Published in Science on August 13, 2004
Neurocircuitry of addiction. Neuropsychopharmacology (2010) 14.22
Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev (2007) 6.36
Review. The incentive sensitization theory of addiction: some current issues. Philos Trans R Soc Lond B Biol Sci (2008) 5.54
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake. Neurosci Biobehav Rev (2007) 5.22
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications. Nat Rev Neurosci (2011) 4.88
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci (2008) 4.85
High impulsivity predicts the switch to compulsive cocaine-taking. Science (2008) 4.76
A multistep general theory of transition to addiction. Psychopharmacology (Berl) (2013) 4.01
Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. Neuron (2011) 3.93
The role of impulsive behavior in drug abuse. Psychopharmacology (Berl) (2008) 3.74
A unified framework for addiction: vulnerabilities in the decision process. Behav Brain Sci (2008) 2.83
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Br J Pharmacol (2008) 2.83
AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine. Neurosci Biobehav Rev (2010) 2.58
Striatal microRNA controls cocaine intake through CREB signalling. Nature (2010) 2.56
Complex interactions between nicotine and nonpharmacological stimuli reveal multiple roles for nicotine in reinforcement. Psychopharmacology (Berl) (2005) 2.49
Reward processing by the opioid system in the brain. Physiol Rev (2009) 2.46
Epigenetic mechanisms in cognition. Neuron (2011) 2.31
Obesity and the brain: how convincing is the addiction model? Nat Rev Neurosci (2012) 2.26
Reward mechanisms in obesity: new insights and future directions. Neuron (2011) 2.21
Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology (2008) 2.16
Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature (2013) 2.15
Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. Psychopharmacology (Berl) (2009) 2.06
Individual differences in the attribution of incentive salience to a reward-related cue: influence on cocaine sensitization. Behav Brain Res (2007) 2.05
Opiate versus psychostimulant addiction: the differences do matter. Nat Rev Neurosci (2011) 2.05
Calculating utility: preclinical evidence for cost-benefit analysis by mesolimbic dopamine. Psychopharmacology (Berl) (2006) 2.03
The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction. Psychopharmacology (Berl) (2012) 1.96
The role of orbitofrontal cortex in drug addiction: a review of preclinical studies. Biol Psychiatry (2007) 1.89
Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments. Front Neuroanat (2011) 1.85
The development and maintenance of drug addiction. Neuropsychopharmacology (2013) 1.76
Compulsive drug seeking by rats under punishment: effects of drug taking history. Psychopharmacology (Berl) (2007) 1.74
A robust automated system elucidates mouse home cage behavioral structure. Proc Natl Acad Sci U S A (2008) 1.69
Addiction as a stress surfeit disorder. Neuropharmacology (2013) 1.68
The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF1 receptors. Neuropsychopharmacology (2005) 1.68
Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat Neurosci (2013) 1.64
Insight into the relationship between impulsivity and substance abuse from studies using animal models. Alcohol Clin Exp Res (2010) 1.62
Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neurosci Biobehav Rev (2010) 1.61
Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats. Learn Mem (2007) 1.59
How to make a rat addicted to cocaine. Prog Neuropsychopharmacol Biol Psychiatry (2007) 1.55
Intense cocaine self-administration after episodic social defeat stress, but not after aggressive behavior: dissociation from corticosterone activation. Psychopharmacology (Berl) (2005) 1.53
Drug abstinence: exploring animal models and behavioral treatment strategies. Psychopharmacology (Berl) (2014) 1.52
The impact of orbitofrontal dysfunction on cocaine addiction. Nat Neurosci (2012) 1.50
Assessment of the kappa opioid agonist, salvinorin A, as a punisher of drug self-administration in monkeys. Psychopharmacology (Berl) (2014) 1.48
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse. Curr Top Behav Neurosci (2010) 1.46
Acute and chronic dopamine receptor stimulation modulates AMPA receptor trafficking in nucleus accumbens neurons cocultured with prefrontal cortex neurons. J Neurosci (2008) 1.40
Excessive cocaine use results from decreased phasic dopamine signaling in the striatum. Nat Neurosci (2014) 1.40
Addiction is a Reward Deficit and Stress Surfeit Disorder. Front Psychiatry (2013) 1.39
Ethanol consumption: how should we measure it? Achieving consilience between human and animal phenotypes. Addict Biol (2010) 1.38
Persistent alterations in cognitive function and prefrontal dopamine D2 receptors following extended, but not limited, access to self-administered cocaine. Neuropsychopharmacology (2008) 1.36
Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci (2013) 1.35
Nicotine as a typical drug of abuse in experimental animals and humans. Psychopharmacology (Berl) (2005) 1.35
High-novelty-preference rats are predisposed to compulsive cocaine self-administration. Neuropsychopharmacology (2010) 1.33
Effects of nicotine in experimental animals and humans: an update on addictive properties. Handb Exp Pharmacol (2009) 1.31
Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology (2007) 1.31
Cocaine is low on the value ladder of rats: possible evidence for resilience to addiction. PLoS One (2010) 1.30
Development of pharmacotherapies for drug addiction: a Rosetta stone approach. Nat Rev Drug Discov (2009) 1.30
On habits and addiction: An associative analysis of compulsive drug seeking. Drug Discov Today Dis Models (2008) 1.28
Sex differences in the neural mechanisms mediating addiction: a new synthesis and hypothesis. Biol Sex Differ (2012) 1.27
The absence of DSM-IV nicotine dependence in moderate-to-heavy daily smokers. Drug Alcohol Depend (2007) 1.27
DNA methylation regulates associative reward learning. Nat Neurosci (2013) 1.27
Self-administration of drugs in animals and humans as a model and an investigative tool. Addiction (2007) 1.27
Different lengths of times for progressions in adolescent substance involvement. Addict Behav (2006) 1.26
Multiple roles for orexin/hypocretin in addiction. Prog Brain Res (2012) 1.26
Intermittent ethanol access schedule in rats as a preclinical model of alcohol abuse. Alcohol (2014) 1.24
Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res (2010) 1.23
Neural substrates of cognitive inflexibility after chronic cocaine exposure. Neuropharmacology (2008) 1.23
Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. J Neurosci (2013) 1.22
New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity. CNS Spectr (2014) 1.22
Essential value of cocaine and food in rats: tests of the exponential model of demand. Psychopharmacology (Berl) (2008) 1.20
Stressor- and corticotropin releasing factor-induced reinstatement and active stress-related behavioral responses are augmented following long-access cocaine self-administration by rats. Psychopharmacology (Berl) (2007) 1.20
Effects of baclofen on operant performance for food pellets and vegetable shortening after a history of binge-type behavior in non-food deprived rats. Pharmacol Biochem Behav (2006) 1.19
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories--indications for novel treatments of addiction. Eur J Neurosci (2014) 1.18
Natural rewards, neuroplasticity, and non-drug addictions. Neuropharmacology (2011) 1.16
Adolescent rats are protected from the conditioned aversive properties of cocaine and lithium chloride. Pharmacol Biochem Behav (2006) 1.16
Repeated intravenous cocaine experience: development and escalation of pre-drug anticipatory 50-kHz ultrasonic vocalizations in rats. Behav Brain Res (2010) 1.16
Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. Neurosci Biobehav Rev (2010) 1.15
Symposium overview--Food addiction: fact or fiction? J Nutr (2009) 1.15
Antecedents and consequences of drug abuse in rats selectively bred for high and low response to novelty. Neuropharmacology (2013) 1.15
Self-administration enhances excitatory synaptic transmission in the bed nucleus of the stria terminalis. Nat Neurosci (2005) 1.15
Chronic cocaine self-administration in rhesus monkeys: impact on associative learning, cognitive control, and working memory. J Neurosci (2011) 1.15
Behavioral economic assessment of price and cocaine consumption following self-administration histories that produce escalation of either final ratios or intake. Neuropsychopharmacology (2008) 1.14
Is food addiction a valid and useful concept? Obes Rev (2012) 1.14
A history of bingeing on fat enhances cocaine seeking and taking. Behav Neurosci (2011) 1.13
Encoding of aversion by dopamine and the nucleus accumbens. Front Neurosci (2012) 1.13
Differential roles of ventral pallidum subregions during cocaine self-administration behaviors. J Comp Neurol (2013) 1.11
Kicking the habit: the neural basis of ingrained behaviors in cocaine addiction. Neurosci Biobehav Rev (2010) 1.09
Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats. Psychopharmacology (Berl) (2005) 1.09
Demand for cocaine and food over time. Pharmacol Biochem Behav (2008) 1.09
Anti-relapse medications: preclinical models for drug addiction treatment. Pharmacol Ther (2009) 1.08
Cocaine self-administration produces a persistent increase in dopamine D2 High receptors. Eur Neuropsychopharmacol (2008) 1.07
Review. Evidence-based treatments of addiction. Philos Trans R Soc Lond B Biol Sci (2008) 1.07
Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model. Cold Spring Harb Perspect Med (2012) 1.07
Trait-like impulsivity does not predict escalation of heroin self-administration in the rat. Psychopharmacology (Berl) (2010) 1.06
Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. Pharmacol Ther (2012) 1.04
Theories of addiction: methamphetamine users' explanations for continuing drug use and relapse. Am J Addict (2009) 1.04
Relevance of rodent models of intravenous MDMA self-administration to human MDMA consumption patterns. Psychopharmacology (Berl) (2006) 1.04
Synaptic mechanisms underlying persistent cocaine craving. Nat Rev Neurosci (2016) 1.03
The nicotinic acetylcholine receptor antagonist mecamylamine prevents escalation of cocaine self-administration in rats with extended daily access. Psychopharmacology (Berl) (2007) 1.03
A conflict rat model of cue-induced relapse to cocaine seeking. Psychopharmacology (Berl) (2007) 1.02
Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PLoS One (2013) 1.02
Methylphenidate treatment in adolescent rats with an attention deficit/hyperactivity disorder phenotype: cocaine addiction vulnerability and dopamine transporter function. Neuropsychopharmacology (2010) 1.02
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction. Philos Trans R Soc Lond B Biol Sci (2008) 4.85
Spatial relational memory requires hippocampal adult neurogenesis. PLoS One (2008) 3.23
Interaction between glucocorticoid hormones, stress and psychostimulant drugs. Eur J Neurosci (2002) 2.16
Opiate versus psychostimulant addiction: the differences do matter. Nat Rev Neurosci (2011) 2.05
Transition to addiction is associated with a persistent impairment in synaptic plasticity. Science (2010) 2.04
Pregnenolone can protect the brain from cannabis intoxication. Science (2014) 1.85
The MAPK pathway and Egr-1 mediate stress-related behavioral effects of glucocorticoids. Nat Neurosci (2005) 1.66
Evidence for enhanced neurobehavioral vulnerability to nicotine during periadolescence in rats. J Neurosci (2003) 1.61
Implication of allopregnanolone in the antinociceptive effect of N-palmitoylethanolamide in acute or persistent pain. Pain (2011) 1.55
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking. Nat Neurosci (2009) 1.51
Changes in extracellular dopamine induced by morphine and cocaine: crucial control by D2 receptors. J Neurosci (2002) 1.50
Bimodal control of stimulated food intake by the endocannabinoid system. Nat Neurosci (2010) 1.49
Interplay of maternal care and genetic influences in programming adult hippocampal neurogenesis. Biol Psychiatry (2012) 1.41
Pattern of intake and drug craving predict the development of cocaine addiction-like behavior in rats. Biol Psychiatry (2008) 1.35
The glucocorticoid receptor as a potential target to reduce cocaine abuse. J Neurosci (2003) 1.34
High-novelty-preference rats are predisposed to compulsive cocaine self-administration. Neuropsychopharmacology (2010) 1.33
Nicotine self-administration impairs hippocampal plasticity. J Neurosci (2002) 1.23
Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens. Neuropsychopharmacology (2010) 1.19
Enriched environment confers resistance to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and cocaine: involvement of dopamine transporter and trophic factors. J Neurosci (2003) 1.16
Differences between brain structures in nuclear translocation and DNA binding of the glucocorticoid receptor during stress and the circadian cycle. Eur J Neurosci (2004) 1.14
Glucocorticoids can induce PTSD-like memory impairments in mice. Science (2012) 1.14
Preexposure during or following adolescence differently affects nicotine-rewarding properties in adult rats. Psychopharmacology (Berl) (2005) 1.09
Influence of cue-conditioning on acquisition, maintenance and relapse of cocaine intravenous self-administration. Eur J Neurosci (2002) 1.08
The basolateral amygdala and nucleus accumbens core mediate dissociable aspects of drug memory reconsolidation. Learn Mem (2010) 1.07
Trait-like impulsivity does not predict escalation of heroin self-administration in the rat. Psychopharmacology (Berl) (2010) 1.06
Susceptibility to amphetamine-induced place preference is predicted by locomotor response to novelty and amphetamine in the mouse. Psychopharmacology (Berl) (2003) 1.05
Double dissociation of the dorsomedial and dorsolateral striatal control over the acquisition and performance of cocaine seeking. Neuropsychopharmacology (2012) 1.00
High impulsivity predicting vulnerability to cocaine addiction in rats: some relationship with novelty preference but not novelty reactivity, anxiety or stress. Psychopharmacology (Berl) (2011) 1.00
N-Acetylcysteine reduces early- and late-stage cocaine seeking without affecting cocaine taking in rats. Addict Biol (2011) 0.96
Cocaine modulation of frontostriatal expression of Zif268, D2, and 5-HT2c receptors in high and low impulsive rats. Neuropsychopharmacology (2013) 0.95
The neurosteroid allopregnanolone increases dopamine release and dopaminergic response to morphine in the rat nucleus accumbens. Eur J Neurosci (2002) 0.92
Gene-environment interactions in vulnerability to cocaine intravenous self-administration: a brief social experience affects intake in DBA/2J but not in C57BL/6J mice. Psychopharmacology (Berl) (2007) 0.91
High anxiety is a predisposing endophenotype for loss of control over cocaine, but not heroin, self-administration in rats. Psychopharmacology (Berl) (2012) 0.89
Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control. Neuropharmacology (2013) 0.88
Intrastriatal shifts mediate the transition from drug-seeking actions to habits. Biol Psychiatry (2012) 0.87
Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: a review. World J Biol Psychiatry (2011) 0.86
Serotonin2C receptors in the medial prefrontal cortex facilitate cocaine-induced dopamine release in the rat nucleus accumbens. Neuropharmacology (2008) 0.86
Endocannabinoids measurement in human saliva as potential biomarker of obesity. PLoS One (2012) 0.86
Transcriptional effects of glucocorticoid receptors in the dentate gyrus increase anxiety-related behaviors. PLoS One (2009) 0.86
Coupled intracerebral microdialysis and electrophysiology for the assessment of dopamine neuron function in vivo. J Pharmacol Toxicol Methods (2012) 0.83
The central serotonin 2B receptor: a new pharmacological target to modulate the mesoaccumbens dopaminergic pathway activity. J Neurochem (2010) 0.82
Palmitoylethanolamide modulates pentobarbital-evoked hypnotic effect in mice: involvement of allopregnanolone biosynthesis. Eur Neuropsychopharmacol (2009) 0.79
Individual vulnerability to substance abuse and affective disorders: role of early environmental influences. Neurotox Res (2002) 0.79
Serotonin2C receptors modulate dopamine transmission in the nucleus accumbens independently of dopamine release: behavioral, neurochemical and molecular studies with cocaine. Addict Biol (2014) 0.77
Serotonin2C receptor stimulation inhibits cocaine-induced Fos expression and DARPP-32 phosphorylation in the rat striatum independently of dopamine outflow. Neuropharmacology (2015) 0.76
Endocannabinoids and striatal function: implications for addiction-related behaviours. Behav Pharmacol (2015) 0.76
Western blot detection of brain phosphoproteins after performing Laser Microdissection and Pressure Catapulting (LMPC). J Neurosci Methods (2011) 0.75
Regular theta-firing neurons in the nucleus incertus during sustained hippocampal activation. Eur J Neurosci (2017) 0.75