Published in J Biol Chem on April 07, 1995
Methylation matters. J Med Genet (2001) 3.00
De novo methylation of CpG island sequences in human fibroblasts overexpressing DNA (cytosine-5-)-methyltransferase. Mol Cell Biol (1996) 2.26
Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A (1996) 1.99
Increased cytosine DNA-methyltransferase activity is target-cell-specific and an early event in lung cancer. Proc Natl Acad Sci U S A (1996) 1.76
DNA methyltransferases: a novel target for prevention and therapy. Front Oncol (2014) 1.62
Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo. Neoplasia (2008) 1.20
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1997) 1.19
DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair. Mol Cell Biol (2002) 1.18
Reduced rates of gene loss, gene silencing, and gene mutation in Dnmt1-deficient embryonic stem cells. Mol Cell Biol (2001) 1.17
DNA methyltransferase 1 knockdown activates a replication stress checkpoint. Mol Cell Biol (2006) 1.14
Concurrent replication and methylation at mammalian origins of replication. Mol Cell Biol (1998) 1.02
Aberrant gene expression in human non small cell lung carcinoma cells exposed to demethylating agent 5-aza-2'-deoxycytidine. Neoplasia (2004) 1.02
Suppression of TET1-dependent DNA demethylation is essential for KRAS-mediated transformation. Cell Rep (2014) 0.92
The dynamic nature of DNA methylation: a role in response to social and seasonal variation. Integr Comp Biol (2014) 0.90
AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability. Mol Cell Biol (2006) 0.90
The role of DNA hypermethylation and demethylation in cancer and cancer therapy. Curr Oncol (2008) 0.88
DNA methylation and carcinogenesis in digestive neoplasms. World J Gastroenterol (1998) 0.87
Laccaic acid A is a direct, DNA-competitive inhibitor of DNA methyltransferase 1. J Biol Chem (2013) 0.87
Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84
DNA demethylating antineoplastic strategies: a comparative point of view. Genes Cancer (2010) 0.83
DNA demethylation and invasive cancer: implications for therapeutics. Br J Pharmacol (2015) 0.83
Neuroscience: In their nurture. Nature (2010) 0.81
Reduction of pancreatic acinar cell tumor multiplicity in Dnmt1 hypomorphic mice. Carcinogenesis (2011) 0.80
Hypermethylation of the WT1 and calcitonin gene promoter regions at chromosome 11p in human colorectal cancer. Br J Cancer (1997) 0.79
Zeranol down-regulates p53 expression in primary cultured human breast cancer epithelial cells through epigenetic modification. Int J Mol Sci (2011) 0.78
An ultrasensitive high throughput screen for DNA methyltransferase 1-targeted molecular probes. PLoS One (2013) 0.77
A mammalian protein with specific demethylase activity for mCpG DNA. Nature (1999) 4.48
DNA methylation patterns. Formation and function. Biochim Biophys Acta (1984) 2.36
Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2010) 2.15
Demethylase activity is directed by histone acetylation. J Biol Chem (2001) 1.91
Replacement of 5-methylcytosine by cytosine: a possible mechanism for transient DNA demethylation during differentiation. Proc Natl Acad Sci U S A (1986) 1.79
DNA methylation is a reversible biological signal. Proc Natl Acad Sci U S A (1999) 1.69
Procaryotic and eucaryotic traits of DNA methylation in spiroplasmas (mycoplasmas). J Bacteriol (1985) 1.62
Variations in DNA methylation during mouse cell differentiation in vivo and in vitro. Proc Natl Acad Sci U S A (1984) 1.59
Regulation of DNA methylation by the Ras signaling pathway. J Biol Chem (1995) 1.56
Organ and gestational age effects of maternal nutrient restriction on global methylation in fetal baboons. J Med Primatol (2009) 1.55
Methylation pattern of mouse mitochondrial DNA. Nucleic Acids Res (1984) 1.54
Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care. J Neuroendocrinol (2008) 1.50
Interleukin-6 regulation of the human DNA methyltransferase (HDNMT) gene in human erythroleukemia cells. J Biol Chem (2001) 1.31
Studies on the biological role of DNA methylation: V. The pattern of E.coli DNA methylation. Nucleic Acids Res (1982) 1.29
Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene. Gene (2000) 1.28
Cellular and viral DNA hypomethylation associated with induction of Epstein-Barr virus lytic cycle. Proc Natl Acad Sci U S A (1985) 1.23
Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway. J Biol Chem (1995) 1.21
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide. Proc Natl Acad Sci U S A (1997) 1.19
Cell cycle-dependent regulation of eukaryotic DNA methylase level. J Biol Chem (1985) 1.17
Methylation of replicating and post-replicated mouse L-cell DNA. Proc Natl Acad Sci U S A (1983) 1.17
The consequences of early-life adversity: neurobiological, behavioural and epigenetic adaptations. J Neuroendocrinol (2014) 1.15
The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter. J Biol Chem (1992) 1.15
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1). J Biol Chem (2000) 1.15
DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J Biol Chem (1999) 1.13
DNA methylation pattern is determined by the intracellular level of the methylase. Proc Natl Acad Sci U S A (1984) 1.11
Inhibition of DNA methyltransferase inhibits DNA replication. J Biol Chem (2000) 1.06
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience (2004) 1.05
Concurrent replication and methylation at mammalian origins of replication. Mol Cell Biol (1998) 1.02
Feedback regulation of DNA methyltransferase gene expression by methylation. Eur J Biochem (1999) 1.01
A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity. J Biol Chem (2001) 0.96
Cell specific DNA methylation patterns; formation and a nucleosome locking model for their function. Prog Clin Biol Res (1985) 0.94
Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus. J Biol Chem (1999) 0.93
Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites. Mol Cell Endocrinol (2001) 0.93
The DNMT1 target recognition domain resides in the N terminus. J Biol Chem (2000) 0.90
Tissue-specific hypomethylation and expression of rat phosphoenolpyruvate carboxykinase gene induced by in vivo treatment of fetuses and neonates with 5-azacytidine. Biochemistry (1985) 0.90
An enhancer element and a functional cyclic AMP-dependent protein kinase are required for expression of adrenocortical 21-hydroxylase. J Biol Chem (1988) 0.89
Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751). Neuroreport (1999) 0.89
High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB. J Neurochem (2007) 0.87
Transgenic mice as a model of pre-clinical Alzheimer's disease. Curr Alzheimer Res (2011) 0.87
Quantitation of single- and double-strand DNA breaks in vitro and in vivo. Anal Biochem (1986) 0.86
A novel regulatory element in the dnmt1 gene that responds to co-activation by Rb and c-Jun. Gene (2001) 0.86
Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene. J Biol Chem (1998) 0.85
DNA demethylase is a processive enzyme. J Biol Chem (1999) 0.85
Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation. Brain Res Mol Brain Res (1999) 0.82
Abeta immunoreactive material is present in several intracellular compartments in transfected, neuronally differentiated, P19 cells expressing the human amyloid beta-protein precursor. J Alzheimers Dis (2000) 0.82
Status inequality in the social worker-nurse collaboration in hospitals. Soc Sci Med (1992) 0.80
Characterization of a tumorigenic murine T-lymphoid-cell line spontaneously derived from an IL-2-dependent T-cell line. Int J Cancer (1986) 0.80
An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene. J Biol Chem (1992) 0.80
Genomic structure of the human DNA methyltransferase gene. Biol Chem (1998) 0.80
Conditional transformation mediated via a pertussis toxin-sensitive receptor signalling pathway. Mol Endocrinol (1992) 0.80
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase. J Biol Chem (1999) 0.79
De novo expression of the Muc2 gene in pancreas carcinoma cells is triggered by promoter demethylation. Tumour Biol (2002) 0.78
Phosphorylation of mitogen-activated protein kinase is altered in neuroectodermal cells overexpressing the human amyloid precursor protein 751 isoform. Brain Res Mol Brain Res (1999) 0.76
Biological role of DNA methylation: sequence-specific single-strand breaks associated with hypomethylation of GATC sites in Escherichia coli DNA. J Bacteriol (1986) 0.76
Functional nicotinic receptor expression in mesodermal cells transfected with MyoD cDNA. Neuroscience (1993) 0.75
Regulation of 21-hydroxylase gene expression. Endocr Res (1989) 0.75