PubRank

Takashi Tsuruo

Author PubWeight™ 146.37‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res 2002 3.01
2 Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol 2004 2.63
3 Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J Cell Biol 2003 2.40
4 Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst 2004 2.30
5 Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res 2008 2.20
6 Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem 2002 2.17
7 Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res 2003 2.04
8 Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell 2005 1.96
9 C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol Cancer Ther 2002 1.95
10 Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell 2005 1.82
11 Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res 2005 1.76
12 Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem 2003 1.67
13 Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res 2005 1.65
14 Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem 2003 1.59
15 Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res 2004 1.58
16 Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Mol Cell Biol 2005 1.56
17 Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem 2002 1.55
18 Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res 2009 1.53
19 Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. Proc Natl Acad Sci U S A 2004 1.49
20 The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. Am J Pathol 2007 1.46
21 Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. Tumour Biol 2005 1.45
22 Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene 2002 1.42
23 Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol 2007 1.39
24 Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet 2004 1.35
25 Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. Int J Cancer 2002 1.29
26 Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway. J Biol Chem 2004 1.29
27 Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene 2005 1.27
28 Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. J Biol Chem 2002 1.26
29 Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol Pharmacol 2003 1.26
30 Cullin 3 promotes proteasomal degradation of the topoisomerase I-DNA covalent complex. Cancer Res 2004 1.25
31 Blocking telomerase by dietary polyphenols is a major mechanism for limiting the growth of human cancer cells in vitro and in vivo. Cancer Res 2003 1.24
32 p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target. J Natl Cancer Inst 2005 1.23
33 B1 integrin/Fak/Src signaling in intestinal epithelial crypt cell survival: integration of complex regulatory mechanisms. Apoptosis 2008 1.22
34 Aggrus: a diagnostic marker that distinguishes seminoma from embryonal carcinoma in testicular germ cell tumors. Oncogene 2004 1.20
35 Functional sialylated O-glycan to platelet aggregation on Aggrus (T1alpha/Podoplanin) molecules expressed in Chinese hamster ovary cells. J Biol Chem 2004 1.20
36 Telomere shortening and growth inhibition of human cancer cells by novel synthetic telomerase inhibitors MST-312, MST-295, and MST-1991. Mol Cancer Ther 2002 1.13
37 Intestinal epithelial cancer cell anoikis resistance: EGFR-mediated sustained activation of Src overrides Fak-dependent signaling to MEK/Erk and/or PI3-K/Akt-1. J Cell Biochem 2009 1.13
38 Freud-1/Aki1, a novel PDK1-interacting protein, functions as a scaffold to activate the PDK1/Akt pathway in epidermal growth factor signaling. Mol Cell Biol 2008 1.13
39 Modulation of heat-shock protein 27 (Hsp27) anti-apoptotic activity by methylglyoxal modification. J Biol Chem 2002 1.13
40 Human intestinal epithelial cell survival and anoikis. Differentiation state-distinct regulation and roles of protein kinase B/Akt isoforms. J Biol Chem 2004 1.12
41 PRMT5, a novel TRAIL receptor-binding protein, inhibits TRAIL-induced apoptosis via nuclear factor-kappaB activation. Mol Cancer Res 2009 1.12
42 Regulation of kinase activity of 3-phosphoinositide-dependent protein kinase-1 by binding to 14-3-3. J Biol Chem 2002 1.10
43 Involvement of the lysophosphatidic acid-generating enzyme autotaxin in lymphocyte-endothelial cell interactions. Am J Pathol 2008 1.08
44 3-Phosphoinositide-dependent protein kinase-1-mediated IkappaB kinase beta (IkkB) phosphorylation activates NF-kappaB signaling. J Biol Chem 2005 1.07
45 Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer. Cancer Res 2002 1.07
46 Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. Acta Neuropathol 2006 1.06
47 Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells. Biol Pharm Bull 2007 1.05
48 Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis. Blood 2008 1.05
49 Human intestinal epithelial crypt cell survival and death: Complex modulations of Bcl-2 homologs by Fak, PI3-K/Akt-1, MEK/Erk, and p38 signaling pathways. J Cell Physiol 2004 1.05
50 Cellular FLIP inhibits beta-catenin ubiquitylation and enhances Wnt signaling. Mol Cell Biol 2004 1.04
51 p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet 2007 1.02
52 A novel endoplasmic reticulum export signal: proline at the +2-position from the signal peptide cleavage site. J Biol Chem 2009 1.01
53 Topotecan inhibits VEGF- and bFGF-induced vascular endothelial cell migration via downregulation of the PI3K-Akt signaling pathway. Int J Cancer 2002 1.01
54 Dofequidar fumarate (MS-209) in combination with cyclophosphamide, doxorubicin, and fluorouracil for patients with advanced or recurrent breast cancer. J Clin Oncol 2006 1.01
55 Hypoxia up-regulates glyceraldehyde-3-phosphate dehydrogenase in mouse brain capillary endothelial cells: involvement of Na+/Ca2+ exchanger. Biochim Biophys Acta 2003 1.00
56 Transforming growth factor-beta1 upregulates the tight junction and P-glycoprotein of brain microvascular endothelial cells. Cell Mol Neurobiol 2004 1.00
57 IL12RB2 and ABCA1 genes are associated with susceptibility to radiation dermatitis. Clin Cancer Res 2008 0.99
58 Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide. Cancer Sci 2009 0.99
59 Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis. Oncogene 2003 0.99
60 Nucleobindin 1 controls the unfolded protein response by inhibiting ATF6 activation. J Biol Chem 2007 0.98
61 Enhancement of L-cystine transport activity and its relation to xCT gene induction at the blood-brain barrier by diethyl maleate treatment. J Pharmacol Exp Ther 2002 0.97
62 Functional subdomain in the ankyrin domain of tankyrase 1 required for poly(ADP-ribosyl)ation of TRF1 and telomere elongation. Mol Cell Biol 2004 0.97
63 Estrone and 17beta-estradiol reverse breast cancer resistance protein-mediated multidrug resistance. Jpn J Cancer Res 2002 0.97
64 Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. Cancer Sci 2009 0.97
65 Mitochondria regulate the unfolded protein response leading to cancer cell survival under glucose deprivation conditions. Cancer Sci 2010 0.96
66 Defects of the apoptotic pathway as therapeutic target against cancer. Drug Resist Updat 2005 0.96
67 Transforming growth factor-beta induces expression of receptor activator of NF-kappa B ligand in vascular endothelial cells derived from bone. J Biol Chem 2002 0.95
68 Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis. Mol Cell Biol 2002 0.95
69 Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol 2006 0.95
70 Involvement of mitochondrial aggregation in arsenic trioxide (As2O3)-induced apoptosis in human glioblastoma cells. Cancer Sci 2005 0.94
71 Impairment of the ubiquitin-proteasome system by cellular FLIP. Genes Cells 2007 0.93
72 CXCL13 is an arrest chemokine for B cells in high endothelial venules. Blood 2005 0.92
73 TUSC4/NPRL2, a novel PDK1-interacting protein, inhibits PDK1 tyrosine phosphorylation and its downstream signaling. Cancer Sci 2008 0.92
74 Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists. Mol Cancer Ther 2003 0.92
75 Reduced sialidase expression in highly metastatic variants of mouse colon adenocarcinoma 26 and retardation of their metastatic ability by sialidase overexpression. Int J Cancer 2002 0.91
76 Uptake and efflux of quinacrine, a candidate for the treatment of prion diseases, at the blood-brain barrier. Cell Mol Neurobiol 2004 0.91
77 Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer. Cancer Res 2002 0.91
78 Caspase-independent necrotic cell death induced by a radiosensitizer, 8-nitrocaffeine. Cancer Sci 2004 0.90
79 Small molecules destabilize cIAP1 by activating auto-ubiquitylation. J Biol Chem 2008 0.90
80 Taxoids and abietanes from callus cultures of Taxus cuspidata. J Nat Prod 2005 0.90
81 Stabilization of integrin-linked kinase by binding to Hsp90. Biochem Biophys Res Commun 2005 0.90
82 TRF1 mediates mitotic abnormalities induced by Aurora-A overexpression. Cancer Res 2010 0.89
83 Modulation of Wnt signaling by the nuclear localization of cellular FLIP-L. J Cell Sci 2010 0.89
84 Preventing the unfolded protein response via aberrant activation of 4E-binding protein 1 by versipelostatin. Cancer Sci 2009 0.89
85 Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K/Akt signaling and suppresses tumor growth in vivo. Cancer Res 2007 0.88
86 Drug resistance in chemotherapy for breast cancer. Cancer Chemother Pharmacol 2005 0.88
87 Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex. Gastroenterology 2007 0.88
88 Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. J Biol Chem 2004 0.88
89 Cross-species difference in telomeric function of tankyrase 1. Cancer Sci 2007 0.87
90 Biodistribution and ultrastructural localization of single-walled carbon nanohorns determined in vivo with embedded Gd2O3 labels. ACS Nano 2009 0.87
91 Bioactive triterpene saponins from the roots of Phytolacca americana. J Nat Prod 2008 0.87
92 Involvement of Fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells. Glia 2009 0.86
93 Prediction of sensitivity to STI571 among chronic myeloid leukemia patients by genome-wide cDNA microarray analysis. Jpn J Cancer Res 2002 0.86
94 Evaluation of MS-209, a novel multidrug-resistance-reversing agent, in tumour-bearing mice by technetium-99m-MIBI imaging. Eur J Nucl Med Mol Imaging 2002 0.86
95 Prevention of carbon nanohorn agglomeration using a conjugate composed of comb-shaped polyethylene glycol and a peptide aptamer. Mol Pharm 2009 0.85
96 HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells. Biochem Biophys Res Commun 2005 0.84
97 Two populations of Thy1-positive mesenchymal cells regulate in vitro maturation of hepatic progenitor cells. Am J Physiol Gastrointest Liver Physiol 2006 0.84
98 SUMO-1 conjugation to intact DNA topoisomerase I amplifies cleavable complex formation induced by camptothecin. Oncogene 2002 0.84
99 Bioactive cardenolides from the stems and twigs of Nerium oleander. J Nat Prod 2007 0.84
100 Saturable distribution of tacrine into the striatal extracellular fluid of the rat: evidence of involvement of multiple organic cation transporters in the transport. Drug Metab Dispos 2004 0.83
101 Nuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs. Cancer Res 2002 0.83
102 Inhibition of transforming growth factor-beta production in brain pericytes contributes to cyclosporin A-induced dysfunction of the blood-brain barrier. Cell Mol Neurobiol 2006 0.82
103 Decreased synthesis of matrix metalloproteinase-7 and adhesion to the extracellular matrix proteins of human colon cancer cells treated with troglitazone. Surg Today 2002 0.82
104 Hypoxic up-regulation of triosephosphate isomerase expression in mouse brain capillary endothelial cells. Arch Biochem Biophys 2004 0.82
105 Adverse effect of cyclosporin A on barrier functions of cerebral microvascular endothelial cells after hypoxia-reoxygenation damage in vitro. Cell Mol Neurobiol 2007 0.82
106 Reconstitution of caspase-3 confers low glucose-enhanced tumor necrosis factor-related apoptosis-inducing ligand cytotoxicity and Akt cleavage. Clin Cancer Res 2004 0.81
107 Chelating compound, chrysoidine, is more effective in both antiprion activity and brain endothelial permeability than quinacrine. Cell Mol Neurobiol 2007 0.81
108 Bioactive tetrahydrofuran lignans from Peperomia dindygulensis. J Nat Prod 2005 0.81
109 P-glycoprotein inhibition by the multidrug resistance-reversing agent MS-209 enhances bioavailability and antitumor efficacy of orally administered paclitaxel. Cancer Chemother Pharmacol 2002 0.80
110 Induction of oncogene addiction shift to NF-kappaB by camptothecin in solid tumor cells. Biochem Biophys Res Commun 2009 0.80
111 Absolute stereochemistry and antitumor activity of iejimalides. Bioorg Med Chem 2005 0.80
112 MS-209, a quinoline-type reversal agent, potentiates antitumor efficacy of docetaxel in multidrug-resistant solid tumor xenograft models. Clin Cancer Res 2002 0.79
113 In vivo veritas: Bcl-2 and Bcl-X(L)mediate tumor cell resistance to chemotherapy. Drug Resist Updat 2000 0.79
114 Transluminal gene transfer into brain capillary endothelial cells in vivo with HVJ-liposomes. J Drug Target 2002 0.79
115 In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells. Hum Gene Ther 2003 0.79
116 Drug-selected co-expression of P-glycoprotein and gp91 in vivo from an MDR1-bicistronic retrovirus vector Ha-MDR-IRES-gp91. J Gene Med 2003 0.79
117 Survival-signaling pathway as a promising target for cancer chemotherapy. Cancer Chemother Pharmacol 2003 0.79
118 Group IID heparin-binding secretory phospholipase A(2) is expressed in human colon carcinoma cells and human mast cells and up-regulated in mouse inflammatory tissues. Eur J Biochem 2002 0.79
119 Evaluation of tankyrase inhibition in whole cells. Methods Mol Biol 2007 0.79
120 Production of biologically active taxoids by a callus culture of Taxus cuspidata. J Nat Prod 2004 0.78
121 Clonal endothelial cells produce humoral factors that inhibit osteoclast-like cell formation in vitro. Endocr J 2002 0.78
122 Pilot study of MDR1 gene transfer into hematopoietic stem cells and chemoprotection in metastatic breast cancer patients. Cancer Sci 2007 0.78
123 Contribution of P-glycoprotein to efflux of ramosetron, a 5-HT3 receptor antagonist, across the blood-brain barrier. J Pharm Pharmacol 2002 0.78
124 Inhibition of P-glycoprotein by flavonoid derivatives in adriamycin-resistant human myelogenous leukemia (K562/ADM) cells. Cancer Lett 2002 0.78
125 Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy. Int J Oncol 2007 0.78
126 Functional characterization of adenosine transport across the BBB in mice. Int J Pharm 2005 0.78
127 Telomere elongation by a mutant tankyrase 1 without TRF1 poly(ADP-ribosyl)ation. Exp Cell Res 2007 0.78
128 Nitric oxide mediates cyclosporine-induced impairment of the blood-brain barrier in cocultures of mouse brain endothelial cells and rat astrocytes. Eur J Pharmacol 2004 0.78
129 Bioactive polyketides from Peperomia duclouxii. J Nat Prod 2007 0.77
130 Tolbutamide uptake via pH- and membrane-potential-dependent transport mechanism in mouse brain capillary endothelial cell line. Drug Metab Pharmacokinet 2004 0.77
131 Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii. J Nat Prod 2006 0.77
132 An inhibitory role of nitric oxide in the dynamic regulation of the blood-brain barrier function. Cell Mol Neurobiol 2007 0.76
133 Screening with COMPARE analysis for telomerase inhibitors. Methods Mol Biol 2002 0.76
134 Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain. J Pharm Sci 2010 0.76
135 Pharmacokinetic characterization of dehydroevodiamine in the rat brain. J Pharm Sci 2004 0.75
136 Effects of various methoxyflavones on vincristine uptake and multidrug resistance to vincristine in P-gp-overexpressing K562/ADM cells. Pharm Res 2007 0.75
137 Transport of somatostatin and substance P by human P-glycoprotein. FEBS Lett 2004 0.75
138 Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells. Bioorg Med Chem Lett 2007 0.75
139 Protective action of indapamide, a thiazide-like diuretic, on ischemia-induced injury and barrier dysfunction in mouse brain microvascular endothelial cells. J Pharmacol Sci 2007 0.75
140 [Cancer prevention]. Gan To Kagaku Ryoho 2005 0.75
141 [Post launch studies]. Gan To Kagaku Ryoho 2002 0.75
142 [Molecule based diagnosis]. Gan To Kagaku Ryoho 2004 0.75
143 The centennial of Cancer Science. Cancer Sci 2007 0.75
144 Structure-activity relationships of some taxoids as multidrug resistance modulator. Bioorg Med Chem Lett 2007 0.75
145 [Anti angiogenesis]. Gan To Kagaku Ryoho 2004 0.75
146 Application of in vivo ESR/spin-probe technique to monitor tumor in vivo in mouse footpad. Antioxid Redox Signal 2007 0.75
147 A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent. Chem Pharm Bull (Tokyo) 2006 0.75
148 [Introduction to the symposium "Bio-informatics for Pharmaceutical Sciences and Pharmacy Education". Foreword]. Yakugaku Zasshi 2008 0.75
149 [Globalization of anti-cancer therapies]. Gan To Kagaku Ryoho 2002 0.75
150 Tumorigenesis facilitated by Pten deficiency in the skin: evidence of p53-Pten complex formation on the initiation phase. Cancer Sci 2005 0.75
151 [Cancer screening]. Gan To Kagaku Ryoho 2005 0.75
152 Molecular targeting therapy for cancer: the Twelfth International Symposium of the Hiroshima Cancer Seminar, November 2002. Cancer Sci 2003 0.75
153 Retraction. Epigenetic regulator polycomb group protein complexes control cell fate and cancer, Cancer Science 2008; 99: 1077-84. Cancer Sci 2008 0.75
154 [Globalization of clinical trials]. Gan To Kagaku Ryoho 2003 0.75
155 [New approach in drug designing: molecular-targeted drugs]. Nihon Naika Gakkai Zasshi 2002 0.75
156 Bioactive lignans from Peperomia duclouxii. J Nat Prod 2007 0.75
157 [Future directions of anticancer drug development in Japan]. Gan To Kagaku Ryoho 2008 0.75