Published in Proc Natl Acad Sci U S A on September 03, 2004
Molecular basis of coiled-coil formation. Proc Natl Acad Sci U S A (2007) 1.44
The folding of single domain proteins--have we reached a consensus? Curr Opin Struct Biol (2010) 1.42
Folding and binding of an intrinsically disordered protein: fast, but not 'diffusion-limited'. J Am Chem Soc (2013) 1.11
Quantifying the structural requirements of the folding transition state of protein A and other systems. J Mol Biol (2008) 1.05
Slow, reversible, coupled folding and binding of the spectrin tetramerization domain. Biophys J (2012) 0.91
Molecular dynamics guided study of salt bridge length dependence in both fluorinated and non-fluorinated parallel dimeric coiled-coils. Proteins (2009) 0.86
Simplified protein models: predicting folding pathways and structure using amino acid sequences. Phys Rev Lett (2013) 0.83
Secondary structure provides a template for the folding of nearby polypeptides. Proc Natl Acad Sci U S A (2006) 0.82
The effects of pK(a) tuning on the thermodynamics and kinetics of folding: design of a solvent-shielded carboxylate pair at the a-position of a coiled-coil. Biophys J (2010) 0.81
Conformational dynamics is more important than helical propensity for the folding of the all α-helical protein Im7. Protein Sci (2013) 0.78
Temperature and chemical denaturant dependence of forced unfolding of titin I27. J Phys Chem B (2009) 0.77
Sequence-resolved free energy profiles of stress-bearing vimentin intermediate filaments. Proc Natl Acad Sci U S A (2014) 0.77
Structural basis of RNA binding by leucine zipper GCN4. Protein Sci (2012) 0.76
Mutational effect of structural parameters on coiled-coil stability of proteins. Proteomics Insights (2013) 0.75
The loop hypothesis: contribution of early formed specific non-local interactions to the determination of protein folding pathways. Biophys Rev (2013) 0.75
Microscopic nucleation and propagation rates of an alanine-based α-helix. Phys Chem Chem Phys (2017) 0.75
Slow folding-unfolding kinetics of an octameric β-peptide bundle. ACS Chem Biol (2013) 0.75
Intrinsic disorder and protein function. Biochemistry (2002) 8.54
Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol (2002) 6.53
Speeding molecular recognition by using the folding funnel: the fly-casting mechanism. Proc Natl Acad Sci U S A (2000) 5.71
Elucidating the folding problem of helical peptides using empirical parameters. Nat Struct Biol (1994) 4.66
Fast events in protein folding: helix melting and formation in a small peptide. Biochemistry (1996) 4.39
Hydrodynamic radii of native and denatured proteins measured by pulse field gradient NMR techniques. Biochemistry (1999) 4.12
Protein-folding dynamics. Nature (1976) 4.11
The complete folding pathway of a protein from nanoseconds to microseconds. Nature (2003) 3.61
Faster superoxide dismutase mutants designed by enhancing electrostatic guidance. Nature (1992) 3.56
Protein folding dynamics: the diffusion-collision model and experimental data. Protein Sci (1994) 3.00
Laser temperature jump study of the helix<==>coil kinetics of an alanine peptide interpreted with a 'kinetic zipper' model. Biochemistry (1997) 2.83
Elucidating the folding problem of alpha-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters. J Mol Biol (1998) 2.78
Helix formation via conformation diffusion search. Proc Natl Acad Sci U S A (2002) 2.34
Preorganized secondary structure as an important determinant of fast protein folding. Nat Struct Biol (2001) 2.00
Engineered metal binding sites map the heterogeneous folding landscape of a coiled coil. Nat Struct Biol (2001) 1.98
The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions. Nat Struct Biol (1997) 1.90
Effect of point mutations on the folding of globular proteins. Methods Enzymol (1987) 1.87
Probing the folding mechanism of a leucine zipper peptide by stopped-flow circular dichroism spectroscopy. Biochemistry (1995) 1.78
The role of helix formation in the folding of a fully alpha-helical coiled coil. Proteins (1996) 1.58
Application of the diffusion-collision model to the folding of three-helix bundle proteins. J Mol Biol (2002) 1.53
Transition state heterogeneity in GCN4 coiled coil folding studied by using multisite mutations and crosslinking. Proc Natl Acad Sci U S A (1999) 1.51
Protein folding dynamics: quantitative comparison between theory and experiment. Biochemistry (1998) 1.31
Trifluoroethanol promotes helix formation by destabilizing backbone exposure: desolvation rather than native hydrogen bonding defines the kinetic pathway of dimeric coiled coil folding. Biochemistry (1998) 1.28
Preformed secondary structure drives the association reaction of GCN4-p1, a model coiled-coil system. J Mol Biol (2000) 1.23
Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects. Nat Struct Biol (2002) 1.20
Extremely fast folding of a very stable leucine zipper with a strengthened hydrophobic core and lacking electrostatic interactions between helices. Biochemistry (1999) 1.19
Folding kinetics of Che Y mutants with enhanced native alpha-helix propensities. J Mol Biol (1997) 1.14
D/H amide kinetic isotope effects reveal when hydrogen bonds form during protein folding. Nat Struct Biol (2000) 1.13
Mechanism of fast protein folding. Annu Rev Biochem (2001) 1.11
Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding. J Mol Biol (1999) 1.02
Energetics of coiled coil folding: the nature of the transition states. Biochemistry (2001) 0.99
Stabilisation of alpha-helices by site-directed mutagenesis reveals the importance of secondary structure in the transition state for acylphosphatase folding. J Mol Biol (2000) 0.97
Mapping the energy surface for the folding reaction of the coiled-coil peptide GCN4-p1. Biochemistry (2001) 0.94
Evidence for partial secondary structure formation in the transition state for arc repressor refolding and dimerization. Biochemistry (2000) 0.86
Proton NMR studies of the association and folding of glucagon in solution. FEBS Lett (1980) 0.83
Random-coil behavior and the dimensions of chemically unfolded proteins. Proc Natl Acad Sci U S A (2004) 4.44
Light-activated DNA binding in a designed allosteric protein. Proc Natl Acad Sci U S A (2008) 2.67
TULIPs: tunable, light-controlled interacting protein tags for cell biology. Nat Methods (2012) 2.59
Statistical coil model of the unfolded state: resolving the reconciliation problem. Proc Natl Acad Sci U S A (2005) 2.32
Outcome of a workshop on applications of protein models in biomedical research. Structure (2009) 2.05
Investigations into sequence and conformational dependence of backbone entropy, inter-basin dynamics and the Flory isolated-pair hypothesis for peptides. J Mol Biol (2003) 2.00
Protein folding: defining a "standard" set of experimental conditions and a preliminary kinetic data set of two-state proteins. Protein Sci (2005) 1.91
Helix, sheet, and polyproline II frequencies and strong nearest neighbor effects in a restricted coil library. Biochemistry (2005) 1.73
Rationally improving LOV domain-based photoswitches. Nat Methods (2010) 1.72
Fast and slow intermediate accumulation and the initial barrier mechanism in protein folding. J Mol Biol (2002) 1.70
Single-molecule studies highlight conformational heterogeneity in the early folding steps of a large ribozyme. Proc Natl Acad Sci U S A (2004) 1.69
Discerning the structure and energy of multiple transition states in protein folding using psi-analysis. J Mol Biol (2004) 1.61
Early collapse is not an obligate step in protein folding. J Mol Biol (2004) 1.45
Folding of noncoding RNAs during transcription facilitated by pausing-induced nonnative structures. Proc Natl Acad Sci U S A (2007) 1.36
Structure of a folding intermediate reveals the interplay between core and peripheral elements in RNA folding. J Mol Biol (2005) 1.31
Mimicking the folding pathway to improve homology-free protein structure prediction. Proc Natl Acad Sci U S A (2009) 1.25
Understanding protein hydrogen bond formation with kinetic H/D amide isotope effects. Nat Struct Biol (2002) 1.20
Minimalist representations and the importance of nearest neighbor effects in protein folding simulations. J Mol Biol (2006) 1.19
Automated real-space refinement of protein structures using a realistic backbone move set. Biophys J (2011) 1.16
Dynamics of hydrogen bond desolvation in protein folding. J Mol Biol (2002) 1.13
The amino-terminal helix modulates light-activated conformational changes in AsLOV2. J Mol Biol (2012) 1.12
Modeling the hydration layer around proteins: applications to small- and wide-angle x-ray scattering. Biophys J (2011) 1.11
Reduced C(beta) statistical potentials can outperform all-atom potentials in decoy identification. Protein Sci (2007) 1.09
Modeling the hydration layer around proteins: HyPred. Biophys J (2010) 1.08
Fully reduced ribonuclease A does not expand at high denaturant concentration or temperature. J Mol Biol (2007) 1.08
Transcriptional pausing coordinates folding of the aptamer domain and the expression platform of a riboswitch. Proc Natl Acad Sci U S A (2012) 1.07
Large-scale context in protein folding: villin headpiece. Biochemistry (2003) 1.07
Protein vivisection reveals elusive intermediates in folding. J Mol Biol (2010) 1.06
On the precision of experimentally determined protein folding rates and phi-values. Protein Sci (2006) 1.06
Quantifying the structural requirements of the folding transition state of protein A and other systems. J Mol Biol (2008) 1.05
Small proteins fold through transition states with native-like topologies. J Mol Biol (2006) 1.04
Folding of a large protein at high structural resolution. Proc Natl Acad Sci U S A (2013) 1.02
Intramolecular cross-linking evaluated as a structural probe of the protein folding transition state. Biochemistry (2007) 1.00
Barrier-limited, microsecond folding of a stable protein measured with hydrogen exchange: Implications for downhill folding. Proc Natl Acad Sci U S A (2004) 1.00
Efficient fluorescence labeling of a large RNA through oligonucleotide hybridization. RNA (2004) 0.99
Folding of a universal ribozyme: the ribonuclease P RNA. Q Rev Biophys (2007) 0.98
Small-angle X-ray scattering and single-molecule FRET spectroscopy produce highly divergent views of the low-denaturant unfolded state. J Mol Biol (2012) 0.97
Single-molecule nonequilibrium periodic Mg2+-concentration jump experiments reveal details of the early folding pathways of a large RNA. Proc Natl Acad Sci U S A (2008) 0.96
Investigating models of protein function and allostery with a widespread mutational analysis of a light-activated protein. Biophys J (2013) 0.94
Ubiquitin is a novel substrate for human insulin-degrading enzyme. J Mol Biol (2010) 0.94
Extended structures in RNA folding intermediates are due to nonnative interactions rather than electrostatic repulsion. J Mol Biol (2010) 0.92
Characterizing protein folding transition States using Psi-analysis. Methods Mol Biol (2007) 0.92
Structural basis for altering the stability of homologous RNAs from a mesophilic and a thermophilic bacterium. RNA (2006) 0.92
Polypeptide motions are dominated by peptide group oscillations resulting from dihedral angle correlations between nearest neighbors. Biochemistry (2007) 0.91
De novo prediction of protein folding pathways and structure using the principle of sequential stabilization. Proc Natl Acad Sci U S A (2012) 0.91
The folding transition state of protein L is extensive with nonnative interactions (and not small and polarized). J Mol Biol (2012) 0.90
Methods for the accurate estimation of confidence intervals on protein folding phi-values. Protein Sci (2006) 0.90
A large collapsed-state RNA can exhibit simple exponential single-molecule dynamics. J Mol Biol (2008) 0.89
Probing the folding transition state of ubiquitin mutants by temperature-jump-induced downhill unfolding. Biochemistry (2008) 0.89
Discovering RNA-protein interactome by using chemical context profiling of the RNA-protein interface. Cell Rep (2013) 0.88
New era of molecular structure and dynamics from solution scattering experiments. Biopolymers (2011) 0.86
Psi-constrained simulations of protein folding transition states: implications for calculating. J Mol Biol (2009) 0.86
Modeling large regions in proteins: applications to loops, termini, and folding. Protein Sci (2011) 0.86
Contribution of hydrogen bonding to protein stability estimated from isotope effects. Biochemistry (2002) 0.86
A probabilistic and continuous model of protein conformational space for template-free modeling. J Comput Biol (2010) 0.85
PII structure in the model peptides for unfolded proteins: studies on ubiquitin fragments and several alanine-rich peptides containing QQQ, SSS, FFF, and VVV. Proteins (2006) 0.84
Metal binding kinetics of bi-histidine sites used in psi analysis: evidence of high-energy protein folding intermediates. Biochemistry (2009) 0.83
Simplified protein models: predicting folding pathways and structure using amino acid sequences. Phys Rev Lett (2013) 0.83
A Probabilistic Graphical Model for Ab Initio Folding. Res Comput Mol Biol (2009) 0.83
Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions. Proc Natl Acad Sci U S A (2009) 0.82
Context and force field dependence of the loss of protein backbone entropy upon folding using realistic denatured and native state ensembles. J Am Chem Soc (2012) 0.82
Discrete structure of an RNA folding intermediate revealed by cryo-electron microscopy. J Am Chem Soc (2010) 0.82
A "Link-Psi" strategy using crosslinking indicates that the folding transition state of ubiquitin is not very malleable. Protein Sci (2012) 0.82
On docking, scoring and assessing protein-DNA complexes in a rigid-body framework. PLoS One (2012) 0.80
Protein structure prediction enhanced with evolutionary diversity: SPEED. Protein Sci (2010) 0.80
Entropic benefit of a cross-link in protein association. Proteins (2002) 0.80
Mechanistic insights on the folding of a large ribozyme during transcription. Biochemistry (2005) 0.79
A novel implicit solvent model for simulating the molecular dynamics of RNA. Biophys J (2013) 0.77
Getting hotter with RNA. Nat Struct Biol (2002) 0.75
D/H amide isotope effect in model alpha-helical peptides. J Am Chem Soc (2002) 0.75