAT pathway controls activity-dependent circadian gene expression in slow skeletal muscle. Mol Metab (2015) 0.86
Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle. Exp Biol Med (Maywood) (2012) 0.83
Lineage-based primary muscle fiber type diversification independent of MEF2 and NFAT in chick embryos. J Muscle Res Cell Motil (2011) 0.83
Acute molecular response of mouse hindlimb muscles to chronic stimulation. Am J Physiol Cell Physiol (2009) 0.83
DNA methylation dynamics in muscle development and disease. Front Aging Neurosci (2015) 0.83
NFATc1 controls skeletal muscle fiber type and is a negative regulator of MyoD activity. Cell Rep (2014) 0.83
Transcription Factor EB Controls Metabolic Flexibility during Exercise. Cell Metab (2016) 0.81
GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells. BMC Mol Biol (2007) 0.80
The Response of Denervated Muscle to Long-Term Stimulation (1985, Revisited here in 2014). Eur J Transl Myol (2014) 0.80
Heart failure alters MyoD and MRF4 expressions in rat skeletal muscle. Int J Exp Pathol (2006) 0.79
Maintenance of slow type I myosin protein and mRNA expression in overwintering prairie dogs (Cynomys leucurus and ludovicianus) and black bears (Ursus americanus). J Comp Physiol B (2006) 0.78
Bursting into the nucleus. Sci Signal (2008) 0.78
Protein kinase C theta (PKCθ) modulates the ClC-1 chloride channel activity and skeletal muscle phenotype: a biophysical and gene expression study in mouse models lacking the PKCθ. Pflugers Arch (2014) 0.78
Regulation of jaw-specific isoforms of myosin-binding protein-C and tropomyosin in regenerating cat temporalis muscle innervated by limb fast and slow motor nerves. J Histochem Cytochem (2010) 0.78
Cycling exercise-induced myofiber transitions in skeletal muscle depend on basal fiber type distribution. Eur J Appl Physiol (2011) 0.77
Exercise and health: can biotechnology confer similar benefits? PLoS Med (2005) 0.76
Atypical behavior of NFATc1 in cultured intercostal myofibers. Skelet Muscle (2014) 0.75
The functional significance of the skeletal muscle clock: lessons from Bmal1 knockout models. Skelet Muscle (2016) 0.75
Chronic low-frequency stimulation transforms cat masticatory muscle fibers into jaw-slow fibers. J Histochem Cytochem (2011) 0.75
Calcineurin-NFAT Signaling and Neurotrophins Control Transformation of Myosin Heavy Chain Isoforms in Rat Soleus Muscle in Response to Aerobic Treadmill Training. J Sports Sci Med (2014) 0.75
The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. Nat Commun (2016) 0.75
Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry. FASEB J (2016) 0.75
Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats. Nutr Metab (Lond) (2017) 0.75
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Physiol Rev (1996) 5.47
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev (1998) 5.14
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (1999) 4.20
MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO J (2000) 3.59
Three myosin heavy chain isoforms in type 2 skeletal muscle fibres. J Muscle Res Cell Motil (1989) 3.38
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity (1995) 3.07
Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ Res (2000) 3.04
cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Circulation (1997) 2.54
A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci U S A (2002) 2.53
Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. J Clin Invest (2003) 2.43
Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Mol Cell Biol (2002) 2.30
A calcineurin-NFATc3-dependent pathway regulates skeletal muscle differentiation and slow myosin heavy-chain expression. Mol Cell Biol (2000) 2.16
Activity-dependent nuclear translocation and intranuclear distribution of NFATc in adult skeletal muscle fibers. J Cell Biol (2001) 2.01
Calcineurin controls nerve activity-dependent specification of slow skeletal muscle fibers but not muscle growth. Proc Natl Acad Sci U S A (2001) 2.01
Cain, a novel physiologic protein inhibitor of calcineurin. J Biol Chem (1998) 2.00
Ras is involved in nerve-activity-dependent regulation of muscle genes. Nat Cell Biol (2000) 1.84
Regulation of the growth of multinucleated muscle cells by an NFATC2-dependent pathway. J Cell Biol (2001) 1.76
Altered skeletal muscle phenotypes in calcineurin Aalpha and Abeta gene-targeted mice. Mol Cell Biol (2003) 1.71
Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc. J Biol Chem (2000) 1.55
Expression of myosin heavy chain isoforms in stimulated fast and slow rat muscles. J Neurosci (1990) 1.55
Altered primary myogenesis in NFATC3(-/-) mice leads to decreased muscle size in the adult. Dev Biol (2001) 1.40
Different pathways regulate expression of the skeletal myosin heavy chain genes. J Biol Chem (2001) 1.38
The calcineurin-NFAT pathway and muscle fiber-type gene expression. Am J Physiol Cell Physiol (2000) 1.37
Sustained NFAT signaling promotes a Th1-like pattern of gene expression in primary murine CD4+ T cells. J Immunol (2002) 1.35
Calcineurin signaling and neural control of skeletal muscle fiber type and size. Trends Pharmacol Sci (2002) 1.34
Fiber-type-specific transcription of the troponin I slow gene is regulated by multiple elements. Mol Cell Biol (1999) 1.24
Type 2X-myosin heavy chain is coded by a muscle fiber type-specific and developmentally regulated gene. J Cell Biol (1993) 1.23
Changes in myosin heavy chain isoforms during chronic low-frequency stimulation of rat fast hindlimb muscles. A single-fiber study. Eur J Biochem (1989) 1.10
In vivo analysis of the myosin heavy chain IIB promoter region. Am J Physiol (1998) 1.03
Fast-to-slow transformation and nuclear import/export kinetics of the transcription factor NFATc1 during electrostimulation of rabbit muscle cells in culture. J Physiol (2002) 0.95
Partial fast-to-slow conversion of regenerating rat fast-twitch muscle by chronic low-frequency stimulation. J Muscle Res Cell Motil (2002) 0.91
Regulation of myosin heavy chain expression during rat skeletal muscle development in vitro. Mol Biol Cell (2001) 0.90
Plasticity of skeletal muscle: regenerating fibers adapt more rapidly than surviving fibers. J Appl Physiol (1985) (1987) 0.87
Regenerated rat fast muscle transplanted to the slow muscle bed and innervated by the slow nerve, exhibits an identical myosin heavy chain repertoire to that of the slow muscle. Histochem Cell Biol (1996) 0.83
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab (2007) 8.90
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab (2007) 8.05
Autophagy is required to maintain muscle mass. Cell Metab (2009) 4.46
Autocrine and paracrine angiopoietin 1/Tie-2 signaling promotes muscle satellite cell self-renewal. Cell Stem Cell (2009) 2.53
A protein kinase B-dependent and rapamycin-sensitive pathway controls skeletal muscle growth but not fiber type specification. Proc Natl Acad Sci U S A (2002) 2.53
Mechanisms regulating skeletal muscle growth and atrophy. FEBS J (2013) 2.40
Muscle stem cell behavior is modified by microRNA-27 regulation of Pax3 expression. Proc Natl Acad Sci U S A (2009) 2.28
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J (2007) 2.21
Determination of maximal lactate steady state in healthy adults: can NIRS help? Med Sci Sports Exerc (2013) 2.05
Downstream of Akt: FoxO3 and mTOR in the regulation of autophagy in skeletal muscle. Autophagy (2008) 1.95
Fibrinogen drives dystrophic muscle fibrosis via a TGFbeta/alternative macrophage activation pathway. Genes Dev (2008) 1.73
Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1. Diabetes (2013) 1.65
Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation. FASEB J (2009) 1.60
Regeneration of mammalian skeletal muscle. Basic mechanisms and clinical implications. Curr Pharm Des (2010) 1.49
Host-derived circulating cells do not significantly contribute to cardiac regeneration in heterotopic rat heart transplants. Cardiovasc Res (2005) 1.48
p38/MKP-1-regulated AKT coordinates macrophage transitions and resolution of inflammation during tissue repair. J Cell Biol (2011) 1.43
Muscle type and fiber type specificity in muscle wasting. Int J Biochem Cell Biol (2013) 1.42
Macrophage plasticity and the role of inflammation in skeletal muscle repair. Mediators Inflamm (2013) 1.40
NFAT isoforms control activity-dependent muscle fiber type specification. Proc Natl Acad Sci U S A (2009) 1.33
Interleukin-6 myokine signaling in skeletal muscle: a double-edged sword? FEBS J (2013) 1.33
Adaptation of mouse skeletal muscle to long-term microgravity in the MDS mission. PLoS One (2012) 1.23
Translational suppression of atrophic regulators by microRNA-23a integrates resistance to skeletal muscle atrophy. J Biol Chem (2011) 1.22
uPA deficiency exacerbates muscular dystrophy in MDX mice. J Cell Biol (2007) 1.22
Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles. J Physiol (2009) 1.20
Akt activation prevents the force drop induced by eccentric contractions in dystrophin-deficient skeletal muscle. Hum Mol Genet (2008) 1.19
PAI-1-regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy. J Cell Biol (2012) 1.18
Mechanisms modulating skeletal muscle phenotype. Compr Physiol (2013) 1.13
Multiple signalling pathways redundantly control glucose transporter GLUT4 gene transcription in skeletal muscle. J Physiol (2009) 1.11
Computational reconstruction of the human skeletal muscle secretome. Proteins (2006) 1.09
NFATc1 nucleocytoplasmic shuttling is controlled by nerve activity in skeletal muscle. J Cell Sci (2006) 1.04
Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases. Cell Cycle (2008) 1.04
NETosis is induced by high glucose and associated with type 2 diabetes. Acta Diabetol (2014) 1.04
Cardiac interstitial cells express GATA4 and control dedifferentiation and cell cycle re-entry of adult cardiomyocytes. J Mol Cell Cardiol (2008) 1.03
Genetic deficiency of p38alpha reveals its critical role in myoblast cell cycle exit: the p38alpha-JNK connection. Cell Cycle (2007) 1.01
Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. J Mol Biol (2003) 0.97
The mitochondrial calcium uniporter (MCU): molecular identity and physiological roles. J Biol Chem (2013) 0.95
Early events of electroporation-mediated intramuscular DNA vaccination potentiate Th1-directed immune responses. J Gene Med (2005) 0.94
Clonal characterization of rat muscle satellite cells: proliferation, metabolism and differentiation define an intrinsic heterogeneity. PLoS One (2010) 0.94
Updating the lamellar hypothesis of hippocampal organization. Front Neural Circuits (2012) 0.93
Activity-dependent plasticity of transmitter release from nerve terminals in rat fast and slow muscles. J Neurosci (2003) 0.91
A novel role for embigin to promote sprouting of motor nerve terminals at the neuromuscular junction. J Biol Chem (2009) 0.90
The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1). Front Biosci (2005) 0.90
Amelioration of Duchenne muscular dystrophy in mdx mice by elimination of matrix-associated fibrin-driven inflammation coupled to the αMβ2 leukocyte integrin receptor. Hum Mol Genet (2012) 0.89
Heart morphogenesis is not affected by overexpression of the Sh3bgr gene mapping to the Down syndrome heart critical region. Hum Genet (2004) 0.89
Expression and activity of cyclooxygenase isoforms in skeletal muscles and myocardium of humans and rodents. J Appl Physiol (1985) (2007) 0.87
Differential regulation of the muscle-specific GLUT4 enhancer in regenerating and adult skeletal muscle. J Biol Chem (2003) 0.87
MKP-1 coordinates ordered macrophage-phenotype transitions essential for stem cell-dependent tissue repair. Cell Cycle (2012) 0.86
Eccentric contractions lead to myofibrillar dysfunction in muscular dystrophy. J Appl Physiol (1985) (2009) 0.86
Autophagy-regulating TP53INP2 mediates muscle wasting and is repressed in diabetes. J Clin Invest (2014) 0.86
No evidence for inositol 1,4,5-trisphosphate-dependent Ca2+ release in isolated fibers of adult mouse skeletal muscle. J Gen Physiol (2012) 0.85
Culture of neonatal rodent microglia, astrocytes, and oligodendrocytes from cortex and spinal cord. Methods Mol Biol (2012) 0.84
The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain. J Neurochem (2006) 0.84
Fast motor axon loss in SMARD1 does not correspond to morphological and functional alterations of the NMJ. Neurobiol Dis (2013) 0.84
Cardiac sympathetic neurons provide trophic signal to the heart via β2-adrenoceptor-dependent regulation of proteolysis. Cardiovasc Res (2012) 0.83
Secondary enhancers synergise with primary enhancers to guarantee fine-tuned muscle gene expression. Dev Biol (2009) 0.82
Determinants of VO(2) kinetics at high power outputs during a ramp exercise protocol. Med Sci Sports Exerc (2002) 0.82
Hybrid cardiomyocytes derived by cell fusion in heterotopic cardiac xenografts. FASEB J (2006) 0.81
Characterization of Pax3-expressing cells from adult blood vessels. J Cell Sci (2011) 0.81
Astrocyte-microglia cooperation in the expression of a pro-inflammatory phenotype. CNS Neurol Disord Drug Targets (2013) 0.81
Targeting functional subtypes of spinal motoneurons and skeletal muscle fibers in vivo by intramuscular injection of adenoviral and adeno-associated viral vectors. Anat Embryol (Berl) (2002) 0.81
Development of tonic firing behavior in rat soleus muscle. J Neurophysiol (2008) 0.80
GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells. BMC Mol Biol (2007) 0.80
Activated Met signalling in the developing mouse heart leads to cardiac disease. PLoS One (2011) 0.79
Effects of pleiotrophin overexpression on mouse skeletal muscles in normal loading and in actual and simulated microgravity. PLoS One (2013) 0.78
Myeloid calcifying cells promote atherosclerotic calcification via paracrine activity and allograft inflammatory factor-1 overexpression. Basic Res Cardiol (2013) 0.78
Indirect immunofluorescence staining of cultured neural cells. Methods Mol Biol (2012) 0.77
Electrical muscle activity pattern and transcriptional and posttranscriptional mechanisms regulate PKA subunit expression in rat skeletal muscle. Mol Cell Neurosci (2002) 0.77
Running economy during a simulated 60-km trial. Int J Sports Physiol Perform (2013) 0.76
Nobel Prize in Physiology or Medicine 2014. Tidsskr Nor Laegeforen (2014) 0.75