Published in Structure on August 01, 2004
The protein structures that shape caspase activity, specificity, activation and inhibition. Biochem J (2004) 4.85
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A (2006) 2.59
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells. Proc Natl Acad Sci U S A (2007) 1.52
Two-state selection of conformation-specific antibodies. Proc Natl Acad Sci U S A (2009) 1.40
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. J Biol Chem (2008) 1.26
Targeting cell death in tumors by activating caspases. Curr Cancer Drug Targets (2008) 1.10
Death by caspase dimerization. Adv Exp Med Biol (2012) 1.04
Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem (2009) 1.00
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Nat Struct Mol Biol (2011) 0.99
Allosteric regulation of protease activity by small molecules. Mol Biosyst (2010) 0.92
A highly potent and selective caspase 1 inhibitor that utilizes a key 3-cyanopropanoic acid moiety. ChemMedChem (2010) 0.91
Solution structure of Archaeglobus fulgidis peptidyl-tRNA hydrolase (Pth2) provides evidence for an extensive conserved family of Pth2 enzymes in archea, bacteria, and eukaryotes. Protein Sci (2005) 0.83
Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. J Biol Chem (2013) 0.82
A designed redox-controlled caspase. Protein Sci (2011) 0.82
Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. J Biol Chem (2011) 0.81
Structural analysis of caspase-1 inhibitors derived from Tethering. Acta Crystallogr Sect F Struct Biol Cryst Commun (2005) 0.80
Caspase-1: an integral regulator of innate immunity. Semin Immunopathol (2015) 0.80
Small Molecule Active Site Directed Tools for Studying Human Caspases. Chem Rev (2015) 0.77
Indole-fused benzooxazepines: a new structural class of anticancer agents. Future Sci OA (2017) 0.75
Tunable allosteric library of caspase-3 identifies coupling between conserved water molecules and conformational selection. Proc Natl Acad Sci U S A (2016) 0.75
Discovery of an allosteric site in the caspases. Proc Natl Acad Sci U S A (2004) 2.51
Fragment-based drug discovery. J Med Chem (2004) 2.07
Targeting p21-activated kinase 1 (PAK1) to induce apoptosis of tumor cells. Proc Natl Acad Sci U S A (2011) 2.01
Allosteric inhibition of protein tyrosine phosphatase 1B. Nat Struct Mol Biol (2004) 1.86
Binding of small molecules to an adaptive protein-protein interface. Proc Natl Acad Sci U S A (2003) 1.78
Bispecific antibodies with natural architecture produced by co-culture of bacteria expressing two distinct half-antibodies. Nat Biotechnol (2013) 1.71
Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death. Nat Chem Biol (2013) 1.65
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II. PLoS One (2010) 1.29
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. J Biol Chem (2008) 1.26
Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling. J Biol Chem (2010) 1.15
Discovery of a potent and selective aurora kinase inhibitor. Bioorg Med Chem Lett (2008) 1.15
In situ assembly of enzyme inhibitors using extended tethering. Nat Biotechnol (2003) 1.11
Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J Am Chem Soc (2003) 1.11
X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists. J Biol Chem (2009) 1.08
Alkylsulfanyl-1,2,4-triazoles, a new class of allosteric valosine containing protein inhibitors. Synthesis and structure-activity relationships. J Med Chem (2013) 1.02
A modular platform for the rapid site-specific radiolabeling of proteins with 18F exemplified by quantitative positron emission tomography of human epidermal growth factor receptor 2. J Med Chem (2009) 0.97
Combination drug scheduling defines a "window of opportunity" for chemopotentiation of gemcitabine by an orally bioavailable, selective ChK1 inhibitor, GNE-900. Mol Cancer Ther (2013) 0.94
Fragment-based discovery of nonpeptidic BACE-1 inhibitors using tethering. Biochemistry (2009) 0.93
Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem (2002) 0.92
Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem (2004) 0.92
Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. J Med Chem (2006) 0.91
Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery. Bioorg Med Chem Lett (2011) 0.91
Development of a human IgG4 bispecific antibody for dual targeting of interleukin-4 (IL-4) and interleukin-13 (IL-13) cytokines. J Biol Chem (2013) 0.90
Tethering identifies fragment that yields potent inhibitors of human caspase-1. Bioorg Med Chem Lett (2005) 0.86
Discovery of a new phosphotyrosine mimetic for PTP1B using breakaway tethering. J Am Chem Soc (2003) 0.85
2-Aminobenzimidazoles as potent Aurora kinase inhibitors. Bioorg Med Chem Lett (2009) 0.84
The relativity of time perception produced by facial emotion stimuli. Cogn Emot (2011) 0.83
Influence of number of CAG repeats on local control in the RTOG 86-10 protocol. Am J Clin Oncol (2006) 0.83
Mouse Aurora A: expression in Escherichia coli and purification. Protein Expr Purif (2007) 0.81
N-Benzoyl amino acids as LFA-1/ICAM inhibitors 1: amino acid structure-activity relationship. Bioorg Med Chem Lett (2003) 0.79
Tissue levels of arsenicals and skin tumor response following administration of monomethylarsonous acid and arsenite to K6/ODC mice. J Environ Pathol Toxicol Oncol (2008) 0.79
Identification of potent and novel small-molecule inhibitors of caspase-3. Bioorg Med Chem Lett (2003) 0.78
Towards a developmental framework of consumer and carer participation in child and adolescent mental health services. Australas Psychiatry (2007) 0.78
N-Benzoyl amino acids as ICAM/LFA-1 inhibitors. Part 2: structure-activity relationship of the benzoyl moiety. Bioorg Med Chem Lett (2004) 0.77
Discovery of small molecule leads in a biotechnology datastream. Drug Discov Today (2003) 0.76
Water-soluble prodrugs of an Aurora kinase inhibitor. Bioorg Med Chem Lett (2009) 0.75
Identification of nonpeptidic small-molecule inhibitors of interleukin-2. Bioorg Med Chem Lett (2005) 0.75
Direct hit. Nurses win with targeted ads. Revolution (2002) 0.75