Antibiotic susceptibility of mammalian mitochondrial translation.

Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Genome Biol (2007) 2.12

The transcription factor FOXM1 is a cellular target of the natural product thiostrepton. Nat Chem (2011) 1.82

The complete structure of the large subunit of the mammalian mitochondrial ribosome. Nature (2014) 1.67

Doxycycline down-regulates DNA-PK and radiosensitizes tumor initiating cells: Implications for more effective radiation therapy. Oncotarget (2015) 1.39

Suppression of the FOXM1 transcriptional programme via novel small molecule inhibition. Nat Commun (2014) 1.05

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism. Cancer Chemother Pharmacol (2008) 0.91

From father to son: transgenerational effect of tetracycline on sperm viability. Sci Rep (2012) 0.86

Disabling Mitochondrial Peroxide Metabolism via Combinatorial Targeting of Peroxiredoxin 3 as an Effective Therapeutic Approach for Malignant Mesothelioma. PLoS One (2015) 0.81

FOXM1 is a downstream target of LPA and YAP oncogenic signaling pathways in high grade serous ovarian cancer. Oncotarget (2015) 0.80

Overexpression of TUF1 restores respiratory growth and fluconazole sensitivity to a Cryptococcus neoformans vad1Delta mutant. Microbiology (2010) 0.80

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function. Chem Rev (2017) 0.79

Thiostrepton interacts covalently with Rpt subunits of the 19S proteasome and proteasome substrates. J Cell Mol Med (2015) 0.77

Role of nonalcoholic fatty liver disease as risk factor for drug-induced hepatotoxicity. J Clin Transl Res (2017) 0.75

Chemical Proteomic Approaches Targeting Cancer Stem Cells: A Review of Current Literature. Cancer Genomics Proteomics (2017) 0.75

Pimet, the Drosophila homolog of HEN1, mediates 2'-O-methylation of Piwi- interacting RNAs at their 3' ends. Genes Dev (2007) 4.68

Selective stabilization of mammalian microRNAs by 3' adenylation mediated by the cytoplasmic poly(A) polymerase GLD-2. Genes Dev (2009) 3.62

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline. Dev Cell (2009) 2.96

Hsc70/Hsp90 chaperone machinery mediates ATP-dependent RISC loading of small RNA duplexes. Mol Cell (2010) 2.91

Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J Neurosci (2006) 2.84

The 3' termini of mouse Piwi-interacting RNAs are 2'-O-methylated. Nat Struct Mol Biol (2007) 2.71

Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. Mol Cell (2006) 2.71

Recurrence pattern of squamous cell carcinoma of the thoracic esophagus after extended radical esophagectomy with three-field lymphadenectomy. J Am Coll Surg (2004) 2.47

Human mitochondrial mRNAs are stabilized with polyadenylation regulated by mitochondria-specific poly(A) polymerase and polynucleotide phosphorylase. J Biol Chem (2005) 2.02

Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. J Biol Chem (2004) 1.97

Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J (2006) 1.95

Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. Nucleic Acids Res (2009) 1.91

An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. Mol Cell (2003) 1.90

Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. EMBO J (2002) 1.82

Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest (2011) 1.80

Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet (2006) 1.79

Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea. Nat Chem Biol (2010) 1.68

Mechanism of mRNA deadenylation: evidence for a molecular interplay between translation termination factor eRF3 and mRNA deadenylases. Genes Dev (2007) 1.68

Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med (2004) 1.60

The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation. J Biol Chem (2007) 1.55

Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA. Nucleic Acids Res (2009) 1.52

Snapshots of tRNA sulphuration via an adenylated intermediate. Nature (2006) 1.51

Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease. Proc Natl Acad Sci U S A (2005) 1.50

Specific residues at every third position of siRNA shape its efficient RNAi activity. Nucleic Acids Res (2007) 1.49

Inosine cyanoethylation identifies A-to-I RNA editing sites in the human transcriptome. Nat Chem Biol (2010) 1.49

Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. J Biol Chem (2004) 1.49

Codon-specific translational defect caused by a wobble modification deficiency in mutant tRNA from a human mitochondrial disease. Proc Natl Acad Sci U S A (2004) 1.47

molecular mechanism of lysidine synthesis that determines tRNA identity and codon recognition. Mol Cell (2005) 1.41

The A-site finger in 23 S rRNA acts as a functional attenuator for translocation. J Biol Chem (2006) 1.41

Direct evidence of astrocytic modulation in the development of rewarding effects induced by drugs of abuse. Neuropsychopharmacology (2006) 1.39

A cyclic form of N6-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification. Nat Chem Biol (2012) 1.37

Wobble modification differences and subcellular localization of tRNAs in Leishmania tarentolae: implication for tRNA sorting mechanism. EMBO J (2003) 1.37

Automated parallel isolation of multiple species of non-coding RNAs by the reciprocal circulating chromatography method. Nucleic Acids Res (2007) 1.32

Conserved loop sequence of helix 69 in Escherichia coli 23 S rRNA is involved in A-site tRNA binding and translational fidelity. J Biol Chem (2006) 1.32

Outcomes of simultaneous resection of synchronous esophageal and extraesophageal carcinomas. J Am Coll Surg (2002) 1.31

Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology (2006) 1.30

Modified uridines with C5-methylene substituents at the first position of the tRNA anticodon stabilize U.G wobble pairing during decoding. J Biol Chem (2008) 1.30

LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria. Nucleic Acids Res (2012) 1.29

Poly(A)-specific ribonuclease mediates 3'-end trimming of Argonaute2-cleaved precursor microRNAs. Cell Rep (2013) 1.28

Dual-mode recognition of noncanonical tRNAs(Ser) by seryl-tRNA synthetase in mammalian mitochondria. EMBO J (2005) 1.26

Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. J Mol Biol (2007) 1.25

Role of delta-opioid receptor function in neurogenesis and neuroprotection. J Neurochem (2006) 1.23

Direct evidence for the involvement of brain-derived neurotrophic factor in the development of a neuropathic pain-like state in mice. J Neurochem (2005) 1.21

Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment. Hippocampus (2011) 1.20

Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice. J Neurochem (2006) 1.20

Structure of d(GCGAAAGC) (hexagonal form): a base-intercalated duplex as a stable structure. Acta Crystallogr D Biol Crystallogr (2003) 1.20

Characterization of the human mitochondrial methionyl-tRNA synthetase. Biochemistry (2004) 1.19

Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats. J Control Release (2002) 1.18

Direct evidence for the involvement of endogenous beta-endorphin in the suppression of the morphine-induced rewarding effect under a neuropathic pain-like state. Neurosci Lett (2008) 1.17

Identification of two tRNA thiolation genes required for cell growth at extremely high temperatures. J Biol Chem (2006) 1.16

Chaplet column chromatography: isolation of a large set of individual RNAs in a single step. Methods Enzymol (2007) 1.15

Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. Nature (2009) 1.15

Neuropathic and chronic pain stimuli downregulate central mu-opioid and dopaminergic transmission. Trends Pharmacol Sci (2010) 1.13

Involvement of the Escherichia coli folate-binding protein YgfZ in RNA modification and regulation of chromosomal replication initiation. Mol Microbiol (2006) 1.11

Implication of activated astrocytes in the development of drug dependence: differences between methamphetamine and morphine. Ann N Y Acad Sci (2008) 1.10

Usefulness of antidepressants for improving the neuropathic pain-like state and pain-induced anxiety through actions at different brain sites. Neuropsychopharmacology (2007) 1.10

Expanding role of the jumonji C domain as an RNA hydroxylase. J Biol Chem (2010) 1.10

Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs. Genes Cells (2002) 1.10

Suppression of the morphine-induced rewarding effect in the rat with neuropathic pain: implication of the reduction in mu-opioid receptor functions in the ventral tegmental area. J Neurochem (2002) 1.10

A biochemical landscape of A-to-I RNA editing in the human brain transcriptome. Genome Res (2014) 1.09

Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors. EMBO J (2008) 1.09

Crystal structure of d(GCGAAAGCT) containing a parallel-stranded duplex with homo base pairs and an anti-parallel duplex with Watson-Crick base pairs. Nucleic Acids Res (2002) 1.09

Thio modification of yeast cytosolic tRNA is an iron-sulfur protein-dependent pathway. Mol Cell Biol (2007) 1.08

Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. Structure (2006) 1.08

Comprehensive genetic selection revealed essential bases in the peptidyl-transferase center. Proc Natl Acad Sci U S A (2006) 1.07

Structure of the Atg12-Atg5 conjugate reveals a platform for stimulating Atg8-PE conjugation. EMBO Rep (2012) 1.07

Enhanced IL-1beta production in response to the activation of hippocampal glial cells impairs neurogenesis in aged mice. Synapse (2010) 1.07

Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. Proc Natl Acad Sci U S A (2009) 1.06

Conserved bases in the TPsi C loop of tRNA are determinants for thermophile-specific 2-thiouridylation at position 54. J Biol Chem (2002) 1.06

The ordered transcription of RNA domains is not essential for ribosome biogenesis in Escherichia coli. Mol Cell (2009) 1.06

The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. EMBO J (2008) 1.06

A unique serine-specific elongation factor Tu found in nematode mitochondria. Nat Struct Biol (2002) 1.06

Modification at position 9 with 1-methyladenosine is crucial for structure and function of nematode mitochondrial tRNAs lacking the entire T-arm. Nucleic Acids Res (2005) 1.05

Human mitochondrial diseases associated with tRNA wobble modification deficiency. RNA Biol (2005) 1.05

Role of extracellular signal-regulated kinase in the ventral tegmental area in the suppression of the morphine-induced rewarding effect in mice with sciatic nerve ligation. J Neurochem (2004) 1.05

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Proc Natl Acad Sci U S A (2005) 1.04

Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. Nucleic Acids Res (2009) 1.03

Loss of ribosomal RNA modification causes developmental defects in zebrafish. Nucleic Acids Res (2011) 1.02

Polyadenylation in mammalian mitochondria: insights from recent studies. Biochim Biophys Acta (2008) 1.02

Unconventional decoding of the AUA codon as methionine by mitochondrial tRNAMet with the anticodon f5CAU as revealed with a mitochondrial in vitro translation system. Nucleic Acids Res (2009) 1.02

Epigenetic transcriptional activation of monocyte chemotactic protein 3 contributes to long-lasting neuropathic pain. Brain (2013) 1.01

Retrograde nuclear import of tRNA precursors is required for modified base biogenesis in yeast. Proc Natl Acad Sci U S A (2011) 1.01

Peritoneovenous shunting for intractable chylous ascites complicated with lymphangioleiomyomatosis. Intern Med (2008) 1.01

Protease-activated receptor-1 and platelet-derived growth factor in spinal cord neurons are implicated in neuropathic pain after nerve injury. J Neurosci (2005) 1.01

Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA. J Biol Chem (2009) 1.01

Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S ribosomal subunit. RNA (2007) 1.00

The minimal tRNA: unique structure of Ascaris suum mitochondrial tRNA(Ser)(UCU) having a short T arm and lacking the entire D arm. FEBS Lett (2002) 1.00