Published in Cancer Res on August 01, 2004
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J Clin Invest (2009) 2.66
Fibroblast activation protein expression by stromal cells and tumor-associated macrophages in human breast cancer. Hum Pathol (2013) 2.06
The metabolic serine hydrolases and their functions in mammalian physiology and disease. Chem Rev (2011) 1.89
Cancer associated fibroblasts (CAFs) in tumor microenvironment. Front Biosci (Landmark Ed) (2010) 1.87
Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy. Mol Cancer Ther (2012) 1.48
The pharmacological landscape and therapeutic potential of serine hydrolases. Nat Rev Drug Discov (2012) 1.39
Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin. Mol Cancer Ther (2009) 1.20
Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes. Arthritis Res Ther (2006) 1.17
Effect of fibroblast activation protein and alpha2-antiplasmin cleaving enzyme on collagen types I, III, and IV. Arch Biochem Biophys (2006) 1.09
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Nat Immunol (2015) 1.07
Dipeptidyl peptidases as survival factors in Ewing sarcoma family of tumors: implications for tumor biology and therapy. J Biol Chem (2011) 1.00
Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions. Clin Exp Metastasis (2011) 0.97
Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma. BMC Cancer (2009) 0.93
Breast tumor microenvironment: proteomics highlights the treatments targeting secretome. J Proteome Res (2008) 0.90
Selective fluorescence probes for dipeptidyl peptidase activity-fibroblast activation protein and dipeptidyl peptidase IV. Bioconjug Chem (2007) 0.90
Photodynamic molecular beacon triggered by fibroblast activation protein on cancer-associated fibroblasts for diagnosis and treatment of epithelial cancers. J Med Chem (2009) 0.87
Elevation of seprase expression and promotion of an invasive phenotype by collagenous matrices in ovarian tumor cells. Int J Cancer (2009) 0.85
Val-boroPro accelerates T cell priming via modulation of dendritic cell trafficking resulting in complete regression of established murine tumors. PLoS One (2013) 0.84
Suppression of tumor growth in mice by rationally designed pseudopeptide inhibitors of fibroblast activation protein and prolyl oligopeptidase. Neoplasia (2015) 0.81
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem (2013) 0.80
Transient removal of CD46 is safe and increases B-cell depletion by rituximab in CD46 transgenic mice and macaques. Mol Ther (2012) 0.80
Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease. Br J Haematol (2009) 0.80
Fibroblast activation protein α in tumor microenvironment: recent progression and implications (review). Mol Med Rep (2015) 0.79
Short hairpin RNA targeting of fibroblast activation protein inhibits tumor growth and improves the tumor microenvironment in a mouse model. BMB Rep (2013) 0.78
A pan-inhibitor of DASH family enzymes induces immune-mediated regression of murine sarcoma and is a potent adjuvant to dendritic cell vaccination and adoptive T-cell therapy. J Immunother (2013) 0.77
Pediatric phase I trial design using maximum target inhibition as the primary endpoint. J Natl Cancer Inst (2010) 0.77
CD20-targeting in B-cell malignancies: novel prospects for antibodies and combination therapies. Invest New Drugs (2016) 0.76
Serum CD26 levels in patients with gastric cancer: a novel potential diagnostic marker. BMC Cancer (2015) 0.76
Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment. Vaccines (Basel) (2016) 0.75
Novel targeted treatment strategies for refractory chronic lymphocytic leukaemia. Ther Adv Hematol (2011) 0.75
Fibroblast activation protein (FAP) as a novel metabolic target. Mol Metab (2016) 0.75
Cancer associated fibroblasts: An essential role in the tumor microenvironment. Oncol Lett (2017) 0.75
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet (2003) 7.98
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood (2005) 6.16
Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550). J Immunol (2011) 2.59
Evidence for onset of antipsychotic effects within the first 24 hours of treatment. Am J Psychiatry (2005) 1.83
Activated regulatory T cells are the major T cell type emigrating from the skin during a cutaneous immune response in mice. J Clin Invest (2010) 1.83
Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis. J Inflamm (Lond) (2010) 1.78
Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells. Bioinformatics (2007) 1.73
JAK inhibition with tofacitinib suppresses arthritic joint structural damage through decreased RANKL production. Arthritis Rheum (2012) 1.67
Genome-wide analysis of gene expression in intestinal-type gastric cancers using a complementary DNA microarray representing 23,040 genes. Cancer Res (2002) 1.46
LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells (2012) 1.36
Identification of Bphs, an autoimmune disease locus, as histamine receptor H1. Science (2002) 1.33
Chitinase 3-like-1 enhances bacterial adhesion to colonic epithelial cells through the interaction with bacterial chitin-binding protein. Lab Invest (2008) 1.28
Inhibition of histamine-mediated signaling confers significant protection against severe malaria in mouse models of disease. J Exp Med (2008) 1.25
Involvement of hypothalamic histamine H1 receptor in the regulation of feeding rhythm and obesity. Diabetes (2004) 1.25
Generation of a synthetic lymphoid tissue-like organoid in mice. Nat Biotechnol (2004) 1.23
Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci U S A (2006) 1.22
The H1 histamine receptor regulates allergic lung responses. J Clin Invest (2006) 1.21
Requirement of interaction between mast cells and skin dendritic cells to establish contact hypersensitivity. PLoS One (2011) 1.21
Chitinases A, B, and C1 of Serratia marcescens 2170 produced by recombinant Escherichia coli: enzymatic properties and synergism on chitin degradation. Biosci Biotechnol Biochem (2002) 1.19
Low nitrogen fertilization adapts rice root microbiome to low nutrient environment by changing biogeochemical functions. Microbes Environ (2014) 1.17
Immune regulation by histamine. Curr Opin Immunol (2002) 1.16
Comparison of rapidly acting intramuscular olanzapine, lorazepam, and placebo: a double-blind, randomized study in acutely agitated patients with dementia. Neuropsychopharmacology (2002) 1.15
The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model. J Infect Dis (2002) 1.08
Expression and diagnostic evaluation of the human tumor-associated antigen RCAS1 in pancreatic cancer. Pancreas (2003) 1.08
22-Oxacalcitriol prevents progressive glomerulosclerosis without adversely affecting calcium and phosphorus metabolism in subtotally nephrectomized rats. Nephrol Dial Transplant (2002) 1.08
Colored floral organs influence pollinator behavior and pollen transfer in Commelina communis (Commelinaceae). Am J Bot (2007) 1.06
Growth retardation and dyslymphopoiesis accompanied by G2/M arrest in APEX2-null mice. Blood (2004) 1.06
Solution structure of the fibronectin type III domain from Bacillus circulans WL-12 chitinase A1. J Biol Chem (2001) 1.06
Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. Nat Commun (2013) 1.05
Maraviroc: in vitro assessment of drug-drug interaction potential. Br J Clin Pharmacol (2008) 1.05
Generation and characterization of severe combined immunodeficiency rats. Cell Rep (2012) 1.04
A distinct human CD4+ T cell subset that secretes CXCL13 in rheumatoid synovium. Arthritis Rheum (2013) 1.03
Prostaglandin I2-IP signaling promotes Th1 differentiation in a mouse model of contact hypersensitivity. J Immunol (2010) 1.01
Histamine H1 receptor promotes atherosclerotic lesion formation by increasing vascular permeability for low-density lipoproteins. Arterioscler Thromb Vasc Biol (2010) 1.01
Dissolution profile, tolerability, and acceptability of the orally disintegrating olanzapine tablet in patients with schizophrenia. Can J Psychiatry (2002) 0.99
Distribution and phylogenetic analysis of family 19 chitinases in Actinobacteria. Appl Environ Microbiol (2004) 0.99
Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol (2013) 0.98
In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis. FASEB J (2003) 0.98
Impaired lymphocyte development and function in Clast5/Stra13/DEC1-transgenic mice. Eur J Immunol (2004) 0.98
Fibroblast activation protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions. Clin Exp Metastasis (2011) 0.97
Structural studies of a two-domain chitinase from Streptomyces griseus HUT6037. J Mol Biol (2006) 0.97
Artificial lymph nodes induce potent secondary immune responses in naive and immunodeficient mice. J Clin Invest (2007) 0.96
The directionality of chitin biosynthesis: a revisit. Biochem J (2003) 0.96
Comparison of enzymatic and antifungal properties between family 18 and 19 chitinases from S. coelicolor A3(2). Biosci Biotechnol Biochem (2006) 0.96
Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade. Blood (2002) 0.96
Histamine regulation in glucose and lipid metabolism via histamine receptors: model for nonalcoholic steatohepatitis in mice. Am J Pathol (2010) 0.95
Phase II assessment of talabostat and cisplatin in second-line stage IV melanoma. BMC Cancer (2009) 0.93
Directional degradation of beta-chitin by chitinase A1 revealed by a novel reducing end labelling technique. FEBS Lett (2002) 0.93
Production of functional spermatids from mouse germline stem cells in ectopically reconstituted seminiferous tubules. Biol Reprod (2006) 0.93
Rho-mDia1 pathway is required for adhesion, migration, and T-cell stimulation in dendritic cells. Blood (2010) 0.93
Involvement of glypican-3 in the recruitment of M2-polarized tumor-associated macrophages in hepatocellular carcinoma. Cancer Biol Ther (2009) 0.92
Clast5/Stra13 is a negative regulator of B lymphocyte activation. Biochem Biophys Res Commun (2002) 0.92
Improgan antinociception does not require neuronal histamine or histamine receptors. Brain Res (2003) 0.92
Intramuscular olanzapine and intramuscular haloperidol in acute schizophrenia: antipsychotic efficacy and extrapyramidal safety during the first 24 hours of treatment. Can J Psychiatry (2003) 0.92
Association between RCAS1 expression and microenvironmental immune cell death in uterine cervical cancer. Gynecol Oncol (2005) 0.92
GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Thromb Res (2005) 0.92
Opsonophagocytic dysfunction in patients with liver cirrhosis and low responses to tumor necrosis factor-alpha and lipopolysaccharide in patients' blood. J Infect Chemother (2004) 0.91
Potential pathophysiological role of D-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain. J Neural Transm (Vienna) (2009) 0.91
Results of total hip arthroplasty with bone graft and support ring for protrusio acetabuli in rheumatoid arthritis. J Orthop Sci (2005) 0.90
Pseudo vocal paralysis caused by a fish bone. Lancet (2002) 0.90
Comparative study of the reaction mechanism of family 18 chitinases from plants and microbes. J Biochem (2002) 0.90
The tumor-associated antigen, RCAS1, can be expressed in immune-mediated diseases as well as in carcinomas of biliary tract. J Hepatol (2002) 0.90
Amyotrophic lateral sclerosis associated with IgG anti-GalNAc-GD1a antibodies. Clin Neurol Neurosurg (2008) 0.90
Phase I trial of PT-100 (PT-100), a cytokine-inducing small molecule, following chemotherapy for solid tumor malignancy. Cancer Invest (2006) 0.90
The role of histamine H1 receptor and H2 receptor in LPS-induced liver injury. FASEB J (2005) 0.90
Identification of secernin 1 as a novel immunotherapy target for gastric cancer using the expression profiles of cDNA microarray. Cancer Sci (2006) 0.90
Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. J Antibiot (Tokyo) (2009) 0.89
Molecular directionality in crystalline beta-chitin: hydrolysis by chitinases A and B from Serratia marcescens 2170. Biochem J (2005) 0.89
In vitro and in vivo glucuronidation of midazolam in humans. Br J Clin Pharmacol (2009) 0.89
Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse. Am J Pathol (2010) 0.89
Importance of exposed aromatic residues in chitinase B from Serratia marcescens 2170 for crystalline chitin hydrolysis. J Biochem (2004) 0.89
Antioxidant defense of rainbow trout (Oncorhynchus mykiss) in relation to dietary n-3 highly unsaturated fatty acids and vitamin E contents. Comp Biochem Physiol C Toxicol Pharmacol (2005) 0.89
RCAS1 expression in immune-mediated liver diseases. J Clin Gastroenterol (2002) 0.89
Clinical significance of RCAS1 as a biomarker of uterine cancer. Gynecol Oncol (2006) 0.88
Two-point-separation in super-resolution fluorescence microscope based on up-conversion fluorescence depletion technique. Opt Express (2003) 0.88
Functional analysis of the chitin-binding domain of a family 19 chitinase from Streptomyces griseus HUT6037: substrate-binding affinity and cis-dominant increase of antifungal function. Biosci Biotechnol Biochem (2002) 0.87
The Kelch repeat protein KLHDC10 regulates oxidative stress-induced ASK1 activation by suppressing PP5. Mol Cell (2012) 0.87
Inducible histamine protects mice from P. acnes-primed and LPS-induced hepatitis through H2-receptor stimulation. Gastroenterology (2004) 0.87
The expression profile of glypican-3 and its relation to macrophage population in human hepatocellular carcinoma. Liver Int (2009) 0.87
Investigation of polarization effects for high-numerical-aperture first-order Laguerre-Gaussian beams by 2D scanning with a single fluorescent microbead. Opt Express (2005) 0.87
Manometric abnormality in dysphagic patients after medullary cerebrovascular accidents. ORL J Otorhinolaryngol Relat Spec (2002) 0.87
Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest (2015) 0.86
Dysregulated generation of follicular helper T cells in the spleen triggers fatal autoimmune hepatitis in mice. Gastroenterology (2011) 0.86
Moesin-deficient mice reveal a non-redundant role for moesin in lymphocyte homeostasis. Int Immunol (2012) 0.86
Preclinical to clinical translation of tofacitinib, a Janus kinase inhibitor, in rheumatoid arthritis. J Pharmacol Exp Ther (2013) 0.86
Auditory brainstem responses and usefulness of hearing aids in hearing impaired children with Cornelia de Lange syndrome. Int J Pediatr Otorhinolaryngol (2002) 0.86
Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin. Infect Immun (2003) 0.86
Uptake of N,N'-diacetylchitobiose [(GlcNAc)2] via the phosphotransferase system is essential for chitinase production by Serratia marcescens 2170. J Bacteriol (2003) 0.85
Expression of RCAS1 in human gastric carcinoma: a potential mechanism of immune escape. Cancer Sci (2004) 0.85
Structure of full-length class I chitinase from rice revealed by X-ray crystallography and small-angle X-ray scattering. Proteins (2010) 0.85
Hematopoietic stimulation by a dipeptidyl peptidase inhibitor reveals a novel regulatory mechanism and therapeutic treatment for blood cell deficiencies. Blood (2003) 0.85
Monitoring visual function in children with syndromic craniosynostosis: a comparison of 3 methods. Arch Ophthalmol (2006) 0.84
Appearance of the LAT protein at an early stage of B-cell development and its possible role. Immunology (2003) 0.84
Expression of tumor-associated membrane antigen, RCAS1, in human colorectal carcinomas and possible role in apoptosis of tumor-infiltrating lymphocytes. Mod Pathol (2003) 0.84
Role of substance P on histamine H(3) antagonist-induced scratching behavior in mice. J Pharmacol Sci (2006) 0.84
Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes. Drug Metab Dispos (2010) 0.83