Published in J Immunol on October 04, 2010
Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy (2016) 7.05
Coordinated changes in AHRR methylation in lymphoblasts and pulmonary macrophages from smokers. Am J Med Genet B Neuropsychiatr Genet (2012) 2.20
Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity. Part Fibre Toxicol (2012) 1.87
Pathogenesis of chronic obstructive pulmonary disease. J Clin Invest (2012) 1.85
Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis. Dig Dis Sci (2011) 1.56
Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro. Environ Health Perspect (2013) 1.47
Autophagy in idiopathic pulmonary fibrosis. PLoS One (2012) 1.45
Histone deacetylase 6-mediated selective autophagy regulates COPD-associated cilia dysfunction. J Clin Invest (2013) 1.29
Induction of inflammasome-dependent pyroptosis by carbon black nanoparticles. J Biol Chem (2011) 1.25
CT-Definable Subtypes of Chronic Obstructive Pulmonary Disease: A Statement of the Fleischner Society. Radiology (2015) 1.24
Characterization of a novel long noncoding RNA, SCAL1, induced by cigarette smoke and elevated in lung cancer cell lines. Am J Respir Cell Mol Biol (2013) 1.16
Contribution of lung macrophages to the inflammatory responses induced by exposure to air pollutants. Mediators Inflamm (2013) 1.14
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. Oncoimmunology (2012) 1.12
zVAD-fmk prevents cisplatin-induced cleavage of autophagy proteins but impairs autophagic flux and worsens renal function. Am J Physiol Renal Physiol (2012) 1.12
Critical role of CFTR-dependent lipid rafts in cigarette smoke-induced lung epithelial injury. Am J Physiol Lung Cell Mol Physiol (2011) 1.09
Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One (2012) 1.03
The emerging importance of autophagy in pulmonary diseases. Chest (2012) 1.03
Autophagy: a core cellular process with emerging links to pulmonary disease. Am J Respir Crit Care Med (2011) 1.00
Autophagy in the immune response to tuberculosis: clinical perspectives. Clin Exp Immunol (2011) 1.00
Cellular targets and mechanisms in the cytotoxic action of non-biodegradable engineered nanoparticles. Curr Drug Metab (2013) 0.95
Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. J Leukoc Biol (2012) 0.93
Tuning the autophagy-inducing activity of lanthanide-based nanocrystals through specific surface-coating peptides. Nat Mater (2012) 0.93
Autophagy in DNA damage response. Int J Mol Sci (2015) 0.93
Autophagy: a potential therapeutic target in lung diseases. Am J Physiol Lung Cell Mol Physiol (2013) 0.92
Regulation and functional significance of autophagy in respiratory cell biology and disease. Am J Respir Cell Mol Biol (2012) 0.89
Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation. Antioxid Redox Signal (2015) 0.89
Emerging role of selective autophagy in human diseases. Front Pharmacol (2014) 0.87
A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER. J Biol Chem (2014) 0.87
UVC-induced mitochondrial degradation via autophagy correlates with mtDNA damage removal in primary human fibroblasts. J Biochem Mol Toxicol (2012) 0.87
Autophagy in Pulmonary Diseases. Am J Respir Crit Care Med (2016) 0.87
Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. Am J Physiol Lung Cell Mol Physiol (2015) 0.85
Chloroquine promotes the anticancer effect of TACE in a rabbit VX2 liver tumor model. Int J Biol Sci (2013) 0.85
Autophagy: a crucial moderator of redox balance, inflammation, and apoptosis in lung disease. Antioxid Redox Signal (2013) 0.83
Nanomaterials and autophagy: new insights in cancer treatment. Cancers (Basel) (2013) 0.83
Nanomaterials toxicity and cell death modalities. J Drug Deliv (2012) 0.82
Size-dependent accumulation of particles in lysosomes modulates dendritic cell function through impaired antigen degradation. Int J Nanomedicine (2014) 0.81
Oxidative stress-induced autophagy: role in pulmonary toxicity. Toxicol Appl Pharmacol (2014) 0.81
Autophagy in lung disease pathogenesis and therapeutics. Redox Biol (2015) 0.80
Co-localization of iron binding on silica with p62/sequestosome1 (SQSTM1) in lung granulomas of mice with acute silicosis. J Clin Biochem Nutr (2014) 0.79
The Unfolded Protein Response in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2016) 0.79
Autophagy deficiency in macrophages enhances NLRP3 inflammasome activity and chronic lung disease following silica exposure. Toxicol Appl Pharmacol (2016) 0.78
Self-eating: friend or foe? The emerging role of autophagy in idiopathic pulmonary fibrosis. Biomed Res Int (2013) 0.78
Mitogen-activated protein kinase phosphatase 1 (MKP-1) in macrophage biology and cardiovascular disease. A redox-regulated master controller of monocyte function and macrophage phenotype. Free Radic Biol Med (2017) 0.75
Making sense of the cause of Crohn's - a new look at an old disease. F1000Res (2016) 0.75
Soft TCPTP Agonism-Novel Target to Rescue Airway Epithelial Integrity by Exogenous Spermidine. Front Pharmacol (2016) 0.75
Autophagy facilitates secretion and protects against degeneration of the Harderian gland. Autophagy (2015) 0.75
Augmenting autophagy for prognosis based intervention of COPD-pathophysiology. Respir Res (2017) 0.75
Autophagy as a Possible Underlying Mechanism of Nanomaterial Toxicity. Nanomaterials (Basel) (2014) 0.75
The cellular selection between apoptosis and autophagy: roles of vitamin D, glucose and immune response in diabetic nephropathy. Endocrine (2017) 0.75
Nicotine Impairs Macrophage Control of Mycobacterium tuberculosis. Am J Respir Cell Mol Biol (2017) 0.75
Autophagy in the pathogenesis of disease. Cell (2008) 34.68
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Methods in mammalian autophagy research. Cell (2010) 20.08
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
Autophagy as a regulated pathway of cellular degradation. Science (2000) 17.27
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell (2004) 12.71
Autophagy suppresses tumorigenesis through elimination of p62. Cell (2009) 9.95
A role for ubiquitin in selective autophagy. Mol Cell (2009) 8.43
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A (2009) 8.25
Selective degradation of mitochondria by mitophagy. Arch Biochem Biophys (2007) 8.24
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1. Nat Cell Biol (2010) 6.95
Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell (2007) 6.39
p62 at the crossroads of autophagy, apoptosis, and cancer. Cell (2009) 5.97
Autophagy, immunity, and microbial adaptations. Cell Host Microbe (2009) 5.84
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol (2009) 5.83
Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell (2005) 5.57
Nix is a selective autophagy receptor for mitochondrial clearance. EMBO Rep (2009) 5.52
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell (2009) 5.18
The mitochondrial permeability transition initiates autophagy in rat hepatocytes. FASEB J (2001) 4.99
The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol (2009) 4.31
Cigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance Team. N Engl J Med (2000) 4.20
Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes. Proc Natl Acad Sci U S A (2008) 3.92
Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med (1974) 3.88
Autophagy genes in immunity. Nat Immunol (2009) 3.76
Evolution and function of ubiquitin-like protein-conjugation systems. Nat Cell Biol (2000) 3.76
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties. Immunity (2010) 3.62
Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice. Gastroenterology (2010) 3.57
Characterization of the role of AMP-activated protein kinase in the regulation of glucose-activated gene expression using constitutively active and dominant negative forms of the kinase. Mol Cell Biol (2000) 3.27
Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6. J Cell Biol (2007) 3.13
Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat Cell Biol (2009) 3.05
Mitophagy in yeast occurs through a selective mechanism. J Biol Chem (2008) 2.80
Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol (2008) 2.70
Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS One (2008) 2.67
Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases. Hum Mol Genet (2007) 2.44
Autophagic proteins regulate cigarette smoke-induced apoptosis: protective role of heme oxygenase-1. Autophagy (2008) 2.38
Cell signaling and function organized by PB1 domain interactions. Mol Cell (2006) 2.34
Autophagy genes protect against Salmonella typhimurium infection and mediate insulin signaling-regulated pathogen resistance. Proc Natl Acad Sci U S A (2009) 2.21
Autophagy in infection. Curr Opin Cell Biol (2010) 2.21
Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells. J Biol Chem (1996) 2.14
Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Mol Cell Biol (2004) 1.86
Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins. J Biol Chem (2008) 1.83
CLEARANCE OF BACTERIA BY THE LOWER RESPIRATORY TRACT. Science (1963) 1.71
Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol (2003) 1.68
Possible mechanisms of emphysema in cigarette smokers. Release of elastase from human polymorphonuclear leukocytes by cigarette smoke condensate in vitro. Am Rev Respir Dis (1978) 1.66
Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66
The fast-growing business of SUMO chains. Mol Cell (2008) 1.66
Biochemistry. All in the ubiquitin family. Science (2000) 1.48
Impact of cigarette smoke on clearance and inflammation after Pseudomonas aeruginosa infection. Am J Respir Crit Care Med (2004) 1.47
Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J Immunol (2008) 1.30
Cigarette smoke: protection of alveolar macrophages by glutathione and cysteine. Science (1968) 1.29
Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters. Autophagy (2009) 1.25
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med (2008) 1.14
Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity. J Biol Chem (1999) 1.12
Accumulation of indigestible substances reduces fusion competence of macrophage lysosomes. J Immunol (1991) 1.08
To aggregate or not to aggregate? A new role for p62. EMBO Rep (2009) 0.98
Pulmonary epithelial neuropilin-1 deletion enhances development of cigarette smoke-induced emphysema. Am J Respir Crit Care Med (2009) 0.93
NDP52: the missing link between ubiquitinated bacteria and autophagy. Nat Immunol (2009) 0.92
Cigarette smoke extract increases S-adenosylmethionine and cystathionine in human lung epithelial-like (A549) cells. Chem Biol Interact (2004) 0.92
Acute exacerbations of idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2007) 6.71
WHO's in second?: A practical review of World Health Organization group 2 pulmonary hypertension. Chest (2013) 4.24
A controlled trial of sildenafil in advanced idiopathic pulmonary fibrosis. N Engl J Med (2010) 4.19
Multigene amplification and massively parallel sequencing for cancer mutation discovery. Proc Natl Acad Sci U S A (2007) 3.93
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell (2010) 3.81
Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense. J Immunol (2008) 2.70
Sarcoidosis. JAMA (2003) 2.21
Comparative genome sequence analysis underscores mycoparasitism as the ancestral life style of Trichoderma. Genome Biol (2011) 2.17
Intraoperative neuromonitoring in single-level spinal procedures: a retrospective propensity score-matched analysis in a national longitudinal database. Spine (Phila Pa 1976) (2014) 2.06
Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol (2006) 1.90
Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin. J Biol Chem (2003) 1.80
Cigarette smoke induces cellular senescence. Am J Respir Cell Mol Biol (2006) 1.66
Vitamin D decreases respiratory syncytial virus induction of NF-kappaB-linked chemokines and cytokines in airway epithelium while maintaining the antiviral state. J Immunol (2009) 1.65
Respiratory syncytial virus inhibits apoptosis and induces NF-kappa B activity through a phosphatidylinositol 3-kinase-dependent pathway. J Biol Chem (2001) 1.54
Specific inhibition of type I interferon signal transduction by respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.49
Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro. Environ Health Perspect (2013) 1.47
Important roles for macrophage colony-stimulating factor, CC chemokine ligand 2, and mononuclear phagocytes in the pathogenesis of pulmonary fibrosis. Am J Respir Crit Care Med (2007) 1.46
Antioxidant therapy for idiopathic pulmonary fibrosis. N Engl J Med (2005) 1.43
Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Bioorg Med Chem Lett (2007) 1.39
Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. J Immunol (2008) 1.30
Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis. J Biol Chem (2004) 1.29
Noninfectious lung pathology in patients with Crohn's disease. Am J Surg Pathol (2003) 1.25
Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. Cancer Res (2006) 1.24
Biodegradable nanoparticles composed entirely of safe materials that rapidly penetrate human mucus. Angew Chem Int Ed Engl (2011) 1.23
Role of repeated lung injury and genetic background in bleomycin-induced fibrosis. Am J Respir Cell Mol Biol (2003) 1.21
Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1. J Immunol (2006) 1.19
Anti-inflammatory response is associated with mortality and severity of infection in sepsis. Am J Physiol Lung Cell Mol Physiol (2004) 1.17
Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. Am J Respir Crit Care Med (2008) 1.14
Transcriptional induction of the Pseudomonas aeruginosa type III secretion system by low Ca2+ and host cell contact proceeds through two distinct signaling pathways. Infect Immun (2006) 1.11
Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17. J Immunol (2007) 1.09
Phosphatidylinositol 3-kinase activity negatively regulates stability of cyclooxygenase 2 mRNA. J Biol Chem (2002) 1.05
Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. J Immunol (2007) 1.04
Cigarette smoking decreases global microRNA expression in human alveolar macrophages. PLoS One (2012) 1.03
Early exposure to IL-4 stabilizes IL-4 mRNA in CD4+ T cells via RNA-binding protein HuR. J Immunol (2006) 1.02
Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway. J Biol Chem (2011) 1.01
Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice. J Immunol (2002) 1.00
Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus. Am J Respir Cell Mol Biol (2004) 1.00
Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses. J Immunol (2014) 0.96
Gene expression and microscopic analysis of Arabidopsis exposed to chloroacetanilide herbicides and explosive compounds. A phytoremediation approach. Plant Physiol (2005) 0.96
Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity. J Immunol (2004) 0.95
Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication. J Biol Chem (2010) 0.95
Cigarette smoke alters respiratory syncytial virus-induced apoptosis and replication. Am J Respir Cell Mol Biol (2009) 0.95
Microfluidic device for studying cell migration in single or co-existing chemical gradients and electric fields. Biomicrofluidics (2012) 0.94
Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure. J Immunol (2003) 0.94
Transgenic alteration of ethylene biosynthesis increases grain yield in maize under field drought-stress conditions. Plant Biotechnol J (2014) 0.94
Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance. Am J Respir Crit Care Med (2008) 0.93
Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression. J Leukoc Biol (2012) 0.93
Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation. J Biol Chem (2005) 0.92
Mitochondrial K(ATP) channel openers activate the ERK kinase by an oxidant-dependent mechanism. Am J Physiol Cell Physiol (2002) 0.92
Aspergillus versicolor, a new causative agent of canine disseminated aspergillosis. J Clin Microbiol (2011) 0.91
Interaction of matrix with integrin receptors is required for optimal LPS-induced MAP kinase activation. Am J Physiol Lung Cell Mol Physiol (2002) 0.89
Severe bacteremia results in a loss of hepatic bacterial clearance. Am J Respir Crit Care Med (2006) 0.89
Strandwise translocation of a DNA glycosylase on undamaged DNA. Proc Natl Acad Sci U S A (2012) 0.89
High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. Am J Respir Cell Mol Biol (2004) 0.89
Oxidant-mediated increases in redox factor-1 nuclear protein and activator protein-1 DNA binding in asbestos-treated macrophages. J Immunol (2002) 0.88
A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER. J Biol Chem (2014) 0.87
Structural and biochemical analysis of DNA helix invasion by the bacterial 8-oxoguanine DNA glycosylase MutM. J Biol Chem (2013) 0.87
Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis. Crit Care Med (2004) 0.87
Sequence-dependent structural variation in DNA undergoing intrahelical inspection by the DNA glycosylase MutM. J Biol Chem (2012) 0.86
Effect of segmental bronchoalveolar lavage on quantitative computed tomography of the lung. Acad Radiol (2011) 0.85
Chronic liver disease impairs bacterial clearance in a human model of induced bacteremia. Clin Transl Sci (2009) 0.84
Pleiotropic functions of TNF-alpha determine distinct IKKbeta-dependent hepatocellular fates in response to LPS. Am J Physiol Gastrointest Liver Physiol (2006) 0.84
Second messenger pathways in pulmonary host defense. Annu Rev Physiol (2002) 0.84
Adenovirus vectors activate survival pathways in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 0.84
Interferons increase cell resistance to Staphylococcal alpha-toxin. Infect Immun (2007) 0.84
The cardiac (pro)renin receptor is primarily expressed in myocyte transverse tubules and is increased in experimental diabetic cardiomyopathy. J Hypertens (2011) 0.83
Magnetic resonance imaging-based treatment planning for prostate brachytherapy. Brachytherapy (2012) 0.83
First-generation adenovirus vectors shorten survival time in a murine model of sepsis. J Immunol (2002) 0.82
Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. J Immunol (2003) 0.82
Two Distinct Categories of Focal Deletions in Cancer Genomes. PLoS One (2013) 0.82
Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis protein. J Immunol (2007) 0.82
Purification and characterization of alkaline pectin lyase from a newly isolated Bacillus clausii and its application in elicitation of plant disease resistance. Appl Biochem Biotechnol (2012) 0.81
Anterior Versus Posterior Approach for Multilevel Degenerative Cervical Disease: A Retrospective Propensity Score-Matched Study of the MarketScan Database. Spine (Phila Pa 1976) (2015) 0.81
Integrin receptors are crucial for the restimulation of activated T lymphocytes. Am J Respir Cell Mol Biol (2003) 0.81
Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein. J Biol Chem (2003) 0.81