PubRank

Victor E Velculescu

Author PubWeight™ 598.09‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The consensus coding sequences of human breast and colorectal cancers. Science 2006 60.02
2 An integrated genomic analysis of human glioblastoma multiforme. Science 2008 51.36
3 The genomic landscapes of human breast and colorectal cancers. Science 2007 38.12
4 Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008 36.02
5 IDH1 and IDH2 mutations in gliomas. N Engl J Med 2009 32.41
6 High frequency of mutations of the PIK3CA gene in human cancers. Science 2004 27.94
7 Cancer genome landscapes. Science 2013 25.33
8 International network of cancer genome projects. Nature 2010 20.35
9 Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010 17.38
10 The colorectal microRNAome. Proc Natl Acad Sci U S A 2006 11.59
11 Allelic variation in human gene expression. Science 2002 11.42
12 Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011 11.12
13 Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 2010 10.78
14 Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A 2008 10.52
15 DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 2011 10.26
16 Using the transcriptome to annotate the genome. Nat Biotechnol 2002 9.04
17 Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med 2014 8.36
18 The genetic landscape of the childhood cancer medulloblastoma. Science 2010 8.34
19 Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 2005 7.87
20 The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther 2004 7.82
21 Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002 7.46
22 Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science 2009 7.39
23 TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A 2013 6.88
24 The antisense transcriptomes of human cells. Science 2008 6.29
25 Development of personalized tumor biomarkers using massively parallel sequencing. Sci Transl Med 2010 6.08
26 The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science 2007 6.01
27 Inactivation of hCDC4 can cause chromosomal instability. Nature 2004 5.71
28 Mutational analysis of the tyrosine kinome in colorectal cancers. Science 2003 5.43
29 Colorectal cancer: mutations in a signalling pathway. Nature 2005 5.42
30 Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009 5.31
31 Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. Cancer Res 2009 4.92
32 Mutational analysis of the tyrosine phosphatome in colorectal cancers. Science 2004 4.67
33 The predictive capacity of personal genome sequencing. Sci Transl Med 2012 4.64
34 Heteroplasmic mitochondrial DNA mutations in normal and tumour cells. Nature 2010 4.53
35 Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet 2011 4.38
36 Mutations of PIK3CA in anaplastic oligodendrogliomas, high-grade astrocytomas, and medulloblastomas. Cancer Res 2004 4.26
37 Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers. Proc Natl Acad Sci U S A 2008 4.13
38 A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res 2007 4.09
39 Digital karyotyping. Proc Natl Acad Sci U S A 2002 3.96
40 Detection of chromosomal alterations in the circulation of cancer patients with whole-genome sequencing. Sci Transl Med 2012 3.92
41 Frequent activating mutations of PIK3CA in ovarian clear cell carcinoma. Am J Pathol 2009 3.90
42 Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat 2011 3.63
43 Genetic progression and the waiting time to cancer. PLoS Comput Biol 2007 3.57
44 Recurrent KRAS codon 146 mutations in human colorectal cancer. Cancer Biol Ther 2006 3.56
45 Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers. Proc Natl Acad Sci U S A 2008 3.52
46 Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science 2011 3.49
47 Oncogenic mutations of PIK3CA in human cancers. Cell Cycle 2004 3.47
48 Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma. Nat Genet 2012 3.38
49 Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients. Proc Natl Acad Sci U S A 2004 3.35
50 ATM mutations in patients with hereditary pancreatic cancer. Cancer Discov 2011 3.27
51 Prevalence of somatic alterations in the colorectal cancer cell genome. Proc Natl Acad Sci U S A 2002 3.25
52 Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia. Cancer Res 2004 3.20
53 Serial assessment of human tumor burdens in mice by the analysis of circulating DNA. Cancer Res 2007 3.05
54 Amplification of the MET receptor drives resistance to anti-EGFR therapies in colorectal cancer. Cancer Discov 2013 2.87
55 Sequence mutations and amplification of PIK3CA and AKT2 genes in purified ovarian serous neoplasms. Cancer Biol Ther 2006 2.76
56 Three classes of genes mutated in colorectal cancers with chromosomal instability. Cancer Res 2004 2.51
57 SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res 2009 2.44
58 Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. Cancer Discov 2012 2.39
59 Identification of OTX2 as a medulloblastoma oncogene whose product can be targeted by all-trans retinoic acid. Cancer Res 2005 2.35
60 Sensitive digital quantification of DNA methylation in clinical samples. Nat Biotechnol 2009 2.34
61 Somatic mutations of EGFR in colorectal cancers and glioblastomas. N Engl J Med 2004 2.33
62 The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. Nat Biotechnol 2006 2.31
63 Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer. Clin Cancer Res 2011 2.02
64 Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T. Proc Natl Acad Sci U S A 2007 1.87
65 Identifying tumor origin using a gene expression-based classification map. Cancer Res 2003 1.78
66 PRL-3 expression in metastatic cancers. Clin Cancer Res 2003 1.73
67 Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation. Proc Natl Acad Sci U S A 2010 1.70
68 Digital karyotyping. Nat Protoc 2007 1.58
69 Low-grade serous carcinomas of the ovary contain very few point mutations. J Pathol 2011 1.56
70 Patient-oriented gene set analysis for cancer mutation data. Genome Biol 2010 1.52
71 Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers. Proc Natl Acad Sci U S A 2009 1.51
72 Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing. Clin Cancer Res 2012 1.47
73 Homozygous deletion of MKK4 in ovarian serous carcinoma. Cancer Biol Ther 2006 1.32
74 Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res 2009 1.28
75 Gene expression analysis goes digital. Nat Biotechnol 2007 1.24
76 Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS. J Clin Endocrinol Metab 2012 1.21
77 Large-scale identification of novel transcripts in the human genome. Genome Res 2007 1.13
78 Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers. Hum Mutat 2006 1.12
79 Somatic mutations of PPP2R1A in ovarian and uterine carcinomas. Am J Pathol 2011 1.08
80 Mutational analysis of gene families in human cancer. Curr Opin Genet Dev 2005 1.07
81 Insights into therapeutic resistance from whole-genome analyses of circulating tumor DNA. Oncotarget 2013 1.03
82 Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment. Clin Cancer Res 2014 1.02
83 Genome-wide linkage scan for colorectal cancer susceptibility genes supports linkage to chromosome 3q. BMC Cancer 2008 0.99
84 Therapeutic potential of the poly(ADP-ribose) polymerase inhibitor rucaparib for the treatment of sporadic human ovarian cancer. Mol Cancer Ther 2013 0.97
85 Identification of microbial DNA in human cancer. BMC Med Genomics 2009 0.95
86 Sodium ion channel mutations in glioblastoma patients correlate with shorter survival. Mol Cancer 2011 0.89
87 Somatic mutations in CCK2R alter receptor activity that promote oncogenic phenotypes. Mol Cancer Res 2012 0.88
88 Transcriptome PETs: a genome's best friends. Nat Methods 2005 0.86
89 Cancer detection using whole-genome sequencing of cell free DNA. Oncotarget 2013 0.84
90 Functional synergies yet distinct modulators affected by genetic alterations in common human cancers. Cancer Res 2011 0.83
91 Rapid characterization of candidate biomarkers for pancreatic cancer using cell microarrays (CMAs). J Proteome Res 2012 0.83