Published in Life Sci on August 13, 2004
An overview of animal models for investigating the pathogenesis and therapeutic strategies in acute hepatic failure. World J Gastroenterol (2009) 1.54
Antioxidant and hepatoprotective effects of the red ginseng essential oil in H(2)O(2)-treated hepG2 cells and CCl(4)-treated mice. Int J Mol Sci (2012) 1.07
Protective effects of polydatin from Polygonum cuspidatum against carbon tetrachloride-induced liver injury in mice. PLoS One (2012) 0.91
Experimental models of hepatotoxicity related to acute liver failure. Toxicol Appl Pharmacol (2015) 0.88
Dihydromyricetin alleviates carbon tetrachloride-induced acute liver injury via JNK-dependent mechanism in mice. World J Gastroenterol (2015) 0.86
Hepatoprotective effects of baicalein against CCl₄-induced acute liver injury in mice. World J Gastroenterol (2012) 0.85
Oroxylin A accelerates liver regeneration in CCl₄-induced acute liver injury mice. PLoS One (2013) 0.84
Increased DNA binding activity of NF-kappaB, STAT-3, SMAD3 and AP-1 in acutely damaged liver. World J Gastroenterol (2006) 0.81
Effect of naked eukaryotic expression plasmid encoding rat augmenter of liver regeneration on acute hepatic injury and hepatic failure in rats. World J Gastroenterol (2005) 0.81
Isorhamnetin-3-O-galactoside Protects against CCl4-Induced Hepatic Injury in Mice. Biomol Ther (Seoul) (2012) 0.79
Effect of ribavirin alone or combined with silymarin on carbon tetrachloride induced hepatic damage in rats. Drug Target Insights (2007) 0.78
Therapeutic effect comparison of hepatocyte-like cells and bone marrow mesenchymal stem cells in acute liver failure of rats. Int J Clin Exp Pathol (2015) 0.76
Protection of regenerating liver after partial hepatectomy from carbon tetrachloride hepatotoxicity in rats: roles of mitochondrial uncoupling protein 2 and ATP stores. Dig Dis Sci (2008) 0.76
Deficiency of DJ-1 Ameliorates Liver Fibrosis through Inhibition of Hepatic ROS Production and Inflammation. Int J Biol Sci (2016) 0.75
Potential effects of samsum ant, Brachyponera sennaarensis, venom on TNF-α/NF-κB mediated inflammation in CCL4-toxicity in vivo. Lipids Health Dis (2016) 0.75
Citrate functionalized Mn3O4 in nanotherapy of hepatic fibrosis by oral administration. Future Sci OA (2016) 0.75
A polysaccharide from Dendrobium huoshanense prevents hepatic inflammatory response caused by carbon tetrachloride. Biotechnol Biotechnol Equip (2014) 0.75
Effect of leflunomide on liver regeneration after partial hepatectomy in rats. Pediatr Surg Int (2010) 0.75
Beneficial effects of fluvastatin on liver microcirculation and regeneration after massive hepatectomy in rats. Dig Dis Sci (2008) 0.75
2-Hydroxy-4-methoxy benzoic acid attenuates the carbon tetra chloride-induced hepatotoxicity and its lipid abnormalities in rats via anti-inflammatory and antioxidant mechanism. Inflamm Res (2017) 0.75
Inhibition of autophagy by 3-MA enhances the effect of 5-FU-induced apoptosis in colon cancer cells. Ann Surg Oncol (2008) 2.56
Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin Cancer Res (2008) 2.05
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Diabetes (2003) 2.05
E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int J Cancer (2008) 2.04
The Rab27a/granuphilin complex regulates the exocytosis of insulin-containing dense-core granules. Mol Cell Biol (2002) 1.87
Relapse-related molecular signature in lung adenocarcinomas identifies patients with dismal prognosis. J Clin Oncol (2009) 1.78
Radiographic evaluation of periapical status and prevalence of endodontic treatment in an adult Japanese population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod (2005) 1.71
Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth. Diabetes (2008) 1.55
Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions. FEBS Lett (2002) 1.50
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys. J Steroid Biochem Mol Biol (2012) 1.38
Origin of exocrine pancreatic cells from nestin-positive precursors in developing mouse pancreas. Mech Dev (2004) 1.31
Roles of achaete-scute homologue 1 in DKK1 and E-cadherin repression and neuroendocrine differentiation in lung cancer. Cancer Res (2008) 1.30
Involvement of Rab27b in the regulated secretion of pituitary hormones. Endocrinology (2002) 1.30
Nestin as a marker for proliferative endothelium in gliomas. Lab Invest (2002) 1.29
Granuphilin modulates the exocytosis of secretory granules through interaction with syntaxin 1a. Mol Cell Biol (2002) 1.22
Reactive oxygen species-mediated pancreatic beta-cell death is regulated by interactions between stress-activated protein kinases, p38 and c-Jun N-terminal kinase, and mitogen-activated protein kinase phosphatases. Endocrinology (2008) 1.21
Rab27 effector granuphilin promotes the plasma membrane targeting of insulin granules via interaction with syntaxin 1a. J Biol Chem (2004) 1.18
Constitutive reactive oxygen species generation from autophagosome/lysosome in neuronal oxidative toxicity. J Biol Chem (2009) 1.17
Composition of the bacterial flora in tonsilloliths. Microbes Infect (2006) 1.16
A study comparing the antisecretory effect of TAK-438, a novel potassium-competitive acid blocker, with lansoprazole in animals. J Pharmacol Exp Ther (2011) 1.16
A dyad oct-binding sequence functions as a maintenance sequence for the unmethylated state within the H19/Igf2-imprinted control region. J Biol Chem (2002) 1.15
Reduction of natural adenovirus tropism to the liver by both ablation of fiber-coxsackievirus and adenovirus receptor interaction and use of replaceable short fiber. J Virol (2003) 1.13
Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv. CH-19 Sweet. Plant J (2009) 1.06
Upregulation of uncoupling proteins by oral administration of capsiate, a nonpungent capsaicin analog. J Appl Physiol (1985) (2003) 1.06
Pungent qualities of sanshool-related compounds evaluated by a sensory test and activation of rat TRPV1. Biosci Biotechnol Biochem (2005) 1.04
Arpp, a new homolog of carp, is preferentially expressed in type 1 skeletal muscle fibers and is markedly induced by denervation. Lab Invest (2002) 1.04
Phosphorescent light-emitting iridium complexes serve as a hypoxia-sensing probe for tumor imaging in living animals. Cancer Res (2010) 1.03
Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate. Eur J Pharmacol (2008) 1.01
Angiotensin type 1 receptor antagonist inhibits lipopolysaccharide-induced stimulation of rat microglial cells by suppressing nuclear factor kappaB and activator protein-1 activation. Eur J Neurosci (2008) 1.01
A nonpungent component of steamed ginger--[10]-shogaol--increases adrenaline secretion via the activation of TRPV1. Nutr Neurosci (2006) 1.01
Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A. J Biol Chem (2003) 1.00
Genomewide linkage analysis of familial prostate cancer in the Japanese population. J Hum Genet (2003) 1.00
Interaction between secretogranin III and carboxypeptidase E facilitates prohormone sorting within secretory granules. J Cell Sci (2005) 0.99
Exophilin4/Slp2-a targets glucagon granules to the plasma membrane through unique Ca2+-inhibitory phospholipid-binding activity of the C2A domain. Mol Biol Cell (2006) 0.99
Cytoplasmic transport signal is involved in phogrin targeting and localization to secretory granules. Traffic (2005) 0.97
Kinetic analyses for species differences in P-glycoprotein-mediated drug transport. J Pharm Sci (2006) 0.96
Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells. Mol Biol Cell (2002) 0.96
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB). J Med Chem (2012) 0.96
Activation of TRPV1 and TRPA1 by black pepper components. Biosci Biotechnol Biochem (2010) 0.96
Species differences of inhibitory effects on P-glycoprotein-mediated drug transport. J Pharm Sci (2007) 0.95
Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate. Br J Pharmacol (2012) 0.94
Relationship of deregulated signaling converging onto mTOR with prognosis and classification of lung adenocarcinoma shown by two independent in silico analyses. Cancer Res (2009) 0.94
Overexpression of autocrine motility factor in metastatic tumor cells: possible association with augmented expression of KIF3A and GDI-beta. Lab Invest (2004) 0.94
Evaluation of the bitterness of green tea catechins by a cell-based assay with the human bitter taste receptor hTAS2R39. Biochem Biophys Res Commun (2011) 0.94
Assessment of the biological similarity of three capsaicin analogs (Capsinoids) found in non-pungent chili pepper (CH-19 Sweet) fruits. Biosci Biotechnol Biochem (2010) 0.93
Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. J Biol Chem (2007) 0.93
Effective gene transfer to human melanomas via integrin-targeted adenoviral vectors. Hum Gene Ther (2002) 0.93
Development of a high-resolution purification method for precise functional characterization of primitive human cord blood-derived CD34-negative SCID-repopulating cells. Exp Hematol (2010) 0.92
Carp, a cardiac ankyrin-repeated protein, and its new homologue, Arpp, are differentially expressed in heart, skeletal muscle, and rhabdomyosarcomas. Am J Pathol (2002) 0.92
Proteasomal non-catalytic subunit PSMD2 as a potential therapeutic target in association with various clinicopathologic features in lung adenocarcinomas. Mol Carcinog (2011) 0.91
Gastrin stimulates the growth of gastric pit cell precursors by inducing its own receptors. Am J Physiol Gastrointest Liver Physiol (2002) 0.91
Oxidative damage of periodontal tissue in the rat periodontitis model: effects of a high-cholesterol diet. FEBS Lett (2006) 0.91
Cytokine-dependent modification of IL-12p70 and IL-23 balance in dendritic cells by ligand activation of Valpha24 invariant NKT cells. J Immunol (2009) 0.91
Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats. J Steroid Biochem Mol Biol (2012) 0.90
Ratiometric molecular sensor for monitoring oxygen levels in living cells. Angew Chem Int Ed Engl (2012) 0.90
Angiogenic endothelium-specific nestin expression is enhanced by the first intron of the nestin gene. Lab Invest (2004) 0.90
Isolation, expression, and characterization of the human ZCRB1 gene mapped to 12q12. Genomics (2006) 0.90
Mechanical stimulation of gingiva reduces plasma 8-OHdG level in rat periodontitis. Arch Oral Biol (2007) 0.88
A subset of p23 localized on secretory granules in pancreatic beta-cells. J Histochem Cytochem (2006) 0.88
Specific hydroxy fatty acids in royal jelly activate TRPA1. J Agric Food Chem (2011) 0.87
Relationship between blood triglyceride levels and periodontal status. Community Dent Health (2004) 0.87
Miogadial and miogatrial with alpha,beta-unsaturated 1,4-dialdehyde moieties--novel and potent TRPA1 agonists. Life Sci (2009) 0.87
Up-regulation of the expression of activins in the pancreatic duct by reduction of the beta-cell mass. Endocrinology (2002) 0.86
Newly mutated putative-aminotransferase in nonpungent pepper (Capsicum annuum) results in biosynthesis of capsinoids, capsaicinoid analogues. J Agric Food Chem (2010) 0.86
Luminal interaction of phogrin with carboxypeptidase E for effective targeting to secretory granules. Traffic (2011) 0.86
Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1. Cancer Sci (2007) 0.86
Effects of targeted overexpression of pleiotrophin on postnatal bone development. Biochem Biophys Res Commun (2002) 0.86
Effects of capsinoid on serum and liver lipids in hyperlipidemic rats. J Nutr Sci Vitaminol (Tokyo) (2004) 0.86
Capsiate, a nonpungent capsaicin analog, increases endurance swimming capacity of mice by stimulation of vanilloid receptors. Biosci Biotechnol Biochem (2006) 0.86
Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol (Tokyo) (2008) 0.86
Capsinoids, non-pungent capsaicin analogs, reduce body fat accumulation without weight rebound unlike dietary restriction in mice. Biosci Biotechnol Biochem (2011) 0.85
A large form of secretogranin III functions as a sorting receptor for chromogranin A aggregates in PC12 cells. Mol Endocrinol (2008) 0.85
Low level of c-kit expression marks deeply quiescent murine hematopoietic stem cells. Stem Cells (2011) 0.85
Cholesterol biosynthesis pathway intermediates and inhibitors regulate glucose-stimulated insulin secretion and secretory granule formation in pancreatic beta-cells. Endocrinology (2010) 0.85
Down-regulation of inducible nitric oxide synthase by lysophosphatidic acid in human respiratory epithelial cells. Mol Cell Biochem (2004) 0.85
Nestin expression in vascular malformations: a novel marker for proliferative endothelium. Neurol Med Chir (Tokyo) (2006) 0.85
Nestin is a novel marker for renal tubulointerstitial injury in immunoglobulin A nephropathy. Nephrology (Carlton) (2010) 0.85
CCAAT/enhancer binding protein-beta (C/EBP-beta), a pivotal regulator of the TATA-less promoter in the rat catalase gene. FEBS Lett (2005) 0.85
TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion. Biosci Biotechnol Biochem (2008) 0.84
A simple method to induce differentiation of murine bone marrow mesenchymal cells to insulin-producing cells using conophylline and betacellulin-delta4. Endocr J (2008) 0.84
Altered expression of ARPP protein in skeletal muscles of patients with muscular dystrophy, congenital myopathy and spinal muscular atrophy. Pathobiology (2004) 0.84
ANP inhibits LPS-induced stimulation of rat microglial cells by suppressing NF-kappaB and AP-1 activations. Biochem Biophys Res Commun (2006) 0.84
Diallyl sulfides in garlic activate both TRPA1 and TRPV1. Biochem Biophys Res Commun (2009) 0.84
Induction of DNA demethylation depending on two sets of Sox2 and adjacent Oct3/4 binding sites (Sox-Oct motifs) within the mouse H19/insulin-like growth factor 2 (Igf2) imprinted control region. J Biol Chem (2012) 0.84
Reverse transformation of hepatic myofibroblast-like cells by TGFbeta1/LAP. Biochem Biophys Res Commun (2003) 0.84
Marginal expression of CXCR4 on c-kit(+)Sca-1 (+)Lineage (-) hematopoietic stem/progenitor cells. Int J Hematol (2009) 0.84
Ingestion of cinnamaldehyde, a TRPA1 agonist, reduces visceral fats in mice fed a high-fat and high-sucrose diet. J Nutr Sci Vitaminol (Tokyo) (2012) 0.83
Cardiac-restricted ankyrin-repeated protein is differentially induced in duchenne and congenital muscular dystrophy. Lab Invest (2003) 0.83
Nestin immunoreactivity of Purkinje cells in Creutzfeldt-Jakob disease. J Neurol Sci (2006) 0.83
Transient receptor potential ankyrin 1 activation enhances hapten sensitization in a T-helper type 2-driven fluorescein isothiocyanate-induced contact hypersensitivity mouse model. Toxicol Appl Pharmacol (2012) 0.82
Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats. Biomed Res (2011) 0.82
Establishment and characterization of hepatic stem-like cell lines from normal adult rat liver. J Biochem (2008) 0.82
Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats. Yonago Acta Med (2011) 0.82
Altered expression of cardiac ankyrin repeat protein and its homologue, ankyrin repeat protein with PEST and proline-rich region, in atrophic muscles in amyotrophic lateral sclerosis. Pathobiology (2003) 0.82
TRPV1 agonist monoacylglycerol increases UCP1 content in brown adipose tissue and suppresses accumulation of visceral fat in mice fed a high-fat and high-sucrose diet. Biosci Biotechnol Biochem (2011) 0.82
Identification of differentially expressed genes in rat hepatoma cell lines using subtraction and microarray. J Biochem (2002) 0.82
Galangal pungent component, 1'-acetoxychavicol acetate, activates TRPA1. Biosci Biotechnol Biochem (2010) 0.82
Bioluminescence imaging of bone formation using hairless osteocalcin-luciferase transgenic mice. Bone (2012) 0.81