Published in Neoplasia on July 16, 2004
Role of ABL family kinases in cancer: from leukaemia to solid tumours. Nat Rev Cancer (2013) 1.92
Tumor suppressor and hepatocellular carcinoma. World J Gastroenterol (2008) 1.09
Nontoxic chemical interdiction of the epithelial-to-mesenchymal transition by targeting cap-dependent translation. ACS Chem Biol (2009) 0.99
Histidine triad nucleotide-binding protein 1 (HINT-1) phosphoramidase transforms nucleoside 5'-O-phosphorothioates to nucleoside 5'-O-phosphates. J Biol Chem (2010) 0.95
Silencing of Hint1, a novel tumor suppressor gene, by promoter hypermethylation in hepatocellular carcinoma. Cancer Lett (2008) 0.95
HINT1 inhibits beta-catenin/TCF4, USF2 and NFkappaB activity in human hepatoma cells. Int J Cancer (2009) 0.94
Hint2, a mitochondrial apoptotic sensitizer down-regulated in hepatocellular carcinoma. Gastroenterology (2006) 0.94
Identification of candidate methylation-responsive genes in ovarian cancer. Mol Cancer (2007) 0.94
The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage. J Cell Biol (2008) 0.90
Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor. J Phys Chem B (2012) 0.87
Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study. J Biol Inorg Chem (2010) 0.86
Immunoscreening of urinary bladder cancer cDNA library and identification of potential tumor antigen. World J Urol (2008) 0.83
Analysis of DNA methylation and gene expression in radiation-resistant head and neck tumors. Epigenetics (2015) 0.79
E. coli histidine triad nucleotide binding protein 1 (ecHinT) is a catalytic regulator of D-alanine dehydrogenase (DadA) activity in vivo. PLoS One (2011) 0.78
Effects of the demethylating agent, 5-azacytidine, on expression of the kallikrein-kinin genes in carcinoma cells of the lung and pleura. Patholog Res Int (2011) 0.78
A review of the past, present, and future directions of neoplasia. Neoplasia (2005) 0.77
Regulation of TIMP-1 in Human Placenta and Fetal Membranes by lipopolysaccharide and demethylating agent 5-aza-2'-deoxycytidine. Reprod Biol Endocrinol (2015) 0.76
ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling. Oncotarget (2017) 0.75
Improved anticancer drug response prediction in cell lines using matrix factorization with similarity regularization. BMC Cancer (2017) 0.75
Post-translational modification of HINT1 mediates activation of MITF transcriptional activity in human melanoma cells. Oncogene (2017) 0.75
The fundamental role of epigenetic events in cancer. Nat Rev Genet (2002) 30.05
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell (1996) 15.19
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat Med (1995) 9.10
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci U S A (1994) 8.47
Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A (1995) 4.28
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A (1984) 3.22
Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A (1994) 2.92
A systematic profile of DNA methylation in human cancer cell lines. Cancer Res (2003) 2.75
DNA methylation: past, present and future directions. Carcinogenesis (2000) 2.58
Aberrant promoter methylation in bronchial epithelium and sputum from current and former smokers. Cancer Res (2002) 2.56
The FHIT gene 3p14.2 is abnormal in lung cancer. Cell (1996) 2.36
Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science (1997) 2.27
A retinoblastoma-binding protein related to a negative regulator of Ras in yeast. Nature (1993) 2.03
Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer. Oncogene (2001) 1.94
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene (2004) 1.90
Hypermethylation of the APC (adenomatous polyposis coli) gene promoter region in human colorectal carcinoma. Int J Cancer (1997) 1.82
Methylation of the BRCA1 gene in sporadic breast cancer. Cancer Res (1997) 1.79
Recent trends in lung cancer mortality in the United States. J Natl Cancer Inst (2001) 1.72
RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein. J Biol Chem (2000) 1.56
5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res (2001) 1.46
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors. Cancer Res (2001) 1.45
Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet Cytogenet (2003) 1.42
Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. Genes Dev (2001) 1.41
Sequential 5-Aza-2 deoxycytidine-depsipeptide FR901228 treatment induces apoptosis preferentially in cancer cells and facilitates their recognition by cytolytic T lymphocytes specific for NY-ESO-1. J Immunother (2001) 1.31
Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. Genes Dev (1999) 1.28
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis. J Biol Chem (1995) 1.28
5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias. Blood (1984) 1.27
Oligonucleotide-based microarray for DNA methylation analysis: principles and applications. J Cell Biochem (2003) 1.26
Aberrant promoter methylation of multiple genes in bronchial brush samples from former cigarette smokers. Cancer Res (2002) 1.22
Review of occupational lung carcinogens. Am J Ind Med (1996) 1.21
Characterization of PKCI and comparative studies with FHIT, related members of the HIT protein family. Exp Cell Res (1998) 1.04
Alterations of the FHIT gene in human hepatocellular carcinoma. Cancer Res (2000) 1.02
Activation of the retinoic acid receptor beta gene by 5-aza-2'-deoxycytidine in human DLD-1 colon carcinoma cells. Anticancer Drugs (1997) 0.86
Chromosome abnormalities in non-small cell lung cancer pleural effusions: cytogenetic indicators of disease subgroups. Genes Chromosomes Cancer (1993) 0.81
Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer. Asian J Androl (2000) 0.81
CGH analysis of radon-induced rat lung tumors indicates similarities with human lung cancers. Genes Chromosomes Cancer (2000) 0.80
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol (2004) 4.87
Large-scale discovery of induced point mutations with high-throughput TILLING. Genome Res (2003) 4.39
Spectrum of chemically induced mutations from a large-scale reverse-genetic screen in Arabidopsis. Genetics (2003) 3.70
Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04
Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82
Discovery of induced point mutations in maize genes by TILLING. BMC Plant Biol (2004) 2.57
Efficient discovery of DNA polymorphisms in natural populations by Ecotilling. Plant J (2004) 2.45
High-penetrance mouse model of acute promyelocytic leukemia with very low levels of PML-RARalpha expression. Blood (2003) 2.26
GTF2IRD1 in craniofacial development of humans and mice. Science (2005) 2.15
DLC-1:a Rho GTPase-activating protein and tumour suppressor. J Cell Mol Med (2007) 2.09
The RhoGAP protein DLC-1 functions as a metastasis suppressor in breast cancer cells. Cancer Res (2005) 1.94
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas. Oncogene (2004) 1.90
Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities. Proc Natl Acad Sci U S A (2007) 1.87
Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell (2007) 1.84
DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity. Oncogene (2003) 1.76
High-throughput TILLING for functional genomics. Methods Mol Biol (2003) 1.70
Increased gene copy number of the transcription factor E2F1 in malignant melanoma. Cancer Biol Ther (2006) 1.69
Restoration of DLC-1 gene expression induces apoptosis and inhibits both cell growth and tumorigenicity in human hepatocellular carcinoma cells. Oncogene (2004) 1.65
Stem cells signal to the niche through the Notch pathway in the Drosophila ovary. Curr Biol (2006) 1.65
Expression profile of the tumor suppressor genes DLC-1 and DLC-2 in solid tumors. Int J Oncol (2006) 1.53
Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Res (2007) 1.51
DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development. FEBS Lett (2005) 1.45
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications. Clin Cancer Res (2006) 1.43
Promoter hypermethylation of DLC-1, a candidate tumor suppressor gene, in several common human cancers. Cancer Genet Cytogenet (2003) 1.42
Mutational activation of the MAP3K8 protooncogene in lung cancer. Genes Chromosomes Cancer (2004) 1.42
Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol (2014) 1.35
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer. Proc Natl Acad Sci U S A (2002) 1.25
POTE paralogs are induced and differentially expressed in many cancers. Cancer Res (2006) 1.19
Stage-specific differences in the requirements for germline stem cell maintenance in the Drosophila ovary. Cell Stem Cell (2007) 1.17
The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer Res (2002) 1.17
Inactivation of the Dlc1 gene cooperates with downregulation of p15INK4b and p16Ink4a, leading to neoplastic transformation and poor prognosis in human cancer. Cancer Res (2012) 1.14
DLC1 suppresses distant dissemination of human hepatocellular carcinoma cells in nude mice through reduction of RhoA GTPase activity, actin cytoskeletal disruption and down-regulation of genes involved in metastasis. Int J Oncol (2008) 1.10
Potential pulmonary effects of engineered carbon nanotubes: in vitro genotoxic effects. Nanotoxicology (2010) 1.07
Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses. Part Fibre Toxicol (2014) 1.05
Amplification and overexpression of the EMS 1 oncogene, a possible prognostic marker, in human hepatocellular carcinoma. J Mol Diagn (2003) 1.05
Role of DLC1 tumor suppressor gene and MYC oncogene in pathogenesis of human hepatocellular carcinoma: potential prospects for combined targeted therapeutics (review). Int J Oncol (2012) 1.05
A polymorphism in the human UGRP1 gene promoter that regulates transcription is associated with an increased risk of asthma. Am J Hum Genet (2002) 1.00
Pulmonary inflammation and tumor induction in lung tumor susceptible A/J and resistant C57BL/6J mice exposed to welding fume. Part Fibre Toxicol (2008) 0.98
Dicer-1-dependent Dacapo suppression acts downstream of Insulin receptor in regulating cell division of Drosophila germline stem cells. Development (2009) 0.97
Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes. FASEB J (2010) 0.97
Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells. Exp Cell Res (2007) 0.95
Dopaminergic neurotoxicity following pulmonary exposure to manganese-containing welding fumes. Arch Toxicol (2010) 0.95
Mild steel welding fume causes manganese accumulation and subtle neuroinflammatory changes but not overt neuronal damage in discrete brain regions of rats after short-term inhalation exposure. Neurotoxicology (2009) 0.94
Gene structure, tissue expression, and linkage mapping of the mouse DLC-1 gene (Arhgap7). Gene (2002) 0.94
The interferon-alpha responsive gene TMEM7 suppresses cell proliferation and is downregulated in human hepatocellular carcinoma. Cancer Genet Cytogenet (2007) 0.94
Inhibition of cell proliferation, induction of apoptosis, reactivation of DLC1, and modulation of other gene expression by dietary flavone in breast cancer cell lines. Cancer Detect Prev (2007) 0.94
High-throughput TILLING for Arabidopsis. Methods Mol Biol (2006) 0.94
DLC1 interaction with S100A10 mediates inhibition of in vitro cell invasion and tumorigenicity of lung cancer cells through a RhoGAP-independent mechanism. Cancer Res (2011) 0.93
Thirteen-exon-motif signature for vertebrate nuclear and mitochondrial type IB topoisomerases. Nucleic Acids Res (2004) 0.92
Proteasome Inhibitor MG132 Induces Apoptosis and Inhibits Invasion of Human Malignant Pleural Mesothelioma Cells. Transl Oncol (2008) 0.91
Chromosomal aberrations in cell lines derived from thyroid tumors spontaneously developed in TRbetaPV/PV mice. Cancer Genet Cytogenet (2005) 0.91
Manganese accumulation in nail clippings as a biomarker of welding fume exposure and neurotoxicity. Toxicology (2011) 0.90
Effect of hepatitis C virus core protein on the molecular profiling of human B lymphocytes. Mol Med (2006) 0.90
Chromosomal changes in high- and low-invasive mouse lung adenocarcinoma cell strains derived from early passage mouse lung adenocarcinoma cell strains. Toxicol Appl Pharmacol (2008) 0.90
Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible a/j mice. Toxicol Pathol (2006) 0.88
Neurotoxicity following acute inhalation exposure to the oil dispersant COREXIT EC9500A. J Toxicol Environ Health A (2011) 0.88
DNA variants of DLC-1, a candidate tumor suppressor gene in human hepatocellular carcinoma. Int J Oncol (2003) 0.88
DLC1 interaction with α-catenin stabilizes adherens junctions and enhances DLC1 antioncogenic activity. Mol Cell Biol (2012) 0.88
Nanotechnology: toxicologic pathology. Toxicol Pathol (2013) 0.87
Exposure to carbon nanotubes leads to changes in the cellular biomechanics. Adv Healthc Mater (2013) 0.87
SMAD5 gene expression, rearrangements, copy number, and amplification at fragile site FRA5C in human hepatocellular carcinoma. Neoplasia (2003) 0.86
In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells. BMC Cancer (2013) 0.84
Specific chromosomal aberrations in mouse lung adenocarcinoma cell lines detected by spectral karyotyping: a comparison with human lung adenocarcinoma. Cancer Res (2002) 0.84
Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics. Int J Oncol (2010) 0.81
TRAIL and proteasome inhibitors combination induces a robust apoptosis in human malignant pleural mesothelioma cells through Mcl-1 and Akt protein cleavages. BMC Cancer (2013) 0.80
Neurotoxicity following acute inhalation of aerosols generated during resistance spot weld-bonding of carbon steel. Inhal Toxicol (2014) 0.79
Preclinical evaluation of combined antineoplastic effect of DLC1 tumor suppressor protein and suberoylanilide hydroxamic acid on prostate cancer cells. Biochem Biophys Res Commun (2012) 0.79
Restoration of senescence in breast and ovarian cancer cells following the transfer of the YAC carrying SEN6A gene located at 6q16.3. Cancer Genomics Proteomics (2011) 0.79
Identification and characterization of a gene encoding a putative mouse Rho GTPase activating protein gene 8, Arhgap8. Gene (2003) 0.78
Acquired genetic and functional alterations associated with transforming growth factor beta type I resistance in Hep3B human hepatocellular carcinoma cell line. J Cell Mol Med (2009) 0.78
Recurrent and nonrandom DNA copy number and chromosome alterations in Myc transgenic mouse model for hepatocellular carcinogenesis: implications for human disease. Cancer Genet Cytogenet (2009) 0.77
The human AKNA gene expresses multiple transcripts and protein isoforms as a result of alternative promoter usage, splicing, and polyadenylation. DNA Cell Biol (2005) 0.77
Role of SV40 integration site at chromosomal interval 1q21.1 in immortalized CRL2504 cells. Cancer Res (2009) 0.76
Rho GTPase activating protein cDNA on chromosome 13q12 is the deleted in liver cancer (DLC2) gene. Biochem Biophys Res Commun (2004) 0.76