Published in Biochem J on December 01, 2004
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep (2006) 4.15
Quantitative analysis of pathways controlling extrinsic apoptosis in single cells. Mol Cell (2008) 3.88
Human caspases: activation, specificity, and regulation. J Biol Chem (2009) 3.67
Modeling a snap-action, variable-delay switch controlling extrinsic cell death. PLoS Biol (2008) 2.63
Cell death in the nervous system. Nature (2006) 2.62
CutDB: a proteolytic event database. Nucleic Acids Res (2006) 2.41
A common allosteric site and mechanism in caspases. Proc Natl Acad Sci U S A (2006) 2.12
Measuring and modeling apoptosis in single cells. Cell (2011) 2.10
Caspases: pharmacological manipulation of cell death. J Clin Invest (2005) 2.10
Emerging principles in protease-based drug discovery. Nat Rev Drug Discov (2010) 2.05
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem (2010) 1.99
Pharmacological manipulation of cell death: clinical applications in sight? J Clin Invest (2005) 1.91
Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci (2010) 1.91
Activation of specific apoptotic caspases with an engineered small-molecule-activated protease. Cell (2010) 1.85
FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. Biochem J (2011) 1.64
Surprising complexity of the ancestral apoptosis network. Genome Biol (2007) 1.63
Inflammatory stimuli regulate caspase substrate profiles. Mol Cell Proteomics (2010) 1.57
Are metacaspases caspases? J Cell Biol (2007) 1.57
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem (2009) 1.44
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell (2010) 1.44
Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species. J Biol Chem (2008) 1.41
Viral subversion of apoptotic enzymes: escape from death row. Annu Rev Microbiol (2008) 1.41
An allosteric circuit in caspase-1. J Mol Biol (2008) 1.38
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J (2009) 1.33
Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL. J Cell Biol (2010) 1.30
Reduced Apaf-1 levels in cardiomyocytes engage strict regulation of apoptosis by endogenous XIAP. J Cell Biol (2005) 1.28
Proteome-wide substrate analysis indicates substrate exclusion as a mechanism to generate caspase-7 versus caspase-3 specificity. Mol Cell Proteomics (2009) 1.27
Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation. J Biol Chem (2008) 1.26
Protease signalling: the cutting edge. EMBO J (2012) 1.24
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis. Proc Natl Acad Sci U S A (2012) 1.23
Protective roles for caspase-8 and cFLIP in adult homeostasis. Cell Rep (2013) 1.23
Inhibition of fatty-acid synthase induces caspase-8-mediated tumor cell apoptosis by up-regulating DDIT4. J Biol Chem (2008) 1.23
Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell (2012) 1.23
Phosphorylation regulates assembly of the caspase-6 substrate-binding groove. Structure (2012) 1.20
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J (2007) 1.20
Cell death in parasitic protozoa: regulated or incidental? Nat Rev Microbiol (2012) 1.20
Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation. EMBO Rep (2010) 1.17
Inhibitor of apoptosis protein family as diagnostic markers and therapeutic targets of colorectal cancer. Surg Today (2011) 1.14
Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct (2011) 1.14
Targeting caspases in cancer therapeutics. Biol Chem (2013) 1.13
Neurodegeneration in Alzheimer's disease: caspases and synaptic element interdependence. Mol Neurodegener (2009) 1.12
Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. Biochemistry (2006) 1.12
Apoptosis and the selective survival of host animals following thermal bleaching in zooxanthellate corals. Proc Natl Acad Sci U S A (2011) 1.11
A plant alternative to animal caspases: subtilisin-like proteases. Cell Death Differ (2011) 1.11
Regulation of apoptotic pathways by Stylophora pistillata (Anthozoa, Pocilloporidae) to survive thermal stress and bleaching. PLoS One (2011) 1.10
Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol (2010) 1.10
Targeting cell death in tumors by activating caspases. Curr Cancer Drug Targets (2008) 1.10
Biomarkers and molecular probes for cell death imaging and targeted therapeutics. Bioconjug Chem (2012) 1.10
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem (2008) 1.09
Highly conserved caspase and Bcl-2 homologues from the sea anemone Aiptasia pallida: lower metazoans as models for the study of apoptosis evolution. J Mol Evol (2006) 1.08
Caspase substrates and inhibitors. Cold Spring Harb Perspect Biol (2013) 1.07
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization. Mol Biol Cell (2006) 1.07
Key note lecture: toward a mechanistic taxonomy for cell death programs. Stroke (2007) 1.06
Emerging role of protein-protein transnitrosylation in cell signaling pathways. Antioxid Redox Signal (2012) 1.06
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta (2011) 1.04
Programmed cell death in Parkinson's disease. Cold Spring Harb Perspect Med (2012) 1.04
Death by caspase dimerization. Adv Exp Med Biol (2012) 1.04
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J (2007) 1.04
Baculovirus resistance in codling moth is virus isolate-dependent and the consequence of a mutation in viral gene pe38. Proc Natl Acad Sci U S A (2014) 1.04
The actin cytoskeleton as a sensor and mediator of apoptosis. Bioarchitecture (2012) 1.03
Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases. Exp Neurol (2012) 1.02
Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc Natl Acad Sci U S A (2013) 1.02
Aberrant expression of miR-638 contributes to benzo(a)pyrene-induced human cell transformation. Toxicol Sci (2011) 1.02
Crystal structure of a Trypanosoma brucei metacaspase. Proc Natl Acad Sci U S A (2012) 1.02
Structural biology of the Bcl-2 family and its mimicry by viral proteins. Cell Death Dis (2013) 1.01
Mevalonate kinase deficiency and neuroinflammation: balance between apoptosis and pyroptosis. Int J Mol Sci (2013) 1.00
Dissecting an allosteric switch in caspase-7 using chemical and mutational probes. J Biol Chem (2009) 1.00
Structural basis for executioner caspase recognition of P5 position in substrates. Apoptosis (2008) 0.99
Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins. Nat Struct Mol Biol (2011) 0.99
Activation and specificity of human caspase-10. Biochemistry (2010) 0.98
Macromolecular assembly-driven processing of the 2/3 cleavage site in the alphavirus replicase polyprotein. J Virol (2011) 0.97
Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. Cell Death Differ (2012) 0.97
An optimized activity-based probe for the study of caspase-6 activation. Chem Biol (2012) 0.97
Copper oxide nanoparticles induced mitochondria mediated apoptosis in human hepatocarcinoma cells. PLoS One (2013) 0.97
Caspases as therapeutic targets in Alzheimer's disease: is it time to "cut" to the chase? Int J Clin Exp Pathol (2008) 0.97
Breakdown of coral colonial form under reduced pH conditions is initiated in polyps and mediated through apoptosis. Proc Natl Acad Sci U S A (2015) 0.95
Caspase-12 and the inflammatory response to Yersinia pestis. PLoS One (2009) 0.94
Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2013) 0.94
Allosteric regulation of protease activity by small molecules. Mol Biosyst (2010) 0.92
Zinc-mediated allosteric inhibition of caspase-6. J Biol Chem (2012) 0.92
Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike. J Biol Chem (2012) 0.92
Porphyromonas gingivalis virulence factor gingipain RgpB shows a unique zymogenic mechanism for cysteine peptidases. J Biol Chem (2013) 0.91
Revisiting caspases in sepsis. Cell Death Dis (2014) 0.91
Importance of the caspase cleavage site in amyloid-β protein precursor. J Alzheimers Dis (2010) 0.90
Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates. Cell Death Differ (2014) 0.89
A comprehensive characterization of the caspase gene family in insects from the order Lepidoptera. BMC Genomics (2011) 0.89
The Arabidopsis metacaspase9 degradome. Plant Cell (2013) 0.88
Anti-apoptotic genes in the survival of monocytic cells during infection. Curr Genomics (2009) 0.88
Bicaudal is a conserved substrate for Drosophila and mammalian caspases and is essential for cell survival. PLoS One (2009) 0.88
New types of metacaspases in phytoplankton reveal diverse origins of cell death proteases. Cell Death Dis (2013) 0.88
Aqueous extract of Azadirachta indica (neem) leaf induces generation of reactive oxygen species and mitochondria-mediated apoptosis in rat oocytes. J Assist Reprod Genet (2011) 0.88
Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc Natl Acad Sci U S A (2013) 0.87
The apoptosome: emerging insights and new potential targets for drug design. Pharm Res (2007) 0.87
Differential affinity of FLIP and procaspase 8 for FADD's DED binding surfaces regulates DISC assembly. Nat Commun (2014) 0.87
Intra- and interdimeric caspase-8 self-cleavage controls strength and timing of CD95-induced apoptosis. Sci Signal (2014) 0.86
Skeletal muscle differentiation evokes endogenous XIAP to restrict the apoptotic pathway. PLoS One (2009) 0.86
Reactive-site cleavage residues confer target specificity to baculovirus P49, a dimeric member of the P35 family of caspase inhibitors. J Virol (2008) 0.86
Specificity of a protein-protein interface: local dynamics direct substrate recognition of effector caspases. Proteins (2013) 0.86
The E. coli effector protein NleF is a caspase inhibitor. PLoS One (2013) 0.86
SCOP: a structural classification of proteins database for the investigation of sequences and structures. J Mol Biol (1995) 74.88
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (2001) 23.42
Mitochondria and apoptosis. Science (1998) 23.41
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell (2002) 20.11
Caspases: enemies within. Science (1998) 19.45
On the size of the active site in proteases. I. Papain. Biochem Biophys Res Commun (1967) 18.32
Death receptors: signaling and modulation. Science (1998) 16.95
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell (1998) 16.08
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature (1995) 15.07
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature (2004) 14.80
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (1998) 13.87
FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex. Cell (1996) 12.07
Caspases: the executioners of apoptosis. Biochem J (1997) 11.99
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science (1995) 11.38
Regulation of cell death protease caspase-9 by phosphorylation. Science (1998) 11.26
The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell (1993) 10.35
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (1994) 10.22
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem (1997) 9.97
IAP family proteins--suppressors of apoptosis. Genes Dev (1999) 9.96
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. Nature (1992) 9.96
Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death. Cell (1996) 9.93
Inhibition of death receptor signals by cellular FLIP. Nature (1997) 9.58
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature (1998) 8.93
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell (2000) 8.69
X-linked IAP is a direct inhibitor of cell-death proteases. Nature (1997) 8.26
Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem (1999) 8.16
Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science (1999) 7.75
Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor. EMBO J (1995) 7.60
Caspases: intracellular signaling by proteolysis. Cell (1997) 7.46
Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature (1996) 7.27
IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol (2002) 7.23
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell (1995) 7.18
Human ICE/CED-3 protease nomenclature. Cell (1996) 7.11
Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. Science (2000) 6.98
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell (1998) 6.79
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature (2001) 6.62
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature (1998) 6.47
Anoikis mechanisms. Curr Opin Cell Biol (2001) 6.36
The coagulation cascade: initiation, maintenance, and regulation. Biochemistry (1991) 6.29
Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature (1997) 6.23
Genetic control of programmed cell death in Drosophila. Science (1994) 6.08
Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity (1998) 6.07
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell (1997) 5.95
RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems. Nature (2002) 5.95
Apoptosis in the nervous system. Nature (2000) 5.82
Evolutionary families of peptidases. Biochem J (1993) 5.81
Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell (2000) 5.69
Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science (1991) 5.65
Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1 beta converting enzyme. Cell (1992) 5.54
The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell (1995) 5.50
Serpin structure, mechanism, and function. Chem Rev (2002) 5.39
Caspase structure, proteolytic substrates, and function during apoptotic cell death. Cell Death Differ (1999) 5.35
Mechanisms of caspase activation and inhibition during apoptosis. Mol Cell (2002) 5.31
Ich-1, an Ice/ced-3-related gene, encodes both positive and negative regulators of programmed cell death. Cell (1994) 5.25
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science (2000) 5.22
An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif. J Virol (1993) 5.15
NODs: intracellular proteins involved in inflammation and apoptosis. Nat Rev Immunol (2003) 5.07
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Mol Cell (1998) 5.06
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med (2000) 5.04
Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science (2002) 4.80
FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J (1997) 4.56
Structure and mechanism of interleukin-1 beta converting enzyme. Nature (1994) 4.44
Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science (1995) 4.41
Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis. Genes Dev (1999) 4.39
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell (2001) 4.24
Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature (2002) 4.21
Molecular cloning of the interleukin-1 beta converting enzyme. Science (1992) 4.19
An induced proximity model for caspase-8 activation. J Biol Chem (1998) 4.18
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science (2004) 4.17
Substrate specificities of caspase family proteases. J Biol Chem (1997) 4.16
A matter of life and death. Cancer Cell (2002) 4.07
Mechanism of XIAP-mediated inhibition of caspase-9. Mol Cell (2003) 4.07
The PYRIN-CARD protein ASC is an activating adaptor for caspase-1. J Biol Chem (2002) 4.02
Structure of a serpin-protease complex shows inhibition by deformation. Nature (2000) 4.02
Structural basis for the inhibition of caspase-3 by XIAP. Cell (2001) 3.91
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem (1998) 3.80
Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell (1998) 3.62
Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ (2003) 3.59
A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. EMBO J (1996) 3.57
Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis. Nat Cell Biol (2003) 3.56
Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature (2000) 3.54
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J (1999) 3.51
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2. Nature (2002) 3.48
Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces. Proc Natl Acad Sci U S A (2003) 3.42
Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem (1997) 3.41
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J Biol Chem (2001) 3.37
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity (2000) 3.29
Defects in regulation of apoptosis in caspase-2-deficient mice. Genes Dev (1998) 3.24
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature (2001) 3.22
Caspase-9 can be activated without proteolytic processing. J Biol Chem (1999) 3.20
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci U S A (2001) 3.19
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein. Nature (1995) 3.18
Protease degradomics: a new challenge for proteomics. Nat Rev Mol Cell Biol (2002) 3.17
Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. Proc Natl Acad Sci U S A (1996) 3.16
Three-dimensional structure of the apoptosome: implications for assembly, procaspase-9 binding, and activation. Mol Cell (2002) 3.06
Biochemical characteristics of caspases-3, -6, -7, and -8. J Biol Chem (1997) 3.04
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature (2011) 6.31
A unified model for apical caspase activation. Mol Cell (2003) 6.12
Mechanisms of caspase activation. Curr Opin Cell Biol (2003) 5.54
The apoptosome: signalling platform of cell death. Nat Rev Mol Cell Biol (2007) 4.64
Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. EMBO Rep (2006) 4.15
Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature (2010) 4.10
Human caspases: activation, specificity, and regulation. J Biol Chem (2009) 3.67
An IAP-IAP complex inhibits apoptosis. J Biol Chem (2004) 2.82
The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. J Biol Chem (2005) 2.47
Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. J Biol Chem (2003) 2.30
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. EMBO J (2005) 2.27
Activity-based probes that target diverse cysteine protease families. Nat Chem Biol (2005) 2.21
The apoptosome activates caspase-9 by dimerization. Mol Cell (2006) 2.20
The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature (2008) 2.11
Activation of caspases-8 and -10 by FLIP(L). Biochem J (2004) 2.11
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Mol Cell (2011) 2.06
Emerging principles in protease-based drug discovery. Nat Rev Drug Discov (2010) 2.05
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. J Biol Chem (2010) 1.99
Caspases: keys in the ignition of cell death. Chem Rev (2002) 1.91
Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci (2010) 1.91
Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. J Biol Chem (2008) 1.85
Profiling constitutive proteolytic events in vivo. Biochem J (2007) 1.78
Role of proteolysis in caspase-8 activation and stabilization. Biochemistry (2007) 1.64
Caspases: opening the boxes and interpreting the arrows. Cell Death Differ (2002) 1.64
Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. J Biol Chem (2007) 1.61
Reprieval from execution: the molecular basis of caspase inhibition. Trends Biochem Sci (2002) 1.53
Structural and kinetic determinants of protease substrates. Nat Struct Mol Biol (2009) 1.52
Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. J Biol Chem (2008) 1.49
Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Mol Cell (2010) 1.44
Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Mol Cell (2006) 1.43
Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem (2003) 1.37
DeSUMOylating enzymes--SENPs. IUBMB Life (2008) 1.37
Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proc Natl Acad Sci U S A (2002) 1.35
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J (2009) 1.33
Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. J Biol Chem (2009) 1.33
Identification of proteolytic cleavage sites by quantitative proteomics. J Proteome Res (2007) 1.32
Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. Biochem J (2005) 1.31
Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proc Natl Acad Sci U S A (2011) 1.30
Sequential autolytic processing activates the zymogen of Arg-gingipain. J Biol Chem (2003) 1.27
Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs). A caspase-independent mechanism for apoptotic inhibition. J Biol Chem (2004) 1.27
Apoptotic caspase activation and activity. Methods Mol Biol (2008) 1.26
Regulating cysteine protease activity: essential role of protease inhibitors as guardians and regulators. Curr Pharm Des (2002) 1.23
Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Mol Cell (2009) 1.22
Mitochondrial pathway of apoptosis is ancestral in metazoans. Proc Natl Acad Sci U S A (2012) 1.21
Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. Biochem J (2007) 1.20
Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. Biochem J (2008) 1.18
Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members. J Biol Chem (2002) 1.15
Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. J Biol Chem (2003) 1.14
Engineered hybrid dimers: tracking the activation pathway of caspase-7. Mol Cell (2006) 1.14
Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. J Neurosci (2011) 1.13
Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein. Biochem J (2003) 1.12
Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. Biochem J (2011) 1.10
Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. J Biol Chem (2008) 1.09
Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). Biochem J (2008) 1.08
Caspase substrates and inhibitors. Cold Spring Harb Perspect Biol (2013) 1.07
Inhibitor specificity of recombinant and endogenous caspase-9. Biochem J (2002) 1.07
XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells. J Exp Med (2003) 1.07
The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. J Biol Chem (2011) 1.06
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochim Biophys Acta (2011) 1.04
Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy (2010) 1.03
Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chem Biol (2010) 1.02
Caspase activation. Biochem Soc Symp (2003) 1.02
Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. PLoS One (2012) 1.00
Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem (2004) 0.99
Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chem Biol (2011) 0.99
Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Exp Neurol (2004) 0.98
Characteristics of the caspase-like catalytic domain of human paracaspase. Biol Chem (2004) 0.98
Activation and specificity of human caspase-10. Biochemistry (2010) 0.98
An optimized activity-based probe for the study of caspase-6 activation. Chem Biol (2012) 0.97
Activation and substrate specificity of caspase-14. Biochemistry (2004) 0.97
Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. J Med Chem (2006) 0.97
The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. Biochem J (2005) 0.97
Caspases on the brain. J Neurosci Res (2002) 0.96
Mechanism and specificity of the human paracaspase MALT1. Biochem J (2012) 0.96
Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. J Biol Chem (2007) 0.95
Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. Neuromolecular Med (2002) 0.95
Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proc Natl Acad Sci U S A (2014) 0.93
Expression, purification, and characterization of caspases. Curr Protoc Protein Sci (2003) 0.92
Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. J Med Chem (2002) 0.92
Small molecules not direct activators of caspases. Nat Chem Biol (2007) 0.92
Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. ACS Chem Biol (2013) 0.89
Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer. J Biol Chem (2006) 0.88
Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chem Biol (2011) 0.87
Vaccinia virus protein F1L is a caspase-9 inhibitor. J Biol Chem (2009) 0.87
Caspase assays: identifying caspase activity and substrates in vitro and in vivo. Methods Enzymol (2008) 0.86
Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Proc Natl Acad Sci U S A (2011) 0.86
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. J Biol Chem (2012) 0.85
The CULt of caspase-8 ubiquitination. Cell (2009) 0.84
Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells. J Biol Chem (2005) 0.84
Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clin Exp Metastasis (2010) 0.83
Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. J Med Chem (2004) 0.81
Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. Biochem J (2007) 0.81
S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. Biochimie (2011) 0.80
N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods Mol Biol (2011) 0.80
Transferring death: a role for tRNA in apoptosis regulation. Mol Cell (2010) 0.79
Caspases. Curr Protoc Protein Sci (2002) 0.78
Chemical ligation--an unusual paradigm in protease inhibition. Mol Cell (2006) 0.78
Activity, specificity, and probe design for the smallpox virus protease K7L. J Biol Chem (2012) 0.77
Glycine fluoromethylketones as SENP-specific activity based probes. Chembiochem (2011) 0.77
The nematode death machine in 3D. Cell (2005) 0.77