Published in J Biol Chem on September 13, 2011
Histone lysine methylation dynamics: establishment, regulation, and biological impact. Mol Cell (2012) 2.85
KDM4/JMJD2 histone demethylases: epigenetic regulators in cancer cells. Cancer Res (2013) 1.65
Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation. J Biol Chem (2013) 1.17
The roles of Jumonji-type oxygenases in human disease. Epigenomics (2014) 1.05
Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase. J Biol Chem (2014) 1.05
Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential. Am J Transl Res (2013) 1.01
Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation. PLoS One (2013) 0.99
RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation. Nucleic Acids Res (2014) 0.91
Investigations on the oxygen dependence of a 2-oxoglutarate histone demethylase. Biochem J (2013) 0.90
Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro. PLoS One (2013) 0.90
Open access target validation is a more efficient way to accelerate drug discovery. PLoS Biol (2015) 0.90
Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates. Epigenetics (2014) 0.88
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J Med Chem (2016) 0.86
HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. PLoS One (2012) 0.86
Reconstitution of nucleosome demethylation and catalytic properties of a Jumonji histone demethylase. Chem Biol (2013) 0.86
Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. Am J Cancer Res (2015) 0.85
KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis. Nucleic Acids Res (2014) 0.85
Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol (2016) 0.84
KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor. J Med Chem (2014) 0.84
Histone demethylase GASC1, a potential prognostic and predictive marker in esophageal squamous cell carcinoma. Am J Cancer Res (2013) 0.81
Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases. Nat Commun (2016) 0.80
Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells. ACS Med Chem Lett (2015) 0.80
Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway. Biol Open (2015) 0.79
Opposing Chromatin Signals Direct and Regulate the Activity of Lysine Demethylase 4C (KDM4C). J Biol Chem (2016) 0.79
Structural investigations of the nickel-induced inhibition of truncated constructs of the JMJD2 family of histone demethylases using X-ray absorption spectroscopy. Biochemistry (2013) 0.78
Substrate- and cofactor-independent inhibition of histone demethylase KDM4C. ACS Chem Biol (2014) 0.78
Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry. Anal Chem (2014) 0.78
H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication. Nucleic Acids Res (2016) 0.77
KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis. Cell Rep (2016) 0.76
KDM4C, a H3K9me3 Histone Demethylase, is Involved in the Maintenance of Human ESCC-Initiating Cells by Epigenetically Enhancing SOX2 Expression. Neoplasia (2016) 0.76
Reader domain specificity and lysine demethylase-4 family function. Nat Commun (2016) 0.76
Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nat Commun (2017) 0.75
KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res (2017) 0.75
The activity of JmjC histone lysine demethylase KDM4A is highly sensitive to oxygen concentrations. ACS Chem Biol (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
The CCP4 suite: programs for protein crystallography. Acta Crystallogr D Biol Crystallogr (1994) 187.88
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
Chromatin modifications and their function. Cell (2007) 55.98
A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80
Likelihood-enhanced fast translation functions. Acta Crystallogr D Biol Crystallogr (2005) 29.38
Automated protein model building combined with iterative structure refinement. Nat Struct Biol (1999) 27.52
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell (2004) 21.30
Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell (2008) 13.49
Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88
Histone demethylation by a family of JmjC domain-containing proteins. Nature (2005) 10.36
Zebrafish hox clusters and vertebrate genome evolution. Science (1998) 8.50
Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell (2006) 7.08
JmjC-domain-containing proteins and histone demethylation. Nat Rev Genet (2006) 6.65
Regulation of histone methylation by demethylimination and demethylation. Nat Rev Mol Cell Biol (2007) 6.13
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell (2007) 6.04
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. Genes Dev (2007) 5.79
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature (2006) 5.51
New nomenclature for chromatin-modifying enzymes. Cell (2007) 5.34
Dynamic regulation of histone lysine methylation by demethylases. Mol Cell (2007) 5.14
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature (2006) 4.74
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science (2006) 4.54
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression. Nat Cell Biol (2007) 3.89
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase. Nat Struct Mol Biol (2007) 3.77
PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell (2007) 3.68
Structural insights into histone demethylation by JMJD2 family members. Cell (2006) 3.37
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells. Genes Dev (2006) 3.24
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation. Am J Hum Genet (2004) 2.99
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature (2010) 2.91
Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases. Nat Struct Mol Biol (2009) 2.87
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell (2010) 2.77
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer. Proc Natl Acad Sci U S A (2007) 2.45
Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor. Nat Struct Mol Biol (2007) 2.22
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol (2010) 2.17
The histone demethylases JMJD1A and JMJD2B are transcriptional targets of hypoxia-inducible factor HIF. J Biol Chem (2008) 2.00
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J (2008) 1.95
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol (2010) 1.91
A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD). Am J Med Genet A (2008) 1.89
Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate. J Med Genet (2005) 1.78
Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D. Biochem Biophys Res Commun (2007) 1.75
Diversity within the JMJD2 histone demethylase family. Biochem Biophys Res Commun (2006) 1.74
Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc Natl Acad Sci U S A (2007) 1.74
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem (2008) 1.74
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One (2010) 1.71
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep (2010) 1.62
Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chem Biol (2010) 1.62
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer. Oncogene (2009) 1.58
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J (2007) 1.58
Members of a family of JmjC domain-containing oncoproteins immortalize embryonic fibroblasts via a JmjC domain-dependent process. Proc Natl Acad Sci U S A (2008) 1.55
Identification and characterization of JMJD2 family genes in silico. Int J Oncol (2004) 1.52
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet (2009) 1.44
Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate. Clin Genet (2007) 1.41
The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth. Cancer Res (2010) 1.40
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem (2010) 1.31
Novel JARID1C/SMCX mutations in patients with X-linked mental retardation. Hum Mutat (2006) 1.26
PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol (2010) 1.25
Histone demethylase JmjD2A regulates neural crest specification. Dev Cell (2010) 1.20
Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol (2007) 1.15
The histone demethylase JMJD2C is stage-specifically expressed in preimplantation mouse embryos and is required for embryonic development. Biol Reprod (2009) 1.07
A novel mutation in JARID1C gene associated with mental retardation. Eur J Hum Genet (2006) 1.07
Structural insights into a novel histone demethylase PHF8. Cell Res (2010) 1.05
Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. J Med Genet (2008) 1.01
Jmjd2c histone demethylase enhances the expression of Mdm2 oncogene. Biochem Biophys Res Commun (2009) 0.99
Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells. Int J Mol Med (2007) 0.93
Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase. FEBS Lett (2010) 0.90
Identification of non-histone substrates for JMJD2A-C histone demethylases. Biochem Biophys Res Commun (2009) 0.89
Studies on substrate specificity of Jmjd2a-c histone demethylases. Biochem Biophys Res Commun (2011) 0.80
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae. Nature (2006) 24.29
The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science (2007) 9.86
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet (2011) 5.56
The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases. EMBO Rep (2011) 4.89
Expanding chemical biology of 2-oxoglutarate oxygenases. Nat Chem Biol (2008) 4.52
High-definition macromolecular composition of yeast RNA-processing complexes. Mol Cell (2004) 4.18
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response. Nature (2012) 4.08
Protein production and purification. Nat Methods (2008) 3.97
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem (2002) 3.91
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL. Nature (2002) 3.78
Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins. J Inorg Biochem (2006) 3.08
Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature (2007) 3.05
The HIF pathway as a therapeutic target. Drug Discov Today (2004) 2.98
Critical residues for structure and catalysis in short-chain dehydrogenases/reductases. J Biol Chem (2002) 2.95
The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs. Proc Natl Acad Sci U S A (2006) 2.73
The CATH extended protein-family database: providing structural annotations for genome sequences. Protein Sci (2002) 2.69
A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet (2009) 2.68
MLST revisited: the gene-by-gene approach to bacterial genomics. Nat Rev Microbiol (2013) 2.64
Short-chain dehydrogenases/reductases (SDRs). Eur J Biochem (2002) 2.62
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases. Structure (2009) 2.59
Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing. Science (2009) 2.37
Structure of factor-inhibiting hypoxia-inducible factor (HIF) reveals mechanism of oxidative modification of HIF-1 alpha. J Biol Chem (2002) 2.29
Oxygenase catalyzed 5-methylcytosine hydroxylation. Chem Biol (2009) 2.28
Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2). Proc Natl Acad Sci U S A (2006) 2.17
Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy. Ann N Y Acad Sci (2007) 2.15
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases. Trends Biochem Sci (2010) 2.12
KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands. Elife (2012) 1.99
Investigating the genetic association between ERAP1 and ankylosing spondylitis. Hum Mol Genet (2009) 1.95
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. Biochem J (2008) 1.95
Inhibition of 2-oxoglutarate dependent oxygenases. Chem Soc Rev (2011) 1.90
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A (2006) 1.87
Elimination of Rhodnius prolixus in Central America. Parasit Vectors (2012) 1.87
The relationship between the chemistry and biological activity of the bisphosphonates. Bone (2011) 1.86
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem (2007) 1.84
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Structure (2002) 1.82
Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study. Protein Expr Purif (2008) 1.82
The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. Chem Biol Interact (2008) 1.77
Structural and mechanistic studies on the inhibition of the hypoxia-inducible transcription factor hydroxylases by tricarboxylic acid cycle intermediates. J Biol Chem (2006) 1.75
Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases. J Med Chem (2008) 1.74
Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits. Proc Natl Acad Sci U S A (2008) 1.72
Structural studies on human 2-oxoglutarate dependent oxygenases. Curr Opin Struct Biol (2010) 1.72
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors. PLoS One (2010) 1.71
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming. Proc Natl Acad Sci U S A (2011) 1.64
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens. EMBO Rep (2010) 1.62
Structural and mechanistic studies on γ-butyrobetaine hydroxylase. Chem Biol (2010) 1.62
Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem J (2002) 1.61
Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs). Chem Biol Interact (2003) 1.61
2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase. Bioorg Med Chem Lett (2003) 1.59
Structural basis of fumarate hydratase deficiency. J Inherit Metab Dis (2011) 1.58
Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay. Biochem J (2007) 1.58
Enzymatic and structural characterization of rTSγ provides insights into the function of rTSβ. Biochemistry (2014) 1.57
Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes. Protein Sci (2002) 1.54
Reversible sequestration of active site cysteines in a 2Fe-2S-bridged dimer provides a mechanism for glutaredoxin 2 regulation in human mitochondria. J Biol Chem (2006) 1.50
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res (2009) 1.49
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair. Genes Dev (2011) 1.46
PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet (2009) 1.44
Epidithiodiketopiperazines block the interaction between hypoxia-inducible factor-1alpha (HIF-1alpha) and p300 by a zinc ejection mechanism. J Biol Chem (2009) 1.44
Activation of octopaminergic receptors by essential oil constituents isolated from aromatic plants: possible mode of action against insect pests. Pest Manag Sci (2002) 1.43
The selectivity and inhibition of AlkB. J Biol Chem (2003) 1.43
Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors. J Biol Chem (2011) 1.42
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase. J Med Chem (2008) 1.37
Phylogeography and genetic variation of Triatoma dimidiata, the main Chagas disease vector in Central America, and its position within the genus Triatoma. PLoS Negl Trop Dis (2008) 1.34
The CATH protein family database: a resource for structural and functional annotation of genomes. Proteomics (2002) 1.33
The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding. J Biol Chem (2006) 1.32
Selective inhibitors of the JMJD2 histone demethylases: combined nondenaturing mass spectrometric screening and crystallographic approaches. J Med Chem (2010) 1.31
Conversion of cysteine into dehydroalanine enables access to synthetic histones bearing diverse post-translational modifications. Angew Chem Int Ed Engl (2012) 1.30
Structure of human phytanoyl-CoA 2-hydroxylase identifies molecular mechanisms of Refsum disease. J Biol Chem (2005) 1.29
Aldehyde dehydrogenase 7A1 (ALDH7A1) is a novel enzyme involved in cellular defense against hyperosmotic stress. J Biol Chem (2010) 1.28
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants. DNA Repair (Amst) (2007) 1.27
A miniaturized screen for inhibitors of Jumonji histone demethylases. Mol Biosyst (2009) 1.27
Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols. Org Biomol Chem (2008) 1.26
Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A. J Mol Biol (2009) 1.25
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein. EMBO J (2010) 1.25