Published in Circulation on September 04, 2006
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle Metabolism | NCT00181259
Global cardiovascular reserve dysfunction in heart failure with preserved ejection fraction. J Am Coll Cardiol (2010) 3.63
Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment. Eur Heart J (2010) 3.62
Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses. Magn Reson Med (2009) 1.83
Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol (2012) 1.66
Impaired ATP kinetics in failing in vivo mouse heart. Circ Cardiovasc Imaging (2010) 1.63
Heart failure with preserved ejection fraction: mechanisms, clinical features, and therapies. Circ Res (2014) 1.56
The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol (2011) 1.54
Metabolomics as a tool for cardiac research. Nat Rev Cardiol (2011) 1.51
Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity. J Magn Reson (2012) 1.37
Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest (2011) 1.26
Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl Acad Sci U S A (2009) 1.25
ATP production rate via creatine kinase or ATP synthase in vivo: a novel superfast magnetization saturation transfer method. Circ Res (2011) 1.23
Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study. Circulation (2009) 1.13
Quantification of protein expression changes in the aging left ventricle of Rattus norvegicus. J Proteome Res (2009) 1.13
Triple repetition time saturation transfer (TRiST) 31P spectroscopy for measuring human creatine kinase reaction kinetics. Magn Reson Med (2010) 1.09
Metabolic rates of ATP transfer through creatine kinase (CK Flux) predict clinical heart failure events and death. Sci Transl Med (2013) 1.08
Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure. J Physiol (2008) 1.08
Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. J Magn Reson (2013) 1.03
Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy. J Magn Reson (2007) 0.99
Novel strategy for measuring creatine kinase reaction rate in the in vivo heart. Am J Physiol Heart Circ Physiol (2009) 0.98
Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart. Circ Res (2014) 0.98
Abnormal energetics and ATP depletion in pressure-overload mouse hearts: in vivo high-energy phosphate concentration measures by noninvasive magnetic resonance. Am J Physiol Heart Circ Physiol (2009) 0.97
Imaging myocardial metabolic remodeling. J Nucl Med (2010) 0.91
Magnetic resonance spectroscopy studies of human metabolism. Diabetes (2011) 0.89
Reduced in vivo high-energy phosphates precede adriamycin-induced cardiac dysfunction. Am J Physiol Heart Circ Physiol (2010) 0.87
Myocardial energetics in left ventricular hypertrophy. Curr Cardiol Rev (2009) 0.87
Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2. Proteome Sci (2011) 0.87
Heart failure with preserved ejection fraction: emerging drug strategies. J Cardiovasc Pharmacol (2013) 0.87
Similarities and Differences between the Pathogenesis and Pathophysiology of Diastolic and Systolic Heart Failure. Cardiol Res Pract (2013) 0.86
Cardiac metabolism in hypertrophy and heart failure: implications for therapy. Heart Fail Rev (2013) 0.85
Lone Atrial Fibrillation Is Associated With Impaired Left Ventricular Energetics That Persists Despite Successful Catheter Ablation. Circulation (2016) 0.85
Quantitative cardiovascular magnetic resonance for molecular imaging. J Cardiovasc Magn Reson (2010) 0.84
Reproducibility of creatine kinase reaction kinetics in human heart: a (31) P time-dependent saturation transfer spectroscopy study. NMR Biomed (2014) 0.83
Clinical applications for cardiovascular magnetic resonance imaging at 3 tesla. Curr Cardiol Rev (2009) 0.83
Expert consensus document: Mitochondrial function as a therapeutic target in heart failure. Nat Rev Cardiol (2016) 0.83
Bloch-Siegert B1+-mapping for human cardiac (31) P-MRS at 7 Tesla. Magn Reson Med (2015) 0.82
Augmentation of Creatine in the Heart. Mini Rev Med Chem (2015) 0.81
Quantification of human high-energy phosphate metabolite concentrations at 3 T with partial volume and sensitivity corrections. NMR Biomed (2013) 0.80
Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy. Am J Cardiol (2013) 0.80
Synergistic role of ADP and Ca(2+) in diastolic myocardial stiffness. J Physiol (2015) 0.80
High-energy phosphate transfer in human muscle: diffusion of phosphocreatine. Am J Physiol Cell Physiol (2011) 0.79
Creatine kinase rate constant in the human heart measured with 3D-localization at 7 tesla. Magn Reson Med (2016) 0.78
Use of metformin in diseases of aging. Curr Diab Rep (2014) 0.77
Magnetic resonance imaging and spectroscopy of the murine cardiovascular system. Am J Physiol Heart Circ Physiol (2013) 0.77
Transmurally differentiated measurement of ATP hydrolysis rates in the in vivo porcine hearts. Magn Reson Med (2016) 0.77
Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I. Circ Heart Fail (2014) 0.77
On the theoretical limits of detecting cyclic changes in cardiac high-energy phosphates and creatine kinase reaction kinetics using in vivo ³¹P MRS. NMR Biomed (2015) 0.77
Two repetition time saturation transfer (TwiST) with spill-over correction to measure creatine kinase reaction rates in human hearts. J Cardiovasc Magn Reson (2015) 0.75
Impaired cardiac and skeletal muscle bioenergetics in children, adolescents, and young adults with Barth syndrome. Physiol Rep (2017) 0.75
Cardiovascular molecular MR imaging. Eur J Nucl Med Mol Imaging (2007) 0.75
Normal cardiac function in mice with supraphysiological cardiac creatine levels. Am J Physiol Heart Circ Physiol (2013) 0.75
Delineation of Molecular Pathways Involved in Cardiomyopathies Caused by Troponin T Mutations. Mol Cell Proteomics (2016) 0.75
A comprehensive review of the bioenergetics of fatty acid and glucose metabolism in the healthy and failing heart in nondiabetic condition. Heart Fail Rev (2017) 0.75
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med (1990) 17.52
The natural history of congestive heart failure: the Framingham study. N Engl J Med (1971) 13.94
Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol (2003) 6.99
Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol (1999) 5.43
Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation (2005) 3.86
Heart failure with preserved left ventricular systolic function; epidemiology, clinical characteristics, and prognosis. J Am Coll Cardiol (2004) 3.58
Measurement of coronary sinus blood flow by continuous thermodilution in man. Circulation (1971) 3.14
Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation (2002) 3.11
Phosphotransfer networks and cellular energetics. J Exp Biol (2003) 2.79
Energetic crosstalk between organelles: architectural integration of energy production and utilization. Circ Res (2001) 2.77
Relationship between carbohydrate and lipid metabolism and the energy balance of heart muscle. Annu Rev Physiol (1974) 2.71
ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci U S A (2005) 2.17
The creatine kinase system in normal and diseased human myocardium. N Engl J Med (1985) 2.06
31P NMR spectroscopy detects metabolic abnormalities in asymptomatic patients with hypertrophic cardiomyopathy. Circulation (1998) 2.06
Quantitative measurements of cardiac phosphorus metabolites in coronary artery disease by 31P magnetic resonance spectroscopy. Circulation (1995) 1.97
Cardiac hypertrophy: useful adaptation or pathologic process? Am J Med (1980) 1.87
Detection of low phosphocreatine to ATP ratio in failing hypertrophied human myocardium by 31P magnetic resonance spectroscopy. Lancet (1991) 1.82
Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy. J Am Coll Cardiol (2002) 1.79
Myocardial oxygenation at high workstates in hearts with left ventricular hypertrophy. Cardiovasc Res (1999) 1.77
Proton magnetic resonance spectroscopy can detect creatine depletion associated with the progression of heart failure in cardiomyopathy. J Am Coll Cardiol (2003) 1.77
31P magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease. Altered cardiac high-energy phosphate metabolism in heart failure. Circulation (1992) 1.71
Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med (2002) 1.58
High-energy phosphate metabolism and creatine kinase in failing hearts: a new porcine model. Circulation (2001) 1.53
Oxidative capacity in failing hearts. Am J Physiol Heart Circ Physiol (2003) 1.51
Bioenergetics. Dissecting the role of creatine kinase. Curr Biol (1994) 1.38
Altered myocardial high-energy phosphate metabolites in patients with dilated cardiomyopathy. Am Heart J (1991) 1.36
Kinetic, thermodynamic, and developmental consequences of deleting creatine kinase isoenzymes from the heart. Reaction kinetics of the creatine kinase isoenzymes in the intact heart. J Biol Chem (2000) 1.30
MYOCARDIAL OXYGEN CONSUMPTION DURING VENTRICULAR CONTRACTION AND RELAXATION. Circ Res (1964) 1.25
Rate equation for creatine kinase predicts the in vivo reaction velocity: 31P NMR surface coil studies in brain, heart, and skeletal muscle of the living rat. Biochemistry (1987) 1.22
Diastolic dysfunction in hypertensive heart disease is associated with altered myocardial metabolism. Circulation (1999) 1.19
Myocardial high-energy phosphate and substrate metabolism in swine with moderate left ventricular hypertrophy. Circulation (1995) 1.17
Human cardiac high-energy phosphate metabolite concentrations by 1D-resolved NMR spectroscopy. Magn Reson Med (1996) 1.17
Phosphate metabolite imaging and concentration measurements in human heart by nuclear magnetic resonance. Magn Reson Med (1990) 1.15
Creatine kinase-deficient hearts exhibit increased susceptibility to ischemia-reperfusion injury and impaired calcium homeostasis. Am J Physiol Heart Circ Physiol (2004) 1.12
MR spectroscopy of the human heart: the status and the challenges. Radiology (1994) 1.10
Contractile failure and high-energy phosphate turnover during hypoxia: 31P-NMR surface coil studies in living rat. Circ Res (1987) 1.10
Myocardial creatine kinase kinetics and isoform expression in hearts with severe LV hypertrophy. Am J Physiol Heart Circ Physiol (2001) 1.09
Transmural high energy phosphate distribution and response to alterations in workload in the normal canine myocardium as studied with spatially localized 31P NMR spectroscopy. Magn Reson Med (1990) 1.08
Regional changes in creatine kinase and myocyte size in hypertensive and nonhypertensive cardiac hypertrophy. Circ Res (1990) 1.02
Simultaneous measurement of myocardial oxygen consumption and blood flow using [1-carbon-11]acetate. J Nucl Med (1998) 1.00
Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with essential hypertension and left ventricular hypertrophy. Circulation (1999) 0.99
Chronic phosphocreatine depletion by the creatine analogue beta-guanidinopropionate is associated with increased mortality and loss of ATP in rats after myocardial infarction. Circulation (2001) 0.99
Role of creatine kinase in cardiac excitation-contraction coupling: studies in creatine kinase-deficient mice. FASEB J (2002) 0.98
Bioenergetic consequences of cardiac phosphocreatine depletion induced by creatine analogue feeding. J Biol Chem (1991) 0.92
Influence of aging or left ventricular hypertrophy on the human heart: contents of phosphorus metabolites measured by 31P MRS. Magn Reson Med (1998) 0.91
Gated in vivo examination of cardiac metabolites with 31P nuclear magnetic resonance. Am J Physiol (1986) 0.90
Altered phosphate metabolism in myocardial infarction: P-31 MR spectroscopy. Radiology (1987) 0.87
The energy cost of relaxation in control and hypertrophic rabbit papillary muscles. Heart Vessels (1990) 0.81
Intracellular high-energy phosphate transfer in normal and hypertrophied myocardium. Circulation (1987) 0.80
Creatine phosphate consumption and the actomyosin crossbridge cycle in cardiac muscles. Circ Res (2003) 0.78
Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med (2005) 17.61
Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet (2012) 9.86
Third universal definition of myocardial infarction. J Am Coll Cardiol (2012) 8.59
A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol (2009) 8.13
Infarct tissue heterogeneity by magnetic resonance imaging identifies enhanced cardiac arrhythmia susceptibility in patients with left ventricular dysfunction. Circulation (2007) 5.09
Noncardiac comorbidity increases preventable hospitalizations and mortality among Medicare beneficiaries with chronic heart failure. J Am Coll Cardiol (2003) 4.57
Relative roles of direct regeneration versus paracrine effects of human cardiosphere-derived cells transplanted into infarcted mice. Circ Res (2010) 4.19
Race, medical researcher distrust, perceived harm, and willingness to participate in cardiovascular prevention trials. Medicine (Baltimore) (2008) 4.14
Is the failing heart energy starved? On using chemical energy to support cardiac function. Circ Res (2004) 3.72
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45
Late gadolinium enhancement by cardiovascular magnetic resonance heralds an adverse prognosis in nonischemic cardiomyopathy. J Am Coll Cardiol (2008) 2.99
The performance of interventional loopless MRI antennae at higher magnetic field strengths. Med Phys (2008) 2.97
Towards real-time intravascular endoscopic magnetic resonance imaging. JACC Cardiovasc Imaging (2010) 2.96
Magnetic resonance assessment of the substrate for inducible ventricular tachycardia in nonischemic cardiomyopathy. Circulation (2005) 2.80
Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circ Res (2008) 2.70
Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class improvement following cardiac resynchronization therapy. JACC Cardiovasc Imaging (2008) 2.64
Combined cardiac magnetic resonance imaging and C-reactive protein levels identify a cohort at low risk for defibrillator firings and death. Circ Cardiovasc Imaging (2012) 2.62
Magnetic resonance imaging overestimates ferumoxide-labeled stem cell survival after transplantation in the heart. Circulation (2008) 2.37
Clinical utility and safety of a protocol for noncardiac and cardiac magnetic resonance imaging of patients with permanent pacemakers and implantable-cardioverter defibrillators at 1.5 tesla. Circulation (2006) 2.36
L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA (2006) 2.24
ATP flux through creatine kinase in the normal, stressed, and failing human heart. Proc Natl Acad Sci U S A (2005) 2.17
Noninvasive visualization of coronary artery endothelial function in healthy subjects and in patients with coronary artery disease. J Am Coll Cardiol (2010) 2.09
Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J Hypertens (2007) 2.01
A randomized trial of the efficacy of multidisciplinary care in heart failure outpatients at high risk of hospital readmission. J Am Coll Cardiol (2002) 1.98
A prototype RF dosimeter for independent measurement of the average specific absorption rate (SAR) during MRI. J Magn Reson Imaging (2007) 1.90
Is stem cell therapy ready for patients? Stem Cell Therapy for Cardiac Repair. Ready for the Next Step . Circulation (2006) 1.87
Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses. Magn Reson Med (2009) 1.83
Tissue sodium concentration in human brain tumors as measured with 23Na MR imaging. Radiology (2003) 1.77
Effects of acute hormone therapy on recurrent ischemia in postmenopausal women with unstable angina. J Am Coll Cardiol (2002) 1.67
Allopurinol acutely increases adenosine triphospate energy delivery in failing human hearts. J Am Coll Cardiol (2012) 1.66
Impaired ATP kinetics in failing in vivo mouse heart. Circ Cardiovasc Imaging (2010) 1.63
Fluorine (19F) MRS and MRI in biomedicine. NMR Biomed (2010) 1.60
Effects of aspirin responsiveness and platelet reactivity on early vein graft thrombosis after coronary artery bypass graft surgery. J Am Coll Cardiol (2011) 1.59
Four-angle saturation transfer (FAST) method for measuring creatine kinase reaction rates in vivo. Magn Reson Med (2002) 1.58
Off-resonance angiography: a new method to depict vessels--phantom and rabbit studies. Radiology (2008) 1.56
ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol (2008) 1.55
Effect of Beta-blocker therapy on rehospitalization rates in women versus men with heart failure and preserved ejection fraction. Am J Cardiol (2010) 1.51
Right, but not left, bundle branch block is associated with large anteroseptal scar. J Am Coll Cardiol (2013) 1.45
MRI endoscopy using intrinsically localized probes. Med Phys (2009) 1.45
Noise figure limits for circular loop MR coils. Magn Reson Med (2009) 1.44
Proton magnetic resonance spectroscopic imaging of human breast cancer: a preliminary study. J Magn Reson Imaging (2004) 1.40
Cardiac MRI scar patterns differ by sex in an implantable cardioverter-defibrillator and cardiac resynchronization therapy cohort. Heart Rhythm (2013) 1.40
A simplified approach to the management of non-ST-segment elevation acute coronary syndromes. JAMA (2005) 1.39
Magnetic resonance Spectroscopy with Linear Algebraic Modeling (SLAM) for higher speed and sensitivity. J Magn Reson (2012) 1.37
Age and gender affect ventricular-vascular coupling during aerobic exercise. J Am Coll Cardiol (2004) 1.37
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using "positive contrast" magnetic resonance imaging. J Am Coll Cardiol (2008) 1.35
A multichannel, real-time MRI RF power monitor for independent SAR determination. Med Phys (2012) 1.33
Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. J Clin Invest (2011) 1.26
Elevated tissue sodium concentration in malignant breast lesions detected with non-invasive 23Na MRI. Breast Cancer Res Treat (2007) 1.21
Skeletal muscle ATP kinetics are impaired in frail mice. Age (Dordr) (2013) 1.18
Coronary magnetic resonance angiography. J Magn Reson Imaging (2007) 1.18
HIF-1alpha-targeted pathways are activated by heat acclimation and contribute to acclimation-ischemic cross-tolerance in the heart. Physiol Genomics (2005) 1.15
Reduced myocardial creatine kinase flux in human myocardial infarction: an in vivo phosphorus magnetic resonance spectroscopy study. Circulation (2009) 1.13
Monitoring and correcting spatio-temporal variations of the MR scanner's static magnetic field. MAGMA (2006) 1.13
Large field-of-view real-time MRI with a 32-channel system. Magn Reson Med (2004) 1.13
Pulse pressure is an age-independent predictor of stroke development after cardiac surgery. Hypertension (2007) 1.11
High prevalence of target organ damage in young, African American inner-city men with hypertension. J Clin Hypertens (Greenwich) (2003) 1.10
Triple repetition time saturation transfer (TRiST) 31P spectroscopy for measuring human creatine kinase reaction kinetics. Magn Reson Med (2010) 1.09
The sex-specific impact of systolic hypertension and systolic blood pressure on arterial-ventricular coupling at rest and during exercise. Am J Physiol Heart Circ Physiol (2008) 1.08
Quantifying in vivo MR spectra with circles. J Magn Reson (2005) 1.08
Computational method for identifying and quantifying shape features of human left ventricular remodeling. Ann Biomed Eng (2009) 1.08
Metabolic rates of ATP transfer through creatine kinase (CK Flux) predict clinical heart failure events and death. Sci Transl Med (2013) 1.08
Measuring human cardiac tissue sodium concentrations using surface coils, adiabatic excitation, and twisted projection imaging with minimal T2 losses. J Magn Reson Imaging (2005) 1.08
Local planar gradients with order-of-magnitude strength and speed advantage. Magn Reson Med (2007) 1.06
Xanthine oxidase inhibitors improve energetics and function after infarction in failing mouse hearts. Am J Physiol Heart Circ Physiol (2005) 1.04
On restoring motion-induced signal loss in single-voxel magnetic resonance spectra. Magn Reson Med (2006) 1.04
Reproducibility of 3D free-breathing magnetic resonance coronary vessel wall imaging. Eur Heart J (2005) 1.04
Lumped-element planar strip array (LPSA) for parallel MRI. Magn Reson Med (2004) 1.04
Highly-accelerated quantitative 2D and 3D localized spectroscopy with linear algebraic modeling (SLAM) and sensitivity encoding. J Magn Reson (2013) 1.03
Cardiac Stem Cell Therapy. Need for Optimization of Efficacy and Safety Monitoring. Circulation (2006) 1.02
Correcting reaction rates measured by saturation-transfer magnetic resonance spectroscopy. J Magn Reson (2007) 0.99