Published in Methods on September 01, 2004
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Structural and dynamic characteristics of a partially folded state of ubiquitin revealed by hydrogen exchange mass spectrometry. Biochemistry (2005) 0.95
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A non-natural variant of human lysozyme (I59T) mimics the in vitro behaviour of the I56T variant that is responsible for a form of familial amyloidosis. Protein Eng Des Sel (2010) 0.93
Protein dynamics at Eph receptor-ligand interfaces as revealed by crystallography, NMR and MD simulations. BMC Biophys (2012) 0.93
Branching in the sequential folding pathway of cytochrome c. Protein Sci (2007) 0.93
Existence of a noncanonical state of iron-bound transferrin at endosomal pH revealed by hydrogen exchange and mass spectrometry. J Mol Biol (2009) 0.93
Enzyme dynamics from NMR spectroscopy. Acc Chem Res (2015) 0.93
Prediction of native-state hydrogen exchange from perfectly funneled energy landscapes. J Am Chem Soc (2011) 0.92
Protein conformation in amorphous solids by FTIR and by hydrogen/deuterium exchange with mass spectrometry. Biophys J (2008) 0.92
Tetrameric beta(3)-peptide bundles. Chembiochem (2008) 0.92
An Achilles' heel in an amyloidogenic protein and its repair: insulin fibrillation and therapeutic design. J Biol Chem (2010) 0.91
Isotope-coded affinity tags with tunable reactivities for protein footprinting. Angew Chem Int Ed Engl (2008) 0.90
Conformational dynamics of the bovine mitochondrial ADP/ATP carrier isoform 1 revealed by hydrogen/deuterium exchange coupled to mass spectrometry. J Biol Chem (2010) 0.90
Beyond microscopic reversibility: Are observable non-equilibrium processes precisely reversible? J Chem Theory Comput (2011) 0.89
Protein footprinting in a complex milieu: identifying the interaction surfaces of the chemotaxis adaptor protein CheW. J Mol Biol (2011) 0.89
AMORE-HX: a multidimensional optimization of radial enhanced NMR-sampled hydrogen exchange. J Biomol NMR (2009) 0.88
Impact of oxidation on protein therapeutics: conformational dynamics of intact and oxidized acid-β-glucocerebrosidase at near-physiological pH. Protein Sci (2010) 0.88
Kinetic asymmetry of subunit exchange of homooligomeric protein as revealed by deuteration-assisted small-angle neutron scattering. Biophys J (2011) 0.86
HDX-analyzer: a novel package for statistical analysis of protein structure dynamics. BMC Bioinformatics (2011) 0.86
Measuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domain. Protein Sci (2011) 0.86
Hexicon 2: automated processing of hydrogen-deuterium exchange mass spectrometry data with improved deuteration distribution estimation. J Am Soc Mass Spectrom (2014) 0.86
Putting the pathway back into protein folding. Proc Natl Acad Sci U S A (2005) 0.86
The extremely slow-exchanging core and acid-denatured state of green fluorescent protein. HFSP J (2008) 0.86
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Role of partial protein unfolding in alcohol-induced protein aggregation. Proteins (2010) 0.85
NMR dynamics of PSE-4 beta-lactamase: an interplay of ps-ns order and mus-ms motions in the active site. Biophys J (2009) 0.85
Advanced mass spectrometry-based methods for the analysis of conformational integrity of biopharmaceutical products. Curr Pharm Biotechnol (2011) 0.84
Emerging mass spectrometry-based approaches to probe protein-receptor interactions: focus on overcoming physiological barriers. Adv Drug Deliv Rev (2013) 0.84
On the role of protein structural dynamics in the catalytic activity and thermostability of serine protease subtilisin Carlsberg. Biotechnol Bioeng (2009) 0.84
Submolecular unfolding units of Pseudomonas aeruginosa cytochrome c-551. J Biol Inorg Chem (2008) 0.84
Structural, stability, dynamic and binding properties of the ALS-causing T46I mutant of the hVAPB MSP domain as revealed by NMR and MD simulations. PLoS One (2011) 0.83
Folding and assembly of large macromolecular complexes monitored by hydrogen-deuterium exchange and mass spectrometry. Microb Cell Fact (2008) 0.83
Subunit Interactions within the Carbon-Phosphorus Lyase Complex from Escherichia coli. Biochemistry (2015) 0.80
Clusters of isoleucine, leucine, and valine side chains define cores of stability in high-energy states of globular proteins: Sequence determinants of structure and stability. Protein Sci (2015) 0.79
Functional dynamics of hexameric helicase probed by hydrogen exchange and simulation. Biophys J (2014) 0.79
Destabilizing mutations alter the hydrogen exchange mechanism in ribonuclease A. Biophys J (2008) 0.79
Long-range side-chain-main-chain interactions play crucial roles in stabilizing the (betaalpha)8 barrel motif of the alpha subunit of tryptophan synthase. Protein Sci (2007) 0.79
Effect of antimicrobial preservatives on partial protein unfolding and aggregation. J Pharm Sci (2012) 0.78
Insight into the role of dynamics in the conformational switch of the small GTP-binding protein Arf1. J Biol Chem (2010) 0.78
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Folding of an all-helical Greek-key protein monitored by quenched-flow hydrogen-deuterium exchange and NMR spectroscopy. Eur Biophys J (2011) 0.77
Protein knotting through concatenation significantly reduces folding stability. Sci Rep (2016) 0.76
NMR investigations on residue level unfolding thermodynamics in DLC8 dimer by temperature dependent native state hydrogen exchange. J Biomol NMR (2009) 0.76
Conformational Destabilization of Immunoglobulin G Increases the Low pH Binding Affinity with the Neonatal Fc Receptor. J Biol Chem (2015) 0.76
Investigating the refolding pathway of human acidic fibroblast growth factor (hFGF-1) from the residual structure(s) obtained by denatured-state hydrogen/deuterium exchange. Biophys J (2011) 0.75
Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome. Sci Rep (2017) 0.75
NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PLoS One (2014) 0.75
Protein Structural Analysis via Mass Spectrometry-Based Proteomics. Adv Exp Med Biol (2016) 0.75
The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS. Structure (2015) 0.75
HDX MS reveals calcium binding properties and allosteric regulation of downstream regulatory element antagonist modulator (DREAM). Biochemistry (2017) 0.75
The case for defined protein folding pathways. Proc Natl Acad Sci U S A (2017) 0.75
Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science (2009) 10.78
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Genomewide association study of leprosy. N Engl J Med (2009) 8.17
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
DEG 5.0, a database of essential genes in both prokaryotes and eukaryotes. Nucleic Acids Res (2008) 2.94
Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase. Mol Cell (2011) 2.84
Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents. Hepatology (2010) 2.55
Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model. Clin Cancer Res (2005) 2.43
Association analyses identify six new psoriasis susceptibility loci in the Chinese population. Nat Genet (2010) 2.41
Protein folding: the stepwise assembly of foldon units. Proc Natl Acad Sci U S A (2005) 2.29
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep (2011) 2.20
Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clin Cancer Res (2013) 2.15
Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry. Proc Natl Acad Sci U S A (2003) 2.09
DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements. Nucleic Acids Res (2013) 2.01
The E46K mutation in alpha-synuclein increases amyloid fibril formation. J Biol Chem (2005) 1.98
IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest (2011) 1.77
Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group. Proc Natl Acad Sci U S A (2009) 1.73
Genome and transcriptome sequencing in prospective metastatic triple-negative breast cancer uncovers therapeutic vulnerabilities. Mol Cancer Ther (2012) 1.72
Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding. J Mol Biol (2002) 1.70
Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level. Proc Natl Acad Sci U S A (2005) 1.65
Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis (2011) 1.64
Protein hydrogen exchange mechanism: local fluctuations. Protein Sci (2003) 1.63
Association of inorganic arsenic exposure with type 2 diabetes mellitus: a meta-analysis. J Epidemiol Community Health (2013) 1.63
Screening of patients with tuberculosis for diabetes mellitus in China. Trop Med Int Health (2012) 1.58
An R package suite for microarray meta-analysis in quality control, differentially expressed gene analysis and pathway enrichment detection. Bioinformatics (2012) 1.54
How cytochrome c folds, and why: submolecular foldon units and their stepwise sequential stabilization. J Mol Biol (2004) 1.51
A pilot study of heel ultrasound to screen for low bone mass in children with leukemia. J Pediatr Hematol Oncol (2006) 1.50
Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.50
Detecting disease-associated genes with confounding variable adjustment and the impact on genomic meta-analysis: with application to major depressive disorder. BMC Bioinformatics (2012) 1.46
A 128-channel 6 mW wireless neural recording IC with spike feature extraction and UWB transmitter. IEEE Trans Neural Syst Rehabil Eng (2009) 1.45
ExMS: data analysis for HX-MS experiments. J Am Soc Mass Spectrom (2011) 1.44
Hyperinsulinemia in African-American adolescents compared with their American white peers despite similar insulin sensitivity: a reflection of upregulated beta-cell function? Diabetes Care (2008) 1.42
Conversion-dependent shrinkage stress and strain in dental resins and composites. Dent Mater (2005) 1.42
Anticancer drugs cause release of exosomes with heat shock proteins from human hepatocellular carcinoma cells that elicit effective natural killer cell antitumor responses in vitro. J Biol Chem (2012) 1.40
Distinct and overlapping roles of single-repeat MYB genes in root epidermal patterning. Dev Biol (2007) 1.39
Cytochrome c folding pathway: kinetic native-state hydrogen exchange. Proc Natl Acad Sci U S A (2002) 1.37
RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem (2007) 1.37
Order of steps in the cytochrome C folding pathway: evidence for a sequential stabilization mechanism. J Mol Biol (2006) 1.36
Cooperative omega loops in cytochrome c: role in folding and function. J Mol Biol (2003) 1.35
Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2013) 1.34
Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini. Proc Natl Acad Sci U S A (2011) 1.33
The N-terminal to C-terminal motif in protein folding and function. Proc Natl Acad Sci U S A (2005) 1.29
Recombinant equine cytochrome c in Escherichia coli: high-level expression, characterization, and folding and assembly mutants. Biochemistry (2002) 1.29
A nanostructure-initiator mass spectrometry-based enzyme activity assay. Proc Natl Acad Sci U S A (2008) 1.27
AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation. Circ Res (2008) 1.23
Protein dynamics viewed by hydrogen exchange. Protein Sci (2012) 1.22
Many overlapping peptides for protein hydrogen exchange experiments by the fragment separation-mass spectrometry method. J Am Soc Mass Spectrom (2011) 1.22
Structural insights into a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res (2010) 1.21
Potentially modifiable factors affecting the progression of autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol (2010) 1.21
Protein hydrogen exchange: testing current models. Protein Sci (2012) 1.20
Hepatitis B virus X (HBx) induces tumorigenicity of hepatic progenitor cells in 3,5-diethoxycarbonyl-1,4-dihydrocollidine-treated HBx transgenic mice. Hepatology (2011) 1.20
Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2. Cell Res (2011) 1.18
Phase I study of vorinostat in patients with advanced solid tumors and hepatic dysfunction: a National Cancer Institute Organ Dysfunction Working Group study. J Clin Oncol (2010) 1.15
Lysine 88 acetylation negatively regulates ornithine carbamoyltransferase activity in response to nutrient signals. J Biol Chem (2009) 1.13
Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides. Nat Protoc (2010) 1.13
Transcriptionally silenced transgenes in maize are activated by three mutations defective in paramutation. Genetics (2006) 1.12
Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution. Proc Natl Acad Sci U S A (2007) 1.12
Effects of extraction solvent mixtures on antioxidant activity evaluation and their extraction capacity and selectivity for free phenolic compounds in barley (Hordeum vulgare L.). J Agric Food Chem (2006) 1.11
Intimate view of a kinetic protein folding intermediate: residue-resolved structure, interactions, stability, folding and unfolding rates, homogeneity. J Mol Biol (2003) 1.11
Folding units govern the cytochrome c alkaline transition. J Mol Biol (2003) 1.11
Corticosteroids inhibit cell death induced by doxorubicin in cardiomyocytes: induction of antiapoptosis, antioxidant, and detoxification genes. Mol Pharmacol (2005) 1.10
Regulatory T cells require mammalian target of rapamycin signaling to maintain both homeostasis and alloantigen-driven proliferation in lymphocyte-replete mice. J Immunol (2011) 1.10
Importance of glycolysis and oxidative phosphorylation in advanced melanoma. Mol Cancer (2012) 1.10
Percutaneous pedicle screw fixation for neurologic intact thoracolumbar burst fractures. J Spinal Disord Tech (2010) 1.10
Hemostatic activation and outcome after recombinant tissue plasminogen activator therapy for acute ischemic stroke. Stroke (2006) 1.10
A unified mechanism for protein folding: predetermined pathways with optional errors. Protein Sci (2007) 1.09
SIRT1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. Free Radic Biol Med (2013) 1.09
The foldon substructure of staphylococcal nuclease. J Mol Biol (2007) 1.09
The expression of androgen-responsive genes is up-regulated in the epithelia of benign prostatic hyperplasia. Prostate (2009) 1.08
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Sleep-disordered breathing in obese adolescents is associated with visceral adiposity and markers of insulin resistance. Int J Pediatr Obes (2010) 1.06
Missing value imputation in high-dimensional phenomic data: imputable or not, and how? BMC Bioinformatics (2014) 1.06
Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study. J Thorac Cardiovasc Surg (2009) 1.05
Depressive behavior in mice due to immune stimulation is accompanied by reduced neural activity in brain regions involved in positively motivated behavior. Biol Psychiatry (2006) 1.05
Minimizing back exchange in the hydrogen exchange-mass spectrometry experiment. J Am Soc Mass Spectrom (2012) 1.05
Sequence analysis for the complete proviral genome of subgroup J Avian Leukosis virus associated with hemangioma: a special 11 bp deletion was observed in U3 region of 3'UTR. Virol J (2011) 1.05
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Self-construal priming modulates visual activity underlying global/local perception. Biol Psychol (2007) 1.03
Folding of a large protein at high structural resolution. Proc Natl Acad Sci U S A (2013) 1.02
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab (2012) 1.02
Induction of antioxidant and detoxification response by oxidants in cardiomyocytes: evidence from gene expression profiling and activation of Nrf2 transcription factor. J Mol Cell Cardiol (2006) 1.01
Pathologic and gene expression features of metastatic melanomas to the brain. Cancer (2013) 1.01
Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2012) 1.00
Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. J Biol Chem (2011) 0.99
Functional role of a protein foldon--an Omega-loop foldon controls the alkaline transition in ferricytochrome c. Proteins (2006) 0.99
Inter-species grafting caused extensive and heritable alterations of DNA methylation in Solanaceae plants. PLoS One (2013) 0.98
New mechanistic studies on the proline-catalyzed aldol reaction. Proc Natl Acad Sci U S A (2004) 0.98
The Mad2 partial unfolding model: regulating mitosis through Mad2 conformational switching. J Cell Biol (2008) 0.97
Abrogation of local cancer recurrence after radiofrequency ablation by dendritic cell-based hyperthermic tumor vaccine. Mol Ther (2009) 0.97
AGEs decrease insulin synthesis in pancreatic β-cell by repressing Pdx-1 protein expression at the post-translational level. PLoS One (2011) 0.96
Histone H4 acetylation differentially modulates arginine methylation by an in Cis mechanism. J Biol Chem (2011) 0.95
Protein misfolding: optional barriers, misfolded intermediates, and pathway heterogeneity. J Mol Biol (2004) 0.95