Published in J Biol Chem on September 21, 2004
Controlled delivery of PDGF-BB for myocardial protection using injectable self-assembling peptide nanofibers. J Clin Invest (2005) 2.80
Endothelial-cardiomyocyte interactions in cardiac development and repair. Annu Rev Physiol (2006) 1.68
Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation (2009) 1.55
Effects of radiation on the epidermal growth factor receptor pathway in the heart. Int J Radiat Biol (2013) 1.49
Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol (2006) 1.35
The role of Neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res (2008) 1.23
Neuregulin in cardiovascular development and disease. Circ Res (2012) 1.23
Endothelium-derived neuregulin protects the heart against ischemic injury. Circulation (2011) 1.10
Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice. PLoS One (2014) 1.06
Endothelial-cardiomyocyte crosstalk enhances pharmacological cardioprotection. J Mol Cell Cardiol (2011) 0.96
Metalloproteinase-dependent cleavage of neuregulin and autocrine stimulation of vascular endothelial cells. FASEB J (2010) 0.96
Neuregulin-1β for the treatment of systolic heart failure. J Mol Cell Cardiol (2011) 0.96
Proteostasis and REDOX state in the heart. Am J Physiol Heart Circ Physiol (2011) 0.93
Gene 33/RALT is induced by hypoxia in cardiomyocytes, where it promotes cell death by suppressing phosphatidylinositol 3-kinase and extracellular signal-regulated kinase survival signaling. Mol Cell Biol (2006) 0.93
Endothelial-derived neuregulin is an important mediator of ischaemia-induced angiogenesis and arteriogenesis. Cardiovasc Res (2011) 0.92
Diminished survival of human cytotrophoblast cells exposed to hypoxia/reoxygenation injury and associated reduction of heparin-binding epidermal growth factor-like growth factor. Am J Obstet Gynecol (2008) 0.91
Circulating neuregulin-1β levels vary according to the angiographic severity of coronary artery disease and ischemia. Coron Artery Dis (2011) 0.88
Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. Proc Natl Acad Sci U S A (2015) 0.87
Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness. Open Biomark J (2009) 0.86
Palmitate alters neuregulin signaling and biology in cardiac myocytes. Biochem Biophys Res Commun (2008) 0.86
Intravenous glial growth factor 2 (GGF2) isoform of neuregulin-1β improves left ventricular function, gene and protein expression in rats after myocardial infarction. PLoS One (2013) 0.86
Systems biology approaches to adverse drug effects: the example of cardio-oncology. Nat Rev Clin Oncol (2015) 0.85
The roles of neuregulin-1 in cardiac development, homeostasis, and disease. Biomark Insights (2015) 0.84
Angiogenic therapy for cardiac repair based on protein delivery systems. Heart Fail Rev (2012) 0.83
Neuregulin-1β regulation of embryonic endothelial progenitor cell survival. Am J Physiol Heart Circ Physiol (2011) 0.83
ErbB2 overexpression upregulates antioxidant enzymes, reduces basal levels of reactive oxygen species, and protects against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol (2015) 0.83
Impairment of endothelial-myocardial interaction increases the susceptibility of cardiomyocytes to ischemia/reperfusion injury. PLoS One (2013) 0.82
Slow down to stay alive: HER4 protects against cellular stress and confers chemoresistance in neuroblastoma. Cancer (2012) 0.82
ErbB4 localization to cardiac myocyte nuclei, and its role in myocyte DNA damage response. Biochem Biophys Res Commun (2012) 0.82
Micro- and Nanoparticles for Treating Cardiovascular Disease. Biomater Sci (2015) 0.81
New insights in (inter)cellular mechanisms by heart failure with preserved ejection fraction. Curr Heart Fail Rep (2014) 0.80
Neuregulin-1β induces embryonic stem cell cardiomyogenesis via ErbB3/ErbB2 receptors. Biochem J (2014) 0.79
Neuregulin as a heart failure therapy and mediator of reverse remodeling. Curr Heart Fail Rep (2014) 0.79
Bidirectional cross-regulation between ErbB2 and β-adrenergic signalling pathways. Cardiovasc Res (2015) 0.79
Platelet endothelial cell adhesion molecule-1 mediates endothelial-cardiomyocyte communication and regulates cardiac function. J Am Heart Assoc (2015) 0.77
Neuregulin-1β induces mature ventricular cardiac differentiation from induced pluripotent stem cells contributing to cardiac tissue repair. Stem Cells Dev (2014) 0.77
Cardiac-Secreted Factors as Peripheral Metabolic Regulators and Potential Disease Biomarkers. J Am Heart Assoc (2016) 0.77
Cardiogenic differentiation of mesenchymal stem cells on elastomeric poly (glycerol sebacate)/collagen core/shell fibers. World J Cardiol (2013) 0.77
ERBB signaling attenuates proinflammatory activation of nonclassical monocytes. Am J Physiol Heart Circ Physiol (2017) 0.76
Novel Biological Therapies Targeting Heart Failure: Myocardial Rejuvenation. Heart Fail Clin (2016) 0.75
Epidermal Growth Factor Receptor Silencing Blunts the Slow Force Response to Myocardial Stretch. J Am Heart Assoc (2016) 0.75
Thioredoxin Uses a GSH-independent Route to Deglutathionylate Endothelial Nitric-oxide Synthase and Protect against Myocardial Infarction. J Biol Chem (2016) 0.75
Tongxinluo modulates cytokine secretion by cardiac microvascular endothelial cells in ischemia/reperfusion injury. Am J Transl Res (2016) 0.75
Diagnostic Utility of Neuregulin for Acute Coronary Syndrome. Dis Markers (2016) 0.75
A Novel Human Tissue-Engineered 3-D Functional Vascularized Cardiac Muscle Construct. Front Cell Dev Biol (2017) 0.75
High glucose facilitated endothelial heparanase transfer to the cardiomyocyte modifies its cell death signature. Cardiovasc Res (2016) 0.75
Timing of the negative effects of trastuzumab on cardiac mechanics after anthracycline chemotherapy. Int J Cardiovasc Imaging (2016) 0.75
Novel biomarkers for cardiovascular risk prediction. J Geriatr Cardiol (2017) 0.75
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Evidence for human lung stem cells. N Engl J Med (2011) 5.67
Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest (2005) 5.48
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
Inflammatory markers and risk of heart failure in elderly subjects without prior myocardial infarction: the Framingham Heart Study. Circulation (2003) 4.09
Heat shock proteins in cancer: chaperones of tumorigenesis. Trends Biochem Sci (2006) 4.04
Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J Biol Chem (2002) 3.22
Cardiac-specific overexpression of GLUT1 prevents the development of heart failure attributable to pressure overload in mice. Circulation (2002) 3.11
CD31- but Not CD31+ cardiac side population cells exhibit functional cardiomyogenic differentiation. Circ Res (2005) 3.03
Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload. Hypertension (2006) 3.01
Relations of plasma total TIMP-1 levels to cardiovascular risk factors and echocardiographic measures: the Framingham heart study. Eur Heart J (2004) 2.58
Loss of cardiac microRNA-mediated regulation leads to dilated cardiomyopathy and heart failure. Circ Res (2009) 2.44
Amyloidogenic light chains induce cardiomyocyte contractile dysfunction and apoptosis via a non-canonical p38alpha MAPK pathway. Proc Natl Acad Sci U S A (2010) 2.41
A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res (2008) 2.38
H(2)O(2) regulates cardiac myocyte phenotype via concentration-dependent activation of distinct kinase pathways. J Mol Cell Cardiol (2003) 2.31
Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab (2008) 2.28
Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy. Circulation (2003) 2.28
Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress. Circulation (2007) 2.26
Human amyloidogenic light chains directly impair cardiomyocyte function through an increase in cellular oxidant stress. Circ Res (2004) 2.25
ERBB2 inhibition and heart failure. N Engl J Med (2012) 2.23
Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med (2007) 2.23
Serum insulin-like growth factor I and risk for heart failure in elderly individuals without a previous myocardial infarction: the Framingham Heart Study. Ann Intern Med (2003) 2.20
Restoration of cardiac progenitor cells after myocardial infarction by self-proliferation and selective homing of bone marrow-derived stem cells. Circ Res (2005) 2.18
Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. Am J Hum Genet (2010) 2.15
Echocardiographic speckle-tracking based strain imaging for rapid cardiovascular phenotyping in mice. Circ Res (2011) 2.06
Anthracycline cardiotoxicity: from bench to bedside. J Clin Oncol (2008) 2.04
Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock. Circ Res (2006) 2.02
Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res (2003) 1.99
Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A (2007) 1.92
PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility. Circ Res (2006) 1.80
Neuregulin-1 protects ventricular myocytes from anthracycline-induced apoptosis via erbB4-dependent activation of PI3-kinase/Akt. J Mol Cell Cardiol (2003) 1.80
Ly-6Chigh monocytes depend on Nr4a1 to balance both inflammatory and reparative phases in the infarcted myocardium. Circ Res (2014) 1.78
mir-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts. Circ Res (2013) 1.72
Method development of efficient protein extraction in bone tissue for proteome analysis. J Proteome Res (2007) 1.71
Doxycycline reduces fibril formation in a transgenic mouse model of AL amyloidosis. Blood (2011) 1.64
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol Cell Biol (2009) 1.63
Use of a DASH food group score to predict excess weight gain in adolescent girls in the National Growth and Health Study. Arch Pediatr Adolesc Med (2011) 1.60
Anthracyclines induce calpain-dependent titin proteolysis and necrosis in cardiomyocytes. J Biol Chem (2003) 1.60
Relations of plasma matrix metalloproteinase-9 to clinical cardiovascular risk factors and echocardiographic left ventricular measures: the Framingham Heart Study. Circulation (2004) 1.59
Beta-adrenergic receptor-stimulated apoptosis in cardiac myocytes is mediated by reactive oxygen species/c-Jun NH2-terminal kinase-dependent activation of the mitochondrial pathway. Circ Res (2003) 1.57
Circulating vascular growth factors and central hemodynamic load in the community. Hypertension (2012) 1.56
Increased glucose uptake and oxidation in mouse hearts prevent high fatty acid oxidation but cause cardiac dysfunction in diet-induced obesity. Circulation (2009) 1.55
Neuregulin-1 beta is associated with disease severity and adverse outcomes in chronic heart failure. Circulation (2009) 1.55
Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload. Circulation (2005) 1.49
Role of reactive oxygen species and NAD(P)H oxidase in alpha(1)-adrenoceptor signaling in adult rat cardiac myocytes. Am J Physiol Cell Physiol (2002) 1.49
Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. Proc Natl Acad Sci U S A (2013) 1.48
Construction and clinical application of a human tissue-engineered epidermal membrane. Plast Reconstr Surg (2010) 1.48
Midlife psychological stress and risk of dementia: a 35-year longitudinal population study. Brain (2010) 1.45
Collagen tissue engineering: development of novel biomaterials and applications. Pediatr Res (2008) 1.45
Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma. Cancer (2014) 1.43
The beta-catenin/T-cell factor/lymphocyte enhancer factor signaling pathway is required for normal and stress-induced cardiac hypertrophy. Mol Cell Biol (2006) 1.41
Akt3 overexpression in the heart results in progression from adaptive to maladaptive hypertrophy. J Mol Cell Cardiol (2005) 1.38
Increased reactive oxygen species production and functional alterations in antioxidant enzymes in human failing myocardium. J Card Fail (2005) 1.38
Alpha-adrenergic receptor-stimulated hypertrophy in adult rat ventricular myocytes is mediated via thioredoxin-1-sensitive oxidative modification of thiols on Ras. Circulation (2005) 1.37
Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro. Exp Cell Res (2005) 1.37
Repair of canine mandibular bone defects with bone marrow stromal cells and porous beta-tricalcium phosphate. Biomaterials (2006) 1.35
Neuregulin activates erbB2-dependent src/FAK signaling and cytoskeletal remodeling in isolated adult rat cardiac myocytes. J Mol Cell Cardiol (2006) 1.35
Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem Biophys Res Commun (2005) 1.35
Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol Cell Biol (2006) 1.34
Glycogen synthase kinase-3beta regulates growth, calcium homeostasis, and diastolic function in the heart. J Biol Chem (2004) 1.33
Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells. Circ Res (2008) 1.31
Pressure overload-induced myocardial hypertrophy in mice does not require gp91phox. Circulation (2004) 1.29
Brd2 disruption in mice causes severe obesity without Type 2 diabetes. Biochem J (2009) 1.26
Clonal analysis of nestin(-) vimentin(+) multipotent fibroblasts isolated from human dermis. J Cell Sci (2007) 1.26
Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. J Biol Chem (2005) 1.25
Heterozygous cellular glutathione peroxidase deficiency in the mouse: abnormalities in vascular and cardiac function and structure. Circulation (2002) 1.24
Neuregulin in cardiovascular development and disease. Circ Res (2012) 1.23
The role of Neuregulin-1beta/ErbB signaling in the heart. Exp Cell Res (2008) 1.23
Regulation of vascular endothelial growth factor expression and vascularization in the myocardium by insulin receptor and PI3K/Akt pathways in insulin resistance and ischemia. Arterioscler Thromb Vasc Biol (2006) 1.21
Tissue engineering of blood vessel. J Cell Mol Med (2007) 1.20
Loss of hypoxia-inducible factor prolyl hydroxylase activity in cardiomyocytes phenocopies ischemic cardiomyopathy. Circulation (2010) 1.20
The cardiotoxicology of anthracycline chemotherapeutics: translating molecular mechanism into preventative medicine. Mol Interv (2005) 1.20
Deletion of Ptpn11 (Shp2) in cardiomyocytes causes dilated cardiomyopathy via effects on the extracellular signal-regulated kinase/mitogen-activated protein kinase and RhoA signaling pathways. Circulation (2008) 1.20
Secular trends in alcohol consumption over 50 years: the Framingham Study. Am J Med (2008) 1.20
MicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling. Circ Res (2013) 1.19
Habitual physical activity levels are associated with performance in measures of physical function and mobility in older men. J Am Geriatr Soc (2010) 1.19
A novel mutant cardiac troponin C disrupts molecular motions critical for calcium binding affinity and cardiomyocyte contractility. Biophys J (2008) 1.18
Molecular and cellular mechanisms of anthracycline cardiotoxicity. Cardiovasc Toxicol (2007) 1.17
Redox-mediated reciprocal regulation of SERCA and Na+-Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes. Free Radic Biol Med (2010) 1.17
Blood pressure trajectories from midlife to late life in relation to dementia in women followed for 37 years. Hypertension (2012) 1.16
Heat shock protein 90 stabilization of ErbB2 expression is disrupted by ATP depletion in myocytes. J Biol Chem (2005) 1.13
Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circ Res (2011) 1.13