Published in J Biol Chem on July 29, 2004
Interactions between heparan sulfate and proteins: the concept of specificity. J Cell Biol (2006) 3.49
Liver heparan sulfate proteoglycans mediate clearance of triglyceride-rich lipoproteins independently of LDL receptor family members. J Clin Invest (2007) 2.53
Mammalian heparanase: what is the message? J Cell Mol Med (2007) 1.91
Enzymatic redesigning of biologically active heparan sulfate. J Biol Chem (2005) 1.89
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Genes Dev (2007) 1.68
Organ-specific heparan sulfate structural phenotypes. J Biol Chem (2009) 1.55
Heparan sulfate 6-O-endosulfatases: discrete in vivo activities and functional co-operativity. Biochem J (2006) 1.48
Glycomics of proteoglycan biosynthesis in murine embryonic stem cell differentiation. J Proteome Res (2007) 1.46
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Significance of heparanase in cancer and inflammation. Cancer Microenviron (2011) 1.46
Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. Proc Natl Acad Sci U S A (2008) 1.45
Secreted sulfatases Sulf1 and Sulf2 have overlapping yet essential roles in mouse neonatal survival. PLoS One (2007) 1.44
Heparan sulfate biosynthesis: regulation and variability. J Histochem Cytochem (2012) 1.25
Extended N-sulfated domains reside at the nonreducing end of heparan sulfate chains. J Biol Chem (2010) 1.22
Isolation and characterization of heparan sulfate from various murine tissues. Glycoconj J (2006) 1.15
Improved hydrophilic interaction chromatography LC/MS of heparinoids using a chip with postcolumn makeup flow. Anal Chem (2010) 1.14
Heparan sulfate 2-O-sulfotransferase is required for triglyceride-rich lipoprotein clearance. J Biol Chem (2009) 1.13
Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells. J Biol Chem (2009) 1.10
Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling. J Biol Chem (2009) 1.07
Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling. J Biol Chem (2010) 1.06
Rapid purification and high sensitivity analysis of heparan sulfate from cells and tissues: toward glycomics profiling. J Biol Chem (2009) 1.06
Genetic analysis of the heparan modification network in Caenorhabditis elegans. J Biol Chem (2011) 1.05
Versatile role of heparanase in inflammation. Matrix Biol (2013) 1.05
On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem (2012) 1.04
A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation. Proc Natl Acad Sci U S A (2008) 1.04
Glycosaminoglycan-dependent restriction of FGF diffusion is necessary for lacrimal gland development. Development (2012) 1.03
Endothelial heparan sulfate in angiogenesis. Prog Mol Biol Transl Sci (2010) 1.02
Deliberate attenuation of chikungunya virus by adaptation to heparan sulfate-dependent infectivity: a model for rational arboviral vaccine design. PLoS Negl Trop Dis (2014) 1.02
The circulating glycosaminoglycan signature of respiratory failure in critically ill adults. J Biol Chem (2014) 1.00
Organ-specific sulfation patterns of heparan sulfate generated by extracellular sulfatases Sulf1 and Sulf2 in mice. J Biol Chem (2012) 1.00
Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood (2012) 0.97
Altered heparan sulfate structure in mice with deleted NDST3 gene function. J Biol Chem (2008) 0.97
Polycystic disease caused by deficiency in xylosyltransferase 2, an initiating enzyme of glycosaminoglycan biosynthesis. Proc Natl Acad Sci U S A (2007) 0.97
Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking α-l-iduronidase. J Biol Chem (2011) 0.93
Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis. Arterioscler Thromb Vasc Biol (2012) 0.91
Loss of the heparan sulfate sulfotransferase, Ndst1, in mammary epithelial cells selectively blocks lobuloalveolar development in mice. PLoS One (2010) 0.90
Heparanase in inflammation and inflammation-associated cancer. FEBS J (2013) 0.90
Heparan sulfate Ndst1 regulates vascular smooth muscle cell proliferation, vessel size and vascular remodeling. J Mol Cell Cardiol (2010) 0.89
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem (2011) 0.89
Glycomics analysis of mammalian heparan sulfates modified by the human extracellular sulfatase HSulf2. PLoS One (2011) 0.89
Characterization of glycosaminoglycan (GAG) sulfatases from the human gut symbiont Bacteroides thetaiotaomicron reveals the first GAG-specific bacterial endosulfatase. J Biol Chem (2014) 0.87
TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated. J Transl Med (2011) 0.87
Fell-Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra. Int J Exp Pathol (2015) 0.87
The endothelial glycocalyx: an important regulator of the pulmonary vascular barrier. Tissue Barriers (2013) 0.86
The endothelial glycocalyx in syndecan-1 deficient mice. Microvasc Res (2013) 0.86
D-glucuronyl C5-epimerase acts in dorso-ventral axis formation in zebrafish. BMC Dev Biol (2005) 0.86
Sulfatase 1 is an inhibitor of ductal morphogenesis with sexually dimorphic expression in the urogenital sinus. Endocrinology (2010) 0.86
Heparan sulfate proteoglycans: a sugar code for vertebrate development? Development (2015) 0.86
Serglycin-independent release of active mast cell proteases in response to Toxoplasma gondii infection. J Biol Chem (2010) 0.84
Mesomelia-synostoses syndrome results from deletion of SULF1 and SLCO5A1 genes at 8q13. Am J Hum Genet (2010) 0.84
The mutual impact of syndecan-1 and its glycosaminoglycan chains--a multivariable puzzle. J Histochem Cytochem (2012) 0.83
Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity. J Cell Biochem (2014) 0.82
Specific sides to multifaceted glycosaminoglycans are observed in embryonic development. Semin Cell Dev Biol (2010) 0.82
Characterization of hepatitis C virus interaction with heparan sulfate proteoglycans. J Virol (2015) 0.82
MicroRNA-24 suppression of N-deacetylase/N-sulfotransferase-1 (NDST1) reduces endothelial cell responsiveness to vascular endothelial growth factor A (VEGFA). J Biol Chem (2013) 0.81
Quantitative phosphoproteomics analysis reveals broad regulatory role of heparan sulfate on endothelial signaling. Mol Cell Proteomics (2013) 0.81
Spinal deformity in aged zebrafish is accompanied by degenerative changes to their vertebrae that resemble osteoarthritis. PLoS One (2013) 0.80
Microglial Heparan Sulfate Proteoglycans Facilitate the Cluster-of-Differentiation 14 (CD14)/Toll-like Receptor 4 (TLR4)-Dependent Inflammatory Response. J Biol Chem (2015) 0.79
Synthesis of heparan sulfate with cyclophilin B-binding properties is determined by cell type-specific expression of sulfotransferases. J Biol Chem (2009) 0.79
Molecular structure of heparan sulfate from Spalax. Implications of heparanase and hypoxia. J Biol Chem (2008) 0.79
Drosophila heparan sulfate, a novel design. J Biol Chem (2012) 0.78
Workflow for combined proteomics and glycomics profiling from histological tissues. Anal Chem (2014) 0.78
Alterations in heparan sulfate in the vessel in response to vascular injury in the mouse. J Cardiovasc Transl Res (2008) 0.78
Podocyte-specific deletion of NDST1, a key enzyme in the sulfation of heparan sulfate glycosaminoglycans, leads to abnormalities in podocyte organization in vivo. Kidney Int (2013) 0.78
Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling. BMC Dev Biol (2011) 0.78
Bioengineered heparin: is there a future for this form of the successful therapeutic? Bioengineered (2014) 0.78
Brittlestars contain highly sulfated chondroitin sulfates/dermatan sulfates that promote fibroblast growth factor 2-induced cell signaling. Glycobiology (2013) 0.77
Sulfated glycosaminoglycans from crown-of-thorns Acanthaster planci - extraction and quantification analysis. Food Sci Nutr (2013) 0.77
Evidence that muscle cells do not express the histidine-rich glycoprotein associated with AMP deaminase but can internalise the plasma protein. Eur J Histochem (2011) 0.77
Heparan sulfate biosynthesis enzymes in embryonic stem cell biology. J Histochem Cytochem (2012) 0.76
Temporal and functional changes in glycosaminoglycan expression during osteogenesis. J Mol Histol (2007) 0.76
Targeting Serglycin Prevents Metastasis in Murine Mammary Carcinoma. PLoS One (2016) 0.76
Analysis of Glycosaminoglycans Using Mass Spectrometry. Curr Proteomics (2015) 0.76
Glycomics approaches for the bioassay and structural analysis of heparin/heparan sulphates. Metabolites (2012) 0.76
High sodium diet converts renal proteoglycans into pro-inflammatory mediators in rats. PLoS One (2017) 0.75
Enzyme overexpression - an exercise toward understanding regulation of heparan sulfate biosynthesis. Sci Rep (2016) 0.75
The role of heparan sulphate in development: the ectodermal story. Int J Exp Pathol (2016) 0.75
Chondroitin / dermatan sulfate modification enzymes in zebrafish development. PLoS One (2015) 0.75
The NDST gene family in zebrafish: role of NDST1B in pharyngeal arch formation. PLoS One (2015) 0.75
NDST2 (N-Deacetylase/N-Sulfotransferase-2) Enzyme Regulates Heparan Sulfate Chain Length. J Biol Chem (2016) 0.75
Nematodes join the family of chondroitin sulfate-synthesizing organisms: Identification of an active chondroitin sulfotransferase in Caenorhabditis elegans. Sci Rep (2016) 0.75
The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages. J Clin Invest (2005) 3.99
Interactions between heparan sulfate and proteins: the concept of specificity. J Cell Biol (2006) 3.49
Heparanase enhances syndecan-1 shedding: a novel mechanism for stimulation of tumor growth and metastasis. J Biol Chem (2007) 2.25
Heparan sulfate in trans potentiates VEGFR-mediated angiogenesis. Dev Cell (2006) 2.16
Generation of "neoheparin" from E. coli K5 capsular polysaccharide. J Med Chem (2005) 2.03
Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity. Proc Natl Acad Sci U S A (2013) 2.01
Abrogation of heparan sulfate synthesis in Drosophila disrupts the Wingless, Hedgehog and Decapentaplegic signaling pathways. Development (2004) 1.80
Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. J Biol Chem (2002) 1.74
Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation. J Biol Chem (2007) 1.70
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development. Genes Dev (2007) 1.68
Surface-exposed amino acid residues of HPV16 L1 protein mediating interaction with cell surface heparan sulfate. J Biol Chem (2007) 1.66
Transgenic expression of mammalian heparanase uncovers physiological functions of heparan sulfate in tissue morphogenesis, vascularization, and feeding behavior. FASEB J (2004) 1.64
Identification of a potential novel type of influenza virus in Bovine in China. Virus Genes (2014) 1.59
Sulfotransferases in glycosaminoglycan biosynthesis. Curr Opin Struct Biol (2003) 1.56
A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils. Blood (2010) 1.53
Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function. J Clin Invest (2008) 1.52
Heparan sulfate on endothelial cells mediates the binding of Plasmodium falciparum-infected erythrocytes via the DBL1alpha domain of PfEMP1. Blood (2002) 1.51
Therapeutic value of glycosaminoglycans in cancer. Mol Cancer Ther (2006) 1.48
Newly generated heparanase knock-out mice unravel co-regulation of heparanase and matrix metalloproteinases. PLoS One (2009) 1.46
Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation. Proc Natl Acad Sci U S A (2008) 1.45
3-O-sulfated oligosaccharide structures are recognized by anti-heparan sulfate antibody HS4C3. J Biol Chem (2005) 1.43
Heparanase overexpression reduces carrageenan-induced mechanical and cold hypersensitivity in mice. Neurosci Lett (2011) 1.41
Heparan sulfate synthesized by mouse embryonic stem cells deficient in NDST1 and NDST2 is 6-O-sulfated but contains no N-sulfate groups. J Biol Chem (2004) 1.39
Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization. Blood (2008) 1.38
Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors. J Biol Chem (2006) 1.35
Heparan sulfate and development: differential roles of the N-acetylglucosamine N-deacetylase/N-sulfotransferase isozymes. Biochim Biophys Acta (2002) 1.34
The AP2/ERF transcription factor AtERF73/HRE1 modulates ethylene responses during hypoxia in Arabidopsis. Plant Physiol (2011) 1.33
Release of sequestered malaria parasites upon injection of a glycosaminoglycan. PLoS Pathog (2006) 1.31
Heparanase is essential for the development of diabetic nephropathy in mice. Diabetes (2011) 1.29
Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression. Carcinogenesis (2009) 1.27
Heparin/heparan sulfate biosynthesis: processive formation of N-sulfated domains. J Biol Chem (2008) 1.27
Heparan sulfate biosynthesis: regulation and variability. J Histochem Cytochem (2012) 1.25
Transgenic or tumor-induced expression of heparanase upregulates sulfation of heparan sulfate. Nat Chem Biol (2007) 1.25
Defective glycosylation of decorin and biglycan, altered collagen structure, and abnormal phenotype of the skin fibroblasts of an Ehlers-Danlos syndrome patient carrying the novel Arg270Cys substitution in galactosyltransferase I (beta4GalT-7). J Mol Med (Berl) (2006) 1.24
Molecular epidemiological surveys of H5 subtype highly pathogenic avian influenza viruses in poultry in China during 2007-2009. J Gen Virol (2010) 1.21
Inhibition by the soluble syndecan-1 ectodomains delays wound repair in mice overexpressing syndecan-1. J Biol Chem (2004) 1.20
Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and E-cadherin-dependent mechanism. Int J Cancer (2012) 1.18
Characterization of anti-heparan sulfate phage display antibodies AO4B08 and HS4E4. J Biol Chem (2007) 1.16
Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2. J Biol Chem (2006) 1.15
Structural basis for the growth factor activity of human adenosine deaminase ADA2. J Biol Chem (2010) 1.14
Identification and characterization of a mammalian 14-kDa phosphohistidine phosphatase. Eur J Biochem (2002) 1.14
Increased expression of syndecan-1 protects against cardiac dilatation and dysfunction after myocardial infarction. Circulation (2007) 1.13
Structural basis of oligosaccharide receptor recognition by human papillomavirus. J Biol Chem (2010) 1.13
Orf virus VEGF-E NZ2 promotes paracellular NRP-1/VEGFR-2 coreceptor assembly via the peptide RPPR. FASEB J (2008) 1.11
Flow cytometry in cancer stem cell analysis and separation. Cytometry A (2012) 1.10
Heparan sulfate C5-epimerase is essential for heparin biosynthesis in mast cells. Nat Chem Biol (2006) 1.10
More than matrix: the multifaceted role of decorin in cancer. Eur J Cell Biol (2012) 1.09
Role of heparan sulfate domain organization in endostatin inhibition of endothelial cell function. EMBO J (2002) 1.07
Heparan sulphate identified on human erythrocytes: a Plasmodium falciparum receptor. Biochem J (2004) 1.07
Lack of L-iduronic acid in heparan sulfate affects interaction with growth factors and cell signaling. J Biol Chem (2009) 1.07
Heparan sulfate domain organization and sulfation modulate FGF-induced cell signaling. J Biol Chem (2010) 1.06
Molecular characterization of transcriptome-wide interactions between highly pathogenic porcine reproductive and respiratory syndrome virus and porcine alveolar macrophages in vivo. Int J Biol Sci (2011) 1.06
On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis. J Biol Chem (2012) 1.04
Heparan sulfate mediates amyloid-beta internalization and cytotoxicity. Glycobiology (2010) 1.04
Microbial subversion of heparan sulfate proteoglycans. Mol Cells (2008) 1.04
Enoxaparin improves the course of dextran sodium sulfate-induced colitis in syndecan-1-deficient mice. Am J Pathol (2009) 1.04
The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease. J Biol Chem (2010) 1.03
Constitutive and accelerated shedding of murine syndecan-1 is mediated by cleavage of its core protein at a specific juxtamembrane site. Biochemistry (2005) 1.03
On the role of endothelin-converting enzyme-1 (ECE-1) and neprilysin in human breast cancer. Breast Cancer Res Treat (2007) 1.02
Disruption of heparan sulfate proteoglycan conformation perturbs B-cell maturation and APRIL-mediated plasma cell survival. Blood (2011) 1.01
Characterization of the hemagglutinin gene of subtype H9 avian influenza viruses isolated in 2007-2009 in China. J Virol Methods (2009) 0.99
Characterization of endometrial mesenchymal stem-like cells obtained by endometrial biopsy during routine diagnostics. Fertil Steril (2011) 0.99
Enzymatically active N-deacetylase/N-sulfotransferase-2 is present in liver but does not contribute to heparan sulfate N-sulfation. J Biol Chem (2006) 0.98
Syndecan-1 modulates β-integrin-dependent and interleukin-6-dependent functions in breast cancer cell adhesion, migration, and resistance to irradiation. FEBS J (2013) 0.98
Role of the heparan sulfate proteoglycan syndecan-1 (CD138) in delayed-type hypersensitivity. J Immunol (2009) 0.98
Mast cell chymase degrades the alarmins heat shock protein 70, biglycan, HMGB1, and interleukin-33 (IL-33) and limits danger-induced inflammation. J Biol Chem (2013) 0.97
Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells. Brain Pathol (2008) 0.97
The role for decorin in delayed-type hypersensitivity. J Immunol (2011) 0.94
Mucopolysaccharidosis type I, unique structure of accumulated heparan sulfate and increased N-sulfotransferase activity in mice lacking α-l-iduronidase. J Biol Chem (2011) 0.93
Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization. Cancer Res (2007) 0.93
Involvement of heparanase in atherosclerosis and other vessel wall pathologies. Matrix Biol (2013) 0.93
Effects of the FSH receptor gene polymorphism p.N680S on cAMP and steroid production in cultured primary human granulosa cells. Reprod Biomed Online (2011) 0.92
Distinct effects on heparan sulfate structure by different active site mutations in NDST-1. Biochemistry (2003) 0.92
Mutational study of human phosphohistidine phosphatase: effect on enzymatic activity. Biochem Biophys Res Commun (2005) 0.92
Functional overlap between chondroitin and heparan sulfate proteoglycans during VEGF-induced sprouting angiogenesis. Arterioscler Thromb Vasc Biol (2012) 0.91
Changes in heparan sulfate are associated with delayed wound repair, altered cell migration, adhesion and contractility in the galactosyltransferase I (beta4GalT-7) deficient form of Ehlers-Danlos syndrome. Hum Mol Genet (2007) 0.91
MicroRNA miR-145 inhibits proliferation, invasiveness, and stem cell phenotype of an in vitro endometriosis model by targeting multiple cytoskeletal elements and pluripotency factors. Fertil Steril (2013) 0.91
Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein. Proc Natl Acad Sci U S A (2011) 0.91
Metformin alters insulin signaling and viability of human granulosa cells. Fertil Steril (2005) 0.91
The anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner. J Biol Chem (2006) 0.91
Heparan sulfate proteoglycans in amyloidosis. Prog Mol Biol Transl Sci (2010) 0.90
Endocytosis of the dermatan sulfate proteoglycan decorin utilizes multiple pathways and is modulated by epidermal growth factor receptor signaling. Biochimie (2007) 0.89
Microarrays of heparin oligosaccharides obtained by nitrous acid depolymerization of isolated heparin. Chem Commun (Camb) (2006) 0.89
Mice deficient in heparan sulfate N-deacetylase/N-sulfotransferase 1. Prog Mol Biol Transl Sci (2010) 0.89
Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin. J Biol Chem (2011) 0.89
Interaction of E2 glycoprotein with heparan sulfate is crucial for cellular infection of Sindbis virus. PLoS One (2010) 0.89
Undersulfation of heparan sulfate restricts differentiation potential of mouse embryonic stem cells. J Biol Chem (2012) 0.88
Heparanase overexpression impairs inflammatory response and macrophage-mediated clearance of amyloid-β in murine brain. Acta Neuropathol (2012) 0.88
Ionothermal synthesis of layered zirconium phosphates and their tribological properties in mineral oil. Inorg Chem (2010) 0.88
Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase. J Immunol (2010) 0.87
Irreversible glucuronyl C5-epimerization in the biosynthesis of heparan sulfate. J Biol Chem (2004) 0.86
Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. J Immunol (2013) 0.86