Regulatory T-cell therapy for inflammatory bowel disease: more questions than answers.

PubWeight™: 1.20‹?› | Rank: Top 10%

🔗 View Article (PMC 3403270)

Published in Immunology on June 01, 2012

Authors

Megan E Himmel1, Yu Yao, Paul C Orban, Theodore S Steiner, Megan K Levings

Author Affiliations

1: Department of Surgery, University of British Columbia & Child and Family Research Centre, Vancouver, BC, Canada.

Associated clinical trials:

T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs (Treg) | NCT01210664

Articles citing this

Type 1 regulatory T cells: a new mechanism of peripheral immune tolerance. Cell Mol Immunol (2015) 1.11

Association between Faecalibacterium prausnitzii Reduction and Inflammatory Bowel Disease: A Meta-Analysis and Systematic Review of the Literature. Gastroenterol Res Pract (2014) 1.02

An IL-27/Lag3 axis enhances Foxp3(+) regulatory T cell-suppressive function and therapeutic efficacy. Mucosal Immunol (2015) 0.89

Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice. World J Gastroenterol (2013) 0.89

Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance. PLoS One (2015) 0.89

Targeting sirtuin-1 alleviates experimental autoimmune colitis by induction of Foxp3+ T-regulatory cells. Mucosal Immunol (2014) 0.87

Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis. Immunology (2013) 0.85

T Regulatory and T Helper 17 Cells in Primary Sjögren's Syndrome: Facts and Perspectives. Mediators Inflamm (2015) 0.82

Mesenchymal Stem Cells of Dental Origin-Their Potential for Antiinflammatory and Regenerative Actions in Brain and Gut Damage. Curr Neuropharmacol (2016) 0.81

Endometrial regenerative cells as a novel cell therapy attenuate experimental colitis in mice. J Transl Med (2014) 0.81

IL-10 Receptor Signaling Is Essential for TR1 Cell Function In Vivo. J Immunol (2016) 0.78

Novel Foxp3(-) IL-10(-) Regulatory T-cells Induced by B-Cells Alleviate Intestinal Inflammation in Vivo. Sci Rep (2016) 0.77

Regulatory T cell transfer ameliorates lymphedema and promotes lymphatic vessel function. JCI Insight (2016) 0.77

Role of Regulatory T Cells (Treg) and the Treg Effector Molecule Fibrinogen-like Protein 2 in Alloimmunity and Autoimmunity. Rambam Maimonides Med J (2015) 0.77

Pathophysiological significance of the two-pore domain K(+) channel K2P5.1 in splenic CD4(+)CD25(-) T cell subset from a chemically-induced murine inflammatory bowel disease model. Front Physiol (2015) 0.77

Human endometrial regenerative cells attenuate renal ischemia reperfusion injury in mice. J Transl Med (2016) 0.76

The gut microbiome as a target for regulatory T cell-based immunotherapy: induction of regulatory lymphocytes by oral administration of anti-LPS enriched colostrum alleviates immune mediated colitis. BMC Gastroenterol (2015) 0.76

Human endometrial regenerative cells alleviate carbon tetrachloride-induced acute liver injury in mice. J Transl Med (2016) 0.75

Stem Cell Therapy for Inflammatory Bowel Disease. Clin Transl Gastroenterol (2017) 0.75

Combination peptide immunotherapy suppresses antibody and helper T-cell responses to the RhD protein in HLA-transgenic mice. Haematologica (2014) 0.75

Distinct kinetics in the frequency of peripheral CD4+ T cells in patients with ulcerative colitis experiencing a flare during treatment with mesalazine or with a herbal preparation of myrrh, chamomile, and coffee charcoal. PLoS One (2014) 0.75

The Intersection of TNF, IBD and the Microbiome. Gut Microbes (2016) 0.75

Lack of correlation between Treg quantification assays in inflammatory bowel disease patients. World J Gastroenterol (2015) 0.75

Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives. Front Immunol (2016) 0.75

Crossover Subsets of CD4(+) T Lymphocytes in the Intestinal Lamina Propria of Patients with Crohn's Disease and Ulcerative Colitis. Dig Dis Sci (2017) 0.75

Empirical Modeling of T cell Activation Predicts Interplay of Host Cytokines and Bacterial Indole. Biotechnol Bioeng (2017) 0.75

Single and combined effect of retinoic acid and rapamycin modulate the generation, activity and homing potential of induced human regulatory T cells. PLoS One (2017) 0.75

Articles cited by this

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57

Unravelling the pathogenesis of inflammatory bowel disease. Nature (2007) 18.52

Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71

A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature (1997) 16.28

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17

CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 14.33

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function. Nature (2008) 14.26

Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82

How regulatory T cells work. Nat Rev Immunol (2008) 11.66

Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol (1993) 9.97

Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82

Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28

The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol (2003) 8.28

The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature (2007) 7.82

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity (2004) 6.89

Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature (2011) 6.43

Ulcerative colitis. N Engl J Med (2011) 6.14

Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity (2009) 6.11

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev (2006) 6.08

The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science (2011) 6.01

Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol (2003) 5.94

Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood (2010) 5.79

Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest (2004) 5.39

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3- precursor cells in the absence of interleukin 10. Nat Immunol (2007) 5.14

Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity (2011) 4.86

Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol (2009) 4.76

Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology (2005) 4.68

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation. Blood (2011) 4.57

Has the microbiota played a critical role in the evolution of the adaptive immune system? Science (2010) 4.29

Phenotypical and functional specialization of FOXP3+ regulatory T cells. Nat Rev Immunol (2011) 4.29

T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med (2005) 4.28

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity. J Exp Med (1994) 4.10

Regulatory lymphocytes and intestinal inflammation. Annu Rev Immunol (2009) 3.80

Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest (2010) 3.59

Regulatory T cells: how do they suppress immune responses? Int Immunol (2009) 3.58

Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut (2009) 3.55

Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest (2010) 3.41

Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent manner. Immunity (2011) 3.38

Human T regulatory cell therapy: take a billion or so and call me in the morning. Immunity (2009) 3.21

Oral tolerance. Immunol Rev (2011) 3.03

Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol (2008) 3.03

Coeliac disease. Lancet (2009) 3.03

CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med (1998) 3.01

Plasticity of CD4(+) FoxP3(+) T cells. Curr Opin Immunol (2009) 2.93

Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterology (2005) 2.78

Blocking Smad7 restores TGF-beta1 signaling in chronic inflammatory bowel disease. J Clin Invest (2001) 2.73

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells. Clin Immunol (2009) 2.71

Regulatory T cells and Foxp3. Immunol Rev (2011) 2.65

Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 2.58

Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood (2006) 2.57

T cell specificity and cross reactivity towards enterobacteria, bacteroides, bifidobacterium, and antigens from resident intestinal flora in humans. Gut (1999) 2.56

Natural and TGF-beta-induced Foxp3(+)CD4(+) CD25(+) regulatory T cells are not mirror images of each other. Trends Immunol (2008) 2.50

A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn's disease. Clin Gastroenterol Hepatol (2006) 2.45

Pathophysiological role of Toll-like receptor 5 engagement by bacterial flagellin in colonic inflammation. Proc Natl Acad Sci U S A (2005) 2.08

Expression of GARP selectively identifies activated human FOXP3+ regulatory T cells. Proc Natl Acad Sci U S A (2009) 2.06

Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease. J Clin Immunol (2010) 1.98

Generation and large-scale expansion of human inducible regulatory T cells that suppress graft-versus-host disease. Am J Transplant (2011) 1.96

Characterization of interleukin-17-producing regulatory T cells in inflamed intestinal mucosa from patients with inflammatory bowel diseases. Gastroenterology (2010) 1.92

Smad7 controls resistance of colitogenic T cells to regulatory T cell-mediated suppression. Gastroenterology (2008) 1.88

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med (2010) 1.86

CD4+FOXP3+ T regulatory cells in human autoimmunity: more than a numbers game. J Immunol (2011) 1.76

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNFα treatment. Gut (2011) 1.75

Intestinal CD103+ dendritic cells: master regulators of tolerance? Trends Immunol (2011) 1.75

Intestinal microbiota in inflammatory bowel disease: friend of foe? World J Gastroenterol (2011) 1.65

Expression and functional characterization of FOXP3+ CD4+ regulatory T cells in ulcerative colitis. Inflamm Bowel Dis (2007) 1.55

Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity (2011) 1.53

Is FOXP3 a bona fide marker for human regulatory T cells? Eur J Immunol (2008) 1.47

Interleukin-12 converts Foxp3+ regulatory T cells to interferon-γ-producing Foxp3+ T cells that inhibit colitis. Gastroenterology (2011) 1.35

Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients. Proc Natl Acad Sci U S A (2007) 1.32

Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr Opin Immunol (2011) 1.28

IL-10 and its related cytokines for treatment of inflammatory bowel disease. World J Gastroenterol (2004) 1.28

Moving to tolerance: clinical application of T regulatory cells. Semin Immunol (2011) 1.25

Functional CD4+CD25high regulatory T cells are enriched in the colonic mucosa of patients with active ulcerative colitis and increase with disease activity. Inflamm Bowel Dis (2006) 1.22

Mouse and human intestinal immunity: same ballpark, different players; different rules, same score. Mucosal Immunol (2011) 1.21

Coeliac disease and gluten sensitivity. J Intern Med (2011) 1.21

Infiltration of forkhead box P3-expressing cells in small intestinal mucosa in coeliac disease but not in type 1 diabetes. Clin Exp Immunol (2008) 1.20

Vitamin A and immune regulation: role of retinoic acid in gut-associated dendritic cell education, immune protection and tolerance. Mol Aspects Med (2011) 1.17

Immunomodulation by commensal and probiotic bacteria. Immunol Invest (2010) 1.13

CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells. Gut (2008) 1.12

Special regulatory T-cell review: Regulatory T cells and the intestinal tract--patrolling the frontier. Immunology (2008) 1.12

De novo production of antigen-specific suppressor cells in vivo. Nat Protoc (2006) 1.12

Intestinal epithelial cells from inflammatory bowel disease patients preferentially stimulate CD4+ T cells to proliferate and secrete interferon-gamma. Am J Physiol Gastrointest Liver Physiol (2007) 1.08

Therapy with anti-TNFα antibody enhances number and function of Foxp3(+) regulatory T cells in inflammatory bowel diseases. Inflamm Bowel Dis (2011) 1.07

Expression of dual TCR on DO11.10 T cells allows for ovalbumin-induced oral tolerance to prevent T cell-mediated colitis directed against unrelated enteric bacterial antigens. J Immunol (2004) 1.07

Balancing acts: the role of TGF-β in the mucosal immune system. Trends Mol Med (2011) 1.06

Impaired control of effector T cells by regulatory T cells: a clue to loss of oral tolerance and autoimmunity in celiac disease? Am J Gastroenterol (2011) 1.03

Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells. J Immunol (2006) 1.00

FOXP3 expression in duodenal mucosa in pediatric patients with celiac disease. Pathobiology (2011) 0.96

Increased FOXP3 expression in small-bowel mucosa of children with coeliac disease and type I diabetes mellitus. Scand J Gastroenterol (2009) 0.95

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis. Inflamm Bowel Dis (2010) 0.93

Infectious tolerance: therapeutic potential. Curr Opin Immunol (2010) 0.90

Environmental influences on T regulatory cells in inflammatory bowel disease. Semin Immunol (2011) 0.87

Increase of regulatory T cells in ileal mucosa of untreated pediatric Crohn's disease patients. Scand J Gastroenterol (2011) 0.85

Molecular regulation of cellular immunity by FOXP3. Adv Exp Med Biol (2009) 0.80

IL-15 modulates the effect of retinoic acid, promoting inflammation rather than oral tolerance to dietary antigens. Expert Rev Gastroenterol Hepatol (2011) 0.78

Articles by these authors

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans. Immunol Rev (2006) 6.08

Activation-induced FOXP3 in human T effector cells does not suppress proliferation or cytokine production. Int Immunol (2007) 5.45

Global regulation of erythroid gene expression by transcription factor GATA-1. Blood (2004) 4.22

The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest (2005) 3.83

Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med (2002) 3.49

Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. J Immunol (2013) 2.96

Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron (2002) 2.93

Defective regulatory and effector T cell functions in patients with FOXP3 mutations. J Clin Invest (2006) 2.58

Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. J Immunol (2005) 2.27

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci (2006) 2.19

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells. Blood (2006) 2.12

CD161 is a marker of all human IL-17-producing T-cell subsets and is induced by RORC. Eur J Immunol (2010) 2.03

The role of retinoic acid-related orphan receptor variant 2 and IL-17 in the development and function of human CD4+ T cells. Eur J Immunol (2009) 1.89

CD4+ T-regulatory cells: toward therapy for human diseases. Immunol Rev (2008) 1.85

miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80

Growth and expansion of human T regulatory type 1 cells are independent from TCR activation but require exogenous cytokines. Eur J Immunol (2002) 1.76

High shear-dependent loss of membrane integrity and defective platelet adhesion following disruption of the GPIbα-filamin interaction. Blood (2010) 1.75

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function. Blood (2009) 1.74

IL-17 promotes p38 MAPK-dependent endothelial activation enhancing neutrophil recruitment to sites of inflammation. J Immunol (2010) 1.65

Generation of potent and stable human CD4+ T regulatory cells by activation-independent expression of FOXP3. Mol Ther (2007) 1.64

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells. Int Immunol (2008) 1.58

Trisomy 21-associated defects in human primitive hematopoiesis revealed through induced pluripotent stem cells. Proc Natl Acad Sci U S A (2012) 1.54

Trisomy 21 enhances human fetal erythro-megakaryocytic development. Blood (2008) 1.47

Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3. Eur J Immunol (2008) 1.45

Flagellin-dependent and -independent inflammatory responses following infection by enteropathogenic Escherichia coli and Citrobacter rodentium. Infect Immun (2008) 1.41

Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol (2010) 1.40

Two nonadjacent regions in enteroaggregative Escherichia coli flagellin are required for activation of toll-like receptor 5. J Biol Chem (2002) 1.37

Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development. Blood (2014) 1.34

Leishmania exosomes modulate innate and adaptive immune responses through effects on monocytes and dendritic cells. J Immunol (2010) 1.32

Distinct intracellular signaling pathways control the synthesis of IL-8 and RANTES in TLR1/TLR2, TLR3 or NOD1 activated human airway epithelial cells. Cell Signal (2008) 1.32

Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate. Blood (2009) 1.28

Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo. PLoS One (2012) 1.26

Moving to tolerance: clinical application of T regulatory cells. Semin Immunol (2011) 1.25

The role of T-regulatory cells and Toll-like receptors in the pathogenesis of human inflammatory bowel disease. Immunology (2008) 1.23

Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) controls activation of extracellular signal-regulated kinase (ERK) signaling in the striatum and long-term behavioral responses to cocaine. Biol Psychiatry (2009) 1.21

Clonal genetic and hematopoietic heterogeneity among human-induced pluripotent stem cell lines. Blood (2013) 1.20

Double restriction-enzyme digestion improves the coverage and accuracy of genome-wide CpG methylation profiling by reduced representation bisulfite sequencing. BMC Genomics (2013) 1.18

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic? Front Immunol (2012) 1.17

Human Th1 and Th17 cells exhibit epigenetic stability at signature cytokine and transcription factor loci. J Immunol (2011) 1.17

Reversal of cerebral radiation necrosis with bevacizumab treatment in 17 Chinese patients. Eur J Med Res (2012) 1.12

MicroRNA expression in maturing murine megakaryocytes. Blood (2010) 1.12

Posterior interbody fusion using a diagonal cage with unilateral transpedicular screw fixation for lumbar stenosis. J Clin Neurosci (2011) 1.10

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest (2011) 1.10

Suppression assays with human T regulatory cells: a technical guide. Eur J Immunol (2011) 1.10

Cutaneous GVHD is associated with the expansion of tissue-localized Th1 and not Th17 cells. Blood (2010) 1.07

Graft-versus-host disease: suppression by statins. Nat Med (2008) 1.05

Cutting edge: PHLPP regulates the development, function, and molecular signaling pathways of regulatory T cells. J Immunol (2011) 1.04

Human CD4+ FOXP3+ regulatory T cells produce CXCL8 and recruit neutrophils. Eur J Immunol (2011) 1.02

SHIP regulates the reciprocal development of T regulatory and Th17 cells. J Immunol (2009) 1.02

Giant cell tumors of the skull: a series of 18 cases and review of the literature. J Neurooncol (2013) 1.02

Immune regulation in obesity-associated adipose inflammation. J Immunol (2013) 1.01

Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. Am J Trop Med Hyg (2003) 1.01

Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells. J Immunol (2006) 1.00

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor. J Clin Invest (2016) 0.99

Flow cytometry-based methods for studying signaling in human CD4+CD25+FOXP3+ T regulatory cells. J Immunol Methods (2007) 0.99

Protein kinase D interaction with TLR5 is required for inflammatory signaling in response to bacterial flagellin. J Immunol (2007) 0.98

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity. J Immunol (2013) 0.98

Inflammatory effects of ex vivo human Th17 cells are suppressed by regulatory T cells. J Immunol (2010) 0.97

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells. Blood (2012) 0.96

HAP1 facilitates effects of mutant huntingtin on inositol 1,4,5-trisphosphate-induced Ca release in primary culture of striatal medium spiny neurons. Eur J Neurosci (2004) 0.95

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses. Am J Physiol Gastrointest Liver Physiol (2012) 0.95

Autoactivation of the AggR regulator of enteroaggregative Escherichia coli in vitro and in vivo. FEMS Immunol Med Microbiol (2010) 0.94

miR-638 suppresses cell proliferation in gastric cancer by targeting Sp2. Dig Dis Sci (2014) 0.94

Enteroaggregative Escherichia coli flagellin-induced interleukin-8 secretion requires Toll-like receptor 5-dependent p38 MAP kinase activation. Immunology (2004) 0.93

TLR5 is not required for flagellin-mediated exacerbation of DSS colitis. Inflamm Bowel Dis (2010) 0.93

The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function. Front Immunol (2012) 0.91

The prognostic value of Foxp3+ tumor-infiltrating lymphocytes in patients with glioblastoma. J Neurooncol (2013) 0.91

SLC35D3 delivery from megakaryocyte early endosomes is required for platelet dense granule biogenesis and is differentially defective in Hermansky-Pudlak syndrome models. Blood (2012) 0.91

Infectious diarrhea: new pathogens and new challenges in developed and developing areas. Clin Infect Dis (2006) 0.91

The single IgG IL-1-related receptor controls TLR responses in differentiated human intestinal epithelial cells. J Immunol (2010) 0.90

The CD133+ tumor stem-like cell-associated antigen may elicit highly intense immune responses against human malignant glioma. J Neurooncol (2011) 0.90

Point mutants of forkhead box P3 that cause immune dysregulation, polyendocrinopathy, enteropathy, X-linked have diverse abilities to reprogram T cells into regulatory T cells. J Allergy Clin Immunol (2010) 0.89

A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin. Biochem Biophys Res Commun (2006) 0.89

ATG-induced expression of FOXP3 in human CD4(+) T cells in vitro is associated with T-cell activation and not the induction of FOXP3(+) T regulatory cells. Blood (2009) 0.89

Environmental influences on T regulatory cells in inflammatory bowel disease. Semin Immunol (2011) 0.87

Weekly intravenous nanoparticle albumin-bound paclitaxel for elderly patients with stage IV non-small-cell lung cancer: a series of 20 cases. J Biomed Res (2012) 0.87

Two ENU-induced mutations in Rasgrf1 and early mouse growth retardation. Mamm Genome (2003) 0.87

Oxidative stress enhances IL-8 and inhibits CCL20 production from intestinal epithelial cells in response to bacterial flagellin. Am J Physiol Gastrointest Liver Physiol (2010) 0.86

Isolation, expansion, and characterization of human natural and adaptive regulatory T cells. Methods Mol Biol (2007) 0.86

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. J Clin Invest (2014) 0.86

Protein kinase D1 and D2 are involved in chemokine release induced by toll-like receptors 2, 4, and 5. Cell Immunol (2010) 0.86

CD4+ Foxp3+ regulatory T cells suppress γδ T-cell effector functions in a model of T-cell-induced mucosal inflammation. Eur J Immunol (2011) 0.86

The stress signal extracellular ATP modulates antiflagellin immune responses in intestinal epithelial cells. Inflamm Bowel Dis (2010) 0.85

Increased LEF1 expression and decreased Notch2 expression are strong predictors of poor outcomes in colorectal cancer patients. Dis Markers (2013) 0.85

Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. J Clin Invest (2015) 0.85

Control of tissue-localized immune responses by human regulatory T cells. Eur J Immunol (2014) 0.85

Wild-type FOXP3 is selectively active in CD4+CD25(hi) regulatory T cells of healthy female carriers of different FOXP3 mutations. Blood (2009) 0.85