Published in Genetics on August 01, 2004
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation. Proc Natl Acad Sci U S A (2005) 1.82
Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan. Autophagy (2012) 1.08
Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model. Proc Jpn Acad Ser B Phys Biol Sci (2008) 0.76
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science (1989) 9.71
Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci U S A (1994) 6.84
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science (1999) 5.20
Random genetic drift in the female germline explains the rapid segregation of mammalian mitochondrial DNA. Nat Genet (1996) 4.68
Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB). J Cell Biol (1968) 4.22
Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA. Nat Med (2001) 3.81
Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet (1989) 3.69
Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria. Nat Genet (2001) 3.55
Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age. Nat Genet (1992) 3.53
Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes. Nat Genet (2000) 3.06
Mitochondrial genetics IX: A model for recombination and segregation of mitochondrial genomes in saccharomyces cerevisiae. Genetics (1974) 2.40
Mosaicism for a specific somatic mitochondrial DNA mutation in adult human brain. Nat Genet (1992) 2.16
Maternal inheritance of mouse mtDNA in interspecific hybrids: segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage. Genetics (1998) 1.73
Human mitochondria and mitochondrial genome function as a single dynamic cellular unit. J Cell Biol (1994) 1.53
Selective and continuous elimination of mitochondria microinjected into mouse eggs from spermatids, but not from liver cells, occurs throughout embryogenesis. Genetics (2000) 1.28
Absence of extensive recombination between inter- and intraspecies mitochondrial DNA in mammalian cells. Exp Cell Res (1985) 1.11
Ageing and mammalian mitochondrial genetics. Trends Genet (1998) 1.09
Non-invasive visualization of sperm mitochondria behavior in transgenic mice with introduced green fluorescent protein (GFP). FEBS Lett (2001) 1.08
Isolation of mitochondrial DNA-less mouse cell lines and their application for trapping mouse synaptosomal mitochondrial DNA with deletion mutations. J Biol Chem (1997) 1.04
Nuclear-recessive mutations of factors involved in mitochondrial translation are responsible for age-related respiration deficiency of human skin fibroblasts. J Biol Chem (1998) 0.95
Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease. Proc Natl Acad Sci U S A (1999) 0.91
Inter-mitochondrial complementation of mtDNA mutations and nuclear context. Nat Genet (2002) 0.84
ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science (2008) 5.54
Depletion of definitive gut endoderm in Sox17-null mutant mice. Development (2002) 4.13
Control of cell polarity and motility by the PtdIns(3,4,5)P3 phosphatase SHIP1. Nat Cell Biol (2006) 3.19
p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria. Genes Cells (2010) 2.91
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J Cell Biol (2011) 2.64
Usher syndrome type I G (USH1G) is caused by mutations in the gene encoding SANS, a protein that associates with the USH1C protein, harmonin. Hum Mol Genet (2003) 2.37
Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. Am J Respir Crit Care Med (2007) 2.33
Basophils play a critical role in the development of IgE-mediated chronic allergic inflammation independently of T cells and mast cells. Immunity (2005) 2.19
Interactions in the network of Usher syndrome type 1 proteins. Hum Mol Genet (2004) 2.16
The alpha/beta interferon response controls tissue tropism and pathogenicity of poliovirus. J Virol (2005) 2.13
The mitochondrial bottleneck occurs without reduction of mtDNA content in female mouse germ cells. Nat Genet (2007) 2.10
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation. Proc Natl Acad Sci U S A (2005) 1.82
A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A (2008) 1.75
Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance. J Biol Chem (2007) 1.75
Reversible regulation of metastasis by ROS-generating mtDNA mutations. Mitochondrion (2008) 1.62
Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci (2008) 1.58
Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits. Genome Res (2008) 1.46
Mutations in a new scaffold protein Sans cause deafness in Jackson shaker mice. Hum Mol Genet (2003) 1.45
Analysis of the effect of surgical lung biopsy on serum KL-6 Levels in patients with interstitial pneumonia: surgical lung biopsy does not elevate serum KL-6 levels. Intern Med (2006) 1.39
Generation of trans-mitochondrial mice carrying homoplasmic mtDNAs with a missense mutation in a structural gene using ES cells. Hum Mol Genet (2006) 1.32
Mitochondria-related male infertility. Proc Natl Acad Sci U S A (2006) 1.32
New evidence confirms that the mitochondrial bottleneck is generated without reduction of mitochondrial DNA content in early primordial germ cells of mice. PLoS Genet (2009) 1.26
Whirlin complexes with p55 at the stereocilia tip during hair cell development. Proc Natl Acad Sci U S A (2006) 1.26
Regulation of anaphylactic responses by phosphatidylinositol phosphate kinase type I {alpha}. J Exp Med (2005) 1.22
Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L. J Cell Sci (2008) 1.21
The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice. Nat Commun (2011) 1.19
Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway. J Biol Chem (2009) 1.19
Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells. FEBS Lett (2010) 1.18
Pathogenesis of hepatitis C virus infection in Tupaia belangeri. J Virol (2010) 1.17
Unique inbred strain MSM/Ms established from the Japanese wild mouse. Exp Anim (2009) 1.13
Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol (2006) 1.12
Origins of mouse inbred strains deduced from whole-genome scanning by polymorphic microsatellite loci. Mamm Genome (2005) 1.12
Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome C oxidase and embryonic development. Mol Cell Biol (2002) 1.11
Phylogeny, recombination, and mechanisms of stepwise mitochondrial genome reorganization in mantellid frogs from Madagascar. Mol Biol Evol (2008) 1.11
CXCL14 deficiency in mice attenuates obesity and inhibits feeding behavior in a novel environment. PLoS One (2010) 1.06
Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice. Biochem Biophys Res Commun (2004) 1.06
Evidence for crucial role of hindgut expansion in directing proper migration of primordial germ cells in mouse early embryogenesis. Dev Biol (2009) 1.05
Rare creation of recombinant mtDNA haplotypes in mammalian tissues. Proc Natl Acad Sci U S A (2005) 1.04
Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development. Proc Natl Acad Sci U S A (2012) 1.03
Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis. FEBS Lett (2008) 1.02
In vivo cleavage of alpha2,6-sialyltransferase by Alzheimer beta-secretase. J Biol Chem (2004) 1.02
Nuclear DNA but not mtDNA controls tumor phenotypes in mouse cells. Biochem Biophys Res Commun (2005) 1.01
Detection of recombinant haplotypes in wild mice (Mus musculus) provides new insights into the origin of Japanese mice. Mol Ecol (2010) 1.00
Transgenic mouse model for the study of enterovirus 71 neuropathogenesis. Proc Natl Acad Sci U S A (2013) 0.99
Physical performance and soleus muscle fiber composition in wild-derived and laboratory inbred mouse strains. J Appl Physiol (1985) (2003) 0.99
Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev Biol (2005) 0.98
Hypoxic induction of hypoxia-inducible factor-1alpha and oxygen-regulated gene expression in mitochondrial DNA-depleted HeLa cells. Biochem Biophys Res Commun (2002) 0.98
Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells. FEBS Lett (2010) 0.97
Deletion-mutant mtDNA increases in somatic tissues but decreases in female germ cells with age. Genetics (2007) 0.97
Correlation of abnormal mitochondrial distribution in mouse oocytes with reduced developmental competence. Tohoku J Exp Med (2006) 0.97
Direct cloning of full-length mouse mitochondrial DNA using a Bacillus subtilis genome vector. Gene (2007) 0.96
The innate immune system in host mice targets cells with allogenic mitochondrial DNA. J Exp Med (2010) 0.96
Mitochondrial DNA mutations regulate metastasis of human breast cancer cells. PLoS One (2011) 0.95
Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons. J Neurosci (2003) 0.94
RP58 regulates the multipolar-bipolar transition of newborn neurons in the developing cerebral cortex. Cell Rep (2013) 0.94
Expression and function of mouse Sox17 gene in the specification of gallbladder/bile-duct progenitors during early foregut morphogenesis. Biochem Biophys Res Commun (2009) 0.92