Published in Chembiochem on September 06, 2004
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies. J Am Chem Soc (2009) 1.72
Fluorous supported modular synthesis of heparan sulfate oligosaccharides. Org Lett (2013) 0.95
Monitoring aminoglycoside-induced conformational changes in 16S rRNA through acrylamide quenching. Bioorg Med Chem (2007) 0.92
Rapid assembly of oligosaccharides: a highly convergent strategy for the assembly of a glycosylated amino acid derived from PSGL-1. J Org Chem (2009) 0.85
New glucuronic acid donors for the modular synthesis of heparan sulfate oligosaccharides. Org Biomol Chem (2014) 0.78
Synthesis of β-C-GlcNAc Ser from β-C-Glc Ser. J Org Chem (2013) 0.75
Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions. Angew Chem Int Ed Engl (2008) 5.90
RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform. Annu Rev Pharmacol Toxicol (2010) 4.86
Single-stranded RNAs use RNAi to potently and allele-selectively inhibit mutant huntingtin expression. Cell (2012) 2.83
Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol (2008) 2.65
Single-stranded siRNAs activate RNAi in animals. Cell (2012) 2.64
A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science (2013) 2.49
A bioinformatics based approach to discover small RNA genes in the Escherichia coli genome. Biosystems (2002) 2.31
Robust immune responses elicited by a fully synthetic three-component vaccine. Nat Chem Biol (2007) 2.24
Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research. Nat Chem (2009) 2.09
Fully 2'-modified oligonucleotide duplexes with improved in vitro potency and stability compared to unmodified small interfering RNA. J Med Chem (2005) 2.05
Potent inhibition of microRNA in vivo without degradation. Nucleic Acids Res (2008) 1.98
Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nat Med (2011) 1.97
Selective labeling of living cells by a photo-triggered click reaction. J Am Chem Soc (2009) 1.89
Rapid identification of emerging pathogens: coronavirus. Emerg Infect Dis (2005) 1.87
A synthetic lectin for O-linked beta-N-acetylglucosamine. Angew Chem Int Ed Engl (2009) 1.81
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol (2003) 1.80
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies. J Am Chem Soc (2009) 1.72
A general strategy for stereoselective glycosylations. J Am Chem Soc (2005) 1.70
Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals. J Med Chem (2009) 1.61
SAR by MS: discovery of a new class of RNA-binding small molecules for the hepatitis C virus: internal ribosome entry site IIA subdomain. J Med Chem (2005) 1.59
Positional effect of chemical modifications on short interference RNA activity in mammalian cells. J Med Chem (2005) 1.57
The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J Biol Chem (2002) 1.53
Allele-selective inhibition of mutant huntingtin expression with antisense oligonucleotides targeting the expanded CAG repeat. Biochemistry (2010) 1.50
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2004) 1.50
Towards a fully synthetic carbohydrate-based anticancer vaccine: synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated tn antigen. Angew Chem Int Ed Engl (2005) 1.49
Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine. Proc Natl Acad Sci U S A (2011) 1.46
Competition for RISC binding predicts in vitro potency of siRNA. Nucleic Acids Res (2006) 1.44
Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat Chem Biol (2012) 1.43
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol (2010) 1.41
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J Proteome Res (2011) 1.41
Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues. J Org Chem (2010) 1.36
Glycopeptides as versatile tools for glycobiology. Glycobiology (2006) 1.36
Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A (2006) 1.35
The immunogenicity of the tumor-associated antigen Lewis(y) may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein. Chemistry (2004) 1.35
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2007) 1.27
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol (2009) 1.26
Rational design of antisense oligonucleotides targeting single nucleotide polymorphisms for potent and allele selective suppression of mutant Huntingtin in the CNS. Nucleic Acids Res (2013) 1.23
Practical approach for the stereoselective introduction of beta-arabinofuranosides. J Am Chem Soc (2006) 1.23
The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog (2011) 1.21
Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity. J Am Chem Soc (2010) 1.19
Stereoselective glycosylation reactions with chiral auxiliaries. Angew Chem Int Ed Engl (2005) 1.19
Protein modification by strain-promoted alkyne-nitrone cycloaddition. Angew Chem Int Ed Engl (2010) 1.17
Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporium. Chemistry (2006) 1.15
Immunotherapy for cancer: synthetic carbohydrate-based vaccines. Chem Commun (Camb) (2009) 1.14
Strain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis. Chembiochem (2011) 1.10
Inhibitor-induced structural change in the HCV IRES domain IIa RNA. Proc Natl Acad Sci U S A (2010) 1.10
Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I{alpha} and S. J Biol Chem (2005) 1.10
Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors. Chembiochem (2009) 1.09
New set of orthogonal protecting groups for the modular synthesis of heparan sulfate fragments. Org Lett (2003) 1.06
Modulation of innate immune responses with synthetic lipid A derivatives. J Am Chem Soc (2007) 1.05
Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: α-dystroglycan and forms of muscular dystrophy. Chembiochem (2013) 1.04
Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site. Angew Chem Int Ed Engl (2004) 1.04
Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications. J Med Chem (2006) 1.04
Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Sci (2006) 1.04
Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol Chem (2011) 1.03
TricycloDNA-modified oligo-2'-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues--a comparative study of oligonucleotide length, design and chemistry. Nucleic Acids Res (2012) 1.03
Synthesis, improved antisense activity and structural rationale for the divergent RNA affinities of 3'-fluoro hexitol nucleic acid (FHNA and Ara-FHNA) modified oligonucleotides. J Am Chem Soc (2011) 1.02
Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity (2007) 1.02
Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells. J Am Chem Soc (2012) 1.01
2-piperidin-4-yl-benzimidazoles with broad spectrum antibacterial activities. Bioorg Med Chem Lett (2003) 1.01
Binding and Cellular Activation Studies Reveal That Toll-like Receptor 2 Can Differentially Recognize Peptidoglycan from Gram-positive and Gram-negative Bacteria. J Biol Chem (2009) 1.01
Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives. J Am Chem Soc (2003) 1.00
Modification of the structure of peptidoglycan is a strategy to avoid detection by nucleotide-binding oligomerization domain protein 1. Infect Immun (2006) 1.00
Stereoselective glycosylations of 2-azido-2-deoxy-glucosides using intermediate sulfonium ions. Org Lett (2007) 1.00
Preparation of well-defined antibody-drug conjugates through glycan remodeling and strain-promoted azide-alkyne cycloadditions. Angew Chem Int Ed Engl (2014) 0.99
An exocyclic methylene group acts as a bioisostere of the 2'-oxygen atom in LNA. J Am Chem Soc (2010) 0.99
ss-siRNAs allele selectively inhibit ataxin-3 expression: multiple mechanisms for an alternative gene silencing strategy. Nucleic Acids Res (2013) 0.99
Role of a cytoplasmic dual-function glycosyltransferase in O2 regulation of development in Dictyostelium. J Biol Chem (2009) 0.98
Multivalency and the mode of action of bacterial sialidases. J Am Chem Soc (2003) 0.98
A fluorogenic probe for the catalyst-free detection of azide-tagged molecules. J Am Chem Soc (2012) 0.98
Differential induction of innate immune responses by synthetic lipid a derivatives. J Biol Chem (2010) 0.97
Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J Am Chem Soc (2008) 0.97
Versatile set of orthogonal protecting groups for the preparation of highly branched oligosaccharides. Org Lett (2010) 0.96
Allele-selective inhibition of mutant atrophin-1 expression by duplex and single-stranded RNAs. Biochemistry (2014) 0.96
Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions. J Am Chem Soc (2006) 0.96
Multivariate analysis of electron detachment dissociation and infrared multiphoton dissociation mass spectra of heparan sulfate tetrasaccharides differing only in hexuronic acid stereochemistry. J Am Soc Mass Spectrom (2011) 0.95
SAR by MS: a ligand based technique for drug lead discovery against structured RNA targets. J Med Chem (2002) 0.95
Fluorous supported modular synthesis of heparan sulfate oligosaccharides. Org Lett (2013) 0.95
Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4. Comp Immunol Microbiol Infect Dis (2009) 0.94
Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs. Nucleic Acids Symp Ser (Oxf) (2008) 0.94
Synthesis and biological evaluation of a lipid A derivative that contains an aminogluconate moiety. Chemistry (2004) 0.94
The positional influence of the helical geometry of the heteroduplex substrate on human RNase H1 catalysis. Mol Pharmacol (2006) 0.94
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria. Bioorg Med Chem Lett (2010) 0.93
Adaptive immune activation: glycosylation does matter. Nat Chem Biol (2013) 0.93
Lipid nanoparticles improve activity of single-stranded siRNA and gapmer antisense oligonucleotides in animals. ACS Chem Biol (2013) 0.93
Synthetic, structural, and biosynthetic studies of an unusual phospho-glycopeptide derived from α-dystroglycan. J Am Chem Soc (2011) 0.93
Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and α-N-acetylglucosaminyltransferase enzymes involved in O₂ signaling in dictyostelium. Biochemistry (2011) 0.92
Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates. Eur J Mass Spectrom (Chichester, Eng) (2011) 0.92
Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched alpha-glucan. Nat Chem (2010) 0.91
Synthesis of glyco(lipo)peptides by liposome-mediated native chemical ligation. Org Lett (2006) 0.91
Configuration of the 5'-methyl group modulates the biophysical and biological properties of locked nucleic acid (LNA) oligonucleotides. J Med Chem (2010) 0.91
High-avidity, low-affinity multivalent interactions and the block to polyspermy in Xenopus laevis. J Am Chem Soc (2002) 0.91