Published in Am J Respir Crit Care Med on August 18, 2004
How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46
Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease. J Immunol (2009) 2.05
Tobacco use increases susceptibility to bacterial infection. Tob Induc Dis (2008) 1.45
Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One (2015) 1.41
Identification of an autophagy defect in smokers' alveolar macrophages. J Immunol (2010) 1.36
Alveolar epithelial type II cells activate alveolar macrophages and mitigate P. Aeruginosa infection. PLoS One (2009) 1.31
Nontypeable Haemophilus influenzae clearance by alveolar macrophages is impaired by exposure to cigarette smoke. Infect Immun (2009) 1.30
The influence of radiographic phenotype and smoking status on peripheral blood biomarker patterns in chronic obstructive pulmonary disease. PLoS One (2009) 1.28
Impact of smoking on inflammation: overview of molecular mechanisms. Inflamm Res (2011) 1.24
Cigarette smoke exposure impairs pulmonary bacterial clearance and alveolar macrophage complement-mediated phagocytosis of Streptococcus pneumoniae. Infect Immun (2009) 1.22
Tobacco upregulates P. gingivalis fimbrial proteins which induce TLR2 hyposensitivity. PLoS One (2010) 1.10
Lung microbiology and exacerbations in COPD. Int J Chron Obstruct Pulmon Dis (2012) 1.01
Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. PLoS One (2010) 1.01
Macrophage phagocytosis: effects of environmental pollutants, alcohol, cigarette smoke, and other external factors. J Leukoc Biol (2011) 0.94
Oxidized phospholipids impair pulmonary antibacterial defenses: evidence in mice exposed to cigarette smoke. Biochem Biophys Res Commun (2012) 0.94
Continuous and discontinuous cigarette smoke exposure differentially affects protective Th1 immunity against pulmonary tuberculosis. PLoS One (2013) 0.94
Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke. Respir Res (2010) 0.92
Smoking as a risk factor for short-term outcomes following primary total hip and total knee replacement in veterans. Arthritis Care Res (Hoboken) (2011) 0.91
Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A. Am J Pathol (2011) 0.90
Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD. Proc Am Thorac Soc (2012) 0.89
The influence of nicotine on granulocytic differentiation - inhibition of the oxidative burst and bacterial killing and increased matrix metalloproteinase-9 release. BMC Cell Biol (2008) 0.88
Why does airway inflammation persist after the smoking stops? Thorax (2006) 0.86
Inhibition by cigarette smoke of nuclear factor-κB-dependent response to bacteria in the airway. Am J Respir Cell Mol Biol (2010) 0.86
IL-22 Defect During Streptococcus pneumoniae Infection Triggers Exacerbation of Chronic Obstructive Pulmonary Disease. EBioMedicine (2015) 0.86
Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. Am J Physiol Lung Cell Mol Physiol (2015) 0.85
Strain differences influence murine pulmonary responses to Stachybotrys chartarum. Am J Respir Cell Mol Biol (2006) 0.85
Antiviral activity of trappin-2 and elafin in vitro and in vivo against genital herpes. J Virol (2013) 0.85
Cigarette smoking and outcomes after allogeneic hematopoietic stem cell transplantation. Biol Blood Marrow Transplant (2011) 0.84
Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts. PLoS One (2015) 0.83
Cigarette Smoke Attenuates the Nasal Host Response to Streptococcus pneumoniae and Predisposes to Invasive Pneumococcal Disease in Mice. Infect Immun (2016) 0.83
Exacerbation of cigarette smoke-induced pulmonary inflammation by Staphylococcus aureus enterotoxin B in mice. Respir Res (2011) 0.82
Exposure to Cigarette Smoke Disrupts CCL20-Mediated Antimicrobial Activity in Respiratory Epithelial Cells. Open Immunol J (2009) 0.82
Environmental risk factors for acute respiratory distress syndrome. Clin Chest Med (2014) 0.80
Cigarette smoke synergizes lipopolysaccharide-induced interleukin-1β and tumor necrosis factor-α secretion from macrophages via substance P-mediated nuclear factor-κB activation. Am J Respir Cell Mol Biol (2010) 0.79
Cigarette smoke represses the innate immune response to asbestos. Physiol Rep (2015) 0.78
Development and characterization of a long-term murine model of Streptococcus pneumoniae infection of the lower airways. Infect Immun (2014) 0.78
Models of Respiratory Infections: Virus-Induced Asthma Exacerbations and Beyond. Allergy Asthma Immunol Res (2015) 0.77
Smoking and predictors of pneumonia among HIV-infected patients receiving care in the HAART era. Open Respir Med J (2008) 0.76
The intake of maqui (Aristotelia chilensis) berry extract normalizes H2O2 and IL-6 concentrations in exhaled breath condensate from healthy smokers - an explorative study. Nutr J (2015) 0.76
In vivo Cigarette Smoke Exposure Decreases CCL20, SLPI, and BD-1 Secretion by Human Primary Nasal Epithelial Cells. Front Psychiatry (2016) 0.75
Mentholation affects the cigarette microbiota by selecting for bacteria resistant to harsh environmental conditions and selecting against potential bacterial pathogens. Microbiome (2017) 0.75
Cigarette Smoke Disrupted Lung Endothelial Barrier Integrity and Increased Susceptibility to Acute Lung Injury via Histone Deacetylase 6. Am J Respir Cell Mol Biol (2016) 0.75
Double-Hit Mouse Model of Cigarette Smoke Priming for Acute Lung Injury. Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Low-Dose Oxygen Enhances Macrophage-Derived Bacterial Clearance following Cigarette Smoke Exposure. J Immunol Res (2016) 0.75
Streptococcus pneumoniae colonization is required to alter the nasal microbiota in cigarette smoke-exposed mice. Infect Immun (2017) 0.75
Myocardial infarction accelerates atherosclerosis. Nature (2012) 4.48
Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity. Nat Med (2011) 2.87
A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease. J Exp Med (2008) 2.78
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med (2009) 2.66
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage. Hum Mol Genet (2007) 2.54
Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice. Neuron (2010) 2.36
Innate response activator B cells protect against microbial sepsis. Science (2012) 2.07
Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography. Arterioscler Thromb Vasc Biol (2011) 1.66
Bacteria challenge in smoke-exposed mice exacerbates inflammation and skews the inflammatory profile. Am J Respir Crit Care Med (2009) 1.61
Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness. Am J Respir Cell Mol Biol (2003) 1.46
Macrophage elastase kills bacteria within murine macrophages. Nature (2009) 1.42
Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease. J Neurosci (2009) 1.40
Cigarette smoke impacts immune inflammatory responses to influenza in mice. Am J Respir Crit Care Med (2006) 1.38
IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS One (2011) 1.37
Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol (2008) 1.29
Cigarette smoke exposure attenuates cytokine production by mouse alveolar macrophages. Am J Respir Cell Mol Biol (2007) 1.27
House dust mite facilitates ovalbumin-specific allergic sensitization and airway inflammation. Am J Respir Crit Care Med (2005) 1.27
Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice. Am J Respir Cell Mol Biol (2009) 1.23
Cigarette smoke impairs NK cell-dependent tumor immune surveillance. J Immunol (2007) 1.18
Interleukin-13-dependent expression of matrix metalloproteinase-12 is required for the development of airway eosinophilia in mice. Am J Respir Cell Mol Biol (2003) 1.18
Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke. J Leukoc Biol (2007) 1.17
Rescue from excitotoxicity and axonal degeneration accompanied by age-dependent behavioral and neuroanatomical alterations in caspase-6-deficient mice. Hum Mol Genet (2012) 1.16
Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes. J Neurosci (2010) 1.15
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis. Hum Mol Genet (2010) 1.14
Chronic exposure to innocuous antigen in sensitized mice leads to suppressed airway eosinophilia that is reversed by granulocyte macrophage colony-stimulating factor. J Immunol (2002) 1.12
Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo. J Neurosci (2010) 1.10
Mainstream tobacco smoke causes paternal germ-line DNA mutation. Cancer Res (2007) 1.06
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models. Nat Med (2013) 1.04
Mouse models of Huntington disease: variations on a theme. Dis Model Mech (2009) 1.02
Treating viral exacerbations of chronic obstructive pulmonary disease: insights from a mouse model of cigarette smoke and H1N1 influenza infection. PLoS One (2010) 1.01
A fully humanized transgenic mouse model of Huntington disease. Hum Mol Genet (2012) 1.01
Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target. Radiology (2012) 1.00
Cigarette smoke suppresses type I interferon-mediated antiviral immunity in lung fibroblast and epithelial cells. J Interferon Cytokine Res (2008) 0.99
Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation (2014) 0.99
Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization. J Immunol (2005) 0.99
Cigarette smoke and platelet-activating factor receptor dependent adhesion of Streptococcus pneumoniae to lower airway cells. Thorax (2012) 0.98
Lung epithelial CCAAT/enhancer-binding protein-β is necessary for the integrity of inflammatory responses to cigarette smoke. Am J Respir Crit Care Med (2011) 0.98
Altered adult hippocampal neurogenesis in the YAC128 transgenic mouse model of Huntington disease. Neurobiol Dis (2010) 0.98
Cutaneous antigen priming via gene gun leads to skin-selective Th2 immune-inflammatory responses. J Immunol (2005) 0.98
Cigarette smoke exposure leads to follicle loss via an alternative ovarian cell death pathway in a mouse model. Toxicol Sci (2011) 0.97
Adjuvant and anti-inflammatory properties of cigarette smoke in murine allergic airway inflammation. Am J Respir Cell Mol Biol (2008) 0.95
Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice. Respir Res (2012) 0.94
From proliferation to proliferation: monocyte lineage comes full circle. Semin Immunopathol (2014) 0.93
Granulocyte macrophage colony-stimulating factor-driven respiratory mucosal sensitization induces Th2 differentiation and function independently of interleukin-4. Am J Respir Cell Mol Biol (2002) 0.90
Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells. Biol Reprod (2013) 0.89
The influence of cigarette smoking on viral infections: translating bench science to impact COPD pathogenesis and acute exacerbations of COPD clinically. Chest (2013) 0.87
On the generation of allergic airway diseases: from GM-CSF to Kyoto. Trends Immunol (2002) 0.86
Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes. Am J Physiol Lung Cell Mol Physiol (2007) 0.86
Detection of lung dysfunction using ventilation and perfusion SPECT in a mouse model of chronic cigarette smoke exposure. J Nucl Med (2013) 0.85
Cigarette smoke attenuation of poly I:C-induced innate antiviral responses in human PBMC is mainly due to inhibition of IFN-beta production. Mol Immunol (2008) 0.85
Impact of cigarette smoke on T and B cell responsiveness. Cell Immunol (2008) 0.84
B7RP-1 is not required for the generation of Th2 responses in a model of allergic airway inflammation but is essential for the induction of inhalation tolerance. J Immunol (2005) 0.83
Neutrophils usher monocytes into sites of inflammation. Circ Res (2013) 0.83
Cigarette smoke-induced inflammation and respiratory host defense: Insights from animal models. Pulm Pharmacol Ther (2012) 0.82
Inhalation tolerance is induced selectively in thoracic lymph nodes but executed pervasively at distant mucosal and nonmucosal tissues. J Immunol (2006) 0.81
Prolonged ovalbumin exposure attenuates airway hyperresponsiveness and T cell function in mice. Int Arch Allergy Immunol (2006) 0.80
Impact of inflammation, emphysema, and smoking cessation on V/Q in mouse models of lung obstruction. Respir Res (2014) 0.80
Animal models of chronic obstructive pulmonary disease exacerbations. Contrib Microbiol (2007) 0.80
Alterations in skeletal muscle cell homeostasis in a mouse model of cigarette smoke exposure. PLoS One (2013) 0.79
Concomitant airway expression of granulocyte-macrophage colony-stimulating factor and decorin, a natural inhibitor of transforming growth factor-beta, breaks established inhalation tolerance. Eur J Immunol (2004) 0.78
Newly discovered innate response activator B cells: crucial responders against microbial sepsis. Expert Rev Clin Immunol (2012) 0.78
Exposure to cigarette smoke suppresses IL-15 generation and its regulatory NK cell functions in poly I:C-augmented human PBMCs. Mol Immunol (2009) 0.78
Cigarette smoke differentially affects eosinophilia and remodeling in a model of house dust mite asthma. Am J Respir Cell Mol Biol (2011) 0.77
Preclinical models: needed in translation? A Pro/Con debate. Mov Disord (2014) 0.75
Erratum: CCL19-CCR7-dependent reverse transendothelial migration of myeloid cells clears Chlamydia muridarum from the arterial intima. Nat Immunol (2017) 0.75