Published in Immunity on June 07, 2012
Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol (2013) 4.72
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 3.72
T follicular helper cell differentiation, function, and roles in disease. Immunity (2014) 3.29
Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol (2013) 2.89
The good, the bad and the ugly - TFH cells in human health and disease. Nat Rev Immunol (2013) 2.33
SAP gene transfer restores cellular and humoral immune function in a murine model of X-linked lymphoproliferative disease. Blood (2012) 1.44
A brief history of T cell help to B cells. Nat Rev Immunol (2015) 1.21
Positive and negative signaling through SLAM receptors regulate synapse organization and thresholds of cytolysis. Immunity (2012) 1.20
Cell distance mapping identifies functional T follicular helper cells in inflamed human renal tissue. Sci Transl Med (2014) 1.14
EAT-2, a SAP-like adaptor, controls NK cell activation through phospholipase Cγ, Ca++, and Erk, leading to granule polarization. J Exp Med (2014) 1.00
Evolving role of 2B4/CD244 in T and NK cell responses during virus infection. Front Immunol (2012) 0.99
Expansion of murine gammaherpesvirus latently infected B cells requires T follicular help. PLoS Pathog (2014) 0.93
SAP-Dependent and -Independent Regulation of Innate T Cell Development Involving SLAMF Receptors. Front Immunol (2014) 0.91
A role for Ly108 in the induction of promyelocytic zinc finger transcription factor in developing thymocytes. J Immunol (2013) 0.91
XLP: clinical features and molecular etiology due to mutations in SH2D1A encoding SAP. J Clin Immunol (2014) 0.90
Modulation of SAP dependent T:B cell interactions as a strategy to improve vaccination. Curr Opin Virol (2013) 0.89
ID'ing innate and innate-like lymphoid cells. Immunol Rev (2014) 0.89
Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance. J Allergy Clin Immunol (2013) 0.88
Cutting edge: Ly9 (CD229), a SLAM family receptor, negatively regulates the development of thymic innate memory-like CD8+ T and invariant NKT cells. J Immunol (2012) 0.88
T follicular helper cells in space-time. Nat Rev Immunol (2016) 0.86
Emerging concepts on T follicular helper cell dynamics in HIV infection. Trends Immunol (2014) 0.85
Co-stimulatory and Co-inhibitory Pathways in Autoimmunity. Immunity (2016) 0.84
Expansion of an osteopontin-expressing T follicular helper cell subset correlates with autoimmunity in B6.Sle1b mice and is suppressed by the H1-isoform of the Slamf6 receptor. FASEB J (2013) 0.84
Immune cell inhibition by SLAMF7 is mediated by a mechanism requiring src kinases, CD45, and SHIP-1 that is defective in multiple myeloma cells. Mol Cell Biol (2014) 0.82
B cell-intrinsic CD84 and Ly108 maintain germinal center B cell tolerance. J Immunol (2015) 0.82
Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Front Immunol (2015) 0.82
Fine specificity and molecular competition in SLAM family receptor signalling. PLoS One (2014) 0.81
Cutting Edge: NFAT Transcription Factors Promote the Generation of Follicular Helper T Cells in Response to Acute Viral Infection. J Immunol (2016) 0.81
A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells. Oncotarget (2016) 0.80
T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX. Immunity (2015) 0.80
T/B-cell interactions are more transient in response to weak stimuli in SLE-prone mice. Eur J Immunol (2014) 0.80
The adaptor molecule signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is essential in mechanisms involving the Fyn tyrosine kinase for induction and progression of collagen-induced arthritis. J Biol Chem (2013) 0.78
SAP signaling: a dual mechanism of action. Immunity (2012) 0.78
SAP modulates B cell functions in a genetic background-dependent manner. Immunol Lett (2013) 0.77
Responses to Microbial Challenges by SLAMF Receptors. Front Immunol (2016) 0.77
Age-related impairment of humoral response to influenza is associated with changes in antigen specific T follicular helper cell responses. Sci Rep (2016) 0.76
CRISPR-Mediated Slamf1Δ/Δ Slamf5Δ/Δ Slamf6Δ/Δ Triple Gene Disruption Reveals NKT Cell Defects but Not T Follicular Helper Cell Defects. PLoS One (2016) 0.76
CRISPR-Mediated Triple Knockout of SLAMF1, SLAMF5 and SLAMF6 Supports Positive Signaling Roles in NKT Cell Development. PLoS One (2016) 0.76
Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies. Immunol Rev (2017) 0.76
Slam haplotype 2 promotes NKT but suppresses Vγ4+ T-cell activation in coxsackievirus B3 infection leading to increased liver damage but reduced myocarditis. Am J Pathol (2012) 0.76
The cell surface receptor Slamf6 modulates innate immune responses during Citrobacter rodentium-induced colitis. Int Immunol (2015) 0.76
Critical role of SAP in progression and reactivation but not maintenance of T cell-dependent humoral immunity. Mol Cell Biol (2013) 0.76
A locus on mouse chromosome 13 inversely regulates CD1d expression and the development of invariant natural killer T-cells. Genes Immun (2015) 0.76
Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody Responses. J Immunol (2015) 0.76
Insights into the development and regulation of T follicular helper cells. Cytokine (2016) 0.76
Increased, durable B-cell and ADCC Responses Associated with T-helper Responses to HIV-1 Envelope in Macaques Vaccinated with gp140 Occluded at the CD4 Receptor Binding Site. J Virol (2017) 0.75
Human Immunodeficiencies Related to Defective APC/T Cell Interaction. Front Immunol (2015) 0.75
Slamf6 negatively regulates autoimmunity. Clin Immunol (2016) 0.75
Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1. J Exp Med (2016) 0.75
Dissection of SAP-dependent and SAP-independent SLAM family signaling in NKT cell development and humoral immunity. J Exp Med (2017) 0.75
The chicken SLAM family. Immunogenetics (2012) 0.75
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Restoring function in exhausted CD8 T cells during chronic viral infection. Nature (2005) 28.04
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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69
Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol (2001) 7.07
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ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 5.59
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell (2010) 5.49
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SAP-controlled T-B cell interactions underlie germinal centre formation. Nature (2008) 5.14
T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse. J Exp Med (2011) 4.71
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med (2010) 4.65
The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature (1998) 4.47
Follicular helper T cells are required for systemic autoimmunity. J Exp Med (2009) 4.25
SAP is required for generating long-term humoral immunity. Nature (2003) 3.85
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Early commitment of naïve human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12. Immunol Cell Biol (2009) 3.51
Homotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage development. Immunity (2007) 3.02
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One (2011) 2.92
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol (2010) 2.85
Association of extensive polymorphisms in the SLAM/CD2 gene cluster with murine lupus. Immunity (2004) 2.82
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Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product. J Exp Med (2005) 2.66
SLAM family receptors and SAP adaptors in immunity. Annu Rev Immunol (2011) 2.52
Regulation of the natural killer cell receptor repertoire. Annu Rev Immunol (2001) 2.38
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol (2012) 2.34
SAP couples Fyn to SLAM immune receptors. Nat Cell Biol (2003) 2.27
SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat Rev Immunol (2009) 2.19
Late interleukin-6 escalates T follicular helper cell responses and controls a chronic viral infection. Science (2011) 2.15
Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J Immunol (2005) 1.98
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SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol (2003) 1.92
Impaired humoral immunity in X-linked lymphoproliferative disease is associated with defective IL-10 production by CD4+ T cells. J Clin Invest (2005) 1.92
Immune regulation by SLAM family receptors and SAP-related adaptors. Nat Rev Immunol (2006) 1.86
The cell surface receptor SLAM controls T cell and macrophage functions. J Exp Med (2004) 1.77
Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product. Nat Immunol (2001) 1.71
Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5. J Virol (2009) 1.69
SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol (2007) 1.68
SLAM is a microbial sensor that regulates bacterial phagosome functions in macrophages. Nat Immunol (2010) 1.68
Functional requirement for SAP in 2B4-mediated activation of human natural killer cells as revealed by the X-linked lymphoproliferative syndrome. J Immunol (2000) 1.66
Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity (2004) 1.63
Molecular basis for positive and negative signaling by the natural killer cell receptor 2B4 (CD244). Blood (2005) 1.61
CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A. J Immunol (2001) 1.61
The dual-function CD150 receptor subfamily: the viral attraction. Nat Immunol (2003) 1.59
Evolution in miniature: selection, survival and distribution of antigen reactive cells in the germinal centre. Immunol Cell Biol (2008) 1.54
Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family. J Immunol (2001) 1.51
Crystal structures of the XLP protein SAP reveal a class of SH2 domains with extended, phosphotyrosine-independent sequence recognition. Mol Cell (1999) 1.47
Selective generation of functional somatically mutated IgM+CD27+, but not Ig isotype-switched, memory B cells in X-linked lymphoproliferative disease. J Clin Invest (2006) 1.44
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Patients with X-linked lymphoproliferative disease have a defect in 2B4 receptor-mediated NK cell cytotoxicity. Eur J Immunol (2000) 1.42
Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J Immunol (2006) 1.36
Signaling lymphocytic activation molecule (CDw150) is homophilic but self-associates with very low affinity. J Biol Chem (2000) 1.34
Restimulation-induced apoptosis of T cells is impaired in patients with X-linked lymphoproliferative disease caused by SAP deficiency. J Clin Invest (2009) 1.33
NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. Immunity (2006) 1.27
CD1 tetramers: a powerful tool for the analysis of glycolipid-reactive T cells. J Immunol Methods (2002) 1.27
Molecular pathogenesis of EBV susceptibility in XLP as revealed by analysis of female carriers with heterozygous expression of SAP. PLoS Biol (2011) 1.27
Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase. Immunity (2010) 1.25
SAP expression in T cells, not in B cells, is required for humoral immunity. Proc Natl Acad Sci U S A (2008) 1.25
Cutting edge: the SLAM family receptor Ly108 controls T cell and neutrophil functions. J Immunol (2005) 1.21
Hypogammaglobulinemia and exacerbated CD8 T-cell-mediated immunopathology in SAP-deficient mice with chronic LCMV infection mimics human XLP disease. Blood (2006) 1.21
Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity. J Biol Chem (2008) 1.19
Interleukin-4 production by follicular helper T cells requires the conserved Il4 enhancer hypersensitivity site V. Immunity (2012) 1.19
SAP is required for Th cell function and for immunity to influenza. J Immunol (2006) 1.18
Structure of CD84 provides insight into SLAM family function. Proc Natl Acad Sci U S A (2007) 1.17
The 3' enhancer CNS2 is a critical regulator of interleukin-4-mediated humoral immunity in follicular helper T cells. Immunity (2012) 1.14
A novel isoform of the Ly108 gene ameliorates murine lupus. J Exp Med (2011) 1.07
The 1-1-1 fallacy. Immunol Rev (2012) 1.06
Biochemical and genetic evidence for a SAP-PKC-theta interaction contributing to IL-4 regulation. J Immunol (2010) 1.06
SLAM family receptors and SAP-related adaptors: matters arising. Trends Immunol (2006) 0.99
Importance and mechanism of 'switch' function of SAP family adapters. Immunol Rev (2009) 0.98
Loss of circulating CD27+ memory B cells and CCR4+ T cells occurring in association with elevated EBV loads in XLP patients surviving primary EBV infection. Blood (2003) 0.98
The smallpox vaccine induces an early neutralizing IgM response. Vaccine (2009) 0.97
Association between SAP and FynT: Inducible SH3 domain-mediated interaction controlled by engagement of the SLAM receptor. Mol Cell Biol (2006) 0.96
NTB-A, a new activating receptor in T cells that regulates autoimmune disease. J Biol Chem (2004) 0.95
Signaling lymphocyte activation molecule-associated protein is a negative regulator of the CD8 T cell response in mice. J Immunol (2005) 0.95
The protein tyrosine phosphatase SHP-1 modulates the suppressive activity of regulatory T cells. J Immunol (2010) 0.92
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Antigen-specific responses and ANA production in B6.Sle1b mice: a role for SAP. J Autoimmun (2008) 0.83
SAP: natural inhibitor or grand SLAM of T cell activation? Nat Immunol (2001) 0.83
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med (2011) 8.26
A critical role for IL-21 in regulating immunoglobulin production. Science (2002) 7.09
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity (2011) 5.59
SAP-controlled T-B cell interactions underlie germinal centre formation. Nature (2008) 5.14
Resolution of a chronic viral infection after interleukin-10 receptor blockade. J Exp Med (2006) 4.97
Follicular helper T cells are required for systemic autoimmunity. J Exp Med (2009) 4.25
SAP is required for generating long-term humoral immunity. Nature (2003) 3.85
Human circulating PD-1+CXCR3-CXCR5+ memory Tfh cells are highly functional and correlate with broadly neutralizing HIV antibody responses. Immunity (2013) 3.72
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science (2005) 3.65
Regulation of NKT cell development by SAP, the protein defective in XLP. Nat Med (2005) 3.62
Profiling the humoral immune response to infection by using proteome microarrays: high-throughput vaccine and diagnostic antigen discovery. Proc Natl Acad Sci U S A (2005) 3.59
STAT5 is a potent negative regulator of TFH cell differentiation. J Exp Med (2012) 3.37
Regulation of microRNA expression and abundance during lymphopoiesis. Immunity (2010) 3.29
A Blueprint for HIV Vaccine Discovery. Cell Host Microbe (2012) 3.27
Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity (2011) 3.24
Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity (2011) 3.06
Optimal germinal center responses require a multistage T cell:B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity (2010) 3.00
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Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities. Immunity (2008) 2.43
Circulating precursor CCR7(lo)PD-1(hi) CXCR5⁺ CD4⁺ T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure. Immunity (2013) 2.37
Bcl6 and Maf cooperate to instruct human follicular helper CD4 T cell differentiation. J Immunol (2012) 2.34
The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J Exp Med (2009) 2.34
Inadequate T follicular cell help impairs B cell immunity during HIV infection. Nat Med (2013) 2.29
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthrax. J Infect Dis (2004) 2.29
SLAM receptors and SAP influence lymphocyte interactions, development and function. Nat Rev Immunol (2009) 2.19
Vaccinia virus H3L envelope protein is a major target of neutralizing antibodies in humans and elicits protection against lethal challenge in mice. J Virol (2005) 2.18
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1. Immunity (2004) 2.18
Balancing selection maintains a form of ERAP2 that undergoes nonsense-mediated decay and affects antigen presentation. PLoS Genet (2010) 2.14
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Expansion of functionally immature transitional B cells is associated with human-immunodeficient states characterized by impaired humoral immunity. J Immunol (2006) 1.96
SAP regulates T cell-mediated help for humoral immunity by a mechanism distinct from cytokine regulation. J Exp Med (2006) 1.92
Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation. Nat Cell Biol (2003) 1.92
Functional and epigenetic studies reveal multistep differentiation and plasticity of in vitro-generated and in vivo-derived follicular T helper cells. Immunity (2011) 1.83
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Redundancy and plasticity of neutralizing antibody responses are cornerstone attributes of the human immune response to the smallpox vaccine. J Virol (2008) 1.77
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat Immunol (2008) 1.73
Bcl6 expressing follicular helper CD4 T cells are fate committed early and have the capacity to form memory. J Immunol (2013) 1.71
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Heavily isotype-dependent protective activities of human antibodies against vaccinia virus extracellular virion antigen B5. J Virol (2009) 1.69
SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol (2007) 1.68
Vaccinia virus-specific CD4+ T cell responses target a set of antigens largely distinct from those targeted by CD8+ T cell responses. J Immunol (2007) 1.66
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TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest (2004) 1.63
Requirements for selection of conventional and innate T lymphocyte lineages. Immunity (2007) 1.59
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Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions. J Med Chem (2003) 1.57
Cutting edge: STAT1 is required for IL-6-mediated Bcl6 induction for early follicular helper cell differentiation. J Immunol (2013) 1.57
Syntaxin 11 is required for NK and CD8⁺ T-cell cytotoxicity and neutrophil degranulation. Eur J Immunol (2012) 1.57
Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton. J Immunol (2005) 1.54
SH2D1A regulates T-dependent humoral autoimmunity. J Exp Med (2004) 1.51
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Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP. Curr Biol (2003) 1.47
Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in vivo. J Virol Methods (2007) 1.45
T-cell signaling regulated by the Tec family kinase, Itk. Cold Spring Harb Perspect Biol (2010) 1.45
Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production. Blood (2010) 1.44
BCL-xL is a target gene regulated by hypoxia-inducible factor-1{alpha}. J Biol Chem (2009) 1.43
Inhibition of NK cell activity by IL-17 allows vaccinia virus to induce severe skin lesions in a mouse model of eczema vaccinatum. J Exp Med (2009) 1.41
Impaired in vitro regulatory T cell function associated with Wiskott-Aldrich syndrome. Clin Immunol (2007) 1.40
Harnessing CD4⁺ T cell responses in HIV vaccine development. Nat Med (2013) 1.39
Ion adsorption components in liquid/solid systems. J Environ Sci (China) (2006) 1.37
Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J Immunol (2006) 1.36
NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi. Proc Natl Acad Sci U S A (2008) 1.35
KLF4 suppresses transformation of pre-B cells by ABL oncogenes. Blood (2006) 1.33
OX40 drives protective vaccinia virus-specific CD8 T cells. J Immunol (2008) 1.33
CD2-associated protein directly interacts with the actin cytoskeleton. Am J Physiol Renal Physiol (2002) 1.32
Tec kinases regulate T-lymphocyte development and function: new insights into the roles of Itk and Rlk/Txk. Immunol Rev (2009) 1.32
Functional hierarchy of the N-terminal tyrosines of SLP-76. J Immunol (2006) 1.29
MicroRNA145 targets BNIP3 and suppresses prostate cancer progression. Cancer Res (2010) 1.26
Altered expression of miR-152 and miR-148a in ovarian cancer is related to cell proliferation. Oncol Rep (2011) 1.23