Published in Blood on August 19, 2004
Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature (2013) 3.39
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med (2008) 3.03
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components. J Exp Med (2009) 2.26
Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J Virol (2006) 2.24
Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation. Clin Immunol (2010) 2.19
HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology (2006) 2.17
HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood (2007) 2.10
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med (2004) 1.71
Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Proc Natl Acad Sci U S A (2011) 1.71
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Human thrombopoietin knockin mice efficiently support human hematopoiesis in vivo. Proc Natl Acad Sci U S A (2011) 1.44
The utilization of humanized mouse models for the study of human retroviral infections. Retrovirology (2009) 1.42
High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med (2013) 1.40
Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection. Clin Vaccine Immunol (2007) 1.39
T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells. J Exp Med (2008) 1.35
Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A (2011) 1.35
Human NK cells of mice with reconstituted human immune system components require preactivation to acquire functional competence. Blood (2010) 1.32
Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One (2010) 1.29
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Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice. Dis Model Mech (2011) 1.16
Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PLoS One (2010) 1.13
IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo. Proc Natl Acad Sci U S A (2011) 1.10
IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice. Mucosal Immunol (2012) 1.09
Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation. J Immunol (2013) 1.06
Mouse models for the study of HCV infection and virus-host interactions. J Hepatol (2008) 1.05
HIV-1 immunopathogenesis in humanized mouse models. Cell Mol Immunol (2012) 1.03
IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs. Nat Immunol (2016) 1.02
From meta-omics to causality: experimental models for human microbiome research. Microbiome (2013) 1.02
From genes to function: the next challenge to understanding multiple sclerosis. Nat Rev Immunol (2009) 1.01
Development of a humanized mouse model to study the role of macrophages in allograft injury. Transplantation (2009) 0.98
Establishing humanized mice using stem cells: maximizing the potential. Clin Exp Immunol (2008) 0.97
HTLV-1 propels thymic human T cell development in "human immune system" Rag2⁻/⁻ gamma c⁻/⁻ mice. PLoS Pathog (2011) 0.96
FER kinase promotes breast cancer metastasis by regulating α6- and β1-integrin-dependent cell adhesion and anoikis resistance. Oncogene (2013) 0.95
Overcoming current limitations in humanized mouse research. J Infect Dis (2013) 0.95
Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci (2010) 0.94
Highly active antiretroviral therapy potently suppresses HIV infection in humanized Rag2-/-gammac-/- mice. AIDS Res Hum Retroviruses (2010) 0.93
Preclinical in vivo evaluation of the safety of a multi-shRNA-based gene therapy against HIV-1. Mol Ther Nucleic Acids (2013) 0.93
Use of humanized severe combined immunodeficient mice for human vaccine development. Expert Rev Vaccines (2009) 0.93
Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS One (2009) 0.92
Titers of lentiviral vectors encoding shRNAs and miRNAs are reduced by different mechanisms that require distinct repair strategies. RNA (2010) 0.92
Humoral immunity in humanized mice: a work in progress. J Infect Dis (2013) 0.92
Characterization of oligophrenin-1, a RhoGAP lost in patients affected with mental retardation: lentiviral injection in organotypic brain slice cultures. Methods Enzymol (2008) 0.89
Correction of murine SCID-X1 by lentiviral gene therapy using a codon-optimized IL2RG gene and minimal pretransplant conditioning. Mol Ther (2011) 0.88
Correction of murine Rag2 severe combined immunodeficiency by lentiviral gene therapy using a codon-optimized RAG2 therapeutic transgene. Mol Ther (2012) 0.87
OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Blood (2014) 0.87
Modeling HIV-associated neurocognitive disorders in mice: new approaches in the changing face of HIV neuropathogenesis. Dis Model Mech (2012) 0.86
Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2rγnull mouse model: a multivariable optimization approach. Clin Immunol (2011) 0.85
A novel mouse model for stable engraftment of a human immune system and human hepatocytes. PLoS One (2015) 0.84
An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice. PLoS One (2010) 0.83
Humanized mice: novel model for studying mechanisms of human immune-based therapies. Immunol Res (2013) 0.82
Selection of RNAi-based inhibitors for anti-HIV gene therapy. World J Virol (2012) 0.81
p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP. Cell Cycle (2012) 0.80
The impact of unprotected T cells in RNAi-based gene therapy for HIV-AIDS. Mol Ther (2013) 0.78
Hematopoietic stem cells. Methods Enzymol (2006) 0.78
Summary of presentations at the NIH/NIAID New Humanized Rodent Models 2007 Workshop. AIDS Res Ther (2008) 0.78
Increasing hematopoietic stem cell yield to develop mice with human immune systems. Biomed Res Int (2013) 0.78
Conserved and divergent aspects of human T-cell development and migration in humanized mice. Immunol Cell Biol (2015) 0.77
New challenges in modern vaccinology. BMC Immunol (2015) 0.77
Isolation and in vitro generation of gene-manipulated human plasmacytoid and conventional dendritic cells. Methods Mol Biol (2010) 0.77
A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion. J Gen Virol (2012) 0.77
Delayed onset of graft-versus-host disease in immunodeficent human leucocyte antigen-DQ8 transgenic, murine major histocompatibility complex class II-deficient mice repopulated by human peripheral blood mononuclear cells. Clin Exp Immunol (2013) 0.76
Novel approaches for immune reconstitution and adaptive immune modeling with human pluripotent stem cells. BMC Med (2011) 0.76
Mesenchymal Cell Invasion Requires Cooperative Regulation of Persistent Microtubule Growth by SLAIN2 and CLASP1. Dev Cell (2016) 0.75
Replication of Epstein-Barr virus primary infection in human tonsil tissue explants. PLoS One (2011) 0.75
cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response. Cell Cycle (2016) 0.75
Modeling Natural Killer Cell Targeted Immunotherapies. Front Immunol (2017) 0.75
Creation of an immunodeficient HLA-transgenic mouse (HUMAMICE) and functional validation of human immunity after transfer of HLA-matched human cells. PLoS One (2017) 0.75
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol (2011) 5.05
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol (2008) 4.94
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 4.84
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol (2009) 4.73
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol (2008) 4.69
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science (2013) 3.90
Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers. J Immunol (2002) 3.35
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity (2012) 3.15
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med (2008) 3.03
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82
Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. J Exp Med (2010) 2.64
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Development of human lymphoid cells. Annu Rev Immunol (2006) 2.22
Development and activation of regulatory T cells in the human fetus. Eur J Immunol (2005) 2.15
Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nat Rev Immunol (2009) 2.04
Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nat Med (2009) 2.03
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol (2008) 1.97
Experimental models to study development and function of the human immune system in vivo. J Immunol (2006) 1.94
The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling. J Exp Med (2004) 1.92
Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis. Blood (2010) 1.86
Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2. Immunity (2010) 1.85
A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice. Blood (2003) 1.74
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med (2004) 1.71
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients. J Clin Oncol (2005) 1.70
Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med (2010) 1.68
Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. Blood (2005) 1.66
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev (2002) 1.65
From interleukin-23 to T-helper 17 cells: human T-helper cell differentiation revisited. Immunol Rev (2008) 1.65
Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59
Immunological and antitumor effects of IL-23 as a cancer vaccine adjuvant. J Immunol (2006) 1.59
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol (2005) 1.57
HIV-1 infection of hematopoietic progenitor cells in vivo in humanized mice. Blood (2013) 1.51
Intermediate expression of CCRL1 reveals novel subpopulations of medullary thymic epithelial cells that emerge in the postnatal thymus. Eur J Immunol (2014) 1.42
High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med (2013) 1.40
Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection. Clin Vaccine Immunol (2007) 1.39
Thrombopoietin cooperates with FLT3-ligand in the generation of plasmacytoid dendritic cell precursors from human hematopoietic progenitors. Blood (2003) 1.37
Persistent gammaherpesvirus replication and dynamic interaction with the host in vivo. J Virol (2008) 1.36
Development of human plasmacytoid dendritic cells depends on the combined action of the basic helix-loop-helix factor E2-2 and the Ets factor Spi-B. Eur J Immunol (2008) 1.36
Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer. Gastroenterology (2002) 1.35
T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells. J Exp Med (2008) 1.35
Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A (2011) 1.35
A common solution to group 2 influenza virus neutralization. Proc Natl Acad Sci U S A (2013) 1.34
The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. Blood (2002) 1.32
Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One (2010) 1.29
The CD40-TRAF6 axis is the key regulator of the CD40/CD40L system in neointima formation and arterial remodeling. Blood (2008) 1.29
The transcription factor encyclopedia. Genome Biol (2012) 1.28
Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J Immunol (2006) 1.28
New insights into the regulation of human B-cell differentiation. Trends Immunol (2009) 1.26
The clone size of peripheral CD8 T cells is regulated by TCR promiscuity. J Exp Med (2006) 1.24
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice. Blood (2006) 1.23
MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis. Circ Res (2012) 1.19
Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection. J Immunol (2004) 1.19
IL-7 enhances thymic human T cell development in "human immune system" Rag2-/-IL-2Rgammac-/- mice without affecting peripheral T cell homeostasis. J Immunol (2009) 1.18
Repopulation efficiencies of adult hepatocytes, fetal liver progenitor cells, and embryonic stem cell-derived hepatic cells in albumin-promoter-enhancer urokinase-type plasminogen activator mice. Am J Pathol (2009) 1.18
Functional Differences between Human NKp44(-) and NKp44(+) RORC(+) Innate Lymphoid Cells. Front Immunol (2012) 1.17
Ectopic hTERT expression extends the life span of human CD4+ helper and regulatory T-cell clones and confers resistance to oxidative stress-induced apoptosis. Blood (2003) 1.17
Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J Exp Med (2009) 1.16
Intrathymic and extrathymic development of human plasmacytoid dendritic cell precursors in vivo. Blood (2002) 1.16
Macrophage microRNA-155 promotes cardiac hypertrophy and failure. Circulation (2013) 1.14
Quantitative events determine the differentiation and function of helper T cells. Nat Immunol (2011) 1.13
Neoantigen landscape dynamics during human melanoma-T cell interactions. Nature (2016) 1.12