Protein structure change studied by hydrogen-deuterium exchange, functional labeling, and mass spectrometry.

PubWeight™: 2.09‹?› | Rank: Top 2%

🔗 View Article (PMC 165829)

Published in Proc Natl Acad Sci U S A on May 28, 2003

Authors

Joan J Englander1, Charyl Del Mar, Will Li, S Walter Englander, Jack S Kim, David D Stranz, Yoshitomo Hamuro, Virgil L Woods

Author Affiliations

1: Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Articles citing this

High-resolution structure prediction and the crystallographic phase problem. Nature (2007) 7.67

Hydrogen exchange and mass spectrometry: A historical perspective. J Am Soc Mass Spectrom (2006) 2.78

Proteases for processing proneuropeptides into peptide neurotransmitters and hormones. Annu Rev Pharmacol Toxicol (2008) 1.82

Hydrogen tunneling links protein dynamics to enzyme catalysis. Annu Rev Biochem (2013) 1.76

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Proc Natl Acad Sci U S A (2004) 1.70

Protein folding and misfolding: mechanism and principles. Q Rev Biophys (2008) 1.68

Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level. Proc Natl Acad Sci U S A (2005) 1.65

Hydrogen/deuterium-exchange (H/D-Ex) of PPARgamma LBD in the presence of various modulators. Protein Sci (2006) 1.59

ExMS: data analysis for HX-MS experiments. J Am Soc Mass Spectrom (2011) 1.44

Theoretical Insights Reveal Novel Motions in Csk's SH3 Domain That Control Kinase Activation. PLoS One (2015) 1.38

Hydra: software for tailored processing of H/D exchange data from MS or tandem MS analyses. BMC Bioinformatics (2009) 1.38

Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method. Proc Natl Acad Sci U S A (2008) 1.38

Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37

Quantifying protein interface footprinting by hydroxyl radical oxidation and molecular dynamics simulation: application to galectin-1. J Am Soc Mass Spectrom (2008) 1.36

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem (2011) 1.32

Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain. J Biol Chem (2009) 1.29

Automated data reduction for hydrogen/deuterium exchange experiments, enabled by high-resolution Fourier transform ion cyclotron resonance mass spectrometry. J Am Soc Mass Spectrom (2010) 1.28

Applications of mass spectrometry to lipids and membranes. Annu Rev Biochem (2011) 1.25

Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem (2009) 1.23

PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry. J Mol Biol (2006) 1.17

Future directions of structural mass spectrometry using hydroxyl radical footprinting. J Mass Spectrom (2010) 1.16

On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171. Protein Sci (2004) 1.11

The spectral networks paradigm in high throughput mass spectrometry. Mol Biosyst (2012) 1.11

Isofagomine induced stabilization of glucocerebrosidase. Chembiochem (2008) 1.09

Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem (2010) 1.05

Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry. Proteins (2009) 1.05

On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase. Biophys J (2010) 1.03

Allosteric signaling in the biotin repressor occurs via local folding coupled to global dampening of protein dynamics. J Mol Biol (2008) 1.02

Structural mass spectrometry of the alpha beta-tubulin dimer supports a revised model of microtubule assembly. Biochemistry (2009) 1.00

Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX. J Am Soc Mass Spectrom (2011) 0.99

Sequence-specific conformational flexibility of SNARE transmembrane helices probed by hydrogen/deuterium exchange. Biophys J (2008) 0.94

Analytical Aspects of Hydrogen Exchange Mass Spectrometry. Annu Rev Anal Chem (Palo Alto Calif) (2015) 0.92

A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold. J Mol Biol (2011) 0.92

Analysis of agonist and antagonist effects on thyroid hormone receptor conformation by hydrogen/deuterium exchange. Mol Endocrinol (2010) 0.91

Conformational studies of the manganese transport regulator (MntR) from Bacillus subtilis using deuterium exchange mass spectrometry. J Biol Inorg Chem (2007) 0.90

Online, high-pressure digestion system for protein characterization by hydrogen/deuterium exchange and mass spectrometry. Anal Chem (2010) 0.90

New protein footprinting: fast photochemical iodination combined with top-down and bottom-up mass spectrometry. J Am Soc Mass Spectrom (2012) 0.86

Structural insights into RNA encapsidation and helical assembly of the Toscana virus nucleoprotein. Nucleic Acids Res (2014) 0.85

Low-resolution molecular models reveal the oligomeric state of the PPAR and the conformational organization of its domains in solution. PLoS One (2012) 0.85

Probing the conformation of a prion protein fibril with hydrogen exchange. J Biol Chem (2010) 0.85

Inter- and intra-molecular interactions of Arabidopsis thaliana DELLA protein RGL1. Biochem J (2011) 0.83

Fourier transform mass spectrometry to monitor hyaluronan-protein interactions: use of hydrogen/deuterium amide exchange. Rapid Commun Mass Spectrom (2007) 0.81

Mass spectrometry guided in situ proteolysis to obtain crystals for X-ray structure determination. J Am Soc Mass Spectrom (2010) 0.81

Mechanism of substrate specificity in 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidases. J Struct Biol (2010) 0.80

The prohormone proenkephalin possesses differential conformational features of subdomains revealed by rapid H-D exchange mass spectrometry. Protein Sci (2012) 0.80

Advances in protein NMR provided by the NIGMS Protein Structure Initiative: impact on drug discovery. Curr Opin Drug Discov Devel (2010) 0.79

ATPase active-site electrostatic interactions control the global conformation of the 100 kDa SecA translocase. J Am Chem Soc (2013) 0.79

Differential accessibilities of dibasic prohormone processing sites of proenkephalin to the aqueous environment revealed by H-D exchange mass spectrometry. Biochemistry (2009) 0.79

Functional dynamics of hexameric helicase probed by hydrogen exchange and simulation. Biophys J (2014) 0.79

Resolving isotopic fine structure to detect and quantify natural abundance- and hydrogen/deuterium exchange-derived isotopomers. Anal Chem (2013) 0.78

Assembling a COMPASS. Epigenetics (2013) 0.78

Structural Analysis of a Temperature-Induced Transition in a Viral Capsid Probed by HDX-MS. Biophys J (2017) 0.76

Dynamic conformations of nucleophosmin (NPM1) at a key monomer-monomer interface affect oligomer stability and interactions with granzyme B. PLoS One (2014) 0.76

Detection of lipid-induced structural changes of the Marburg virus matrix protein VP40 using hydrogen/deuterium exchange-mass spectrometry. J Biol Chem (2017) 0.75

Isotope Labeling of Biomolecules: Structural Analysis of Viruses by HDX-MS. Methods Enzymol (2015) 0.75

High Resolution Mapping of Bactericidal Monoclonal Antibody Binding Epitopes on Staphylococcus aureus Antigen MntC. PLoS Pathog (2016) 0.75

Computational method allowing Hydrogen-Deuterium Exchange Mass Spectrometry at single amide Resolution. Sci Rep (2017) 0.75

Dynamic distinctions in the sodium-calcium exchanger adopting the inward- and outward-facing conformational states. J Biol Chem (2017) 0.75

Articles cited by this

Primary structure effects on peptide group hydrogen exchange. Proteins (1993) 10.79

Hydrogen exchange and structural dynamics of proteins and nucleic acids. Q Rev Biophys (1983) 9.14

Hydrogen exchange in proteins. Adv Protein Chem (1966) 7.02

Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation. Protein Sci (1993) 5.85

The stereochemical mechanism of the cooperative effects in hemoglobin revisited. Annu Rev Biophys Biomol Struct (1998) 3.47

Isotope effects in peptide group hydrogen exchange. Proteins (1993) 3.21

X-ray diffraction study of binding of 2,3-diphosphoglycerate to human deoxyhaemoglobin. Nature (1972) 3.02

Stable submolecular folding units in a non-compact form of cytochrome c. J Mol Biol (1991) 2.67

Protein folding intermediates and pathways studied by hydrogen exchange. Annu Rev Biophys Biomol Struct (2000) 2.57

Mechanisms and uses of hydrogen exchange. Curr Opin Struct Biol (1996) 2.48

Protein hydrogen exchange studied by the fragment separation method. Anal Biochem (1985) 2.12

An experimental procedure for increasing the structural resolution of chemical hydrogen-exchange measurements on proteins: application to ribonuclease S peptide. J Mol Biol (1979) 1.99

The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. Proc Natl Acad Sci U S A (1998) 1.93

Determinants of protein hydrogen exchange studied in equine cytochrome c. Protein Sci (1998) 1.92

Biochemistry without oxygen. Anal Biochem (1987) 1.77

High resolution, high-throughput amide deuterium exchange-mass spectrometry (DXMS) determination of protein binding site structure and dynamics: utility in pharmaceutical design. J Cell Biochem Suppl (2001) 1.74

Protein hydrogen exchange mechanism: local fluctuations. Protein Sci (2003) 1.63

Hydrogen exchange measurement of the free energy of structural and allosteric change in hemoglobin. Science (1992) 1.60

Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS). J Mol Biol (2002) 1.53

Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol (2003) 1.29

Hydrogen exchange study of some polynucleotides and transfer RNA. J Mol Biol (1972) 1.27

The pKa values of two histidine residues in human haemoglobin, the Bohr effect, and the dipole moments of alpha-helices. J Mol Biol (1985) 1.25

Deciphering the molecular code of hemoglobin allostery. Adv Protein Chem (1998) 1.25

Individual breathing reactions measured in hemoglobin by hydrogen exchange methods. Biophys J (1980) 1.22

Domain organization of D-AKAP2 revealed by enhanced deuterium exchange-mass spectrometry (DXMS). J Mol Biol (2002) 1.19

Hydrogen exchange studies of protein structure. Curr Opin Biotechnol (1998) 1.18

Identification of an allosterically sensitive unfolding unit in hemoglobin. J Mol Biol (1983) 1.13

Long-range changes in a protein antigen due to antigen-antibody interaction. Biochemistry (1992) 1.11

Structure and energy change in hemoglobin by hydrogen exchange labeling. Methods Enzymol (1994) 1.09

Individual breathing reactions measured by functional labeling and hydrogen exchange methods. Methods Enzymol (1986) 1.00

The slowest allosterically responsive hydrogens in hemoglobin. Completion of the hydrogen exchange survey. J Biol Chem (1980) 0.96

Allosteric energy at the hemoglobin beta chain C terminus studied by hydrogen exchange. J Mol Biol (1988) 0.95

Hydrogen exchnge studies of respiratory proteins. II. Detection of discrete, ligand-induced changes in hemoglobin. J Biol Chem (1972) 0.94

Allosteric sensitivity in hemoglobin at the alpha-subunit N-terminus studied by hydrogen exchange. Biochemistry (1986) 0.94

Salt, phosphate and the Bohr effect at the hemoglobin beta chain C terminus studied by hydrogen exchange. J Mol Biol (1988) 0.92

Energetic components of the allosteric machinery in hemoglobin measured by hydrogen exchange. J Mol Biol (1998) 0.92

Signal transmission between subunits in the hemoglobin T-state. J Mol Biol (1998) 0.91

A high energy structure change in hemoglobin studied by difference hydrogen exchange. J Biol Chem (1980) 0.88

The pathway of allosteric control as revealed by hemoglobin intermediate states. FASEB J (1995) 0.88

Hydrogen exchange techniques. Methods Mol Biol (1995) 0.85

Single residue modification of only one dimer within the hemoglobin tetramer reveals autonomous dimer function. Proc Natl Acad Sci U S A (2002) 0.80

Articles by these authors

Structural determinants for generating centromeric chromatin. Nature (2004) 4.25

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature (2008) 3.44

Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40

Hydrogen exchange methods to study protein folding. Methods (2004) 2.47

Conformational changes in the G protein Gs induced by the β2 adrenergic receptor. Nature (2011) 2.43

Protein folding: the stepwise assembly of foldon units. Proc Natl Acad Sci U S A (2005) 2.29

Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB. Nature (2006) 2.24

An epigenetic mark generated by the incorporation of CENP-A into centromeric nucleosomes. Proc Natl Acad Sci U S A (2007) 2.23

Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex. Proc Natl Acad Sci U S A (2011) 2.03

Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins. Nature (2008) 2.03

The E46K mutation in alpha-synuclein increases amyloid fibril formation. J Biol Chem (2005) 1.98

Vibrio cholerae toxin-coregulated pilus structure analyzed by hydrogen/deuterium exchange mass spectrometry. Structure (2008) 1.92

Rapid analysis of protein structure and dynamics by hydrogen/deuterium exchange mass spectrometry. J Biomol Tech (2003) 1.85

Urea, but not guanidinium, destabilizes proteins by forming hydrogen bonds to the peptide group. Proc Natl Acad Sci U S A (2009) 1.73

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. Proc Natl Acad Sci U S A (2004) 1.70

Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding. J Mol Biol (2002) 1.70

Structure and properties of alpha-synuclein and other amyloids determined at the amino acid level. Proc Natl Acad Sci U S A (2005) 1.65

Protein hydrogen exchange mechanism: local fluctuations. Protein Sci (2003) 1.63

Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS). J Mol Biol (2002) 1.53

How cytochrome c folds, and why: submolecular foldon units and their stepwise sequential stabilization. J Mol Biol (2004) 1.51

Mapping intersubunit interactions of the regulatory subunit (RIalpha) in the type I holoenzyme of protein kinase A by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Mol Biol (2004) 1.51

Crystal structure of the Lassa virus nucleoprotein-RNA complex reveals a gating mechanism for RNA binding. Proc Natl Acad Sci U S A (2011) 1.51

Helical structure and stability in human apolipoprotein A-I by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2009) 1.50

Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression. Proc Natl Acad Sci U S A (2009) 1.48

ExMS: data analysis for HX-MS experiments. J Am Soc Mass Spectrom (2011) 1.44

Identification and characterization of ambroxol as an enzyme enhancement agent for Gaucher disease. J Biol Chem (2009) 1.39

Cytochrome c folding pathway: kinetic native-state hydrogen exchange. Proc Natl Acad Sci U S A (2002) 1.37

Allosteric inhibition of complement function by a staphylococcal immune evasion protein. Proc Natl Acad Sci U S A (2010) 1.37

Order of steps in the cytochrome C folding pathway: evidence for a sequential stabilization mechanism. J Mol Biol (2006) 1.36

Catalytic independent functions of a protein kinase as revealed by a kinase-dead mutant: study of the Lys72His mutant of cAMP-dependent kinase. J Mol Biol (2005) 1.35

Cooperative omega loops in cytochrome c: role in folding and function. J Mol Biol (2003) 1.35

Stepwise protein folding at near amino acid resolution by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2013) 1.34

Replacement of histone H3 with CENP-A directs global nucleosome array condensation and loosening of nucleosome superhelical termini. Proc Natl Acad Sci U S A (2011) 1.33

Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci (2005) 1.32

Mechanism of intracellular cAMP sensor Epac2 activation: cAMP-induced conformational changes identified by amide hydrogen/deuterium exchange mass spectrometry (DXMS). J Biol Chem (2011) 1.32

Structural determinants for the binding of anthrax lethal factor to oligomeric protective antigen. J Biol Chem (2005) 1.30

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase. Proc Natl Acad Sci U S A (2006) 1.30

Allosteric network of cAMP-dependent protein kinase revealed by mutation of Tyr204 in the P+1 loop. J Mol Biol (2004) 1.30

The N-terminal to C-terminal motif in protein folding and function. Proc Natl Acad Sci U S A (2005) 1.29

Molecular mimicry in innate immunity: crystal structure of a bacterial TIR domain. J Biol Chem (2009) 1.29

Dynamics of cAPK type IIbeta activation revealed by enhanced amide H/2H exchange mass spectrometry (DXMS). J Mol Biol (2003) 1.29

Recombinant equine cytochrome c in Escherichia coli: high-level expression, characterization, and folding and assembly mutants. Biochemistry (2002) 1.29

Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc Natl Acad Sci U S A (2012) 1.27

Epitope mapping by amide hydrogen/deuterium exchange coupled with immobilization of antibody, on-line proteolysis, liquid chromatography and mass spectrometry. Rapid Commun Mass Spectrom (2009) 1.27

Localizing the membrane binding region of Group VIA Ca2+-independent phospholipase A2 using peptide amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem (2009) 1.23

Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion. PLoS Negl Trop Dis (2011) 1.23

A conserved MutS homolog connector domain interface interacts with MutL homologs. Proc Natl Acad Sci U S A (2009) 1.22

Protein dynamics viewed by hydrogen exchange. Protein Sci (2012) 1.22

Many overlapping peptides for protein hydrogen exchange experiments by the fragment separation-mass spectrometry method. J Am Soc Mass Spectrom (2011) 1.22

Global consequences of activation loop phosphorylation on protein kinase A. J Biol Chem (2009) 1.21

Protein hydrogen exchange: testing current models. Protein Sci (2012) 1.20

Fibrin derived from patients with chronic thromboembolic pulmonary hypertension is resistant to lysis. Am J Respir Crit Care Med (2006) 1.20

The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold. PLoS Pathog (2012) 1.20

Interaction of group IA phospholipase A2 with metal ions and phospholipid vesicles probed with deuterium exchange mass spectrometry. Biochemistry (2008) 1.18

Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol (2005) 1.18

PAS domain allostery and light-induced conformational changes in photoactive yellow protein upon I2 intermediate formation, probed with enhanced hydrogen/deuterium exchange mass spectrometry. J Mol Biol (2006) 1.17

Structural basis for differential neutralization of ebolaviruses. Viruses (2012) 1.15

Calcium binding rigidifies the C2 domain and the intradomain interaction of GIVA phospholipase A2 as revealed by hydrogen/deuterium exchange mass spectrometry. J Biol Chem (2008) 1.14

A phospholipid substrate molecule residing in the membrane surface mediates opening of the lid region in group IVA cytosolic phospholipase A2. J Biol Chem (2008) 1.12

Folding trajectories of human dihydrofolate reductase inside the GroEL GroES chaperonin cavity and free in solution. Proc Natl Acad Sci U S A (2007) 1.12

On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171. Protein Sci (2004) 1.11

Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange. J Virol (2010) 1.11

Intimate view of a kinetic protein folding intermediate: residue-resolved structure, interactions, stability, folding and unfolding rates, homogeneity. J Mol Biol (2003) 1.11

Folding units govern the cytochrome c alkaline transition. J Mol Biol (2003) 1.11

Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem (2008) 1.10

A unified mechanism for protein folding: predetermined pathways with optional errors. Protein Sci (2007) 1.09

Isofagomine induced stabilization of glucocerebrosidase. Chembiochem (2008) 1.09

Conformational analysis of Epac activation using amide hydrogen/deuterium exchange mass spectrometry. J Biol Chem (2007) 1.09

The foldon substructure of staphylococcal nuclease. J Mol Biol (2007) 1.09

A common property of amyotrophic lateral sclerosis-associated variants: destabilization of the copper/zinc superoxide dismutase electrostatic loop. J Biol Chem (2009) 1.08

Plasticity of cytochrome P450 2B4 as investigated by hydrogen-deuterium exchange mass spectrometry and X-ray crystallography. J Biol Chem (2010) 1.08

Characterization of the human folate receptor alpha via novel antibody-based probes. Oncotarget (2011) 1.06

Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol Pharmacol (2005) 1.06

Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometry. Proteins (2009) 1.05

Cofactor molecules induce structural transformation during infectious prion formation. Structure (2013) 1.05

Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry. J Biol Chem (2010) 1.05

Minimizing back exchange in the hydrogen exchange-mass spectrometry experiment. J Am Soc Mass Spectrom (2012) 1.05

Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity. Biochemistry (2011) 1.05

Location of inhibitors bound to group IVA phospholipase A2 determined by molecular dynamics and deuterium exchange mass spectrometry. J Am Chem Soc (2009) 1.03

Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J Mol Biol (2004) 1.02

Folding of a large protein at high structural resolution. Proc Natl Acad Sci U S A (2013) 1.02

Structure of IL-17A in complex with a potent, fully human neutralizing antibody. J Mol Biol (2009) 1.02

The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry. Biochemistry (2006) 1.01

Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication. Structure (2011) 1.01

Apolipoprotein A-I helical structure and stability in discoidal high-density lipoprotein (HDL) particles by hydrogen exchange and mass spectrometry. Proc Natl Acad Sci U S A (2012) 1.00

Discovery of a novel series of inhibitors of lymphoid tyrosine phosphatase with activity in human T cells. J Med Chem (2011) 1.00

High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. Blood (2009) 1.00

Structural insights into glucan phosphatase dynamics using amide hydrogen-deuterium exchange mass spectrometry. Biochemistry (2009) 1.00

Quantitative assessment of protein structural models by comparison of H/D exchange MS data with exchange behavior accurately predicted by DXCOREX. J Am Soc Mass Spectrom (2011) 0.99