Published in Blood on April 10, 2003
Telomere length of transferred lymphocytes correlates with in vivo persistence and tumor regression in melanoma patients receiving cell transfer therapy. J Immunol (2005) 4.10
Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer's disease patients. J Immunol (2007) 3.20
Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol (2004) 3.20
Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods (2009) 2.78
Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes (2008) 2.52
Homeostasis of the naive CD4+ T cell compartment during aging. J Immunol (2008) 2.48
Telomere length and heredity: Indications of paternal inheritance. Proc Natl Acad Sci U S A (2005) 2.10
Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci U S A (2004) 1.83
Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A (2009) 1.54
Persistence of tumor infiltrating lymphocytes in adoptive immunotherapy correlates with telomere length. J Immunother (2007) 1.46
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood (2005) 1.37
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol (2008) 1.34
Telomeres and immunological diseases of aging. Gerontology (2009) 1.22
Telomerase activity of HIV-1-specific CD8+ T cells: constitutive up-regulation in controllers and selective increase by blockade of PD ligand 1 in progressors. Blood (2008) 1.20
HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes. Blood (2010) 1.13
Telomere and adaptive immunity. Mech Ageing Dev (2007) 1.02
Making the most of a little: dosage effects in eukaryotic telomere length maintenance. Chromosome Res (2005) 0.95
Telomere loss, senescence, and genetic instability in CD4+ T lymphocytes overexpressing hTERT. Blood (2005) 0.94
Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome. PLoS One (2012) 0.90
Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One (2014) 0.88
An antiapoptotic role for telomerase RNA in human immune cells independent of telomere integrity or telomerase enzymatic activity. Blood (2014) 0.84
A challenge for the future: aging and HIV infection. Immunol Res (2010) 0.83
A balanced transcription between telomerase and the telomeric DNA-binding proteins TRF1, TRF2 and Pot1 in resting, activated, HTLV-1-transformed and Tax-expressing human T lymphocytes. Retrovirology (2005) 0.82
Telomerase is involved in IL-7-mediated differential survival of naive and memory CD4+ T cells. J Immunol (2008) 0.82
p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP. Cell Cycle (2012) 0.80
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Functional assessment of pharmacological telomerase activators in human T cells. Cells (2013) 0.75
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Immortalization of human and rhesus macaque primary antigen-specific T cells by retrovirally transduced telomerase reverse transcriptase. Curr Protoc Immunol (2011) 0.75
Accelerated telomere shortening in peripheral blood lymphocytes after occupational polychlorinated biphenyls exposure. Arch Toxicol (2016) 0.75
The Maintenance of Telomere Length in CD28+ T Cells During T Lymphocyte Stimulation. Sci Rep (2017) 0.75
Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells. N Engl J Med (2004) 12.20
Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med (2007) 8.23
Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med (2005) 7.09
Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates. J Clin Invest (2008) 6.15
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol (2003) 5.38
Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol (2011) 5.05
Human fetal lymphoid tissue-inducer cells are interleukin 17-producing precursors to RORC+ CD127+ natural killer-like cells. Nat Immunol (2008) 4.94
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med (2006) 4.84
Telomeres and aging. Physiol Rev (2008) 4.79
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from T(H)-17, T(H)1 and T(H)2 cells. Nat Immunol (2009) 4.73
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol (2008) 4.69
TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. Am J Hum Genet (2008) 4.12
Flow cytometry and FISH to measure the average length of telomeres (flow FISH). Nat Protoc (2006) 4.00
Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus. Science (2013) 3.90
Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc Natl Acad Sci U S A (2008) 3.86
Very short telomere length by flow fluorescence in situ hybridization identifies patients with dyskeratosis congenita. Blood (2007) 3.86
Disruption of dog-1 in Caenorhabditis elegans triggers deletions upstream of guanine-rich DNA. Nat Genet (2002) 3.50
The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells. Immunity (2012) 3.15
IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J Exp Med (2008) 3.03
Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol (2008) 3.03
Regulation of murine telomere length by Rtel: an essential gene encoding a helicase-like protein. Cell (2004) 2.91
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol (2013) 2.82
Late presentation of dyskeratosis congenita as apparently acquired aplastic anaemia due to mutations in telomerase RNA. Lancet (2003) 2.76
Mutations of the human telomerase RNA gene (TERC) in aplastic anemia and myelodysplastic syndrome. Blood (2003) 2.73
Human NKp44+IL-22+ cells and LTi-like cells constitute a stable RORC+ lineage distinct from conventional natural killer cells. J Exp Med (2010) 2.64
Humanized mice for modeling human infectious disease: challenges, progress, and outlook. Cell Host Microbe (2009) 2.58
Constitutional hypomorphic telomerase mutations in patients with acute myeloid leukemia. Proc Natl Acad Sci U S A (2009) 2.44
Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol (2010) 2.27
Development of human lymphoid cells. Annu Rev Immunol (2006) 2.22
Development and activation of regulatory T cells in the human fetus. Eur J Immunol (2005) 2.15
Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells. J Immunol (2004) 2.04
Interleukin-22-producing innate immune cells: new players in mucosal immunity and tissue repair? Nat Rev Immunol (2009) 2.04
Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming. Nat Med (2009) 2.03
The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A (2005) 2.01
STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol (2008) 1.97
Experimental models to study development and function of the human immune system in vivo. J Immunol (2006) 1.94
CD27 expression promotes long-term survival of functional effector-memory CD8+ cytotoxic T lymphocytes in HIV-infected patients. J Exp Med (2004) 1.92
The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling. J Exp Med (2004) 1.92
DNA template strand sequencing of single-cells maps genomic rearrangements at high resolution. Nat Methods (2012) 1.85
Regulation of cytokine secretion in human CD127(+) LTi-like innate lymphoid cells by Toll-like receptor 2. Immunity (2010) 1.85
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo. Nat Genet (2012) 1.81
Telomere length measurement-caveats and a critical assessment of the available technologies and tools. Mutat Res (2011) 1.79
A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice. Blood (2003) 1.74
Telomere length is associated with disease severity and declines with age in dyskeratosis congenita. Haematologica (2011) 1.71
The ETS transcription factor Spi-B is required for human plasmacytoid dendritic cell development. J Exp Med (2004) 1.71
Skin-depigmenting agent monobenzone induces potent T-cell autoimmunity toward pigmented cells by tyrosinase haptenation and melanosome autophagy. J Invest Dermatol (2011) 1.71
Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients. J Clin Oncol (2005) 1.70
Delta-like1-induced Notch1 signaling regulates the human plasmacytoid dendritic cell versus T-cell lineage decision through control of GATA-3 and Spi-B. Blood (2005) 1.66
A senescence rescue screen identifies BCL6 as an inhibitor of anti-proliferative p19(ARF)-p53 signaling. Genes Dev (2002) 1.65
Synchrony of telomere length among hematopoietic cells. Exp Hematol (2010) 1.63
Mutations in the SBDS gene in acquired aplastic anemia. Blood (2007) 1.62
Multiparameter grouping delineates heterogeneous populations of human IL-17 and/or IL-22 T-cell producers that share antigen specificities with other T-cell subsets. Eur J Immunol (2011) 1.59
STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression. Nat Immunol (2005) 1.57
A spectrum of severe familial liver disorders associate with telomerase mutations. PLoS One (2009) 1.57
Functional characterization of natural telomerase mutations found in patients with hematologic disorders. Blood (2006) 1.57
Collapse of telomere homeostasis in hematopoietic cells caused by heterozygous mutations in telomerase genes. PLoS Genet (2012) 1.57
Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients. J Invest Dermatol (2009) 1.56
RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Mol Cell Biol (2006) 1.54
Detection of G-quadruplex DNA in mammalian cells. Nucleic Acids Res (2013) 1.53
Identification of sister chromatids by DNA template strand sequences. Nature (2009) 1.53
In vivo vitiligo induction and therapy model: double-blind, randomized clinical trial. Pigment Cell Melanoma Res (2011) 1.50
Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum Mol Genet (2003) 1.48
Telomere length measurement by fluorescence in situ hybridization and flow cytometry: tips and pitfalls. Cytometry (2002) 1.43
High-throughput identification of antigen-specific TCRs by TCR gene capture. Nat Med (2013) 1.40
Use of a novel chimeric mouse model with a functionally active human immune system to study human immunodeficiency virus type 1 infection. Clin Vaccine Immunol (2007) 1.39
Identification and functional characterization of 2 variant alleles of the telomerase RNA template gene (TERC) in a patient with dyskeratosis congenita. Blood (2005) 1.37
Telomere length measurements in leukocyte subsets by automated multicolor flow-FISH. Cytometry A (2003) 1.36
Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. J Immunol (2007) 1.36
Generation of regulatory gut-homing human T lymphocytes using ex vivo interleukin 10 gene transfer. Gastroenterology (2002) 1.35
T cell-independent development and induction of somatic hypermutation in human IgM+ IgD+ CD27+ B cells. J Exp Med (2008) 1.35
IL-22 participates in an innate anti-HIV-1 host-resistance network through acute-phase protein induction. J Immunol (2007) 1.35
Functional CD47/signal regulatory protein alpha (SIRP(alpha)) interaction is required for optimal human T- and natural killer- (NK) cell homeostasis in vivo. Proc Natl Acad Sci U S A (2011) 1.35
A common solution to group 2 influenza virus neutralization. Proc Natl Acad Sci U S A (2013) 1.34
Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol (2004) 1.33
Functional characterization of telomerase RNA variants found in patients with hematologic disorders. Blood (2004) 1.33
The transcription factor Spi-B is expressed in plasmacytoid DC precursors and inhibits T-, B-, and NK-cell development. Blood (2002) 1.32
Autoimmune etiology of generalized vitiligo. Curr Dir Autoimmun (2008) 1.31
Induction of a peptide with activity against a broad spectrum of pathogens in the Aedes aegypti salivary gland, following Infection with Dengue Virus. PLoS Pathog (2011) 1.30
Generation of human antigen-specific monoclonal IgM antibodies using vaccinated "human immune system" mice. PLoS One (2010) 1.29
A Fluorospot assay to detect single T lymphocytes simultaneously producing multiple cytokines. J Immunol Methods (2003) 1.29
Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genet (2011) 1.29
Telomere length in subpopulations of human hematopoietic cells. Stem Cells (2003) 1.28
Constitutively active beta-catenin promotes expansion of multipotent hematopoietic progenitors in culture. J Immunol (2006) 1.28
RTEL1 contributes to DNA replication and repair and telomere maintenance. Mol Biol Cell (2012) 1.28
Longitudinal data on telomere length in leukocytes from newborn baboons support a marked drop in stem cell turnover around 1 year of age. Aging Cell (2006) 1.28
Hematopoietic stem-cell behavior in nonhuman primates. Blood (2007) 1.27
RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination. Nucleic Acids Res (2010) 1.27
Telomere length in human natural killer cell subsets. Ann N Y Acad Sci (2007) 1.25
Dengue-virus-infected dendritic cells trigger vascular leakage through metalloproteinase overproduction. EMBO Rep (2006) 1.24
Transient accumulation of human mature thymocytes and regulatory T cells with CD28 superagonist in "human immune system" Rag2(-/-)gammac(-/-) mice. Blood (2006) 1.23
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res (2002) 1.20
Telomere restoration and extension of proliferative lifespan in dyskeratosis congenita fibroblasts. Aging Cell (2007) 1.20
Endogenous IFN-alpha production by plasmacytoid dendritic cells exerts an antiviral effect on thymic HIV-1 infection. J Immunol (2004) 1.19