Published in Genes Dev on March 15, 2002
Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation. Nat Immunol (2010) 3.48
Cell cycle inhibition by FoxO forkhead transcription factors involves downregulation of cyclin D. Mol Cell Biol (2002) 3.20
Making sense of cancer genomic data. Genes Dev (2011) 3.01
What has senescence got to do with cancer? Cancer Cell (2005) 2.55
Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood (2007) 2.28
CD20 deficiency in humans results in impaired T cell-independent antibody responses. J Clin Invest (2009) 2.15
Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nat Med (2009) 2.03
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol (2008) 1.97
Transcriptional profiling of antigen-dependent murine B cell differentiation and memory formation. J Immunol (2007) 1.63
BCL6 is critical for the development of a diverse primary B cell repertoire. J Exp Med (2010) 1.56
Histone acetyltransferase activity of p300 is required for transcriptional repression by the promyelocytic leukemia zinc finger protein. Mol Cell Biol (2005) 1.52
Novel retroviral vectors to facilitate expression screens in mammalian cells. Nucleic Acids Res (2002) 1.51
Repression of BCL-6 is required for the formation of human memory B cells in vitro. J Exp Med (2007) 1.41
Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J (2009) 1.33
Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One (2010) 1.29
How to become immortal: let MEFs count the ways. Aging (Albany NY) (2010) 1.14
p16 and ARF: activation of teenage proteins in old age. J Clin Invest (2004) 1.04
C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev (2002) 1.02
B-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells. BMC Cancer (2014) 0.99
Building an outcome predictor model for diffuse large B-cell lymphoma. Am J Pathol (2004) 0.99
Wild-type and Hupki (human p53 knock-in) murine embryonic fibroblasts: p53/ARF pathway disruption in spontaneous escape from senescence. J Biol Chem (2010) 0.97
miR-127 regulates cell proliferation and senescence by targeting BCL6. PLoS One (2013) 0.94
Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol (2004) 0.92
BCL6-mediated attenuation of DNA damage sensing triggers growth arrest and senescence through a p53-dependent pathway in a cell context-dependent manner. J Biol Chem (2008) 0.90
Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proc Natl Acad Sci U S A (2008) 0.90
Circadian disruption-induced microRNAome deregulation in rat mammary gland tissues. Oncoscience (2015) 0.89
Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. PLoS One (2012) 0.89
Cell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition. Mol Biol Cell (2015) 0.85
BACH2-BCL6 balance regulates selection at the pre-B cell receptor checkpoint. Trends Immunol (2013) 0.85
Suppression of human B cell activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin involves altered regulation of B cell lymphoma-6. Toxicol Sci (2014) 0.83
Role of Peroxisome Proliferator-Activated Receptor β/δ and B-Cell Lymphoma-6 in Regulation of Genes Involved in Metastasis and Migration in Pancreatic Cancer Cells. PPAR Res (2013) 0.83
Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Hum Mol Genet (2013) 0.81
Cancer gene discovery in mouse and man. Biochim Biophys Acta (2009) 0.81
Inhibition of doxorubicin-induced senescence by PPARδ activation agonists in cardiac muscle cells: cooperation between PPARδ and Bcl6. PLoS One (2012) 0.80
ADAR1 protein induces adenosine-targeted DNA mutations in senescent Bcl6 gene-deficient cells. J Biol Chem (2012) 0.79
Immunosenescence is associated with altered gene expression and epigenetic regulation in primary and secondary immune organs. Front Genet (2013) 0.79
Integrative genomic approaches to understanding cancer. Biochim Biophys Acta (2009) 0.78
The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain. PLoS One (2014) 0.78
Stable long-term cultures of self-renewing B cells and their applications. Immunol Rev (2016) 0.78
Role of the Transcriptional Repressor BCL6 in Allergic Response and Inflammation. World Allergy Organ J (2008) 0.77
Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5. PLoS One (2011) 0.76
BTB-Zinc Finger Oncogenes Are Required for Ras and Notch-Driven Tumorigenesis in Drosophila. PLoS One (2015) 0.76
BCL6 modulation of acute lymphoblastic leukemia response to chemotherapy. Oncotarget (2016) 0.76
Cross-species gene modules emerge from a systems biology approach to osteoarthritis. NPJ Syst Biol Appl (2017) 0.75
Synthetic Lethal Screen Demonstrates That a JAK2 Inhibitor Suppresses a BCL6-dependent IL10RA/JAK2/STAT3 Pathway in High Grade B-cell Lymphoma. J Biol Chem (2016) 0.75
Inhibition of the transcriptional repressor complex Bcl-6/BCoR induces endothelial sprouting but does not promote tumor growth. Oncotarget (2016) 0.75
The Krüppel-like factor 9 cistrome in mouse hippocampal neurons reveals predominant transcriptional repression via proximal promoter binding. BMC Genomics (2017) 0.75
BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A (2017) 0.75
Identity, proliferation capacity, genomic stability and novel senescence markers of mesenchymal stem cells isolated from low volume of human bone marrow. Oncotarget (2016) 0.75
An essential EBV latent antigen 3C binds Bcl6 for targeted degradation and cell proliferation. PLoS Pathog (2017) 0.75
Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell (1997) 29.13
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature (1992) 25.54
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature (1999) 12.60
Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell (1997) 12.41
Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev (1998) 9.03
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00
mdm2 expression is induced by wild type p53 activity. EMBO J (1993) 8.01
Specific protection against breast cancers by cyclin D1 ablation. Nature (2001) 6.94
Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell (1995) 6.08
Association of human cyclin E with a periodic G1-S phase protein kinase. Science (1992) 5.98
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation. Nat Genet (1997) 5.55
BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity (2000) 5.36
Cellular senescence: mitotic clock or culture shock? Cell (2000) 5.17
p14ARF links the tumour suppressors RB and p53. Nature (1998) 4.78
MDMX: a novel p53-binding protein with some functional properties of MDM2. EMBO J (1996) 4.13
In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene (1993) 4.03
Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science (1993) 3.89
Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions. Genes Dev (2000) 3.74
Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature (2001) 3.57
Long-term human B cell lines dependent on interleukin-4 and antibody to CD40. Science (1991) 3.56
BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor. Proc Natl Acad Sci U S A (1996) 3.10
Senescence bypass screen identifies TBX2, which represses Cdkn2a (p19(ARF)) and is amplified in a subset of human breast cancers. Nat Genet (2000) 2.87
Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts. Curr Biol (1998) 2.42
Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras. Oncogene (1999) 2.00
Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo. Genes Dev (1998) 1.88
A genetic screen to identify genes that rescue the slow growth phenotype of c-myc null fibroblasts. Oncogene (2000) 1.67
Differential effects of p19(Arf) and p16(Ink4a) loss on senescence of murine bone marrow-derived preB cells and macrophages. Proc Natl Acad Sci U S A (2001) 1.51
p16 INK4a can initiate an autonomous senescence program. Oncogene (2000) 1.50
Escape from premature senescence is not sufficient for oncogenic transformation by Ras. Nat Cell Biol (2001) 1.36
The molecular and cellular origins of Hodgkin's disease. J Exp Med (2000) 1.21
Expression of the BCL6 gene in the pre- and postnatal mouse. Biochem Biophys Res Commun (1998) 1.04
Enrichment of an antigen-specific T cell response by retrovirally transduced human dendritic cells. Cell Immunol (1999) 0.97
Conditional transformation of mouse liver epithelial cells. An in vitro model for analysis of genetic events in hepatocarcinogenesis. Am J Pathol (1995) 0.91
Common-variable immunodeficiency-related lymphomas associate with mutations and rearrangements of BCL-6: pathogenetic and histogenetic implications. Hum Pathol (2000) 0.83
Gene expression profiling predicts clinical outcome of breast cancer. Nature (2002) 71.36
A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med (2002) 58.15
A system for stable expression of short interfering RNAs in mammalian cells. Science (2002) 35.21
Reprogramming of human somatic cells to pluripotency with defined factors. Nature (2007) 30.84
Disease-specific induced pluripotent stem cells. Cell (2008) 16.95
Selective blockade of microRNA processing by Lin28. Science (2008) 14.39
Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell (2010) 14.18
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell (2007) 11.21
Targeted and genome-scale strategies reveal gene-body methylation signatures in human cells. Nat Biotechnol (2009) 11.18
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat Genet (2009) 10.54
Somatic coding mutations in human induced pluripotent stem cells. Nature (2011) 9.50
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature (2012) 9.39
A genomic and functional inventory of deubiquitinating enzymes. Cell (2005) 9.36
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell (2009) 8.97
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature (2008) 8.69
A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature (2004) 8.67
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res (2008) 8.12
YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol (2007) 8.11
Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer Cell (2005) 7.99
Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell (2002) 7.88
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming. Nat Biotechnol (2009) 7.59
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature (2007) 7.55
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature (2011) 7.43
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells. Cell Stem Cell (2011) 7.41
Live cell imaging distinguishes bona fide human iPS cells from partially reprogrammed cells. Nat Biotechnol (2009) 6.76
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature (2003) 6.53
Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet (2009) 6.35
Comprehensive methylome map of lineage commitment from haematopoietic progenitors. Nature (2010) 6.06
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors. Cell (2002) 5.71
Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell (2003) 5.71
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature (2011) 5.68
Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells. Nat Genet (2010) 5.37
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol (2011) 5.05
The promise of induced pluripotent stem cells in research and therapy. Nature (2012) 5.05
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol (2008) 4.94
Generation of induced pluripotent stem cells from human blood. Blood (2009) 4.92
Haploid genetic screens in human cells identify host factors used by pathogens. Science (2009) 4.91
Yap1 acts downstream of α-catenin to control epidermal proliferation. Cell (2011) 4.85
Generation of human-induced pluripotent stem cells. Nat Protoc (2008) 4.85
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 4.84
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol (2009) 4.73
In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs. Mayo Clin Proc (2015) 4.70
Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell (2009) 4.69
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol (2008) 4.69
Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol (2006) 4.67
The Lin28/let-7 axis regulates glucose metabolism. Cell (2011) 4.65
Converting a breast cancer microarray signature into a high-throughput diagnostic test. BMC Genomics (2006) 4.57
Derivation of embryonic germ cells and male gametes from embryonic stem cells. Nature (2003) 4.56
Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy. Cell (2002) 4.56
Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. Nat Cell Biol (2006) 4.54
Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep (2003) 4.52
Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem (2008) 4.40
The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway. Mol Cell (2005) 4.40
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene. Nat Cell Biol (2005) 4.29
Enabling personalized cancer medicine through analysis of gene-expression patterns. Nature (2008) 4.24
Chromatin-modifying enzymes as modulators of reprogramming. Nature (2012) 4.22
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature (2009) 4.14
MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling. Cell (2012) 4.01
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol (2011) 3.97
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature (2009) 3.93
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science (2013) 3.90
Protein phosphatase 2A regulatory subunits and cancer. Biochim Biophys Acta (2008) 3.74
Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235. Cancer Res (2008) 3.70
Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature (2010) 3.39
Lin28: A microRNA regulator with a macro role. Cell (2010) 3.39
Generation of functional human hepatic endoderm from human induced pluripotent stem cells. Hepatology (2010) 3.36
Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells. Nat Biotechnol (2011) 3.25
Human immunodeficiency virus type 1 escapes from RNA interference-mediated inhibition. J Virol (2004) 3.23
Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat Struct Mol Biol (2008) 3.18
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity (2012) 3.15
Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell (2010) 3.08
Lin28 enhances tissue repair by reprogramming cellular metabolism. Cell (2013) 3.08
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med (2008) 3.03
Broader implications of defining standards for the pluripotency of iPSCs. Cell Stem Cell (2009) 3.03
Biomechanical forces promote embryonic haematopoiesis. Nature (2009) 2.99
Influence of threonine metabolism on S-adenosylmethionine and histone methylation. Science (2012) 2.98
Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival. Cell (2011) 2.98
Reprogramming of T cells from human peripheral blood. Cell Stem Cell (2010) 2.93
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell (2009) 2.93
An shRNA barcode screen provides insight into cancer cell vulnerability to MDM2 inhibitors. Nat Chem Biol (2006) 2.91
A role for Lin28 in primordial germ-cell development and germ-cell malignancy. Nature (2009) 2.88
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice. PLoS One (2011) 2.86
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82
A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells. PLoS Genet (2009) 2.78
High-efficiency RNA interference in human embryonic stem cells. Stem Cells (2005) 2.76
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling. Cell (2005) 2.73
Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet (2010) 2.72
Midbody accumulation through evasion of autophagy contributes to cellular reprogramming and tumorigenicity. Nat Cell Biol (2011) 2.65
Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. J Exp Med (2010) 2.64
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells (2009) 2.59
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Induced pluripotent stem cells--opportunities for disease modelling and drug discovery. Nat Rev Drug Discov (2011) 2.58
Teratoma formation assays with human embryonic stem cells: a rationale for one type of human-animal chimera. Cell Stem Cell (2007) 2.56