Published in J Nat Prod on November 01, 2005
A synthetic entry to pladienolide B and FD-895. Bioorg Med Chem Lett (2007) 0.92
Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells by inhibition of DNA methyltransferase. Cancer Sci (2016) 0.75
Global quantification of mammalian gene expression control. Nature (2011) 22.36
High-quality binary protein interaction map of the yeast interactome network. Science (2008) 10.65
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Evidence for substantial fine-scale variation in recombination rates across the human genome. Nat Genet (2004) 6.99
miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades. Nucleic Acids Res (2011) 5.83
The oyster genome reveals stress adaptation and complexity of shell formation. Nature (2012) 5.30
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo. EMBO J (2003) 3.96
Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest (2009) 3.45
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release. Circ Res (2002) 3.01
Mice lacking histone deacetylase 6 have hyperacetylated tubulin but are viable and develop normally. Mol Cell Biol (2008) 2.85
Mapping translocation breakpoints by next-generation sequencing. Genome Res (2008) 2.73
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function. Nat Cell Biol (2004) 2.63
Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation (2012) 2.58
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes. Nat Immunol (2010) 2.53
Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J Cell Biol (2003) 2.40
Ablation of beta1 integrin in mammary epithelium reveals a key role for integrin in glandular morphogenesis and differentiation. J Cell Biol (2005) 2.33
Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatol (2010) 2.33
Effect on tumor cells of blocking survival response to glucose deprivation. J Natl Cancer Inst (2004) 2.30
A protein domain-based interactome network for C. elegans early embryogenesis. Cell (2008) 2.23
Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. Cancer Res (2008) 2.20
Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization. J Biol Chem (2002) 2.17
Asymmetric dimethylarginine in response to recombinant tissue-type plasminogen activator and erythropoietin in acute stroke. Stroke (2013) 2.07
Predominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptide. Cancer Res (2003) 2.04
Artificial muscles from fishing line and sewing thread. Science (2014) 2.04
Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling. Am J Pathol (2008) 1.97
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell (2005) 1.96
C421A polymorphism in the human breast cancer resistance protein gene is associated with low expression of Q141K protein and low-level drug resistance. Mol Cancer Ther (2002) 1.95
Smad3 signaling critically regulates fibroblast phenotype and function in healing myocardial infarction. Circ Res (2010) 1.94
Aging-related defects are associated with adverse cardiac remodeling in a mouse model of reperfused myocardial infarction. J Am Coll Cardiol (2008) 1.90
Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell (2011) 1.89
Molecular targeting therapy of cancer: drug resistance, apoptosis and survival signal. Cancer Sci (2003) 1.86
Large-scale sorting of C. elegans embryos reveals the dynamics of small RNA expression. Nat Methods (2009) 1.82
Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. Biochem Biophys Res Commun (2011) 1.82
Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell (2005) 1.82
Electrically, chemically, and photonically powered torsional and tensile actuation of hybrid carbon nanotube yarn muscles. Science (2012) 1.80
Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development (2013) 1.79
Endogenous thrombospondin 1 protects the pressure-overloaded myocardium by modulating fibroblast phenotype and matrix metabolism. Hypertension (2011) 1.79
Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production. Brain Res (2005) 1.76
Plasma microRNAs, miR-223, miR-21 and miR-218, as novel potential biomarkers for gastric cancer detection. PLoS One (2012) 1.70
OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology (2005) 1.69
Molecular identification of Aggrus/T1alpha as a platelet aggregation-inducing factor expressed in colorectal tumors. J Biol Chem (2003) 1.67
A novel retinoic acid receptor beta isoform and retinoid resistance in lung carcinogenesis. J Natl Cancer Inst (2005) 1.67
Ribozyme catalysis of metabolism in the RNA world. Chem Biodivers (2007) 1.66
Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab (2008) 1.65
Blockade of the stromal cell-derived factor-1/CXCR4 axis attenuates in vivo tumor growth by inhibiting angiogenesis in a vascular endothelial growth factor-independent manner. Cancer Res (2005) 1.65
Findings of perinatal ocular examination performed on 3573, healthy full-term newborns. Br J Ophthalmol (2013) 1.64
CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm (2012) 1.63
Novel genetic variants contributing to left ventricular hypertrophy: the HyperGEN study. J Hypertens (2009) 1.61
Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem (2003) 1.59
Comprehensive survey of human brain microRNA by deep sequencing. BMC Genomics (2010) 1.59
Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res (2004) 1.58
Interplay of mevalonate and Hippo pathways regulates RHAMM transcription via YAP to modulate breast cancer cell motility. Proc Natl Acad Sci U S A (2013) 1.57
MicroRNA-driven developmental remodeling in the brain distinguishes humans from other primates. PLoS Biol (2011) 1.57
A self-assembled DNA nanostructure-amplified quartz crystal microbalance with dissipation biosensing platform for nucleic acids. Chem Commun (Camb) (2012) 1.56
Coordinated ciliary beating requires Odf2-mediated polarization of basal bodies via basal feet. Cell (2012) 1.56
Widespread expression of piRNA-like molecules in somatic tissues. Nucleic Acids Res (2011) 1.56
Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Mol Cell Biol (2005) 1.56
Involvement of Hsp90 in signaling and stability of 3-phosphoinositide-dependent kinase-1. J Biol Chem (2002) 1.55
SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells. PLoS One (2012) 1.55
The hydrogen sulfide donor NaHS promotes angiogenesis in a rat model of hind limb ischemia. Antioxid Redox Signal (2010) 1.54
Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation. Cancer Res (2009) 1.53
Paired-end sequencing of Fosmid libraries by Illumina. Genome Res (2012) 1.52
Cellular FLIP (long form) regulates CD8+ T cell activation through caspase-8-dependent NF-kappa B activation. J Immunol (2005) 1.51
Toll-like receptor 3 is an essential component of the innate stress response in virus-induced cardiac injury. Am J Physiol Heart Circ Physiol (2006) 1.50
Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. Proc Natl Acad Sci U S A (2004) 1.49
SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol (2011) 1.48
The platelet aggregation-inducing factor aggrus/podoplanin promotes pulmonary metastasis. Am J Pathol (2007) 1.46
Characterization of the inflammatory and fibrotic response in a mouse model of cardiac pressure overload. Histochem Cell Biol (2008) 1.45
Enhanced expression of Aggrus (T1alpha/podoplanin), a platelet-aggregation-inducing factor in lung squamous cell carcinoma. Tumour Biol (2005) 1.45
Ideal cardiovascular health metrics and the risks of ischemic and intracerebral hemorrhagic stroke. Stroke (2013) 1.45
A nonpeptidic agonist of glucagon-like peptide 1 receptors with efficacy in diabetic db/db mice. Proc Natl Acad Sci U S A (2007) 1.43
Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene (2002) 1.42
Activation of the receptor for advanced glycation end products (RAGE) exacerbates experimental autoimmune myasthenia gravis symptoms. Clin Immunol (2011) 1.42
Gene expression differences in mice divergently selected for methamphetamine sensitivity. Mamm Genome (2005) 1.41
Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res (2012) 1.41
Spectrotemporal receptive fields in the inferior colliculus revealing selectivity for spectral motion in conspecific vocalizations. J Neurosci (2007) 1.40
Simvastatin suppresses the proangiogenic microenvironment of human hepatic stellate cells via the Kruppel-like factor 2 pathway. Rev Esp Enferm Dig (2015) 1.39
Fak/Src signaling in human intestinal epithelial cell survival and anoikis: differentiation state-specific uncoupling with the PI3-K/Akt-1 and MEK/Erk pathways. J Cell Physiol (2007) 1.39
Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension (2010) 1.39
The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activation-induced cell death of lymphocytes. Mol Cell Biol (2002) 1.36
Circulatory miR34a as an RNAbased, noninvasive biomarker for brain aging. Aging (Albany NY) (2011) 1.35
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839). Hum Mol Genet (2004) 1.35
Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol (2008) 1.34
Intergenic and repeat transcription in human, chimpanzee and macaque brains measured by RNA-Seq. PLoS Comput Biol (2010) 1.33
Identification of MyD88 as a novel target of miR-155, involved in negative regulation of Helicobacter pylori-induced inflammation. FEBS Lett (2010) 1.33
Up-regulated microRNA-146a negatively modulate Helicobacter pylori-induced inflammatory response in human gastric epithelial cells. Microbes Infect (2010) 1.33
SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network. Cancer Lett (2013) 1.32
Pseudorabies virus variant in Bartha-K61-vaccinated pigs, China, 2012. Emerg Infect Dis (2013) 1.31
Dominant-negative inhibition of breast cancer resistance protein as drug efflux pump through the inhibition of S-S dependent homodimerization. Int J Cancer (2002) 1.29
Involvement of 3-phosphoinositide-dependent protein kinase-1 in the MEK/MAPK signal transduction pathway. J Biol Chem (2004) 1.29
Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation (2013) 1.29
A p53-dominant transcriptional response to cisplatin in testicular germ cell tumor-derived human embryonal carcinoma. Oncogene (2005) 1.28
Subtyping Cryptosporidium ubiquitum,a zoonotic pathogen emerging in humans. Emerg Infect Dis (2014) 1.28
Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res (2012) 1.27
Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene (2005) 1.27
High recombination rates and hotspots in a Plasmodium falciparum genetic cross. Genome Biol (2011) 1.27