Published in Angew Chem Int Ed Engl on May 23, 2014
Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug Chem (2015) 1.58
Recent advances in the construction of antibody-drug conjugates. Nat Chem (2016) 1.18
Chemoenzymatic strategy for the synthesis of site-specifically labeled immunoconjugates for multimodal PET and optical imaging. Bioconjug Chem (2014) 0.88
Site-Specifically Labeled Immunoconjugates for Molecular Imaging-Part 1: Cysteine Residues and Glycans. Mol Imaging Biol (2016) 0.85
A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins. Angew Chem Int Ed Engl (2014) 0.81
Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov (2017) 0.80
Microscale screening of antibody libraries as maytansinoid antibody-drug conjugates. MAbs (2016) 0.76
Methods to Make Homogenous Antibody Drug Conjugates. Pharm Res (2014) 0.76
A PEGylated photocleavable auxiliary mediates the sequential enzymatic glycosylation and native chemical ligation of peptides. Angew Chem Int Ed Engl (2015) 0.76
Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Angew Chem Int Ed Engl (2016) 0.76
Improved variants of SrtA for site-specific conjugation on antibodies and proteins with high efficiency. Sci Rep (2016) 0.75
Straightforward Glycoengineering Approach to Site-Specific Antibody-Pyrrolobenzodiazepine Conjugates. ACS Med Chem Lett (2016) 0.75
Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nat Protoc (2017) 0.75
Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control. Sci Rep (2017) 0.75
Cell surface engineering by a modified Staudinger reaction. Science (2000) 8.09
Cu-catalyzed azide-alkyne cycloaddition. Chem Rev (2008) 6.21
Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions. Angew Chem Int Ed Engl (2008) 5.90
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index. Nat Biotechnol (2008) 5.54
Cu-free click cycloaddition reactions in chemical biology. Chem Soc Rev (2010) 3.89
Glycosylation as a strategy to improve antibody-based therapeutics. Nat Rev Drug Discov (2009) 3.66
Studies on the chemical and enzymatic modification of glycoproteins. A general method for the tritiation of sialic acid-containing glycoproteins. J Biol Chem (1971) 3.45
A decade of rituximab: improving survival outcomes in non-Hodgkin's lymphoma. Annu Rev Med (2008) 2.44
A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries. J Am Chem Soc (2005) 2.22
Antibody-drug conjugates: linking cytotoxic payloads to monoclonal antibodies. Bioconjug Chem (2010) 2.06
Synthesis of site-specific antibody-drug conjugates using unnatural amino acids. Proc Natl Acad Sci U S A (2012) 1.99
Biocompatible copper(I) catalysts for in vivo imaging of glycans. J Am Chem Soc (2010) 1.98
Biochemical engineering of the N-acyl side chain of sialic acid: biological implications. Glycobiology (2001) 1.93
Bioconjugation with strained alkenes and alkynes. Acc Chem Res (2011) 1.89
Physical and chemical studies on ceruloplasmin. IV. Preparation of radioactive, sialic acid-free ceruloplasmin labeled with tritium on terminal D-galactose residues. J Biol Chem (1966) 1.84
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chem Biol (2013) 1.82
NMR characterization of immunoglobulin G Fc glycan motion on enzymatic sialylation. Biochemistry (2012) 1.60
Chemoenzymatic glycoengineering of intact IgG antibodies for gain of functions. J Am Chem Soc (2012) 1.44
Azide: a unique dipole for metal-free bioorthogonal ligations. Chembiochem (2010) 1.40
Enzymes in the synthesis of glycoconjugates. Chem Rev (2011) 1.27
Cellular consequences of copper complexes used to catalyze bioorthogonal click reactions. J Am Chem Soc (2011) 1.25
trans-Cyclooctene--a stable, voracious dienophile for bioorthogonal labeling. Curr Opin Chem Biol (2013) 1.25
Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity. J Am Chem Soc (2010) 1.19
Protein modification by strain-promoted alkyne-nitrone cycloaddition. Angew Chem Int Ed Engl (2010) 1.17
Bioconjugation via azide-Staudinger ligation: an overview. Chem Soc Rev (2011) 1.13
Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids. J Mol Biol (2011) 1.08
Site specific conjugation of fluoroprobes to the remodeled Fc N-glycans of monoclonal antibodies using mutant glycosyltransferases: application for cell surface antigen detection. Bioconjug Chem (2009) 1.08
Antibody-drug conjugates. Nat Rev Drug Discov (2013) 1.08
Site-specific covalent modification of monoclonal antibodies: in vitro and in vivo evaluations. Proc Natl Acad Sci U S A (1986) 1.06
Antibody-drug conjugates - a perfect synergy. Expert Opin Biol Ther (2012) 1.04
Antibody drug conjugates - Trojan horses in the war on cancer. J Pharmacol Toxicol Methods (2011) 1.04
Metabolic engineering of monoclonal antibody carbohydrates for antibody-drug conjugation. Bioconjug Chem (2013) 0.95
Selective exo-enzymatic labeling of N-glycans on the surface of living cells by recombinant ST6Gal I. Angew Chem Int Ed Engl (2013) 0.86
Fucose-specific conjugation of hydrazide derivatives to a vascular-targeting monoclonal antibody in IgG format. Chem Commun (Camb) (2012) 0.84
Synthesis of CMP-9''-modified-sialic acids as donor substrate analogues for mammalian and bacterial sialyltransferases. Carbohydr Res (2007) 0.81
Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions. Angew Chem Int Ed Engl (2008) 5.90
Pannexin-1-mediated intracellular delivery of muramyl dipeptide induces caspase-1 activation via cryopyrin/NLRP3 independently of Nod2. J Immunol (2008) 2.65
A general strategy for the chemoenzymatic synthesis of asymmetrically branched N-glycans. Science (2013) 2.49
Robust immune responses elicited by a fully synthetic three-component vaccine. Nat Chem Biol (2007) 2.24
Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research. Nat Chem (2009) 2.09
Peptidoglycan recognition proteins kill bacteria by activating protein-sensing two-component systems. Nat Med (2011) 1.97
Selective labeling of living cells by a photo-triggered click reaction. J Am Chem Soc (2009) 1.89
A synthetic lectin for O-linked beta-N-acetylglucosamine. Angew Chem Int Ed Engl (2009) 1.81
An angiogenic switch in macrophages involving synergy between Toll-like receptors 2, 4, 7, and 9 and adenosine A(2A) receptors. Am J Pathol (2003) 1.80
Modular synthesis of heparan sulfate oligosaccharides for structure-activity relationship studies. J Am Chem Soc (2009) 1.72
A general strategy for stereoselective glycosylations. J Am Chem Soc (2005) 1.70
The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J Biol Chem (2002) 1.53
Structural basis for peptidoglycan binding by peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2004) 1.50
Towards a fully synthetic carbohydrate-based anticancer vaccine: synthesis and immunological evaluation of a lipidated glycopeptide containing the tumor-associated tn antigen. Angew Chem Int Ed Engl (2005) 1.49
Immune recognition of tumor-associated mucin MUC1 is achieved by a fully synthetic aberrantly glycosylated MUC1 tripartite vaccine. Proc Natl Acad Sci U S A (2011) 1.46
Disease-specific non-reducing end carbohydrate biomarkers for mucopolysaccharidoses. Nat Chem Biol (2012) 1.43
Glycopeptide-specific monoclonal antibodies suggest new roles for O-GlcNAc. Nat Chem Biol (2010) 1.41
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignment. J Proteome Res (2011) 1.41
Glycopeptides as versatile tools for glycobiology. Glycobiology (2006) 1.36
Dual strategies for peptidoglycan discrimination by peptidoglycan recognition proteins (PGRPs). Proc Natl Acad Sci U S A (2006) 1.35
The immunogenicity of the tumor-associated antigen Lewis(y) may be suppressed by a bifunctional cross-linker required for coupling to a carrier protein. Chemistry (2004) 1.35
Structural insights into the bactericidal mechanism of human peptidoglycan recognition proteins. Proc Natl Acad Sci U S A (2007) 1.27
Clathrin- and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation. J Immunol (2009) 1.26
Practical approach for the stereoselective introduction of beta-arabinofuranosides. J Am Chem Soc (2006) 1.23
The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization. PLoS Pathog (2011) 1.21
Metal-free sequential [3 + 2]-dipolar cycloadditions using cyclooctynes and 1,3-dipoles of different reactivity. J Am Chem Soc (2010) 1.19
Stereoselective glycosylation reactions with chiral auxiliaries. Angew Chem Int Ed Engl (2005) 1.19
Protein modification by strain-promoted alkyne-nitrone cycloaddition. Angew Chem Int Ed Engl (2010) 1.17
MicroRNA-200b regulates cyclin D1 expression and promotes S-phase entry by targeting RND3 in HeLa cells. Mol Cell Biochem (2010) 1.15
Synthesis and antigenic analysis of the BclA glycoprotein oligosaccharide from the Bacillus anthracis exosporium. Chemistry (2006) 1.15
Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage. Sci Total Environ (2011) 1.15
Immunotherapy for cancer: synthetic carbohydrate-based vaccines. Chem Commun (Camb) (2009) 1.14
Strain-promoted alkyne-azide cycloadditions (SPAAC) reveal new features of glycoconjugate biosynthesis. Chembiochem (2011) 1.10
Selective recognition of synthetic lysine and meso-diaminopimelic acid-type peptidoglycan fragments by human peptidoglycan recognition proteins I{alpha} and S. J Biol Chem (2005) 1.10
Increasing the antigenicity of synthetic tumor-associated carbohydrate antigens by targeting Toll-like receptors. Chembiochem (2009) 1.09
New set of orthogonal protecting groups for the modular synthesis of heparan sulfate fragments. Org Lett (2003) 1.06
Modulation of innate immune responses with synthetic lipid A derivatives. J Am Chem Soc (2007) 1.05
Dissecting the molecular basis of the role of the O-mannosylation pathway in disease: α-dystroglycan and forms of muscular dystrophy. Chembiochem (2013) 1.04
Crystal structure of human peptidoglycan recognition protein I alpha bound to a muramyl pentapeptide from Gram-positive bacteria. Protein Sci (2006) 1.04
Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity (2007) 1.02
Polar dibenzocyclooctynes for selective labeling of extracellular glycoconjugates of living cells. J Am Chem Soc (2012) 1.01
Binding and Cellular Activation Studies Reveal That Toll-like Receptor 2 Can Differentially Recognize Peptidoglycan from Gram-positive and Gram-negative Bacteria. J Biol Chem (2009) 1.01
Synthesis and biological evaluation of Rhizobium sin-1 lipid A derivatives. J Am Chem Soc (2003) 1.00
Stereoselective glycosylations of 2-azido-2-deoxy-glucosides using intermediate sulfonium ions. Org Lett (2007) 1.00
Modification of the structure of peptidoglycan is a strategy to avoid detection by nucleotide-binding oligomerization domain protein 1. Infect Immun (2006) 1.00
Role of a cytoplasmic dual-function glycosyltransferase in O2 regulation of development in Dictyostelium. J Biol Chem (2009) 0.98
Multivalency and the mode of action of bacterial sialidases. J Am Chem Soc (2003) 0.98
A fluorogenic probe for the catalyst-free detection of azide-tagged molecules. J Am Chem Soc (2012) 0.98
Differential induction of innate immune responses by synthetic lipid a derivatives. J Biol Chem (2010) 0.97
Probing the substrate specificity of Golgi alpha-mannosidase II by use of synthetic oligosaccharides and a catalytic nucleophile mutant. J Am Chem Soc (2008) 0.97
Versatile set of orthogonal protecting groups for the preparation of highly branched oligosaccharides. Org Lett (2010) 0.96
Structural basis of the inhibition of Golgi alpha-mannosidase II by mannostatin A and the role of the thiomethyl moiety in ligand-protein interactions. J Am Chem Soc (2006) 0.96
Multivariate analysis of electron detachment dissociation and infrared multiphoton dissociation mass spectra of heparan sulfate tetrasaccharides differing only in hexuronic acid stereochemistry. J Am Soc Mass Spectrom (2011) 0.95
Fluorous supported modular synthesis of heparan sulfate oligosaccharides. Org Lett (2013) 0.95
An efficient fragment-based approach for predicting the ground-state energies and structures of large molecules. J Am Chem Soc (2005) 0.94
Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4. Comp Immunol Microbiol Infect Dis (2009) 0.94
Synthesis and biological evaluation of a lipid A derivative that contains an aminogluconate moiety. Chemistry (2004) 0.94
Adaptive immune activation: glycosylation does matter. Nat Chem Biol (2013) 0.93
Synthetic, structural, and biosynthetic studies of an unusual phospho-glycopeptide derived from α-dystroglycan. J Am Chem Soc (2011) 0.93
Negative electron transfer dissociation Fourier transform mass spectrometry of glycosaminoglycan carbohydrates. Eur J Mass Spectrom (Chichester, Eng) (2011) 0.92
Requirements for Skp1 processing by cytosolic prolyl 4(trans)-hydroxylase and α-N-acetylglucosaminyltransferase enzymes involved in O₂ signaling in dictyostelium. Biochemistry (2011) 0.92
Synthesis of glyco(lipo)peptides by liposome-mediated native chemical ligation. Org Lett (2006) 0.91
MiR-138 downregulates miRNA processing in HeLa cells by targeting RMND5A and decreasing Exportin-5 stability. Nucleic Acids Res (2013) 0.91
Endolysins of Bacillus anthracis bacteriophages recognize unique carbohydrate epitopes of vegetative cell wall polysaccharides with high affinity and selectivity. J Am Chem Soc (2012) 0.91
Chiral-auxiliary-mediated 1,2-cis-glycosylations for the solid-supported synthesis of a biologically important branched alpha-glucan. Nat Chem (2010) 0.91
High-avidity, low-affinity multivalent interactions and the block to polyspermy in Xenopus laevis. J Am Chem Soc (2002) 0.91
The 2-aminogluconate isomer of rhizobium sin-1 lipid A can antagonize TNF-alpha production induced by enteric LPS. Chembiochem (2006) 0.90
Innate immune responses of synthetic lipid A derivatives of Neisseria meningitidis. Chemistry (2008) 0.90
Multifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactions. J Am Chem Soc (2011) 0.90
Chemical synthesis and immunological evaluation of the inner core oligosaccharide of Francisella tularensis. J Am Chem Soc (2012) 0.89
Disaccharide mimetics of the aminoglycoside antibiotic neamine. Chembiochem (2004) 0.89
Direct and stereoselective synthesis of alpha-linked 2-deoxyglycosides. Org Lett (2008) 0.89
Stereoelectronic effects determine oxacarbenium vs β-sulfonium ion mediated glycosylations. Org Lett (2010) 0.88
Sevoflurane postconditioning reduces myocardial reperfusion injury in rat isolated hearts via activation of PI3K/Akt signaling and modulation of Bcl-2 family proteins. J Zhejiang Univ Sci B (2010) 0.88
Synthesis and proinflammatory properties of muramyl tripeptides containing lysine and diaminopimelic acid moieties. Chembiochem (2005) 0.87
Synthetic tetra-acylated derivatives of lipid A from Porphyromonas gingivalis are antagonists of human TLR4. Org Biomol Chem (2008) 0.87
Selective exo-enzymatic labeling of N-glycans on the surface of living cells by recombinant ST6Gal I. Angew Chem Int Ed Engl (2013) 0.86
The influence of the long chain fatty acid on the antagonistic activities of Rhizobium sin-1 lipid A. Bioorg Med Chem (2007) 0.86
Rapid assembly of oligosaccharides: a highly convergent strategy for the assembly of a glycosylated amino acid derived from PSGL-1. J Org Chem (2009) 0.85
Asymmetric Henry reaction catalyzed by C2-symmetric tridentate bis(oxazoline) and bis(thiazoline) complexes: metal-controlled reversal of enantioselectivity. J Org Chem (2005) 0.85
Comparative toxicity of nano-ZnO and bulk ZnO suspensions to zebrafish and the effects of sedimentation, ˙OH production and particle dissolution in distilled water. J Environ Monit (2011) 0.84
Chemical synthesis and proinflammatory responses of monophosphoryl lipid A adjuvant candidates. European J Org Chem (2010) 0.84
Immune and anticancer responses elicited by fully synthetic aberrantly glycosylated MUC1 tripartite vaccines modified by a TLR2 or TLR9 agonist. Chembiochem (2014) 0.84
Convergent assembly and surface modification of multifunctional dendrimers by three consecutive click reactions. Chemistry (2010) 0.84
Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study. Bioorg Med Chem (2011) 0.83
[Spectral feature-based hyperspectral RS image retrieval]. Guang Pu Xue Yu Guang Pu Fen Xi (2005) 0.83
Crystal structure of a peptidoglycan recognition protein (PGRP) in complex with a muramyl tripeptide from Gram-positive bacteria. J Endotoxin Res (2005) 0.83
Spin-labeled analogs of CMP-NeuAc as NMR probes of the alpha-2,6-sialyltransferase ST6Gal I. Chem Biol (2007) 0.83
Surface modification of polymeric micelles by strain-promoted alkyne-azide cycloadditions. Chemistry (2010) 0.83
ELECTRON DETACHMENT DISSOCIATION OF SYNTHETIC HEPARAN SULFATE GLYCOSAMINOGLYCAN TETRASACCHARIDES VARYING IN DEGREE OF SULFATION AND HEXURONIC ACID STEREOCHEMISTRY. Int J Mass Spectrom (2012) 0.82
Kinetics of the oxidation of MCRR by potassium permanganate. Toxicon (2005) 0.82
A highly convergent chemical synthesis of conformational epitopes of rhamnogalacturonan II. Angew Chem Int Ed Engl (2007) 0.82
Optical stealth transmission based on super-continuum generation in highly nonlinear fiber over WDM network. Opt Lett (2015) 0.82
Effects of sevoflurane preconditioning and postconditioning on rat myocardial stunning in ischemic reperfusion injury. J Zhejiang Univ Sci B (2010) 0.82
Antibody responses to a spore carbohydrate antigen as a marker of nonfatal inhalation anthrax in rhesus macaques. Clin Vaccine Immunol (2011) 0.82
Agonistic and antagonistic properties of a Rhizobium sin-1 lipid A modified by an ether-linked lipid. Org Biomol Chem (2007) 0.82
High-field asymmetric-waveform ion mobility spectrometry and electron detachment dissociation of isobaric mixtures of glycosaminoglycans. J Am Soc Mass Spectrom (2013) 0.82
Inhibition of Golgi mannosidase II with mannostatin A analogues: synthesis, biological evaluation, and structure-activity relationship studies. Chembiochem (2004) 0.82