Published in J Immunol Res on February 15, 2017
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science (2002) 49.51
Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun (1984) 20.07
Regulatory T cells and immune tolerance. Cell (2008) 18.77
Inflammation and Alzheimer's disease. Neurobiol Aging (2000) 12.56
The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron (2008) 10.19
Variant of TREM2 associated with the risk of Alzheimer's disease. N Engl J Med (2012) 10.16
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology (1992) 9.30
Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28
Structural and functional features of central nervous system lymphatic vessels. Nature (2015) 8.73
Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet (2008) 8.51
The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature (2011) 6.71
Nomenclature of monocytes and dendritic cells in blood. Blood (2010) 6.63
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med (2003) 5.14
Three or more routes for leukocyte migration into the central nervous system. Nat Rev Immunol (2003) 4.76
Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms. Neuron (1992) 4.22
Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med (2014) 3.75
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J Exp Med (2005) 3.42
Chemokine receptors and their role in inflammation and infectious diseases. Blood (2000) 3.40
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat Neurosci (2011) 3.06
Neuroinflammation in Alzheimer's disease. Lancet Neurol (2015) 3.02
The role of chemokines in linking innate and adaptive immunity. Curr Opin Immunol (2002) 2.94
Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. Brain Pathol (2008) 2.90
Chemokines in pathology and medicine. J Intern Med (2001) 2.83
CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat Neurosci (2013) 2.51
Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution. J Neuropathol Exp Neurol (1995) 2.35
Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain (2008) 2.34
Chemokines in the systemic organization of immunity. Immunol Rev (2003) 2.25
Immune attack: the role of inflammation in Alzheimer disease. Nat Rev Neurosci (2015) 2.25
The microglial "activation" continuum: from innate to adaptive responses. J Neuroinflammation (2005) 2.23
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease. Nat Med (2016) 2.22
Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science (2014) 2.22
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta. J Neurosci (2005) 2.21
Capture, crawl, cross: the T cell code to breach the blood-brain barriers. Trends Immunol (2012) 2.01
Leukocyte extravasation: chemokine transport and presentation by the endothelium. Blood (2002) 1.92
Tumor necrosis factor-alpha, interleukin-1beta, and interferon-gamma stimulate gamma-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway. J Biol Chem (2004) 1.88
Dystrophic microglia in the aging human brain. Glia (2004) 1.79
Choroid plexus: biology and pathology. Acta Neuropathol (2009) 1.70
Involvement of the choroid plexus in central nervous system inflammation. Microsc Res Tech (2001) 1.69
The gene defects responsible for familial Alzheimer's disease. Neurobiol Dis (1996) 1.68
Neurological diseases in relation to the blood-brain barrier. J Cereb Blood Flow Metab (2012) 1.62
Intrathecal inflammation precedes development of Alzheimer's disease. J Neurol Neurosurg Psychiatry (2003) 1.62
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs. Br J Clin Pharmacol (2012) 1.62
Activation of microglia by aggregated beta-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-gamma and IL-4 render them protective. Mol Cell Neurosci (2005) 1.59
Reactive astrocytes secrete lcn2 to promote neuron death. Proc Natl Acad Sci U S A (2013) 1.59
Immunologic messenger molecules: cytokines, interferons, and chemokines. J Allergy Clin Immunol (2009) 1.58
Genes contributing to Alzheimer's disease. Mol Psychiatry (1996) 1.55
Neuroprotection by IL-10-producing MOG CD4+ T cells following ischemic stroke. J Neurol Sci (2005) 1.54
Inflammatory repertoire of Alzheimer's disease and nondemented elderly microglia in vitro. Glia (2001) 1.53
Systemic inflammatory cells fight off neurodegenerative disease. Nat Rev Neurol (2010) 1.52
Neuronal-glial interactions mediated by interleukin-1 enhance neuronal acetylcholinesterase activity and mRNA expression. J Neurosci (2000) 1.48
Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function. Neurobiol Aging (2010) 1.45
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases. J Neuroimmunol (2002) 1.45
CNS infiltration of peripheral immune cells: D-Day for neurodegenerative disease? J Neuroimmune Pharmacol (2009) 1.43
Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biol Psychiatry (2014) 1.42
Mechanisms regulating regional localization of inflammation during CNS autoimmunity. Immunol Rev (2012) 1.39
Blood-brain barrier pathology in Alzheimer's and Parkinson's disease: implications for drug therapy. Cell Transplant (2007) 1.38
Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem (2010) 1.37
Induction of cytokines in glial cells surrounding cortical beta-amyloid plaques in transgenic Tg2576 mice with Alzheimer pathology. Int J Dev Neurosci (2000) 1.32
Abeta-induced meningoencephalitis is IFN-gamma-dependent and is associated with T cell-dependent clearance of Abeta in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 1.30
Mechanisms of cell signaling and inflammation in Alzheimer's disease. Curr Drug Targets Inflamm Allergy (2005) 1.29
Lipocalin 2 is a choroid plexus acute-phase protein. J Cereb Blood Flow Metab (2007) 1.28
Neurogenesis and neuroprotection induced by peripheral immunomodulatory treatment of experimental autoimmune encephalomyelitis. J Neurosci (2005) 1.27
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia (2012) 1.26
Neuroprotective role of IL-4 against activated microglia. J Immunol (1993) 1.26
Potential inflammatory biomarkers in Alzheimer's disease. J Alzheimers Dis (2005) 1.26
IFN-γ-dependent activation of the brain's choroid plexus for CNS immune surveillance and repair. Brain (2013) 1.26
Selective ablation of bone marrow-derived dendritic cells increases amyloid plaques in a mouse Alzheimer's disease model. Eur J Neurosci (2007) 1.24
CCL2 is associated with a faster rate of cognitive decline during early stages of Alzheimer's disease. PLoS One (2012) 1.21
The case for rejecting the amyloid cascade hypothesis. Nat Neurosci (2015) 1.21
Tight junctions in brain barriers during central nervous system inflammation. Antioxid Redox Signal (2011) 1.21
Inflammation in Alzheimer's disease: relevance to pathogenesis and therapy. Alzheimers Res Ther (2010) 1.20
Secreted protein lipocalin-2 promotes microglial M1 polarization. FASEB J (2012) 1.20
Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer's disease: potential significance for tau protein phosphorylation. Neurochem Int (2001) 1.19
Interleukin-1 promotes expression and phosphorylation of neurofilament and tau proteins in vivo. Exp Neurol (2000) 1.17
The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus. EMBO J (2013) 1.16
CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging. Proc Natl Acad Sci U S A (2013) 1.16
Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma. Eur J Immunol (2005) 1.15
Interactions between APP secretases and inflammatory mediators. J Neuroinflammation (2008) 1.14
Diverse activation of microglia by chemokine (C-C motif) ligand 2 overexpression in brain. J Neuroinflammation (2013) 1.13
Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain. J Neurochem (2003) 1.13
Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions. J Leukoc Biol (2010) 1.13
Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease. Neurobiol Aging (2006) 1.13
Cytokines: principles and prospects. Immunol Cell Biol (1998) 1.11
CNS-specific T cells shape brain function via the choroid plexus. Brain Behav Immun (2013) 1.11
Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis. J Neurosci (2007) 1.10
A possible role for CSF turnover and choroid plexus in the pathogenesis of late onset Alzheimer's disease. J Alzheimers Dis (2012) 1.10
Changes in the levels of plasma soluble fractalkine in patients with mild cognitive impairment and Alzheimer's disease. Neurosci Lett (2008) 1.09
Prototype Alzheimer's disease epitope vaccine induced strong Th2-type anti-Abeta antibody response with Alum to Quil A adjuvant switch. Vaccine (2005) 1.09
Altered lymphocyte distribution in Alzheimer's disease. J Psychiatr Res (2006) 1.08
Modulation of interleukin-1beta mediated inflammatory response in human astrocytes by flavonoids: implications in neuroprotection. Brain Res Bull (2007) 1.05
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology. Nat Commun (2015) 1.04
The role of chemokines in the recruitment of lymphocytes to the liver. Dig Dis (2010) 1.04
The role and therapeutic potential of monocytic cells in Alzheimer's disease. Glia (2010) 1.04
Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. CNS Neurol Disord Drug Targets (2010) 1.03
IFN-γ Production by amyloid β-specific Th1 cells promotes microglial activation and increases plaque burden in a mouse model of Alzheimer's disease. J Immunol (2013) 1.03
RANTES upregulation in the Alzheimer's disease brain: a possible neuroprotective role. Neurobiol Aging (2008) 1.02
Peripheral chemokine receptors, their ligands, cytokines and Alzheimer's disease. J Alzheimers Dis (2008) 1.02
Hyperglycemia modulates extracellular amyloid-β concentrations and neuronal activity in vivo. J Clin Invest (2015) 1.02
Whether, when and how chronic inflammation increases the risk of developing late-onset Alzheimer's disease. Alzheimers Res Ther (2012) 1.02
The early involvement of the innate immunity in the pathogenesis of late-onset Alzheimer's disease: neuropathological, epidemiological and genetic evidence. Curr Alzheimer Res (2011) 1.02