Published in Trends Microbiol on October 01, 2004
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. Proc Natl Acad Sci U S A (2006) 1.41
Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F. Biochemistry (2009) 1.41
Subunit vaccine against the seven serotypes of botulism. Infect Immun (2007) 1.39
Botulinum neurotoxin D uses synaptic vesicle protein SV2 and gangliosides as receptors. PLoS Pathog (2011) 1.24
Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol (2006) 1.23
Novel application of human neurons derived from induced pluripotent stem cells for highly sensitive botulinum neurotoxin detection. Toxicol Sci (2012) 1.21
The Bacteroides fragilis toxin binds to a specific intestinal epithelial cell receptor. Infect Immun (2006) 1.20
Characterization of the antibody response to the receptor binding domain of botulinum neurotoxin serotypes A and E. Infect Immun (2005) 1.10
Recombinant holotoxoid vaccine against botulism. Infect Immun (2007) 1.09
Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. FEBS Lett (2010) 1.07
Entering neurons: botulinum toxins and synaptic vesicle recycling. EMBO Rep (2006) 1.05
Assembly and function of the botulinum neurotoxin progenitor complex. Curr Top Microbiol Immunol (2013) 1.00
The analgesic effect on neuropathic pain of retrogradely transported botulinum neurotoxin A involves Schwann cells and astrocytes. PLoS One (2012) 1.00
The identification and biochemical characterization of drug-like compounds that inhibit botulinum neurotoxin serotype A endopeptidase activity. Toxicon (2009) 0.93
Identification of fibroblast growth factor receptor 3 (FGFR3) as a protein receptor for botulinum neurotoxin serotype A (BoNT/A). PLoS Pathog (2013) 0.91
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. Nat Struct Mol Biol (2016) 0.90
Unique ganglioside recognition strategies for clostridial neurotoxins. J Biol Chem (2011) 0.90
Sensitive and quantitative detection of botulinum neurotoxin in neurons derived from mouse embryonic stem cells. Biochem Biophys Res Commun (2010) 0.90
Botulinum neurotoxin for pain management: insights from animal models. Toxins (Basel) (2010) 0.88
Botulinum Neurotoxins: Biology, Pharmacology, and Toxicology. Pharmacol Rev (2017) 0.87
On botulinum neurotoxin variability. MBio (2015) 0.87
Preferential entry of botulinum neurotoxin A Hc domain through intestinal crypt cells and targeting to cholinergic neurons of the mouse intestine. PLoS Pathog (2012) 0.86
Association of botulinum neurotoxins with synaptic vesicle protein complexes. Toxicon (2009) 0.85
CD44 Promotes intoxication by the clostridial iota-family toxins. PLoS One (2012) 0.85
Botulinum Toxin as a Pain Killer: Players and Actions in Antinociception. Toxins (Basel) (2015) 0.84
Immunological Characterization and Neutralizing Ability of Monoclonal Antibodies Directed Against Botulinum Neurotoxin Type H. J Infect Dis (2016) 0.84
Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons. J Pharmacol Exp Ther (2009) 0.83
Characterisation of a panel of anti-tetanus toxin single-chain Fvs reveals cooperative binding. Mol Immunol (2010) 0.82
Monoclonal Antibodies Targeting the Alpha-Exosite of Botulinum Neurotoxin Serotype/A Inhibit Catalytic Activity. PLoS One (2015) 0.79
Integration of ganglioside GT1b receptor into DPPE and DPPC phospholipid monolayers: an X-ray reflectivity and grazing-incidence diffraction study. Biophys J (2008) 0.79
Recombinant rabies virus particles presenting botulinum neurotoxin antigens elicit a protective humoral response in vivo. Mol Ther Methods Clin Dev (2014) 0.78
Cargo-delivery platforms for targeted delivery of inhibitor cargos against botulism. Curr Top Med Chem (2014) 0.77
Model for studying Clostridium botulinum neurotoxin using differentiated motor neuron-like NG108-15 cells. Biochem Biophys Res Commun (2012) 0.77
The C-terminal heavy-chain domain of botulinum neurotoxin a is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions. Infect Immun (2015) 0.77
Emerging opportunities for serotypes of botulinum neurotoxins. Toxins (Basel) (2012) 0.77
Tetanus Toxin Hc Fragment Induces the Formation of Ceramide Platforms and Protects Neuronal Cells against Oxidative Stress. PLoS One (2013) 0.76
Comparative in vitro and in vivo assessment of toxin neutralization by anti-tetanus toxin monoclonal antibodies. Hum Vaccin Immunother (2013) 0.76
Production and characterization of recombinant light chain and carboxyterminal heavy chain fragments of tetanus toxin. Avicenna J Med Biotechnol (2013) 0.75
Vaccines against Botulism. Toxins (Basel) (2017) 0.75
Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science (2003) 4.40
Rab5 and Rab7 control endocytic sorting along the axonal retrograde transport pathway. Neuron (2006) 2.79
Activation of MDA5 requires higher-order RNA structures generated during virus infection. J Virol (2009) 2.37
A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice. J Cell Biol (2005) 2.01
Immunocytochemical techniques reveal multiple, distinct cellular pools of PtdIns4P and PtdIns(4,5)P(2). Biochem J (2009) 2.00
Purification and characterization of the human elongator complex. J Biol Chem (2001) 1.97
Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron (2009) 1.96
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures. Science (2005) 1.92
Long-distance retrograde effects of botulinum neurotoxin A. J Neurosci (2008) 1.66
Deficits in axonal transport precede ALS symptoms in vivo. Proc Natl Acad Sci U S A (2010) 1.66
ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1. Proc Natl Acad Sci U S A (2011) 1.60
SNARE complexes and neuroexocytosis: how many, how close? Trends Biochem Sci (2005) 1.58
SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization. Neuron (2004) 1.56
A hitchhiker's guide to the nervous system: the complex journey of viruses and toxins. Nat Rev Microbiol (2010) 1.39
Analysis of retrograde transport in motor neurons reveals common endocytic carriers for tetanus toxin and neurotrophin receptor p75NTR. J Cell Biol (2002) 1.38
Long chain polyunsaturated fatty acids are required for efficient neurotransmission in C. elegans. J Cell Sci (2003) 1.38
Botulinum neurotoxins: from paralysis to recovery of functional neuromuscular transmission. J Physiol Paris (2001) 1.36
CAR-associated vesicular transport of an adenovirus in motor neuron axons. PLoS Pathog (2009) 1.35
Interaction of tau protein with the dynactin complex. EMBO J (2007) 1.33
Coordinated regulation of AP2 uncoating from clathrin-coated vesicles by rab5 and hRME-6. J Cell Biol (2008) 1.31
The dystonia-associated protein torsinA modulates synaptic vesicle recycling. J Biol Chem (2007) 1.23
The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol (2003) 1.23
Molecular landmarks along the axonal route: axonal transport in health and disease. Curr Opin Cell Biol (2008) 1.23
Tetanus toxin is internalized by a sequential clathrin-dependent mechanism initiated within lipid microdomains and independent of epsin1. J Cell Biol (2006) 1.23
Spastin and microtubules: Functions in health and disease. J Neurosci Res (2007) 1.22
Spatially distinct binding of Cdc42 to PAK1 and N-WASP in breast carcinoma cells. Mol Cell Biol (2005) 1.21
Myosin Va and microtubule-based motors are required for fast axonal retrograde transport of tetanus toxin in motor neurons. J Cell Sci (2003) 1.20
Human spastin has multiple microtubule-related functions. J Neurochem (2005) 1.16
Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol Biol Cell (2005) 1.16
Tetanus toxin is transported in a novel neuronal compartment characterized by a specialized pH regulation. J Biol Chem (2005) 1.14
Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport. Traffic (2007) 1.14
Evidence for anterograde transport and transcytosis of botulinum neurotoxin A (BoNT/A). J Neurosci (2011) 1.11
Elimination of plasma membrane phosphatidylinositol (4,5)-bisphosphate is required for exocytosis from mast cells. J Cell Sci (2006) 1.10
Analysis of lectin binding to glycolipid complexes using combinatorial glycoarrays. Glycobiology (2009) 1.06
Kidins220/ARMS regulates Rac1-dependent neurite outgrowth by direct interaction with the RhoGEF Trio. J Cell Sci (2010) 1.05
Kidins220/ARMS is transported by a kinesin-1-based mechanism likely to be involved in neuronal differentiation. Mol Biol Cell (2006) 1.05
Entering neurons: botulinum toxins and synaptic vesicle recycling. EMBO Rep (2006) 1.05
Central effects of tetanus and botulinum neurotoxins. Toxicon (2009) 1.05
Modification of superoxide dismutase 1 (SOD1) properties by a GFP tag--implications for research into amyotrophic lateral sclerosis (ALS). PLoS One (2010) 1.05
TorsinA and dystonia: from nuclear envelope to synapse. J Neurochem (2009) 1.04
Antiepileptic effects of botulinum neurotoxin E. J Neurosci (2005) 1.03
Internalization and mechanism of action of clostridial toxins in neurons. Neurotoxicology (2005) 1.01
Botulinum neurotoxins A and E undergo retrograde axonal transport in primary motor neurons. PLoS Pathog (2012) 1.00
Mutant torsinA, which causes early-onset primary torsion dystonia, is redistributed to membranous structures enriched in vesicular monoamine transporter in cultured human SH-SY5Y cells. Mov Disord (2005) 1.00
The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane. Biochem Biophys Res Commun (2009) 1.00
Botulinum neurotoxins: mechanism of action. Toxicon (2012) 0.99
Glycerotoxin from Glycera convoluta stimulates neurosecretion by up-regulating N-type Ca2+ channel activity. EMBO J (2002) 0.99
Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor. J Cell Sci (2009) 0.99
Large-scale pathways-based association study in amyotrophic lateral sclerosis. Brain (2007) 0.98
Endocytosis and retrograde axonal traffic in motor neurons. Biochem Soc Symp (2005) 0.97
Traffic of botulinum toxins A and E in excitatory and inhibitory neurons. Traffic (2007) 0.97
Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration. Curr Opin Neurobiol (2008) 0.97
Functional involvement of VAMP/synaptobrevin-2 in cAMP-stimulated aquaporin 2 translocation in renal collecting duct cells. J Cell Sci (2002) 0.97
Assay of diffusion of different botulinum neurotoxin type a formulations injected in the mouse leg. Muscle Nerve (2009) 0.96
Receptor-dependent and -independent axonal retrograde transport of poliovirus in motor neurons. J Virol (2009) 0.96
Transient synaptic silencing of developing striate cortex has persistent effects on visual function and plasticity. J Neurosci (2007) 0.96
The SOD1 transgene in the G93A mouse model of amyotrophic lateral sclerosis lies on distal mouse chromosome 12. Amyotroph Lateral Scler Other Motor Neuron Disord (2005) 0.95
VAMP/synaptobrevin cleavage by tetanus and botulinum neurotoxins is strongly enhanced by acidic liposomes. FEBS Lett (2003) 0.95
Kidins220/ARMS as a functional mediator of multiple receptor signalling pathways. J Cell Sci (2012) 0.95
Alternative fates of newly formed PrPSc upon prion conversion on the plasma membrane. J Cell Sci (2013) 0.93
The phagocytic capacity of neurones. Eur J Neurosci (2007) 0.93
Different types of botulinum toxin in humans. Mov Disord (2004) 0.92
Absence of disturbed axonal transport in spinal and bulbar muscular atrophy. Hum Mol Genet (2011) 0.91
A motor-driven mechanism for cell-length sensing. Cell Rep (2012) 0.90
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process. EMBO J (2010) 0.90
Functional recycling of C2 domains throughout evolution: a comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches. J Mol Biol (2003) 0.90
Disruption of the coxsackievirus and adenovirus receptor-homodimeric interaction triggers lipid microdomain- and dynamin-dependent endocytosis and lysosomal targeting. J Biol Chem (2013) 0.90
Double anchorage to the membrane and intact inter-chain disulfide bond are required for the low pH induced entry of tetanus and botulinum neurotoxins into neurons. Cell Microbiol (2011) 0.90
Toxicity of botulinum neurotoxins in central nervous system of mice. Toxicon (2003) 0.89
Neuromuscular paralysis and recovery in mice injected with botulinum neurotoxins A and C. Eur J Neurosci (2007) 0.89
Sustained synaptic-vesicle recycling by bulk endocytosis contributes to the maintenance of high-rate neurotransmitter release stimulated by glycerotoxin. J Cell Sci (2010) 0.88
The elusive compass of clostridial neurotoxins: deciding when and where to go? Curr Top Microbiol Immunol (2013) 0.88
Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice. Brain Res (2006) 0.87
Tetanus neurotoxin-induced epilepsy in mouse visual cortex. Epilepsia (2012) 0.87
Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity. Toxins (Basel) (2011) 0.87
The thioredoxin reductase-thioredoxin system is involved in the entry of tetanus and botulinum neurotoxins in the cytosol of nerve terminals. FEBS Lett (2012) 0.87
Mass spectrometry analysis of the phospholipase A(2) activity of snake pre-synaptic neurotoxins in cultured neurons. J Neurochem (2009) 0.87
Botulinum neurotoxin serotype D is poorly effective in humans: an in vivo electrophysiological study. Clin Neurophysiol (2012) 0.85
Synthetic self-assembling clostridial chimera for modulation of sensory functions. Bioconjug Chem (2013) 0.85
Evidence for a radial SNARE super-complex mediating neurotransmitter release at the Drosophila neuromuscular junction. J Cell Sci (2013) 0.85
Botulinum neurotoxin type A is internalized and translocated from small synaptic vesicles at the neuromuscular junction. Mol Neurobiol (2013) 0.85
Evidence-based review and assessment of botulinum neurotoxin for the treatment of secretory disorders. Toxicon (2012) 0.84
Calcium influx and mitochondrial alterations at synapses exposed to snake neurotoxins or their phospholipid hydrolysis products. J Biol Chem (2007) 0.84
Calcium overload in nerve terminals of cultured neurons intoxicated by alpha-latrotoxin and snake PLA2 neurotoxins. Toxicon (2009) 0.83
Snake presynaptic neurotoxins with phospholipase A2 activity induce punctate swellings of neurites and exocytosis of synaptic vesicles. J Cell Sci (2004) 0.83
Evidence-based review and assessment of botulinum neurotoxin for the treatment of urologic conditions. Toxicon (2013) 0.83
Arg206 of SNAP-25 is essential for neuroexocytosis at the Drosophila melanogaster neuromuscular junction. J Cell Sci (2010) 0.83
Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin. Acta Neuropathol (2012) 0.83
Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells. J Neurochem (2007) 0.83
The more, the better: the BICD family gets bigger. EMBO J (2010) 0.82
Glycerotoxin stimulates neurotransmitter release from N-type Ca2+ channel expressing neurons. J Neurochem (2006) 0.82
TorsinA and DYT1 dystonia: a synaptopathy? Biochem Soc Trans (2010) 0.82
Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells. J Neurochem (2003) 0.82
Activated leukocyte cell adhesion molecule modulates neurotrophin signaling. J Neurochem (2012) 0.81