Published in Immunology on January 01, 1992
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77
A better cell line for making hybridomas secreting specific antibodies. Nature (1978) 15.13
Sequences at the somatic recombination sites of immunoglobulin light-chain genes. Nature (1979) 11.83
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol (1986) 6.16
A simple method for polyethylene glycol-promoted hybridization of mouse myeloma cells. Somatic Cell Genet (1977) 5.65
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc Natl Acad Sci U S A (1984) 5.49
Production of single-stranded DNA templates by exonuclease digestion following the polymerase chain reaction. Nucleic Acids Res (1989) 4.70
T cell-derived B cell differentiation factor(s). Effect on the isotype switch of murine B cells. J Exp Med (1982) 4.51
Somatic mutation and the maturation of immune response to 2-phenyl oxazolone. Nature (1984) 4.45
Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med (1984) 4.14
Structure and function of anti-DNA autoantibodies derived from a single autoimmune mouse. Proc Natl Acad Sci U S A (1987) 3.90
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterparts. Nature (1981) 3.86
Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin. J Exp Med (1985) 3.54
Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J (1988) 2.81
Molecular events during maturation of the immune response to oxazolone. Nature (1985) 2.78
Switch circular DNA formed in cytokine-treated mouse splenocytes: evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell (1990) 2.30
A mouse IgM allotypic determinant (Igh-6.5) recognized by a monoclonal rat antibody. J Immunol (1981) 2.27
Somatic evolution of variable region structures during an immune response. Proc Natl Acad Sci U S A (1986) 2.23
Somatic evolution of diversity among anti-phosphocholine antibodies induced with Proteus morganii. J Immunol (1987) 1.78
IL-4 induces co-expression of intrinsic membrane IgG1 and IgE by murine B cells stimulated with lipopolysaccharide. J Immunol (1988) 1.66
Different joining region J elements of the murine kappa immunoglobulin light chain locus are used at markedly different frequencies. Proc Natl Acad Sci U S A (1984) 1.60
The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes. Cell (1985) 1.59
Somatic diversification of immunoglobulins. Proc Natl Acad Sci U S A (1984) 1.59
Influence of clonal selection on the expression of immunoglobulin variable region genes. Science (1984) 1.57
V kappa and J kappa gene segments of A/J Ars-A antibodies: somatic recombination generates the essential arginine at the junction of the variable and joining regions. Proc Natl Acad Sci U S A (1987) 1.53
Induced differentiation of a transformed clone of Ly-1+ B cells by clonal T cells and antigen. Proc Natl Acad Sci U S A (1986) 1.46
Immunoglobulin chain loss in hybridoma lines. Proc Natl Acad Sci U S A (1980) 1.44
The role of class II molecules in human B cell activation. Association with phosphatidyl inositol turnover, protein tyrosine phosphorylation, and proliferation. J Immunol (1990) 1.42
Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysates. Proc Natl Acad Sci U S A (1984) 1.30
Restriction in IgM expression. IV. Affinity analysis of monoclonal anti-phosphorylcholine antibodies. J Immunol (1983) 1.30
Ligand-induced desensitization of B-cell membrane immunoglobulin-mediated Ca2+ mobilization and protein kinase C translocation. Proc Natl Acad Sci U S A (1988) 1.27
Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte. J Exp Med (1989) 1.26
Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J Exp Med (1989) 1.21
Mitogen-driven B cell proliferation and differentiation are not accompanied by hypermutation of immunoglobulin variable region genes. J Immunol (1987) 1.20
Heavy-chain class switch does not terminate somatic mutation. J Exp Med (1990) 1.16
Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate. J Exp Med (1987) 1.13
Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking. J Immunol (1991) 1.01
Early biochemical events after MHC class II-mediated signaling on human B lymphocytes. J Immunol (1990) 0.84
Interleukin-induced increase in Ia expression by normal mouse B cells. J Exp Med (1984) 4.14
Recruitment and activation of PTP1C in negative regulation of antigen receptor signaling by Fc gamma RIIB1. Science (1995) 3.24
Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit. Science (1994) 2.98
The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science (1992) 2.41
B lymphocyte antigen receptors (mIg) are non-covalently associated with a disulfide linked, inducibly phosphorylated glycoprotein complex. EMBO J (1990) 2.24
Molecular mechanisms of transmembrane signaling in B lymphocytes. Annu Rev Immunol (1987) 2.22
Di- and trinucleotide target preferences of somatic mutagenesis in normal and autoreactive B cells. J Immunol (1996) 2.08
Ia binding ligands and cAMP stimulate nuclear translocation of PKC in B lymphocytes. Nature (1987) 1.93
The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR. Cell (1989) 1.91
Human and mouse killer-cell inhibitory receptors recruit PTP1C and PTP1D protein tyrosine phosphatases. J Immunol (1996) 1.90
The RasGAP-binding protein p62dok is a mediator of inhibitory FcgammaRIIB signals in B cells. Immunity (2000) 1.88
Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell (1998) 1.78
B cell activation. III. B cell plasma membrane depolarization and hyper-Ia antigen expression induced by receptor immunoglobulin cross-linking are coupled. J Exp Med (1983) 1.77
The B-cell antigen receptor complex. Immunol Today (1991) 1.74
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes. Proc Natl Acad Sci U S A (1991) 1.67
B cell activation. VIII. Membrane immunoglobulins transduce signals via activation of phosphatidylinositol hydrolysis. J Immunol (1984) 1.66
Regulation of B cell antigen receptor signal transduction and phosphorylation by CD45. Science (1991) 1.66
New nomenclature for the Reth motif (or ARH1/TAM/ARAM/YXXL) Immunol Today (1995) 1.65
Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med (1995) 1.62
Identification and characterization of a loss-of-function human MPYS variant. Genes Immun (2011) 1.60
B cell activation. I. Anti-immunoglobulin-induced receptor cross-linking results in a decrease in the plasma membrane potential of murine B lymphocytes. J Exp Med (1983) 1.56
B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol (1999) 1.55
Level of mIa expression on mitogen-stimulated murine B lymphocytes is dependent on position in cell cycle. J Immunol (1983) 1.54
Activation and anergy in bone marrow B cells of a novel immunoglobulin transgenic mouse that is both hapten specific and autoreactive. Immunity (2001) 1.54
The B-cell antigen receptor complex: structure and signal transduction. Immunol Today (1994) 1.53
Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. J Immunol (1995) 1.51
Differential susceptibility of neonatal and adult murine spleen cells to in vitro induction of B-cell tolerance. J Exp Med (1976) 1.50
Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A (1994) 1.49
Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses. J Exp Med (1998) 1.47
Translocation of protein kinase C during membrane immunoglobulin-mediated transmembrane signaling in B lymphocytes. J Immunol (1986) 1.45
Anti-Ig induces release of inositol 1,4,5-trisphosphate, which mediates mobilization of intracellular Ca++ stores in B lymphocytes. J Immunol (1986) 1.43
Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J (1994) 1.43
Differential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP). J Exp Med (2000) 1.34
B-cell tolerance. III. Effect of papain-mediated cleavage of cell surface IgD on tolerance susceptibility of murine B cells. J Exp Med (1977) 1.32
Transmembrane signals and intracellular "second messengers" in the regulation of quiescent B-lymphocyte activation. Immunol Rev (1987) 1.32
TCR-induced transmembrane signaling by peptide/MHC class II via associated Ig-alpha/beta dimers. Science (2001) 1.31
Fc epsilon receptor I-associated lyn-dependent phosphorylation of Fc gamma receptor IIB during negative regulation of mast cell activation. J Immunol (1998) 1.28
Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking. Nature (1987) 1.25
Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. J Exp Med (1997) 1.25
Negative regulation of FcepsilonRI signaling by FcgammaRII costimulation in human blood basophils. J Allergy Clin Immunol (2000) 1.24
Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene (1998) 1.24
Induction of c-fos and c-myc expression during B cell activation by IL-4 and immunoglobulin binding ligands. J Immunol (1989) 1.22
Transmembrane signaling through B cell MHC class II molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction. J Immunol (1987) 1.21
Altered I-A protein-mediated transmembrane signaling in B cells that express truncated I-Ak protein. Proc Natl Acad Sci U S A (1989) 1.21
B cell activation. IV. Induction of cell membrane depolarization and hyper-I-A expression by phorbol diesters suggests a role for protein kinase C in murine B lymphocyte activation. J Immunol (1984) 1.21
B-cell tolerance. IV. Differential role of surface IgM and IgD in determining tolerance susceptibility of murine B cells. J Exp Med (1977) 1.21
Ia-mediated signal transduction leads to proliferation of primed B lymphocytes. J Exp Med (1989) 1.21
Gene conversion and the generation of antibody diversity. Annu Rev Biochem (1989) 1.20
Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med (2001) 1.19
mIgM:mIgD ratios on B cells: mean mIgD expression exceeds mIgM by 10-fold on most splenic B cells. J Immunol (1984) 1.17
The role of receptor IgM and IgD in determining triggering and induction of tolerance in murine B cells. Immunol Rev (1979) 1.15
Alpha beta T cell receptor and CD3 transduce different signals in immature T cells. Implications for selection and tolerance. J Immunol (1989) 1.12
Unique signaling properties of B cell antigen receptor in mature and immature B cells: implications for tolerance and activation. J Immunol (2001) 1.12
B-cell antigen receptor competence regulates B-lymphocyte selection and survival. Immunol Rev (2000) 1.12
B cell activation. V. Differentiation signaling of B cell membrane depolarization, increased I-A expression, G0 to G1 transition, and thymidine uptake by anti-IgM and anti-IgD antibodies. J Immunol (1984) 1.11
Antigen-stimulated dissociation of BCR mIg from Ig-alpha/Ig-beta: implications for receptor desensitization. Immunity (1999) 1.10
Blocking of primary in vitro antibody responses to thymus-independent and thymus-dependent antigens with antiserum specific for IgM or IgD. Proc Natl Acad Sci U S A (1978) 1.10
Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase. J Immunol (1999) 1.09
Transforming growth factor beta 1 has differential effects on B cell proliferation and activation antigen expression. J Immunol (1990) 1.09
B lymphocyte activation: entry into cell cycle is accompanied by decreased expression of IgD but not IgM. Eur J Immunol (1983) 1.08
Cytoplasmic protein tyrosine phosphatases SHP-1 and SHP-2: regulators of B cell signal transduction. Curr Opin Immunol (2000) 1.08
B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1. J Immunol (1993) 1.08
Fc gammaRIIB1 inhibition of BCR-mediated phosphoinositide hydrolysis and Ca2+ mobilization is integrated by CD19 dephosphorylation. Immunity (1997) 1.07
Differential association of phosphatases with hematopoietic co-receptors bearing immunoreceptor tyrosine-based inhibition motifs. Eur J Immunol (1997) 1.07
Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells. J Exp Med (1999) 1.06
Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma. J Biol Chem (1993) 1.04
The role of L3T4+ cells in the pathogenesis of lupus in lpr-bearing mice. I. Defects in the production of interleukins 2 and 3. Eur J Immunol (1987) 1.04
Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J Immunol (1991) 1.04
Activating and inhibitory signaling in mast cells: new opportunities for therapeutic intervention? J Allergy Clin Immunol (2000) 1.04
Asymmetrical phosphorylation and function of immunoreceptor tyrosine-based activation motif tyrosines in B cell antigen receptor signal transduction. J Immunol (1998) 1.04
Sorting of B lymphoblasts based upon cell diameter provides cell populations enriched in different stages of cell cycle. J Immunol Methods (1983) 1.02
Modeling of T cell contact-dependent B cell activation. IL-4 and antigen receptor ligation primes quiescent B cells to mobilize calcium in response to Ia cross-linking. J Immunol (1991) 1.01
Cell cycle dependence for expression of membrane associated IgD, IgM and Ia antigen on mitogen-stimulated murine B-lymphocytes. Ann N Y Acad Sci (1982) 1.01
Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells. J Immunol (1990) 1.01
Definition of conditions that enable antigen-specific activation of the majority of isolated trinitrophenol-binding B cells. J Exp Med (1982) 1.01
gp120 ligation of CD4 induces p56lck activation and TCR desensitization independent of TCR tyrosine phosphorylation. J Immunol (1994) 1.00
A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro. J Immunol (2000) 1.00
B cell antigen receptor desensitization: disruption of receptor coupling to tyrosine kinase activation. J Immunol (1997) 0.99
B cell activation. II. Receptor cross-linking by thymus-independent and thymus-dependent antigens induces a rapid decrease in the plasma membrane potential of antigen-binding B lymphocytes. J Immunol (1983) 0.97
Selective in vivo recruitment of the phosphatidylinositol phosphatase SHIP by phosphorylated Fc gammaRIIB during negative regulation of IgE-dependent mouse mast cell activation. Immunol Lett (1996) 0.97
Ligation of membrane Ig leads to calcium-mediated phosphorylation of the proto-oncogene product, Ets-1. J Immunol (1991) 0.96
Production of multiple lymphokines by the A20.1 B cell lymphoma after cross-linking of membrane Ig by immobilized anti-Ig. J Immunol (1989) 0.95
Syk, but not Lyn, recruitment to B cell antigen receptor and activation following stimulation of CD45- B cells. J Immunol (1997) 0.94
T-cell development and transmembrane signaling: changing biological responses through an unchanging receptor. Immunol Today (1991) 0.94
Divalent cation regulation of phosphoinositide metabolism. Naturally occurring B lymphoblasts contain a Mg2(+)-regulated phosphatidylinositol-specific phospholipase C. J Biol Chem (1990) 0.94
Fc gamma RIIB activation leads to inhibition of signalling by independently ligated receptors. Biochem Soc Trans (2003) 0.93
Ligation of membrane immunoglobulin leads to inactivation of the signal-transducing ability of membrane immunoglobulin, CD19, CD21, and B-cell gp95. Proc Natl Acad Sci U S A (1990) 0.92
Two immunochemically and physicochemically distinct secretory components from rat exocrine secretion. J Immunol (1976) 0.92
Supernatant from a cloned helper T cell stimulates most small resting B cells to undergo increased I-A expression, blastogenesis, and progression through cell cycle. J Immunol (1986) 0.92
Point mutations define a mIgM transmembrane region motif that determines intersubunit signal transduction in the antigen receptor. J Immunol (1994) 0.91
The SHIP phosphatase becomes associated with Fc gammaRIIB1 and is tyrosine phosphorylated during 'negative' signaling. Immunol Lett (1996) 0.91
Desferoxamine blocks IL 2 receptor expression on human T lymphocytes. J Immunol (1986) 0.91
Co-receptor and accessory regulation of B-cell antigen receptor signal transduction. Immunol Rev (1997) 0.91
Single cell analysis of calcium mobilization in anti-immunoglobulin-stimulated B lymphocytes. J Immunol (1986) 0.90
B cell activation. VII. Independent and synergistic effects of mobilized calcium and diacylglycerol on membrane potential and I-A expression. J Immunol (1986) 0.90
Increased plasma membrane permeability to Ca2+ in anti-Ig-stimulated B lymphocytes is dependent on activation of phosphoinositide hydrolysis. J Immunol (1988) 0.89