Targeting of the Yersinia pestis YopM protein into HeLa cells and intracellular trafficking to the nucleus.

PubWeight™: 1.62‹?› | Rank: Top 4%

🔗 View Article (PMID 9988481)

Published in Mol Microbiol on December 01, 1998

Authors

E Skrzypek1, C Cowan, S C Straley

Author Affiliations

1: Department of Microbiology and Immunology, Albert B. Chandler Medical Center, University of Kentucky, Lexington 40536-0084, USA.

Articles citing this

Yersinia type III secretion: send in the effectors. J Cell Biol (2002) 3.04

Molecular and cell biology aspects of plague. Proc Natl Acad Sci U S A (2000) 2.07

Generation of the Brucella melitensis ORFeome version 1.1. Genome Res (2004) 1.86

Virulence role of V antigen of Yersinia pestis at the bacterial surface. Infect Immun (1999) 1.80

Contribution of the major secreted yops of Yersinia enterocolitica O:8 to pathogenicity in the mouse infection model. Infect Immun (2004) 1.73

The plague virulence protein YopM targets the innate immune response by causing a global depletion of NK cells. Infect Immun (2004) 1.66

Requirement of the Yersinia pseudotuberculosis effectors YopH and YopE in colonization and persistence in intestinal and lymph tissues. Infect Immun (2003) 1.64

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG. J Bacteriol (1998) 1.60

Invasion of epithelial cells by Yersinia pestis: evidence for a Y. pestis-specific invasin. Infect Immun (2000) 1.56

Expression of microbial virulence proteins in Saccharomyces cerevisiae models mammalian infection. EMBO J (2001) 1.51

Nuclear translocated Ehrlichia chaffeensis ankyrin protein interacts with a specific adenine-rich motif of host promoter and intronic Alu elements. Infect Immun (2009) 1.32

Type III secretion: a bacterial device for close combat with cells of their eukaryotic host. Philos Trans R Soc Lond B Biol Sci (2000) 1.30

MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system. J Bacteriol (2002) 1.27

A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression. Infect Immun (2003) 1.25

YscP of Yersinia pestis is a secreted component of the Yop secretion system. J Bacteriol (1999) 1.18

LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism. Infect Immun (1999) 1.16

The C-terminal tail of Yersinia pseudotuberculosis YopM is critical for interacting with RSK1 and for virulence. Infect Immun (2010) 1.14

Effect of low- and high-virulence Yersinia enterocolitica strains on the inflammatory response of human umbilical vein endothelial cells. Infect Immun (2002) 1.13

Gr1+ cells control growth of YopM-negative yersinia pestis during systemic plague. Infect Immun (2009) 1.12

Delineation of regions of the Yersinia YopM protein required for interaction with the RSK1 and PRK2 host kinases and their requirement for interleukin-10 production and virulence. Infect Immun (2010) 1.12

YopK regulates the Yersinia pestis type III secretion system from within host cells. Mol Microbiol (2011) 1.11

Mechanical fractionation reveals structural requirements for enteropathogenic Escherichia coli Tir insertion into host membranes. Infect Immun (2000) 1.05

Modeling the function of bacterial virulence factors in Saccharomyces cerevisiae. Eukaryot Cell (2004) 1.05

Yersinia virulence factor YopM induces sustained RSK activation by interfering with dephosphorylation. PLoS One (2010) 1.02

Yersinia pestis YscG protein is a Syc-like chaperone that directly binds yscE. Infect Immun (2000) 1.01

Application of a Saccharomyces cerevisiae model to study requirements for trafficking of Yersinia pestis YopM in eucaryotic cells. Infect Immun (2003) 1.00

A leucine-rich motif targets Pseudomonas aeruginosa ExoS within mammalian cells. Infect Immun (2005) 0.99

Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague. Infect Immun (2010) 0.97

Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect Immun (2012) 0.94

Interferon consensus sequence binding protein confers resistance against Yersinia enterocolitica. Infect Immun (2000) 0.93

The Yersinia pestis YscY protein directly binds YscX, a secreted component of the type III secretion machinery. J Bacteriol (2000) 0.90

The cytotoxic necrotizing factor of Yersinia pseudotuberculosis (CNFY) enhances inflammation and Yop delivery during infection by activation of Rho GTPases. PLoS Pathog (2013) 0.89

Membrane localization contributes to the in vivo ADP-ribosylation of Ras by Pseudomonas aeruginosa ExoS. Infect Immun (2002) 0.88

Attenuated Yersinia enterocolitica mutant strains exhibit differential virulence in cytokine-deficient mice: implications for the development of novel live carrier vaccines. Infect Immun (2003) 0.84

Toward a molecular pathogenic pathway for Yersinia pestis YopM. Front Cell Infect Microbiol (2012) 0.83

Caspase-3 mediates the pathogenic effect of Yersinia pestis YopM in liver of C57BL/6 mice and contributes to YopM's function in spleen. PLoS One (2014) 0.82

Manipulation of pro-inflammatory cytokine production by the bacterial cell-penetrating effector protein YopM is independent of its interaction with host cell kinases RSK1 and PRK2. Virulence (2014) 0.82

Yersinia virulence factors - a sophisticated arsenal for combating host defences. F1000Res (2016) 0.81

In vitro intracellular trafficking of virulence antigen during infection by Yersinia pestis. PLoS One (2009) 0.80

Proteomic insights into intra- and intercellular plant-bacteria symbiotic association during root nodule formation. Front Plant Sci (2013) 0.78

Pathogenic Yersinia Promotes Its Survival by Creating an Acidic Fluid-Accessible Compartment on the Macrophage Surface. PLoS One (2015) 0.78

A type III secretion system inhibitor targets YopD while revealing differential regulation of secretion in calcium-blind mutants of Yersinia pestis. Antimicrob Agents Chemother (2013) 0.78

Yersinia type III effectors perturb host innate immune responses. World J Biol Chem (2016) 0.77

Immunosuppressive Yersinia Effector YopM Binds DEAD Box Helicase DDX3 to Control Ribosomal S6 Kinase in the Nucleus of Host Cells. PLoS Pathog (2016) 0.76

Distribution and Evolution of Yersinia Leucine-Rich Repeat Proteins. Infect Immun (2016) 0.75

Yersinia pestis YopK inhibits bacterial adhesion to host cells by binding to the extracellular matrix adaptor protein matrilin-2. Infect Immun (2017) 0.75

Articles by these authors

Virulence genes regulated at the transcriptional level by Ca2+ in Yersinia pestis include structural genes for outer membrane proteins. Infect Immun (1986) 6.92

Heparin and the formation of white thrombi. J Physiol (1938) 4.56

Cytoplasmic and membrane proteins of yersiniae cultivated under conditions simulating mammalian intracellular environment. Proc Natl Acad Sci U S A (1981) 4.43

Genetic analysis of the low calcium response in Yersinia pestis mu d1(Ap lac) insertion mutants. J Bacteriol (1984) 3.90

LcrD, a membrane-bound regulator of the Yersinia pestis low-calcium response. J Bacteriol (1991) 3.43

Health spending in 1998: signals of change. The Health Accounts Team. Health Aff (Millwood) (2000) 2.92

Health spending growth up in 1999; faster growth expected in the future. Health Aff (Millwood) (2001) 2.77

Carcinoid tumor metastatic to the breast. Arch Surg (1998) 2.71

Growth in mouse peritoneal macrophages of Yersinia pestis lacking established virulence determinants. Infect Immun (1984) 2.60

YopM inhibits platelet aggregation and is necessary for virulence of Yersinia pestis in mice. Infect Immun (1990) 2.53

Yersinia pestis grows within phagolysosomes in mouse peritoneal macrophages. Infect Immun (1984) 2.52

Pigment content and molar extinction coefficients of photochemical reaction centers from Rhodopseudomonas spheroides. Biochim Biophys Acta (1973) 2.43

Molecular analysis of lcrGVH, the V antigen operon of Yersinia pestis. J Bacteriol (1989) 2.41

A low-Ca2+ response operon encodes the V antigen of Yersinia pestis. Infect Immun (1986) 2.39

The yopM gene of Yersinia pestis encodes a released protein having homology with the human platelet surface protein GPIb alpha. J Bacteriol (1989) 2.37

Yersinia pestis pH 6 antigen: genetic, biochemical, and virulence characterization of a protein involved in the pathogenesis of bubonic plague. Infect Immun (1990) 2.30

The Yersinia pestis V antigen is a regulatory protein necessary for Ca2(+)-dependent growth and maximal expression of low-Ca2+ response virulence genes. J Bacteriol (1991) 2.30

Localization in Yersinia pestis of peptides associated with virulence. Infect Immun (1982) 2.26

DNA sequencing and analysis of the low-Ca2+-response plasmid pCD1 of Yersinia pestis KIM5. Infect Immun (1998) 2.26

Use of touch preps for intraoperative diagnosis of sentinel lymph node metastases in breast cancer. Ann Surg Oncol (1998) 2.22

lcrH, a gene necessary for virulence of Yersinia pestis and for the normal response of Y. pestis to ATP and calcium. Infect Immun (1989) 2.12

LcrG, a secreted protein involved in negative regulation of the low-calcium response in Yersinia pestis. J Bacteriol (1993) 2.08

Probing the phagolysosomal environment of human macrophages with a Ca2+-responsive operon fusion in Yersinia pestis. Nature (1986) 1.95

Differential effects of deletions in lcrV on secretion of V antigen, regulation of the low-Ca2+ response, and virulence of Yersinia pestis. J Bacteriol (1995) 1.93

A low-Ca2+ response (LCR) secretion (ysc) locus lies within the lcrB region of the LCR plasmid in Yersinia pestis. J Bacteriol (1994) 1.88

Multiple effects of lcrD mutations in Yersinia pestis. J Bacteriol (1993) 1.87

Virulence role of V antigen of Yersinia pestis at the bacterial surface. Infect Immun (1999) 1.80

YopD of Yersinia pestis plays a role in negative regulation of the low-calcium response in addition to its role in translocation of Yops. J Bacteriol (1998) 1.72

Yersinia pestis LcrV forms a stable complex with LcrG and may have a secretion-related regulatory role in the low-Ca2+ response. J Bacteriol (1997) 1.71

Yersinia pestis YopM: thrombin binding and overexpression. Infect Immun (1992) 1.69

Subareolar versus peritumoral injection for location of the sentinel lymph node. Ann Surg (1999) 1.63

Mutations in yscC, yscD, and yscG prevent high-level expression and secretion of V antigen and Yops in Yersinia pestis. J Bacteriol (1995) 1.62

The V antigen of Yersinia pestis regulates Yop vectorial targeting as well as Yop secretion through effects on YopB and LcrG. J Bacteriol (1998) 1.60

Outpatient ureteric procedures: a new method for retrograde ureteropyelography and ureteric stent placement. BJU Int (2001) 1.59

Invasion of epithelial cells by Yersinia pestis: evidence for a Y. pestis-specific invasin. Infect Immun (2000) 1.56

National health expenditures in 1997: more slow growth. Health Aff (Millwood) (1999) 1.56

Structure and regulation of the Yersinia pestis yscBCDEF operon. J Bacteriol (1992) 1.50

lcrR, a low-Ca2(+)-response locus with dual Ca2(+)-dependent functions in Yersinia pestis. J Bacteriol (1990) 1.41

New suicide vector for gene replacement in yersiniae and other gram-negative bacteria. Plasmid (1993) 1.34

A randomised controlled study of an audiovisual patient information intervention on informed consent and recruitment to cancer clinical trials. Br J Cancer (2007) 1.30

Assessing fluid responsiveness by stroke volume variation in mechanically ventilated patients with severe sepsis. Eur J Anaesthesiol (2004) 1.29

Molecular cloning of p67, a lysosomal membrane glycoprotein from Trypanosoma brucei. Mol Biochem Parasitol (1999) 1.28

Regulation of expression of V antigen and outer membrane proteins in Yersinia pestis. Contrib Microbiol Immunol (1987) 1.26

Chemotaxis toward amino acids by Bdellovibrio bacteriovorus. J Bacteriol (1977) 1.23

Effect of Yersinia pestis YopM on experimental plague. Infect Immun (1997) 1.23

YscP of Yersinia pestis is a secreted component of the Yop secretion system. J Bacteriol (1999) 1.18

LcrV of Yersinia pestis enters infected eukaryotic cells by a virulence plasmid-independent mechanism. Infect Immun (1999) 1.16

Exon size affects competition between splicing and cleavage-polyadenylation in the immunoglobulin mu gene. Mol Cell Biol (1994) 1.11

Sentinel lymph node biopsy for staging breast cancer. Am J Surg (1998) 1.08

Photochemical electron transport in photosynthetic reaction centers. IV. Observations related to the reduced photoproducts. Biophys J (1972) 1.07

Feasibility and applicability of coronary stent implantation with the direct brachial approach: results of a single-center study. Am Heart J (1997) 1.02

YscO of Yersinia pestis is a mobile core component of the Yop secretion system. J Bacteriol (1998) 1.02

An optical absorption change that could be due to reduction of the primary photochemical electron acceptor in photosynthetic reaction centers. Biochem Biophys Res Commun (1970) 1.00

Patient understanding of research: developing and testing of a new questionnaire. Eur J Cancer Care (Engl) (2007) 1.00

Chemotaxis in Bdellovibrio bacteriovorus. J Bacteriol (1974) 0.99

Chemotaxis by Bdellovibrio bacteriovorus toward prey. J Bacteriol (1977) 0.97

A comparative study of nitroglycerin and propranolol. Circulation (1967) 0.96

The influence of diet upon liver function tests and serum lipids in healthy male volunteers resident in a Phase I unit. Br J Clin Pharmacol (2004) 0.95

The effects of nitroglycerin on myocardial blood flow in man, measured by coincidence counting and bolus injections of 84-rubidium. Am J Cardiol (1969) 0.94

Structure-function analysis of Yersinia pestis YopM's interaction with alpha-thrombin to rule on its significance in systemic plague and to model YopM's mechanism of binding host proteins. Microb Pathog (2001) 0.92

Food safety knowledge of consumers and the microbiological and temperature status of their refrigerators. J Food Prot (2005) 0.91

Failure to detect binding of LcrH to the V antigen of Yersinia pestis. Infect Immun (1997) 0.88

Chemotaxis of Bdellovibrio bacteriovorus toward pure compounds. J Bacteriol (1979) 0.86

A longitudinal study of maternal dose response to low molecular weight heparin in pregnancy. Obstet Gynecol (2003) 0.86

Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia (2011) 0.85

Use of UV-irradiated bacteriophage T6 to kill extracellular bacteria in tissue culture infectivity assays. J Immunol Methods (1983) 0.85

Duplicative activation mechanisms of two trypanosome telomeric VSG genes with structurally simple 5' flanks. Nucleic Acids Res (1990) 0.84

Development, characterization and distribution of adoptively transferred peripheral blood lymphocytes primed by human papillomavirus 18 E7--pulsed autologous dendritic cells in a patient with metastatic adenocarcinoma of the uterine cervix. Eur J Gynaecol Oncol (2000) 0.84

Unexpected results from the application of signature-tagged mutagenesis to identify Yersinia pestis genes required for adherence and invasion. Microb Pathog (2005) 0.83

Tolerance to glyceryl trinitrate patches: prevention by intermittent dosing. Br Med J (Clin Res Ed) (1987) 0.81

Interaction between Yersinia pestis YopM protein and human alpha-thrombin. Thromb Res (1996) 0.81

Metabolism of infarcted heart muscle during tissue repair. Am J Cardiol (1968) 0.81

Development and therapeutic effect of adoptively transferred T cells primed by tumor lysate-pulsed autologous dendritic cells in a patient with metastatic endometrial cancer. Gynecol Obstet Invest (2000) 0.81

Storage and metabolism of norepinephrine after experimental myocardial infarction. Am J Physiol (1971) 0.81

The effect of gonadotrophic stimulation on integrin expression in the endometrium. Hum Reprod (2002) 0.79

Determination of effective and total coronary blood flow using Rb84. Am J Med Sci (1969) 0.79

Fatty acyl-CoAs inhibit retinoic acid-induced apoptosis in Hep3B cells. Cancer Lett (2000) 0.78

Roflumilast for asthma and chronic obstructive pulmonary disease. Issues Emerg Health Technol (2005) 0.76

Bevacizumab demonstrates activity in advanced refractory fallopian tube carcinoma. Int J Gynecol Cancer (2007) 0.76

Degenerative changes in myometrium simulating diffuse leiomyomatosis after treatment with gonadotrophin releasing hormone analogue. J Clin Pathol (1995) 0.75

Second Report of Private Medical Practice for 1841. Prov Med J Retrosp Med Sci (1843) 0.75

Second Report of Private Medical Practice for 1841. Prov Med J Retrosp Med Sci (1843) 0.75

The quality coach--the facilitators' perspective. Hosp Top (1996) 0.75

Retrospective Address of the Reading Pathological Society. Prov Med J Retrosp Med Sci (1842) 0.75

Second Report of Private Medical Practice for 1841. Prov Med J Retrosp Med Sci (1843) 0.75

Personality disorders in people with learning disabilities: a community survey. J Intellect Disabil Res (1997) 0.75

Extraction of oxidized bacteriochlorophyll from illuminated photosynthetic reaction center particles. Biochim Biophys Acta (1973) 0.75

Second Report of Private Medical Practice for 1841. Prov Med J Retrosp Med Sci (1843) 0.75

A two-year-old boy with language regression and unusual social interactions. J Dev Behav Pediatr (2001) 0.75

A two-year-old boy with language regression and unusual social interactions. J Dev Behav Pediatr (2000) 0.75

Abnormal upper body soft tissue uptake on skeletal scintigraphy: a sign of superior vena cava obstruction. Clin Nucl Med (2001) 0.75

Dramatic effects. Nurs Times (2001) 0.75

Second Report of Private Medical Practice for 1841. Prov Med J Retrosp Med Sci (1843) 0.75

Observations on Cholera. Prov Med Surg J (1848) 0.75

Thyrotoxicosis increases right to left shunt in congenital cyanotic heart disease. Clin Endocrinol (Oxf) (1993) 0.75

Case of Diabetes: Showing the Importance of Bread as an Article of Diet. Prov Med J Retrosp Med Sci (1843) 0.75

Two Cases of Encephaloid Carcinoma of the Brain; with Observations. Prov Med Surg J (1845) 0.75