Published in Trends Cell Biol on August 01, 2004
Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics (2008) 1.70
Requirements for selection of conventional and innate T lymphocyte lineages. Immunity (2007) 1.59
PI3K and STAT3: a new alliance. Cancer Discov (2011) 1.31
Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.98
The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites. J Leukoc Biol (2008) 0.93
The actin-bundling protein L-plastin supports T-cell motility and activation. Immunol Rev (2013) 0.89
Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells. J Immunol (2010) 0.86
Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells. Clin Exp Immunol (2007) 0.86
ITK inhibitors in inflammation and immune-mediated disorders. Curr Top Med Chem (2009) 0.86
Actin-mediated feedback loops in B-cell receptor signaling. Immunol Rev (2013) 0.79
The actin cytoskeleton coordinates the signal transduction and antigen processing functions of the B cell antigen receptor. Front Biol (Beijing) (2013) 0.75
A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med (2011) 8.26
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
SAP-controlled T-B cell interactions underlie germinal centre formation. Nature (2008) 5.14
Follicular helper T cells are required for systemic autoimmunity. J Exp Med (2009) 4.25
SAP is required for generating long-term humoral immunity. Nature (2003) 3.85
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity (2011) 3.06
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
A role for thymic stromal lymphopoietin in CD4(+) T cell development. J Exp Med (2004) 2.81
Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity (2010) 2.79
Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity (2006) 2.77
Tec family kinases in T lymphocyte development and function. Annu Rev Immunol (2005) 2.76
SLAM family receptors and SAP adaptors in immunity. Annu Rev Immunol (2011) 2.52
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinase. Immunity (2009) 2.51
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J Exp Med (2009) 2.34
The receptor Ly108 functions as a SAP adaptor-dependent on-off switch for T cell help to B cells and NKT cell development. Immunity (2012) 2.19
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol (2003) 1.92
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
Improved generation of C57BL/6J mouse embryonic stem cells in a defined serum-free media. Genesis (2004) 1.79
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol (2008) 1.73
TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest (2004) 1.63
Requirements for selection of conventional and innate T lymphocyte lineages. Immunity (2007) 1.59
Molecular and cellular pathogenesis of X-linked lymphoproliferative disease. Immunol Rev (2005) 1.57
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol (2005) 1.54
SH2D1A regulates T-dependent humoral autoimmunity. J Exp Med (2004) 1.51
Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol (2003) 1.47
T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol (2010) 1.45
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol (2007) 1.40
Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev (2009) 1.32
Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol (2006) 1.29
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A (2006) 1.21
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity (2012) 1.20
TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest (2009) 1.20
SAP is required for Th cell function and for immunity to influenza. J Immunol (2006) 1.18
Requirement for Tec kinases in chemokine-induced migration and activation of Cdc42 and Rac. Curr Biol (2004) 1.17
Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells. J Exp Med (2014) 1.16
T follicular helper cell diversity and plasticity. Trends Immunol (2013) 1.14
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein. Blood (2010) 1.14
Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses. J Immunol (2008) 1.11
Tec kinases, actin, and cell adhesion. Immunol Rev (2007) 1.09
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol (2010) 1.06
Rheumatologic and autoimmune manifestations of primary immunodeficiency disorders. Curr Opin Rheumatol (2009) 1.06
Beyond calcium: new signaling pathways for Tec family kinases. J Cell Sci (2002) 1.05
Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A (2008) 1.04
Type I IFN induces binding of STAT1 to Bcl6: divergent roles of STAT family transcription factors in the T follicular helper cell genetic program. J Immunol (2014) 1.03
Tec kinases regulate TCR-mediated recruitment of signaling molecules and integrin-dependent cell adhesion. J Immunol (2005) 1.01
A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice. Genomics (2002) 1.00
The expression of Wiskott-Aldrich syndrome protein (WASP) is dependent on WASP-interacting protein (WIP). Int Immunol (2007) 0.96
Tec family kinases Itk and Rlk / Txk in T lymphocytes: cross-regulation of cytokine production and T-cell fates. FEBS J (2011) 0.94
The murine NK receptor 2B4 (CD244) exhibits inhibitory function independent of signaling lymphocytic activation molecule-associated protein expression. J Immunol (2004) 0.92
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol (2013) 0.91
Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs. Nucleic Acids Res (2008) 0.90
The human condition: an immunological perspective. Nat Immunol (2011) 0.88
Development of promyelocytic leukemia zinc finger-expressing innate CD4 T cells requires stronger T-cell receptor signals than conventional CD4 T cells. Proc Natl Acad Sci U S A (2012) 0.88
Phenotypic differences between mice deficient in XIAP and SAP, two factors targeted in X-linked lymphoproliferative syndrome (XLP). Cell Immunol (2009) 0.88
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood (2006) 0.87
Characterization of Ly108 in the thymus: evidence for distinct properties of a novel form of Ly108. J Immunol (2012) 0.86
Perturbation of B cell activation in SLAM-associated protein-deficient mice is associated with changes in gammaherpesvirus latency reservoirs. J Immunol (2007) 0.86
Cbl enforces an SLP76-dependent signaling pathway for T cell differentiation. J Biol Chem (2008) 0.84
Cellular and molecular requirements for the selection of in vitro-generated CD8 T cells reveal a role for Notch. J Immunol (2013) 0.84
Lymph node choreography: B cells take the lead. Nat Immunol (2012) 0.81
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice. Eur J Immunol (2014) 0.80
Fine-tuning lymphocyte regulation: what's new with tyrosine kinases and phosphatases? Curr Opin Immunol (2004) 0.79
Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency. PLoS Genet (2005) 0.78
To B or not to B. Blood (2010) 0.75
Ncking BCR-mediated PI3K activation. EMBO Rep (2013) 0.75