Published in Biochemistry on August 03, 2004
Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. PLoS Biol (2012) 1.80
Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis. PLoS One (2016) 1.39
Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization. J Med Chem (2012) 1.35
Overexpression of human mitochondrial valyl tRNA synthetase can partially restore levels of cognate mt-tRNAVal carrying the pathogenic C25U mutation. Nucleic Acids Res (2008) 1.11
Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA. Nucleic Acids Res (2004) 1.06
The human mitochondrial tRNAMet: structure/function relationship of a unique modification in the decoding of unconventional codons. J Mol Biol (2010) 1.03
Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria. Biochemistry (2009) 1.03
Unconventional decoding of the AUA codon as methionine by mitochondrial tRNAMet with the anticodon f5CAU as revealed with a mitochondrial in vitro translation system. Nucleic Acids Res (2009) 1.02
Inhibition of methionyl-tRNA synthetase by REP8839 and effects of resistance mutations on enzyme activity. Antimicrob Agents Chemother (2008) 1.01
Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening. J Biomol Screen (2014) 1.00
NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met). Nat Chem Biol (2016) 0.99
tRNA Modification and Genetic Code Variations in Animal Mitochondria. J Nucleic Acids (2011) 0.93
A disease-causing point mutation in human mitochondrial tRNAMet rsults in tRNA misfolding leading to defects in translational initiation and elongation. J Biol Chem (2008) 0.87
A counterintuitive Mg2+-dependent and modification-assisted functional folding of mitochondrial tRNAs. J Mol Biol (2006) 0.84
Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One (2013) 0.83
Biochemical characterization of pathogenic mutations in human mitochondrial methionyl-tRNA formyltransferase. J Biol Chem (2014) 0.82
Purification, crystallization and preliminary X-ray characterization of a human mitochondrial phenylalanyl-tRNA synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun (2007) 0.80
Identity elements for the aminoacylation of metazoan mitochondrial tRNA(Arg) have been widely conserved throughout evolution and ensure the fidelity of the AGR codon reassignment. RNA Biol (2014) 0.79
Chimeric human mitochondrial PheRS exhibits editing activity to discriminate nonprotein amino acids. Protein Sci (2015) 0.75
Novel, compound heterozygous, single-nucleotide variants in MARS2 associated with developmental delay, poor growth, and sensorineural hearing loss. Hum Mutat (2015) 0.75
Dealing with an Unconventional Genetic Code in Mitochondria: The Biogenesis and Pathogenic Defects of the 5-Formylcytosine Modification in Mitochondrial tRNA(Met). Biomolecules (2017) 0.75
A homology model for Clostridium difficile methionyl tRNA synthetase: active site analysis and docking interactions. J Mol Model (2010) 0.75
Structure of the mammalian mitochondrial ribosome reveals an expanded functional role for its component proteins. Cell (2003) 3.28
Reporter proteins for in vivo fluorescence without oxygen. Nat Biotechnol (2007) 2.11
Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem (2004) 1.97
An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. Mol Cell (2003) 1.90
Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. EMBO J (2002) 1.82
EF-G2mt is an exclusive recycling factor in mammalian mitochondrial protein synthesis. Mol Cell (2009) 1.82
Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet (2006) 1.79
Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J Biol Chem (2004) 1.49
Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A (2004) 1.47
Wobble modification differences and subcellular localization of tRNAs in Leishmania tarentolae: implication for tRNA sorting mechanism. EMBO J (2003) 1.37
Identification of mammalian mitochondrial translational initiation factor 3 and examination of its role in initiation complex formation with natural mRNAs. J Biol Chem (2002) 1.36
Structural basis for template-independent RNA polymerization. Nature (2004) 1.35
Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J Biol Chem (2008) 1.30
Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria. EMBO J (2005) 1.26
Mechanism of protein biosynthesis in mammalian mitochondria. Biochim Biophys Acta (2011) 1.26
Lack of secondary structure characterizes the 5' ends of mammalian mitochondrial mRNAs. RNA (2008) 1.25
Structure of d(GCGAAAGC) (hexagonal form): a base-intercalated duplex as a stable structure. Acta Crystallogr D Biol Crystallogr (2003) 1.20
Flavin mononucleotide-based fluorescent reporter proteins outperform green fluorescent protein-like proteins as quantitative in vivo real-time reporters. Appl Environ Microbiol (2010) 1.19
Identification of two tRNA thiolation genes required for cell growth at extremely high temperatures. J Biol Chem (2006) 1.16
Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs. Genes Cells (2002) 1.10
Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors. EMBO J (2008) 1.09
Crystal structure of d(GCGAAAGCT) containing a parallel-stranded duplex with homo base pairs and an anti-parallel duplex with Watson-Crick base pairs. Nucleic Acids Res (2002) 1.09
Interaction of mitochondrial initiation factor 2 with mitochondrial fMet-tRNA. Nucleic Acids Res (2004) 1.06
Conserved bases in the TPsi C loop of tRNA are determinants for thermophile-specific 2-thiouridylation at position 54. J Biol Chem (2002) 1.06
RsfA (YbeB) proteins are conserved ribosomal silencing factors. PLoS Genet (2012) 1.06
A unique serine-specific elongation factor Tu found in nematode mitochondria. Nat Struct Biol (2002) 1.06
Modification at position 9 with 1-methyladenosine is crucial for structure and function of nematode mitochondrial tRNAs lacking the entire T-arm. Nucleic Acids Res (2005) 1.05
Chaperone properties of mammalian mitochondrial translation elongation factor Tu. J Biol Chem (2006) 1.04
The human mitochondrial tRNAMet: structure/function relationship of a unique modification in the decoding of unconventional codons. J Mol Biol (2010) 1.03
Evidence for an active role of IF3mt in the initiation of translation in mammalian mitochondria. Biochemistry (2009) 1.03
Unconventional decoding of the AUA codon as methionine by mitochondrial tRNAMet with the anticodon f5CAU as revealed with a mitochondrial in vitro translation system. Nucleic Acids Res (2009) 1.02
Identification and characterization of CHCHD1, AURKAIP1, and CRIF1 as new members of the mammalian mitochondrial ribosome. Front Physiol (2013) 1.02
Isolation and characterization of mitochondrial ribosomes and ribosomal subunits from Leishmania tarentolae. Mol Biochem Parasitol (2006) 1.01
The effect of mutated mitochondrial ribosomal proteins S16 and S22 on the assembly of the small and large ribosomal subunits in human mitochondria. Mitochondrion (2008) 1.00
The minimal tRNA: unique structure of Ascaris suum mitochondrial tRNA(Ser)(UCU) having a short T arm and lacking the entire D arm. FEBS Lett (2002) 1.00
A novel T7 RNA polymerase dependent expression system for high-level protein production in the phototrophic bacterium Rhodobacter capsulatus. Protein Expr Purif (2009) 1.00
The 7472insC mitochondrial DNA mutation impairs the synthesis and extent of aminoacylation of tRNASer(UCN) but not its structure or rate of turnover. J Biol Chem (2002) 1.00
Comprehensive detection of human terminal oligo-pyrimidine (TOP) genes and analysis of their characteristics. Nucleic Acids Res (2008) 0.99
Antibiotic susceptibility of mammalian mitochondrial translation. FEBS Lett (2005) 0.99
Low conservation and species-specific evolution of alternative splicing in humans and mice: comparative genomics analysis using well-annotated full-length cDNAs. Nucleic Acids Res (2008) 0.97
Antibiotic effects on mitochondrial translation and in patients with mitochondrial translational defects. Mitochondrion (2009) 0.97
HMRF1L is a human mitochondrial translation release factor involved in the decoding of the termination codons UAA and UAG. Genes Cells (2008) 0.97
Temperature-dependent biosynthesis of 2-thioribothymidine of Thermus thermophilus tRNA. J Biol Chem (2005) 0.96
Divergent evolutions of trinucleotide polymerization revealed by an archaeal CCA-adding enzyme structure. EMBO J (2003) 0.96
The interaction of mammalian mitochondrial translational initiation factor 3 with ribosomes: evolution of terminal extensions in IF3mt. Nucleic Acids Res (2007) 0.96
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. FEBS Lett (2005) 0.95
The phylogenetic status of Paxillosida (Asteroidea) based on complete mitochondrial DNA sequences. Mol Phylogenet Evol (2005) 0.94
The interaction of mitochondrial translational initiation factor 2 with the small ribosomal subunit. Biochim Biophys Acta (2005) 0.94
Overexpression and purification of mammalian mitochondrial translational initiation factor 2 and initiation factor 3. Methods Enzymol (2007) 0.94
Properties of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L and its interactions with mammalian mitochondrial ribosomes. J Biol Chem (2010) 0.93
Proteomics and electron microscopic characterization of the unusual mitochondrial ribosome-related 45S complex in Leishmania tarentolae. Mol Biochem Parasitol (2007) 0.92
The cephalopod Loligo bleekeri mitochondrial genome: multiplied noncoding regions and transposition of tRNA genes. J Mol Evol (2002) 0.92
Role of the N- and C-terminal extensions on the activity of mammalian mitochondrial translational initiation factor 3. Nucleic Acids Res (2005) 0.92
Human G-proteins, ObgH1 and Mtg1, associate with the large mitochondrial ribosome subunit and are involved in translation and assembly of respiratory complexes. Nucleic Acids Res (2013) 0.91
Preferential selection of the 5'-terminal start codon on leaderless mRNAs by mammalian mitochondrial ribosomes. J Biol Chem (2010) 0.90
Unusual usage of wobble modifications in mitochondrial tRNAs of the nematode Ascaris suum. FEBS Lett (2005) 0.89
Mutagenesis of glutamine 290 in Escherichia coli and mitochondrial elongation factor Tu affects interactions with mitochondrial aminoacyl-tRNAs and GTPase activity. Biochemistry (2004) 0.88
RNA-binding proteins of mammalian mitochondria. Mitochondrion (2003) 0.88
The discovery of modified nucleosides from the early days to the present: a personal perspective. J Biosci (2006) 0.88
A disease-causing point mutation in human mitochondrial tRNAMet rsults in tRNA misfolding leading to defects in translational initiation and elongation. J Biol Chem (2008) 0.87
A unique tRNA recognition mechanism of Caenorhabditis elegans mitochondrial EF-Tu2. Nucleic Acids Res (2005) 0.86
Insertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1. Proc Natl Acad Sci U S A (2011) 0.86
Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors. Nucleic Acids Res (2012) 0.86
Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron. RNA (2002) 0.86
Interaction of mitochondrial elongation factor Tu with aminoacyl-tRNAs. Mitochondrion (2004) 0.86
Classification of RNA structures based on hydrogen bond and base-base stacking patterns: application for NMR structures. J Biochem (2002) 0.86
The human mitochondrial translation release factor HMRF1L is methylated in the GGQ motif by the methyltransferase HMPrmC. Biochem Biophys Res Commun (2008) 0.84
Characterization of the interaction between the nucleotide exchange factor EF-Ts from nematode mitochondria and elongation factor Tu. Nucleic Acids Res (2002) 0.84
Roles of the N- and C-terminal domains of mammalian mitochondrial initiation factor 3 in protein biosynthesis. J Mol Biol (2008) 0.84
Chemical synthesis of novel taurine-containing uridine derivatives. Nucleic Acids Res Suppl (2002) 0.84
Taurine-containing uridine modifications in tRNA anticodons are required to decipher non-universal genetic codes in ascidian mitochondria. J Biol Chem (2011) 0.84
A counterintuitive Mg2+-dependent and modification-assisted functional folding of mitochondrial tRNAs. J Mol Biol (2006) 0.84
Native tertiary structure and nucleoside modifications suppress tRNA's intrinsic ability to activate the innate immune sensor PKR. PLoS One (2013) 0.83
The effect of spermine on the initiation of mitochondrial protein synthesis. Biochem Biophys Res Commun (2009) 0.83
Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. Hum Mol Genet (2006) 0.83
A protein extension to shorten RNA: elongated elongation factor-Tu recognizes the D-arm of T-armless tRNAs in nematode mitochondria. Biochem J (2006) 0.82
Contacts between mammalian mitochondrial translational initiation factor 3 and ribosomal proteins in the small subunit. Biochim Biophys Acta (2011) 0.82
Identification of protein-protein and protein-ribosome interacting regions of the C-terminal tail of human mitochondrial inner membrane protein Oxa1L. J Biol Chem (2010) 0.82
Analysis of the functional consequences of lethal mutations in mitochondrial translational elongation factors. Biochim Biophys Acta (2010) 0.81
Wobble modification defect suppresses translational activity of tRNAs with MERRF and MELAS mutations. Mitochondrion (2002) 0.81
Expression and characterization of isoform 1 of human mitochondrial elongation factor G. Protein Expr Purif (2004) 0.81
Discovery of the first light-dependent protochlorophyllide oxidoreductase in anoxygenic phototrophic bacteria. Mol Microbiol (2014) 0.81
Crystallization and preliminary X-ray diffraction study of mammalian mitochondrial seryl-tRNA synthetase. Acta Crystallogr D Biol Crystallogr (2004) 0.81
Structures of d(GCGAAGC) and d(GCGAAAGC) (tetragonal form): a switching of partners of the sheared G.A pairs to form a functional G.AxA.G crossing. Acta Crystallogr D Biol Crystallogr (2004) 0.81
Simple and rapid synthesis of siRNA derived from in vitro transcribed shRNA. Nucleic Acids Res Suppl (2003) 0.80
Isolation and physiochemical properties of protein-rich nematode mitochondrial ribosomes. Biochemistry (2005) 0.80
A bacterial elongation factor G homologue exclusively functions in ribosome recycling in the spirochaete Borrelia burgdorferi. Mol Microbiol (2010) 0.80
Quick two-step RNA ligation employing periodate oxidation. Nucleic Acids Res (2003) 0.80
Effects of mutagenesis of residue 221 on the properties of bacterial and mitochondrial elongation factor EF-Tu. Biochim Biophys Acta (2004) 0.79
Mutagenesis of Arg335 in bovine mitochondrial elongation factor Tu and the corresponding residue in the Escherichia coli factor affects interactions with mitochondrial aminoacyl-tRNAs. RNA Biol (2004) 0.79
ICT1 comes to the rescue of mitochondrial ribosomes. EMBO J (2010) 0.78
In situ kinetic trapping reveals a fingerprint of reversible protein thiol oxidation in the mitochondrial matrix. Free Radic Biol Med (2011) 0.78
The pathogenic A4269G mutation in human mitochondrial tRNA(Ile) alters the T-stem structure and decreases the binding affinity for elongation factor Tu. Genes Cells (2004) 0.78
Quality control of translation through the kinetic discrimination of tRNAs in the network of aminoacyl-tRNA synthetases. Nucleic Acids Res Suppl (2002) 0.77
Effects of mutagenesis of Gln97 in the switch II region of Escherichia coli elongation factor Tu on its interaction with guanine nucleotides, elongation factor Ts, and aminoacyl-tRNA. Biochemistry (2003) 0.77
Nuclear respiratory factor 2 activates transcription of human mitochondrial translation initiation factor 2 gene. Mitochondrion (2006) 0.77