Living without creatine: unchanged exercise capacity and response to chronic myocardial infarction in creatine-deficient mice.

PubWeight™: 1.13‹?› | Rank: Top 10%

🔗 View Article (PMC 4182017)

Published in Circ Res on January 16, 2013

Authors

Craig A Lygate1, Dunja Aksentijevic, Dana Dawson, Michiel ten Hove, Darci Phillips, Joseph P de Bono, Debra J Medway, Liam Sebag-Montefiore, Imre Hunyor, Keith M Channon, Kieran Clarke, Sevasti Zervou, Hugh Watkins, Robert S Balaban, Stefan Neubauer

Author Affiliations

1: Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, UK. clygate@well.ox.ac.uk

Articles citing this

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol (2013) 3.39

Mitochondrial reticulum for cellular energy distribution in muscle. Nature (2015) 1.88

Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart. Circ Res (2014) 0.98

Myocardial perfusion and oxygenation are impaired during stress in severe aortic stenosis and correlate with impaired energetics and subclinical left ventricular dysfunction. J Cardiovasc Magn Reson (2014) 0.90

X-linked creatine transporter deficiency: clinical aspects and pathophysiology. J Inherit Metab Dis (2014) 0.86

Age-related changes of myocardial ATP supply and demand mechanisms. Trends Endocrinol Metab (2013) 0.83

Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association. Circ Res (2016) 0.82

Augmentation of Creatine in the Heart. Mini Rev Med Chem (2015) 0.81

Unchanged mitochondrial organization and compartmentation of high-energy phosphates in creatine-deficient GAMT-/- mouse hearts. Am J Physiol Heart Circ Physiol (2013) 0.80

Heart failure and loss of metabolic control. J Cardiovasc Pharmacol (2014) 0.79

The location of energetic compartments affects energetic communication in cardiomyocytes. Front Physiol (2014) 0.78

Myocardial creatine levels do not influence response to acute oxidative stress in isolated perfused heart. PLoS One (2014) 0.78

Advanced physiological roles of guanidinoacetic acid. Eur J Nutr (2015) 0.77

Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension. J Mol Cell Cardiol (2015) 0.76

Metabolic flux as a predictor of heart failure prognosis. Circ Res (2014) 0.76

Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles. Einstein (Sao Paulo) (2014) 0.76

Normal cardiac function in mice with supraphysiological cardiac creatine levels. Am J Physiol Heart Circ Physiol (2013) 0.75

Mechanotransduction and Metabolism in Cardiomyocyte Microdomains. Biomed Res Int (2016) 0.75

Creatine--a dispensable metabolite? Circ Res (2013) 0.75

Recent advances in mitochondrial research. Circ Res (2013) 0.75

Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiol (Oxf) (2014) 0.75

Metabolic compartmentation in rainbow trout cardiomyocytes: coupling of hexokinase but not creatine kinase to mitochondrial respiration. J Comp Physiol B (2016) 0.75

Cellular bioenergetics of guanidinoacetic acid: the role of mitochondria. J Bioenerg Biomembr (2015) 0.75

The acute effect of beta-guanidinopropionic acid versus creatine or placebo in healthy men (ABC-Trial): a randomized controlled first-in-human trial. Br J Clin Pharmacol (2017) 0.75

Articles cited by this

Creatine and creatinine metabolism. Physiol Rev (2000) 5.76

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem (2006) 4.28

Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res (2004) 3.72

Myocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation (1997) 2.65

A simple analysis of the "phosphocreatine shuttle". Am J Physiol (1984) 2.31

Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol (1985) (2002) 2.15

Energy metabolism in heart failure. J Physiol (2003) 2.10

Evolution and physiological roles of phosphagen systems. Annu Rev Physiol (2001) 2.02

Reentry and fibrillation in the mouse heart. A challenge to the critical mass hypothesis. Circ Res (1999) 1.82

Mitochondrial creatine kinase in human health and disease. Biochim Biophys Acta (2005) 1.82

Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice. Circulation (2004) 1.79

Reaction rates of creatine kinase and ATP synthesis in the isolated rat heart. A 31P NMR magnetization transfer study. J Biol Chem (1985) 1.71

Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol (2005) 1.70

Mitochondrial uncoupling, with low concentration FCCP, induces ROS-dependent cardioprotection independent of KATP channel activation. Cardiovasc Res (2006) 1.56

Creatine: endogenous metabolite, dietary, and therapeutic supplement. Annu Rev Nutr (2007) 1.46

Strain-dependent differences in responses to exercise training in inbred and hybrid mice. Am J Physiol Regul Integr Comp Physiol (2004) 1.44

Severely altered guanidino compound levels, disturbed body weight homeostasis and impaired fertility in a mouse model of guanidinoacetate N-methyltransferase (GAMT) deficiency. Hum Mol Genet (2004) 1.37

Impairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest (1995) 1.34

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation (2005) 1.33

The metabolic burden of creatine synthesis. Amino Acids (2011) 1.30

Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest (2011) 1.26

Energetic basis for reduced contractile reserve in isolated rat hearts. Am J Physiol (1996) 1.24

The creatine kinase energy transport system in the failing mouse heart. J Mol Cell Cardiol (2007) 1.17

Creatine and creatine deficiency syndromes: biochemical and clinical aspects. Pediatr Neurol (2010) 1.15

Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis. Am J Physiol Heart Circ Physiol (2004) 1.12

Multimodal functional cardiac MRI in creatine kinase-deficient mice reveals subtle abnormalities in myocardial perfusion and mechanics. Am J Physiol Heart Circ Physiol (2006) 1.07

Proteomic changes associated with diabetes in the BB-DP rat. Am J Physiol Endocrinol Metab (2008) 1.05

Concentrations of glycolytic enzymes and other cytosolic proteins in the diffusible fraction of a vertebrate muscle proteome. Mol Cell Proteomics (2005) 1.04

The utilisation of creatine and its analogues by cytosolic and mitochondrial creatine kinase. Biochim Biophys Acta (1996) 1.01

Impaired voluntary running capacity of creatine kinase-deficient mice. J Physiol (2005) 1.00

Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction. Circulation (2001) 0.99

Creatine transporter activity and content in the rat heart supplemented by and depleted of creatine. Am J Physiol Endocrinol Metab (2003) 0.98

Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res (2012) 0.97

Cardiac phenotype of mitochondrial creatine kinase knockout mice is modified on a pure C57BL/6 genetic background. J Mol Cell Cardiol (2008) 0.94

Control analysis of energy metabolism in mitochondria. Biochem Soc Trans (1995) 0.89

Lower force and impaired performance during high-intensity electrical stimulation in skeletal muscle of GAMT-deficient knockout mice. Am J Physiol Cell Physiol (2005) 0.87

Cardiac structure and function during ageing in energetically compromised Guanidinoacetate N-methyltransferase (GAMT)-knockout mice - a one year longitudinal MRI study. J Cardiovasc Magn Reson (2008) 0.86

In vivo effects of myocardial creatine depletion on left ventricular function morphology and lipid metabolism: study in a mouse model. J Card Fail (2008) 0.84

Phosphocretine production coupled to the glycolytic reactions in the cytosol of cardiac cells. Biochim Biophys Acta (1980) 0.84

Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age. Basic Res Cardiol (2012) 0.82

Functional and energetic consequences of chronic myocardial creatine depletion by beta-guanidinopropionate in perfused hearts and in intact rats. J Mol Cell Cardiol (1999) 0.81

In vivo magnetic resonance spectroscopy of transgenic mouse models with altered high-energy phosphoryl transfer metabolism. NMR Biomed (2007) 0.80

In vivo effects of myocardial creatine depletion on left ventricular function, morphology, and energy metabolism--consequences in acute myocardial infarction. J Card Fail (2007) 0.77

Articles by these authors

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08

Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature (2010) 20.01

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25

Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet (2012) 12.10

Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med (2009) 8.73

Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet (2012) 7.59

Left ventricular non-compaction: insights from cardiovascular magnetic resonance imaging. J Am Coll Cardiol (2005) 5.63

Loss-of-function mutations in APOC3, triglycerides, and coronary disease. N Engl J Med (2014) 5.47

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease. JAMA (2009) 5.32

Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies. Lancet (2010) 5.31

2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J (2014) 5.21

Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations. PLoS Genet (2009) 4.97

Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med (2014) 4.94

Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Heart Rhythm (2011) 4.31

The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity. J Biol Chem (2006) 4.28

Shortened Modified Look-Locker Inversion recovery (ShMOLLI) for clinical myocardial T1-mapping at 1.5 and 3 T within a 9 heartbeat breathhold. J Cardiovasc Magn Reson (2010) 4.10

Susceptibility to coronary artery disease and diabetes is encoded by distinct, tightly linked SNPs in the ANRIL locus on chromosome 9p. Hum Mol Genet (2007) 4.09

Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes (2010) 4.07

Current state of knowledge on aetiology, diagnosis, management, and therapy of peripartum cardiomyopathy: a position statement from the Heart Failure Association of the European Society of Cardiology Working Group on peripartum cardiomyopathy. Eur J Heart Fail (2010) 3.90

Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. N Engl J Med (2016) 3.88

Mechanisms of increased vascular superoxide production in human diabetes mellitus: role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation (2002) 3.71

Noncontrast T1 mapping for the diagnosis of cardiac amyloidosis. JACC Cardiovasc Imaging (2013) 3.53

Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement. J Cardiovasc Magn Reson (2013) 3.52

Prognostic significance of myocardial fibrosis in hypertrophic cardiomyopathy. J Am Coll Cardiol (2010) 3.50

Normal human left and right ventricular and left atrial dimensions using steady state free precession magnetic resonance imaging. J Cardiovasc Magn Reson (2005) 3.47

Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40

The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter. Nat Cell Biol (2013) 3.39

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet (2013) 3.25

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nat Genet (2011) 3.18

Society for Cardiovascular Magnetic Resonance guidelines for reporting cardiovascular magnetic resonance examinations. J Cardiovasc Magn Reson (2009) 3.17

Modernising medical careers, medical training application service, and the postgraduate medical education and training board: time for the emperors to don their clothes. Lancet (2007) 3.12

Evaluation and management of the cardiac amyloidosis. J Am Coll Cardiol (2007) 3.12

Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet (2012) 3.04

Aortic dilation in bicuspid aortic valve disease: flow pattern is a major contributor and differs with valve fusion type. Circ Cardiovasc Imaging (2013) 3.04

Myocardial tissue characterization using magnetic resonance noncontrast t1 mapping in hypertrophic and dilated cardiomyopathy. Circ Cardiovasc Imaging (2012) 3.01

With the "universal definition," measurement of creatine kinase-myocardial band rather than troponin allows more accurate diagnosis of periprocedural necrosis and infarction after coronary intervention. J Am Coll Cardiol (2011) 2.99

Uncoupling proteins in human heart. Lancet (2004) 2.85

FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A (2008) 2.69

Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity. J Am Coll Cardiol (2009) 2.57

Four paraoxonase gene polymorphisms in 11212 cases of coronary heart disease and 12786 controls: meta-analysis of 43 studies. Lancet (2004) 2.55

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: this document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA). Europace (2011) 2.54

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice. Arterioscler Thromb Vasc Biol (2004) 2.53

Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. Am J Hum Genet (2012) 2.53

Value of delayed-enhancement cardiovascular magnetic resonance imaging in predicting myocardial viability after surgical revascularization. Circulation (2004) 2.50

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood (2003) 2.50

The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging. Obesity (Silver Spring) (2010) 2.43

The role of cardiovascular magnetic resonance imaging in heart failure. J Am Coll Cardiol (2009) 2.41

Severe disease expression of cardiac troponin C and T mutations in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol (2004) 2.40

Myocardial oxygenation in coronary artery disease: insights from blood oxygen level-dependent magnetic resonance imaging at 3 tesla. J Am Coll Cardiol (2012) 2.38

Cardiac myosin binding protein C: its role in physiology and disease. Circ Res (2004) 2.38

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression. J Clin Invest (2003) 2.36

Non-contrast T1-mapping detects acute myocardial edema with high diagnostic accuracy: a comparison to T2-weighted cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2012) 2.34

A myocardial Nox2 containing NAD(P)H oxidase contributes to oxidative stress in human atrial fibrillation. Circ Res (2005) 2.29

Absolute myocardial perfusion in canines measured by using dual-bolus first-pass MR imaging. Radiology (2004) 2.29

Early diagnosis of perioperative myocardial infarction after coronary bypass grafting: a study using biomarkers and cardiac magnetic resonance imaging. Ann Thorac Surg (2011) 2.27

Impaired synaptic plasticity and motor learning in mice with a point mutation implicated in human speech deficits. Curr Biol (2008) 2.27

Role of mitochondrial Ca2+ in the regulation of cellular energetics. Biochemistry (2012) 2.26

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol (2003) 2.25

Genetically determined height and coronary artery disease. N Engl J Med (2015) 2.24

Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging. J Mol Cell Cardiol (2003) 2.24

Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment. Circulation (2005) 2.23

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes (2011) 2.21

Preterm heart in adult life: cardiovascular magnetic resonance reveals distinct differences in left ventricular mass, geometry, and function. Circulation (2012) 2.21

Gene transfer of neuronal nitric oxide synthase to carotid body reverses enhanced chemoreceptor function in heart failure rabbits. Circ Res (2005) 2.20

Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study. J Am Coll Cardiol (2013) 2.18

Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. Cardiovasc Res (2005) 2.17

Detecting acute coronary syndrome in the emergency department with cardiac magnetic resonance imaging. Circulation (2003) 2.14

Identification of novel interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations. Circ Res (2002) 2.13

Plaque volume and occurrence and location of periprocedural myocardial necrosis after percutaneous coronary intervention: insights from delayed-enhancement magnetic resonance imaging, thrombolysis in myocardial infarction myocardial perfusion grade analysis, and intravascular ultrasound. Circulation (2006) 2.13

Feedback inhibition of catecholamine release by two different alpha2-adrenoceptor subtypes prevents progression of heart failure. Circulation (2002) 2.10

Mitochondrial matrix phosphoproteome: effect of extra mitochondrial calcium. Biochemistry (2006) 2.06

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J (2009) 2.05

Association of atrial nicotinamide adenine dinucleotide phosphate oxidase activity with the development of atrial fibrillation after cardiac surgery. J Am Coll Cardiol (2008) 2.05

Cardiovascular magnetic resonance by non contrast T1-mapping allows assessment of severity of injury in acute myocardial infarction. J Cardiovasc Magn Reson (2012) 2.03

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol (2004) 2.01

Carotid artery atherosclerosis: in vivo morphologic characterization with gadolinium-enhanced double-oblique MR imaging initial results. Radiology (2002) 2.01

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation (2003) 2.01

Identification and assessment of Anderson-Fabry disease by cardiovascular magnetic resonance noncontrast myocardial T1 mapping. Circ Cardiovasc Imaging (2013) 1.99

nNOS gene deletion exacerbates pathological left ventricular remodeling and functional deterioration after myocardial infarction. Circulation (2005) 1.97

Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J Magn Reson Imaging (2003) 1.97

Tissue heterogeneity of the mammalian mitochondrial proteome. Am J Physiol Cell Physiol (2006) 1.97

Dynamic changes of edema and late gadolinium enhancement after acute myocardial infarction and their relationship to functional recovery and salvage index. Circ Cardiovasc Imaging (2011) 1.97