Exomic sequencing of medullary thyroid cancer reveals dominant and mutually exclusive oncogenic mutations in RET and RAS.

PubWeight™: 1.21‹?› | Rank: Top 10%

🔗 View Article (PMC 3565108)

Published in J Clin Endocrinol Metab on December 21, 2012

Authors

Nishant Agrawal1, Yuchen Jiao, Mark Sausen, Rebecca Leary, Chetan Bettegowda, Nicholas J Roberts, Sheetal Bhan, Allen S Ho, Zubair Khan, Justin Bishop, William H Westra, Laura D Wood, Ralph H Hruban, Ralph P Tufano, Bruce Robinson, Henning Dralle, Sergio P A Toledo, Rodrigo A Toledo, Luc G T Morris, Ronald A Ghossein, James A Fagin, Timothy A Chan, Victor E Velculescu, Bert Vogelstein, Kenneth W Kinzler, Nickolas Papadopoulos, Barry D Nelkin, Douglas W Ball

Author Affiliations

1: Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Baltimore, Maryland 21287, USA. nagrawal@jhmi.edu

Articles citing this

Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma. Thyroid (2015) 2.67

The role of Cdk5 in neuroendocrine thyroid cancer. Cancer Cell (2013) 1.30

Mutation of NRAS but not KRAS significantly reduces myeloma sensitivity to single-agent bortezomib therapy. Blood (2013) 1.21

Exomic sequencing of four rare central nervous system tumor types. Oncotarget (2013) 1.17

TET proteins and the control of cytosine demethylation in cancer. Genome Med (2015) 1.13

Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update. J Clin Endocrinol Metab (2013) 1.05

Identification of Driving ALK Fusion Genes and Genomic Landscape of Medullary Thyroid Cancer. PLoS Genet (2015) 1.02

Clinical, genomic, and metagenomic characterization of oral tongue squamous cell carcinoma in patients who do not smoke. Head Neck (2014) 0.98

Molecular approaches to thyroid cancer diagnosis. Endocr Relat Cancer (2014) 0.93

Mitochondria-targeted nitroxide, Mito-CP, suppresses medullary thyroid carcinoma cell survival in vitro and in vivo. J Clin Endocrinol Metab (2013) 0.91

Differential expression of cell cycle regulators in CDK5-dependent medullary thyroid carcinoma tumorigenesis. Oncotarget (2015) 0.86

Mortalin (GRP75/HSPA9) upregulation promotes survival and proliferation of medullary thyroid carcinoma cells. Oncogene (2014) 0.85

High-throughput mutation profiling improves diagnostic stratification of sporadic medullary thyroid carcinomas. Virchows Arch (2014) 0.85

Development and clinical application of an integrative genomic approach to personalized cancer therapy. Genome Med (2016) 0.84

Advances in thyroid cancer treatment: latest evidence and clinical potential. Ther Adv Med Oncol (2015) 0.84

Recombinant leukemia inhibitory factor suppresses human medullary thyroid carcinoma cell line xenografts in mice. Cancer Lett (2013) 0.83

Translational research in endocrine surgery. Surg Oncol Clin N Am (2013) 0.81

Cellular signaling pathway alterations and potential targeted therapies for medullary thyroid carcinoma. Int J Endocrinol (2013) 0.81

The Role of STAT3 in Thyroid Cancer. Cancers (Basel) (2014) 0.80

My, How Things Have Changed in Multiple Endocrine Neoplasia Type 2A! J Clin Endocrinol Metab (2015) 0.79

Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. Oncotarget (2016) 0.78

Overview and management of dermatologic events associated with targeted therapies for medullary thyroid cancer. Thyroid (2014) 0.78

Putative BRAF activating fusion in a medullary thyroid cancer. Cold Spring Harb Mol Case Stud (2016) 0.77

A differential diagnosis of inherited endocrine tumors and their tumor counterparts. Clinics (Sao Paulo) (2013) 0.77

Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul) (2015) 0.77

Postoperative Nomogram for Predicting Cancer-Specific Mortality in Medullary Thyroid Cancer. Ann Surg Oncol (2014) 0.77

Molecular diagnosis and comprehensive treatment of multiple endocrine neoplasia type 2 in Southeastern Chinese. Hered Cancer Clin Pract (2015) 0.77

Thyroid C-Cell Biology and Oncogenic Transformation. Recent Results Cancer Res (2015) 0.75

Selective use of vandetanib in the treatment of thyroid cancer. Drug Des Devel Ther (2015) 0.75

Comprehensive Genomic Profiling of Clinically Advanced Medullary Thyroid Carcinoma. Oncology (2016) 0.75

Genetic and epigenetic background and protein expression profiles in relation to telomerase activation in medullary thyroid carcinoma. Oncotarget (2016) 0.75

Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations. Sci Rep (2017) 0.75

Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma. Int J Endocrinol (2017) 0.75

Medullary Thyroid Cancer: Clinical Characteristics and New Insights into Therapeutic Strategies Targeting Tyrosine Kinases. Mol Diagn Ther (2017) 0.75

Articles cited by this

Cancer statistics, 2012. CA Cancer J Clin (2012) 87.38

The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43

KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med (2005) 13.40

Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12

SF3B1 and other novel cancer genes in chronic lymphocytic leukemia. N Engl J Med (2011) 11.07

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78

Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial. J Clin Oncol (2011) 7.65

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia. Nat Genet (2011) 6.43

BRAF mutation in thyroid cancer. Endocr Relat Cancer (2005) 5.65

Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet (2011) 4.38

Mutations in CIC and FUBP1 contribute to human oligodendroglioma. Science (2011) 3.49

KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinomas. Nucleic Acids Res (1988) 3.31

Focus on pancreas cancer. Cancer Cell (2002) 2.82

Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study. J Clin Endocrinol Metab (2007) 2.74

Prognosis of medullary thyroid carcinoma: demographic, clinical, and pathologic predictors of survival in 1252 cases. Cancer (2006) 2.73

Targeting protein prenylation for cancer therapy. Nat Rev Cancer (2011) 2.60

Ductal pancreatic cancer in humans and mice. Cold Spring Harb Symp Quant Biol (2005) 2.41

The GDNF/RET signaling pathway and human diseases. Cytokine Growth Factor Rev (2001) 2.05

New therapeutic approaches to treat medullary thyroid carcinoma. Nat Clin Pract Endocrinol Metab (2008) 1.76

Low-grade serous carcinomas of the ovary contain very few point mutations. J Pathol (2011) 1.56

Uncommon mutation, but common amplifications, of the PIK3CA gene in thyroid tumors. J Clin Endocrinol Metab (2005) 1.51

High prevalence of RAS mutations in RET-negative sporadic medullary thyroid carcinomas. J Clin Endocrinol Metab (2011) 1.39

Medullary thyroid cancer: monitoring and therapy. Endocrinol Metab Clin North Am (2007) 1.14

Somatic RAS mutations occur in a large proportion of sporadic RET-negative medullary thyroid carcinomas and extend to a previously unidentified exon. J Clin Endocrinol Metab (2012) 1.13

The cellular response to DNA damage: a focus on MDC1 and its interacting proteins. Nucleus (2009) 1.13

Inhibitors of chronically active ras: potential for treatment of human malignancies. Recent Pat Anticancer Drug Discov (2008) 1.12

Molecular genetics of medullary thyroid carcinoma: the quest for novel therapeutic targets. J Mol Endocrinol (2009) 1.08

gamma-H2AX as a therapeutic target for improving the efficacy of radiation therapy. Curr Cancer Drug Targets (2006) 1.05

Mutational screening of RET, HRAS, KRAS, NRAS, BRAF, AKT1, and CTNNB1 in medullary thyroid carcinoma. Anticancer Res (2011) 0.99

Absence of TP53 alterations in pheochromocytomas and medullary thyroid carcinomas. Genes Chromosomes Cancer (1997) 0.98

The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins. Cancer Res (2006) 0.98

Systemic therapy for advanced or metastatic colorectal cancer: National Comprehensive Cancer Network guidelines for combining anti-vascular endothelial growth factor and anti-epidermal growth factor receptor monoclonal antibodies with chemotherapy. Pharmacotherapy (2008) 0.93

Inactivation of the p53 gene is not required for tumorigenesis of medullary thyroid carcinoma or pheochromocytoma. Jpn J Cancer Res (1992) 0.92

Medullary thyroid carcinoma: who's on first? Thyroid (2012) 0.81

Articles by these authors

The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02

IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41

High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94

Cancer genome landscapes. Science (2013) 25.33

Cancer genes and the pathways they control. Nat Med (2004) 24.22

Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med (2010) 22.74

International network of cancer genome projects. Nature (2010) 20.35

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature (2010) 17.38

Case-control study of human papillomavirus and oropharyngeal cancer. N Engl J Med (2007) 16.39

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc Natl Acad Sci U S A (2003) 12.91

Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J Natl Cancer Inst (2008) 12.77

The colorectal microRNAome. Proc Natl Acad Sci U S A (2006) 11.59

Allelic variation in human gene expression. Science (2002) 11.42

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78

Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52

Circulating mutant DNA to assess tumor dynamics. Nat Med (2007) 10.33

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature (2012) 10.17

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature (2011) 9.70

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40

Using the transcriptome to annotate the genome. Nat Biotechnol (2002) 9.04

High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res (2003) 8.67

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature (2012) 8.66

Pancreatic cancer. Lancet (2011) 8.54

Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36

The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31

IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature (2012) 7.95