Published in J Biol Chem on September 03, 2004
Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci (2008) 3.90
A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest (2005) 3.44
Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology. Proc Natl Acad Sci U S A (2013) 2.45
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice. Am J Pathol (2007) 2.05
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective. J Neuroinflammation (2008) 2.03
Early correlation of microglial activation with enhanced tumor necrosis factor-alpha and monocyte chemoattractant protein-1 expression specifically within the entorhinal cortex of triple transgenic Alzheimer's disease mice. J Neuroinflammation (2005) 1.64
Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology. Neurobiol Dis (2009) 1.60
Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation. J Neuroinflammation (2008) 1.59
Chronic neuron-specific tumor necrosis factor-alpha expression enhances the local inflammatory environment ultimately leading to neuronal death in 3xTg-AD mice. Am J Pathol (2008) 1.55
IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice. J Immunol (2010) 1.55
Interleukin-1 mediates Alzheimer and Lewy body pathologies. J Neuroinflammation (2006) 1.47
RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB J (2009) 1.39
Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice. Anesthesiology (2010) 1.38
Tumor necrosis factor-alpha mediated signaling in neuronal homeostasis and dysfunction. Cell Signal (2010) 1.34
Sustained interleukin-1β overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci (2013) 1.32
The comorbidity of HIV-associated neurocognitive disorders and Alzheimer's disease: a foreseeable medical challenge in post-HAART era. J Neuroimmune Pharmacol (2008) 1.31
The role of G protein-coupled receptors in the pathology of Alzheimer's disease. Nat Rev Neurosci (2011) 1.30
Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase. J Biol Chem (2008) 1.27
Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection. Prostaglandins Leukot Essent Fatty Acids (2009) 1.19
TREM2 and the neuroimmunology of Alzheimer's disease. Biochem Pharmacol (2013) 1.18
Targeting TNF-α to elucidate and ameliorate neuroinflammation in neurodegenerative diseases. CNS Neurol Disord Drug Targets (2011) 1.16
Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer's disease. J Neuroinflammation (2005) 1.16
Tumor necrosis factor-α synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease. J Neuroinflammation (2012) 1.13
Inflammatory process in Alzheimer's Disease. Front Integr Neurosci (2013) 1.10
p75 neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-alpha-converting enzyme/ADAM17. J Biol Chem (2010) 1.09
Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection. J Neurovirol (2009) 1.06
Neuroinflammation and neuronal loss precede Aβ plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease. PLoS One (2013) 1.04
Processing of the synaptic cell adhesion molecule neurexin-3beta by Alzheimer disease alpha- and gamma-secretases. J Biol Chem (2010) 1.03
Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep (2014) 1.02
Notch and Wnt signaling mediated rod photoreceptor regeneration by Müller cells in adult mammalian retina. PLoS One (2010) 1.01
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Protease regulation: the Yin and Yang of neural development and disease. Neuron (2011) 1.00
Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide. J Cell Mol Med (2011) 0.99
Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells. FASEB J (2010) 0.96
Inhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells. J Neuroinflammation (2011) 0.95
Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures. J Neuroinflammation (2011) 0.93
Discovery of a novel pharmacological and structural class of gamma secretase modulators derived from the extract of Actaea racemosa. ACS Chem Neurosci (2012) 0.92
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener (2011) 0.91
Ocular changes in TgF344-AD rat model of Alzheimer's disease. Invest Ophthalmol Vis Sci (2014) 0.91
Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein. Mol Cell Biol (2005) 0.90
Traumatic brain injury, microglia, and Beta amyloid. Int J Alzheimers Dis (2012) 0.90
RAGE is a key cellular target for Abeta-induced perturbation in Alzheimer's disease. Front Biosci (Schol Ed) (2012) 0.89
Brain injury, neuroinflammation and Alzheimer's disease. Front Aging Neurosci (2013) 0.89
Studies on brain volume, Alzheimer-related proteins and cytokines in mice with chronic overexpression of IL-1 receptor antagonist. J Cell Mol Med (2007) 0.88
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. Mol Biol Cell (2008) 0.88
The role of microglia in human disease: therapeutic tool or target? Acta Neuropathol (2014) 0.85
Restoration of lipoxin A4 signaling reduces Alzheimer's disease-like pathology in the 3xTg-AD mouse model. J Alzheimers Dis (2015) 0.85
CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models. J Neuroinflammation (2006) 0.82
The adipocyte differentiation protein APMAP is an endogenous suppressor of Aβ production in the brain. Hum Mol Genet (2014) 0.82
Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease? J Alzheimers Dis (2011) 0.81
Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease. Br J Pharmacol (2015) 0.80
Nutrients, Microglia Aging, and Brain Aging. Oxid Med Cell Longev (2016) 0.78
The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro. Int J Mol Epidemiol Genet (2011) 0.77
Magnesium ion influx reduces neuroinflammation in Aβ precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1β. Cell Mol Immunol (2015) 0.77
The evolving biology of microglia in Alzheimer's disease. Neurotherapeutics (2015) 0.77
Amyloidosis in Retinal Neurodegenerative Diseases. Front Neurol (2016) 0.76
Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein. ACS Chem Neurosci (2013) 0.76
Targeting neuroinflammation in Alzheimer's disease. J Inflamm Res (2016) 0.76
MD-2 is involved in the stimulation of matrix metalloproteinase-1 expression by interferon-γ and high glucose in mononuclear cells - a potential role of MD-2 in Toll-like receptor 4-independent signalling. Immunology (2013) 0.76
Evaluation of inflammation-related genes polymorphisms in Mexican with Alzheimer's disease: a pilot study. Front Cell Neurosci (2015) 0.76
The blockage of the Nogo/NgR signal pathway in microglia alleviates the formation of Aβ plaques and tau phosphorylation in APP/PS1 transgenic mice. J Neuroinflammation (2016) 0.75
Targeting Tumor Necrosis Factor Alpha for Alzheimer's Disease. Curr Alzheimer Res (2016) 0.75
The FDA-approved natural product dihydroergocristine reduces the production of the Alzheimer's disease amyloid-β peptides. Sci Rep (2015) 0.75
T Lymphocytes and Inflammatory Mediators in the Interplay between Brain and Blood in Alzheimer's Disease: Potential Pools of New Biomarkers. J Immunol Res (2017) 0.75
Inhibition of STAT3- and MAPK-dependent PGE2 synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells. J Neuroinflammation (2016) 0.75
ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proc Natl Acad Sci U S A (2017) 0.75
Prostaglandin I2 Attenuates Prostaglandin E2-Stimulated Expression of Interferon γ in a β-Amyloid Protein- and NF-κB-Dependent Mechanism. Sci Rep (2016) 0.75
FTY720 Attenuates Infection-Induced Enhancement of Aβ Accumulation in APP/PS1 Mice by Modulating Astrocytic Activation. J Neuroimmune Pharmacol (2017) 0.75
Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders. PLoS One (2017) 0.75
Tumor necrosis factor α Inhibition for Alzheimer's Disease. J Cent Nerv Syst Dis (2017) 0.75
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Notch mediates TGF alpha-induced changes in epithelial differentiation during pancreatic tumorigenesis. Cancer Cell (2003) 5.36
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Substrate-targeting gamma-secretase modulators. Nature (2008) 3.38
Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2. Proc Natl Acad Sci U S A (2003) 3.36
The surface of articular cartilage contains a progenitor cell population. J Cell Sci (2004) 3.28
Presenilin: running with scissors in the membrane. Cell (2007) 2.55
Purification and characterization of the human gamma-secretase complex. Biochemistry (2004) 2.18
Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate. Proc Natl Acad Sci U S A (2002) 2.16
Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Proc Natl Acad Sci U S A (2005) 2.08
Presenilins and γ-secretase: structure, function, and role in Alzheimer Disease. Cold Spring Harb Perspect Med (2012) 2.02
Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem (2008) 2.00
A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP. Proc Natl Acad Sci U S A (2002) 1.97
Notch signaling augments T cell responsiveness by enhancing CD25 expression. J Immunol (2003) 1.95
A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc Natl Acad Sci U S A (2003) 1.92
Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin. J Biol Chem (2003) 1.83
Electron microscopic structure of purified, active gamma-secretase reveals an aqueous intramembrane chamber and two pores. Proc Natl Acad Sci U S A (2006) 1.77
Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution. J Mol Biol (2008) 1.75
A G-rich element forms a G-quadruplex and regulates BACE1 mRNA alternative splicing. J Neurochem (2012) 1.70
Active gamma-secretase complexes contain only one of each component. J Biol Chem (2007) 1.69
Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex. Biochemistry (2004) 1.61
The initial substrate-binding site of gamma-secretase is located on presenilin near the active site. Proc Natl Acad Sci U S A (2005) 1.59
gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site. J Biol Chem (2005) 1.45
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J (2002) 1.43
Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). Biochemistry (2003) 1.42
Signal peptide peptidase: biochemical properties and modulation by nonsteroidal antiinflammatory drugs. Biochemistry (2006) 1.41
Designed helical peptides inhibit an intramembrane protease. J Am Chem Soc (2003) 1.33
Dissociation between the processivity and total activity of γ-secretase: implications for the mechanism of Alzheimer's disease-causing presenilin mutations. Biochemistry (2011) 1.30
A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis. J Biol Chem (2007) 1.28
Stabilization of the tau exon 10 stem loop alters pre-mRNA splicing. J Biol Chem (2006) 1.22
Differential effects of inhibitors on the gamma-secretase complex. Mechanistic implications. J Biol Chem (2003) 1.15
Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci (2003) 1.14
Signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor. J Biol Chem (2004) 1.11
Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates. Neurobiol Dis (2003) 1.11
Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nat Commun (2010) 1.10
Toward structural elucidation of the gamma-secretase complex. Structure (2009) 1.07
Structural basis for stabilization of the tau pre-mRNA splicing regulatory element by novantrone (mitoxantrone). Chem Biol (2009) 1.06
Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation. J Biol Chem (2002) 1.06
Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease. J Neurochem (2007) 1.05
Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins. Semin Cell Dev Biol (2009) 1.05
Effects of membrane lipids on the activity and processivity of purified γ-secretase. Biochemistry (2012) 1.03
Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma. Clin Cancer Res (2010) 1.02
Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci (2003) 1.01
Identity and function of gamma-secretase. J Neurosci Res (2003) 1.00
Autophagy: a double-edged sword in Alzheimer's disease. J Biosci (2012) 1.00
Identification of tau stem loop RNA stabilizers. J Biomol Screen (2007) 0.97
Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage. J Biol Chem (2005) 0.95
Promotion of BACE1 mRNA alternative splicing reduces amyloid beta-peptide production. J Biol Chem (2008) 0.95
Mitoxantrone analogues as ligands for a stem-loop structure of tau pre-mRNA. J Med Chem (2009) 0.94
A high-throughput screen to identify inhibitors of amyloid beta-protein precursor processing. J Biomol Screen (2005) 0.94
Discovery of a Subnanomolar helical D-tridecapeptide inhibitor of gamma-secretase. J Med Chem (2004) 0.93
Pc 4 photodynamic therapy of U87-derived human glioma in the nude rat. Lasers Surg Med (2005) 0.92
Unnatural amino acid-substituted (hydroxyethyl)urea peptidomimetics inhibit gamma-secretase and promote the neuronal differentiation of neuroblastoma cells. Mol Pharmacol (2006) 0.92
Proteolysis of chimeric beta-amyloid precursor proteins containing the Notch transmembrane domain yields amyloid beta-like peptides. J Biol Chem (2002) 0.92
Alternative polyadenylation and miR-34 family members regulate tau expression. J Neurochem (2013) 0.91
Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly. J Biol Chem (2011) 0.89
Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin. Mol Biol Cell (2008) 0.88
Effect of transforming growth factor beta 2 on marrow-infused foam poly(propylene fumarate) tissue-engineered constructs for the repair of critical-size cranial defects in rabbits. Tissue Eng (2005) 0.88
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase. Nat Cell Biol (2002) 0.86
Inhibition of Notch signaling biases rat thymocyte development towards the NK cell lineage. Eur J Immunol (2004) 0.86
Targeting a pre-mRNA structure with bipartite antisense molecules modulates tau alternative splicing. Nucleic Acids Res (2012) 0.85
Identification of GRP75 as an independent favorable prognostic marker of neuroblastoma by a proteomics analysis. Clin Cancer Res (2008) 0.85
Deducing the transmembrane domain organization of presenilin-1 in gamma-secretase by cysteine disulfide cross-linking. Biochemistry (2006) 0.84
Sodium selenite inhibits gamma-secretase activity through activation of ERK. Neurosci Lett (2008) 0.84
The search for gamma-secretase and development of inhibitors. Curr Med Chem (2002) 0.84
Poly(propylene fumarate) and poly(DL-lactic-co-glycolic acid) as scaffold materials for solid and foam-coated composite tissue-engineered constructs for cranial reconstruction. Tissue Eng (2003) 0.83
Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem (2003) 0.81
Identification of a cis-acting element involved in the regulation of BACE1 mRNA alternative splicing. J Neurochem (2009) 0.81
DNA loop repair by Escherichia coli cell extracts. J Biol Chem (2003) 0.81
Caveolin-1 regulates γ-secretase-mediated AβPP processing by modulating spatial distribution of γ-secretase in membrane. J Alzheimers Dis (2010) 0.80
Bicyclic 1,2,3-triazolium ionic liquids: synthesis, characterization, and application to rutaecarpine synthesis. Org Lett (2011) 0.80
Microgrooved patterns enhanced PC12 cell growth, orientation, neurite elongation, and neuritogenesis. J Biomed Mater Res A (2012) 0.80
Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells. Cancer Gene Ther (2004) 0.80
New 1,2,3,4-tetrahydroisoquinoline derivatives as modulators of proteolytic cleavage of amyloid precursor proteins. Bioorg Med Chem (2007) 0.79
Structural biology: Membrane enzyme cuts a fine figure. Nature (2012) 0.79
Probing pockets S2-S4' of the gamma-secretase active site with (hydroxyethyl)urea peptidomimetics. Bioorg Med Chem Lett (2004) 0.79
Alzheimer's γ-secretase under arrestin. Nat Med (2013) 0.79
Conditioning vaccination site with irradiated MIP-3alpha-transfected tumor cells enhances efficacy of dendritic cell-based cancer vaccine. J Immunother (2009) 0.79
Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry (2014) 0.78
Distinct pharmacological effects of inhibitors of signal peptide peptidase and gamma-secretase. J Biol Chem (2008) 0.78
Presenilin-1 regulates the expression of p62 to govern p62-dependent tau degradation. Mol Neurobiol (2013) 0.77
Membrane-embedded protease poses for photoshoot. Proc Natl Acad Sci U S A (2007) 0.77
γ-Secretase-mediated growth hormone receptor proteolysis: mapping of the intramembranous cleavage site. Biochem Biophys Res Commun (2011) 0.77
From rhomboid function to structure and back again. Proc Natl Acad Sci U S A (2007) 0.76
Calreticulin Regulates VEGF-A in Neuroblastoma Cells. Mol Neurobiol (2014) 0.76
Retinoic acid-elicited RARα/RXRα signaling attenuates Aβ production by directly inhibiting γ-secretase-mediated cleavage of amyloid precursor protein. ACS Chem Neurosci (2013) 0.76
Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies. J Neurochem (2014) 0.76
Stereochemical analysis of (hydroxyethyl)urea peptidomimetic inhibitors of gamma-secretase. J Med Chem (2004) 0.75
Substituted thiazolamide coupled to a redox delivery system: a new gamma-secretase inhibitor with enhanced pharmacokinetic profile. Org Biomol Chem (2005) 0.75
Alzheimer protease hitches a ride. Nat Med (2006) 0.75
Ligand-dependent activation of EphA4 signaling regulates the proteolysis of amyloid precursor protein through a Lyn-mediated pathway. Mol Neurobiol (2013) 0.75
Evaluation of a modified infraorbital approach for a maxillary nerve block for rhinoscopy with nasal biopsy of dogs. Am J Vet Res (2017) 0.75