Published in Circ Res on July 23, 2004
Identifying Targets of Maladaptive Metabolic Responses in Heart Failure | NCT03032627
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci U S A (2008) 6.53
Elevated cytosolic Na+ decreases mitochondrial Ca2+ uptake during excitation-contraction coupling and impairs energetic adaptation in cardiac myocytes. Circ Res (2006) 3.03
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A (2006) 2.71
Return to the fetal gene program protects the stressed heart: a strong hypothesis. Heart Fail Rev (2007) 2.67
Energy metabolism in heart failure and remodelling. Cardiovasc Res (2008) 2.37
Muscle KATP channels: recent insights to energy sensing and myoprotection. Physiol Rev (2010) 2.06
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail (2012) 1.82
Excitation-contraction coupling and mitochondrial energetics. Basic Res Cardiol (2007) 1.74
A computational model integrating electrophysiology, contraction, and mitochondrial bioenergetics in the ventricular myocyte. Biophys J (2006) 1.69
Up-regulation of ectopic trypsins in the myocardium by influenza A virus infection triggers acute myocarditis. Cardiovasc Res (2010) 1.69
Mitochondrial criticality: a new concept at the turning point of life or death. Biochim Biophys Acta (2005) 1.68
Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol (2012) 1.66
PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol (2008) 1.63
Impaired ATP kinetics in failing in vivo mouse heart. Circ Cardiovasc Imaging (2010) 1.63
Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol (2009) 1.56
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res (2013) 1.56
The fundamental organization of cardiac mitochondria as a network of coupled oscillators. Biophys J (2006) 1.55
The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol (2011) 1.54
AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice. Hypertension (2008) 1.54
Diabetic cardiomyopathy: pathophysiology and clinical features. Heart Fail Rev (2013) 1.44
Multiple ion binding equilibria, reaction kinetics, and thermodynamics in dynamic models of biochemical pathways. Methods Enzymol (2009) 1.41
Modeling of oxygen transport and cellular energetics explains observations on in vivo cardiac energy metabolism. PLoS Comput Biol (2006) 1.40
Potential therapeutic benefits of strategies directed to mitochondria. Antioxid Redox Signal (2010) 1.40
Modulation of anthracycline-induced cardiotoxicity by aerobic exercise in breast cancer: current evidence and underlying mechanisms. Circulation (2011) 1.30
Ketone body metabolism and cardiovascular disease. Am J Physiol Heart Circ Physiol (2013) 1.29
Mitochondrial centrality in heart failure. Heart Fail Rev (2008) 1.28
The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation (2016) 1.27
Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One (2009) 1.27
Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest (2011) 1.26
Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl Acad Sci U S A (2009) 1.25
Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease. Circulation (2011) 1.24
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation (2011) 1.23
Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases. J Tissue Eng Regen Med (2010) 1.23
Protein kinase Cepsilon interacts with cytochrome c oxidase subunit IV and enhances cytochrome c oxidase activity in neonatal cardiac myocyte preconditioning. Biochem J (2006) 1.23
ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method. Circ Res (2011) 1.23
Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Mol Cell Biol (2007) 1.16
Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta (2010) 1.13
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet (2010) 1.13
Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice. Circ Res (2013) 1.13
Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure. J Lipid Res (2008) 1.12
Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility. J Mol Cell Cardiol (2010) 1.11
The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise. Am J Physiol Heart Circ Physiol (2008) 1.08
Metabolomic analysis of pressure-overloaded and infarcted mouse hearts. Circ Heart Fail (2014) 1.08
Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure. J Physiol (2008) 1.08
Adaptation of myocardial substrate metabolism to a ketogenic nutrient environment. J Biol Chem (2010) 1.06
Shifts in the myosin heavy chain isozymes in the mouse heart result in increased energy efficiency. J Mol Cell Cardiol (2006) 1.05
Long-term cardiovascular risks associated with an elevated heart rate: the Framingham Heart Study. J Am Heart Assoc (2014) 1.03
Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity. J Mol Cell Cardiol (2009) 1.02
Transcriptional remodeling of rapidly stimulated HL-1 atrial myocytes exhibits concordance with human atrial fibrillation. J Mol Cell Cardiol (2009) 1.01
GLUT4, GLUT1, and GLUT8 are the dominant GLUT transcripts expressed in the murine left ventricle. Cardiovasc Diabetol (2012) 1.00
Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy. J Magn Reson (2007) 0.99
Novel strategy for measuring creatine kinase reaction rate in the in vivo heart. Am J Physiol Heart Circ Physiol (2009) 0.98
Transcriptional control of cardiac fuel metabolism and mitochondrial function. Cold Spring Harb Symp Quant Biol (2011) 0.98
Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart. Circ Res (2014) 0.98
Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure. Circ Res (2014) 0.98
New insights into the role of mitochondrial dynamics and autophagy during oxidative stress and aging in the heart. Oxid Med Cell Longev (2014) 0.98
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res (2012) 0.97
Impaired myocardial perfusion reserve and fibrosis in Friedreich ataxia: a mitochondrial cardiomyopathy with metabolic syndrome. Eur Heart J (2010) 0.97
Reductions in mitochondrial O(2) consumption and preservation of high-energy phosphate levels after simulated ischemia in chronic hibernating myocardium. Am J Physiol Heart Circ Physiol (2009) 0.97
Abnormal energetics and ATP depletion in pressure-overload mouse hearts: in vivo high-energy phosphate concentration measures by noninvasive magnetic resonance. Am J Physiol Heart Circ Physiol (2009) 0.97
Noncanonical EF-hand motif strategically delays Ca2+ buffering to enhance cardiac performance. Nat Med (2013) 0.96
Dietary fat supply to failing hearts determines dynamic lipid signaling for nuclear receptor activation and oxidation of stored triglyceride. Circulation (2014) 0.95
Luminal Ca2+ controls activation of the cardiac ryanodine receptor by ATP. J Gen Physiol (2012) 0.94
Myocardial oxidative stress, osteogenic phenotype, and energy metabolism are differentially involved in the initiation and early progression of delta-sarcoglycan-null cardiomyopathy. Mol Cell Biochem (2008) 0.94
Creatine uptake in mouse hearts with genetically altered creatine levels. J Mol Cell Cardiol (2008) 0.93
Heart failure: a model of cardiac and skeletal muscle energetic failure. Pflugers Arch (2006) 0.90
Using exercise to measure and modify cardiac function. Cell Metab (2015) 0.90
Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease. Adv Exp Med Biol (2013) 0.90
Mitochondria and heart failure: new insights into an energetic problem. Minerva Cardioangiol (2010) 0.90
Genome-wide expression patterns in physiological cardiac hypertrophy. BMC Genomics (2010) 0.89
Altered myocardial calcium cycling and energetics in heart failure-a rational approach for disease treatment. Cell Metab (2015) 0.89
GLP-1 agonist therapy for advanced heart failure with reduced ejection fraction: design and rationale for the functional impact of GLP-1 for heart failure treatment study. Circ Heart Fail (2014) 0.88
Regression of pathological cardiac hypertrophy: signaling pathways and therapeutic targets. Pharmacol Ther (2012) 0.88
Metabolic modulation and cellular therapy of cardiac dysfunction and failure. J Cell Mol Med (2009) 0.87
Mitochondrial protein phosphorylation as a regulatory modality: implications for mitochondrial dysfunction in heart failure. Congest Heart Fail (2011) 0.87
CHIP protects against cardiac pressure overload through regulation of AMPK. J Clin Invest (2013) 0.87
Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2. Proteome Sci (2011) 0.87
Cardiac, skeletal, and smooth muscle mitochondrial respiration: are all mitochondria created equal? Am J Physiol Heart Circ Physiol (2014) 0.86
The PPARalpha-PGC-1alpha Axis Controls Cardiac Energy Metabolism in Healthy and Diseased Myocardium. PPAR Res (2008) 0.86
Tissue-specific changes in fatty acid oxidation in hypoxic heart and skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2013) 0.85
Molecular and subcellular-scale modeling of nucleotide diffusion in the cardiac myofilament lattice. Biophys J (2013) 0.85
Modelling sarcomeric cardiomyopathies in the dish: from human heart samples to iPSC cardiomyocytes. Cardiovasc Res (2015) 0.85
Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo. Int J Mol Sci (2010) 0.85
Cardiac energy metabolic alterations in pressure overload-induced left and right heart failure (2013 Grover Conference Series). Pulm Circ (2015) 0.85
Long-Term survival of anoxia despite rapid ATP decline in embryos of the annual killifish Austrofundulus limnaeus. J Exp Zool A Ecol Genet Physiol (2012) 0.84
Thymidine kinase and mtDNA depletion in human cardiomyopathy: epigenetic and translational evidence for energy starvation. Physiol Genomics (2013) 0.84
Effects of myosin heavy chain manipulation in experimental heart failure. J Mol Cell Cardiol (2009) 0.83
Compromised myocardial energetics in hypertrophied mouse hearts diminish the beneficial effect of overexpressing SERCA2a. J Biol Chem (2011) 0.83
Mesenchymal stem cell transplantation for the infarcted heart: therapeutic potential for insulin resistance beyond the heart. Cardiovasc Diabetol (2013) 0.83
Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation. J Mol Cell Cardiol (2015) 0.82
Mechanisms of reduced mitochondrial Ca2+ accumulation in failing hamster heart. Pflugers Arch (2007) 0.82
Left ventricular assist device effects on metabolic substrates in the failing heart. PLoS One (2013) 0.82
(1)H-MR spectroscopy for analysis of cardiac lipid and creatine metabolism. Heart Fail Rev (2013) 0.82
Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age. Basic Res Cardiol (2012) 0.82
Cardiac-specific VLCAD deficiency induces dilated cardiomyopathy and cold intolerance. Am J Physiol Heart Circ Physiol (2013) 0.81
Altered systemic ketone body metabolism in advanced heart failure. Tex Heart Inst J (2011) 0.81
Elevated rates of force development and MgATP binding in F764L and S532P myosin mutations causing dilated cardiomyopathy. J Mol Cell Cardiol (2013) 0.81
Alterations in mitochondrial function in cardiac hypertrophy and heart failure. Heart Fail Rev (2013) 0.81
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation (2005) 2.80
Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy. JACC Cardiovasc Imaging (2008) 2.64
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (2008) 2.37
Clinical utility and safety of a protocol for noncardiac and cardiac magnetic resonance imaging of patients with permanent pacemakers and implantable-cardioverter defibrillators at 1.5 tesla. Circulation (2006) 2.36
Noninvasive visualization of coronary artery endothelial function in healthy subjects and in patients with coronary artery disease. J Am Coll Cardiol (2010) 2.09
Altered creatine kinase adenosine triphosphate kinetics in failing hypertrophied human myocardium. Circulation (2006) 1.84
Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses. Magn Reson Med (2009) 1.83
Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol (2012) 1.66
Impaired ATP kinetics in failing in vivo mouse heart. Circ Cardiovasc Imaging (2010) 1.63
Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med (2002) 1.58
Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies. Radiology (2008) 1.56
ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol (2008) 1.55
Right, but not left, bundle branch block is associated with large anteroseptal scar. J Am Coll Cardiol (2013) 1.45
Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort. Heart Rhythm (2013) 1.40
Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity. J Magn Reson (2012) 1.37
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging. J Am Coll Cardiol (2008) 1.35
Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest (2011) 1.26
Skeletal muscle ATP kinetics are impaired in frail mice. Age (Dordr) (2013) 1.18
Coronary magnetic resonance angiography. J Magn Reson Imaging (2007) 1.18
Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study. Circulation (2009) 1.13
Triple repetition time saturation transfer (TRiST) 31P spectroscopy for measuring human creatine kinase reaction kinetics. Magn Reson Med (2010) 1.09
Computational method for identifying and quantifying shape features of human left ventricular remodeling. Ann Biomed Eng (2009) 1.08
Metabolic rates of ATP transfer through creatine kinase (CK Flux) predict clinical heart failure events and death. Sci Transl Med (2013) 1.08
Measuring human cardiac tissue sodium concentrations using surface coils, adiabatic excitation, and twisted projection imaging with minimal T2 losses. J Magn Reson Imaging (2005) 1.08
Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts. Am J Physiol Heart Circ Physiol (2005) 1.04
On restoring motion-induced signal loss in single-voxel magnetic resonance spectra. Magn Reson Med (2006) 1.04
Reproducibility of 3D free-breathing magnetic resonance coronary vessel wall imaging. Eur Heart J (2005) 1.04
Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. J Magn Reson (2013) 1.03
Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy. J Magn Reson (2007) 0.99
Abnormal energetics and ATP depletion in pressure-overload mouse hearts: in vivo high-energy phosphate concentration measures by noninvasive magnetic resonance. Am J Physiol Heart Circ Physiol (2009) 0.97
Tissue sodium concentration in myocardial infarction in humans: a quantitative 23Na MR imaging study. Radiology (2008) 0.94
Regional coronary endothelial function is closely related to local early coronary atherosclerosis in patients with mild coronary artery disease: pilot study. Circ Cardiovasc Imaging (2012) 0.92
Delayed contrast-enhanced MRI of the coronary artery wall in takayasu arteritis. PLoS One (2012) 0.89
Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium. Am J Physiol Heart Circ Physiol (2012) 0.89
Coronary artery distensibility assessed by 3.0 Tesla coronary magnetic resonance imaging in subjects with and without coronary artery disease. Am J Cardiol (2011) 0.87
Strain-encoding cardiovascular magnetic resonance for assessment of right-ventricular regional function. J Cardiovasc Magn Reson (2008) 0.87
Non-invasive detection of coronary endothelial response to sequential handgrip exercise in coronary artery disease patients and healthy adults. PLoS One (2013) 0.85
Phase-sensitive black-blood coronary vessel wall imaging. Magn Reson Med (2010) 0.85
Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON). J Magn Reson Imaging (2008) 0.83
Combined functional and viability cardiac MR imaging in a single breathhold. Magn Reson Med (2007) 0.81
Gadolinium Enhanced MR Coronary Vessel Wall Imaging at 3.0 Tesla. Cardiol Res Pract (2010) 0.81
Coronary MR imaging: lumen and wall. Magn Reson Imaging Clin N Am (2009) 0.80
Spatially selective implementation of the adiabatic T2Prep sequence for magnetic resonance angiography of the coronary arteries. Magn Reson Med (2012) 0.80
Quantification of human high-energy phosphate metabolite concentrations at 3 T with partial volume and sensitivity corrections. NMR Biomed (2013) 0.80
Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy. Am J Cardiol (2013) 0.80
High-energy phosphate transfer in human muscle: diffusion of phosphocreatine. Am J Physiol Cell Physiol (2011) 0.79
Use of 2D sensitivity encoding for slow-infusion contrast-enhanced isotropic 3-T whole-heart coronary MR angiography. AJR Am J Roentgenol (2011) 0.79
Cardiac Motion Analysis in Ischemic and Non-Ischemic Cardiomyopathy Using Parallel Transport. Proc IEEE Int Symp Biomed Imaging (2009) 0.79
Creatine kinase-overexpression improves myocardial energetics, contractile dysfunction and survival in murine doxorubicin cardiotoxicity. PLoS One (2013) 0.79
Robust volume-targeted balanced steady-state free-precession coronary magnetic resonance angiography in a breathhold at 3.0 Tesla: a reproducibility study. J Cardiovasc Magn Reson (2014) 0.78
VESSEL CENTERLINE TRACKING AND BOUNDARY SEGMENTATION IN CORONARY MRA WITH MINIMAL MANUAL INTERACTION. Proc IEEE Int Symp Biomed Imaging (2012) 0.78
Cine cardiac imaging using black-blood steady-state free precession (BB-SSFP) at 3T. J Magn Reson Imaging (2009) 0.78
Effects of a pharmacologically-induced shift of hemoglobin-oxygen dissociation on myocardial energetics during ischemia in patients with coronary artery disease. J Cardiovasc Magn Reson (2005) 0.78
Right coronary artery flow velocity and volume assessment with spiral K-space sampled breathhold velocity-encoded MRI at 3 tesla: accuracy and reproducibility. J Magn Reson Imaging (2010) 0.78
Left ventricular mechanical dyssynchrony by cardiac magnetic resonance is greater in patients with strict vs nonstrict electrocardiogram criteria for left bundle-branch block. Am Heart J (2013) 0.78
Exercise-induced decrease in myocardial high-energy phosphate metabolites in patients with Chagas heart disease. J Card Fail (2013) 0.77
The effect of orientation on quantification of muscle creatine by 1H MR spectroscopy. Magn Reson Imaging (2003) 0.77
Identification of different heart tissues from MRI C-SENC images using an unsupervised multi-stage fuzzy clustering technique. J Magn Reson Imaging (2008) 0.77
Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias. Circ Arrhythm Electrophysiol (2013) 0.77
Magnetic resonance imaging and spectroscopy of the murine cardiovascular system. Am J Physiol Heart Circ Physiol (2013) 0.77
Stimulated-echo acquisition mode (STEAM) MRI for black-blood delayed hyperenhanced myocardial imaging. J Magn Reson Imaging (2008) 0.76
Evaluation of the metabolism of high energy phosphates in patients with Chagas' disease. Arq Bras Cardiol (2010) 0.76
Estimating dense cardiac 3D motion using sparse 2D tagged MRI cross-sections. Conf Proc IEEE Eng Med Biol Soc (2014) 0.75
Localization of myocardial scar in patients with cardiomyopathy and left bundle branch block using electrocardiographic Selvester QRS scoring. J Electrocardiol (2013) 0.75
Long-term effects of stem cell transplantation in the postinfarct heart: benefits and mechanisms. Am J Physiol Heart Circ Physiol (2010) 0.75
Coronary artery endothelial dysfunction is present in HIV positive individuals without significant coronary artery disease. AIDS (2017) 0.75
Coronary magnetic resonance imaging. Curr Pharm Des (2008) 0.75