DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei.

PubWeight™: 3.89‹?› | Rank: Top 1%

🔗 View Article (PMID 15448701)

Published in Nat Cell Biol on September 26, 2004

Authors

Stina Simonsson1, John Gurdon

Author Affiliations

1: Wellcome Trust/Cancer Research UK Gurdon Institute and Department of Zoology, University of Cambridge, Cambridge CB2 1QR, UK.

Articles citing this

Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16

Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20

Nuclear reprogramming to a pluripotent state by three approaches. Nature (2010) 5.26

Epigenetic reprogramming and induced pluripotency. Development (2009) 4.90

Induced pluripotency: history, mechanisms, and applications. Genes Dev (2010) 4.89

Active DNA demethylation mediated by DNA glycosylases. Annu Rev Genet (2009) 3.66

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol (2008) 3.33

Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci (2011) 3.27

Reprogramming efficiency following somatic cell nuclear transfer is influenced by the differentiation and methylation state of the donor nucleus. Stem Cells (2006) 3.07

GADD45A does not promote DNA demethylation. PLoS Genet (2008) 2.36

Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell (2007) 2.31

Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol (2007) 2.15

Epigenetic programming and reprogramming during development. Nat Struct Mol Biol (2013) 2.13

Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell (2013) 2.10

Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet (2008) 2.01

DNA methylation and cellular reprogramming. Trends Cell Biol (2010) 1.77

DNA methylation in development and human disease. Mutat Res (2008) 1.74

Significant improvement in cloning efficiency of an inbred miniature pig by histone deacetylase inhibitor treatment after somatic cell nuclear transfer. Biol Reprod (2009) 1.74

Induction of dedifferentiation, genomewide transcriptional programming, and epigenetic reprogramming by extracts of carcinoma and embryonic stem cells. Mol Biol Cell (2005) 1.69

G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells (2008) 1.68

Nuclear actin polymerization is required for transcriptional reprogramming of Oct4 by oocytes. Genes Dev (2011) 1.67

DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation. Cell Cycle (2009) 1.64

Mechanisms of nuclear reprogramming by eggs and oocytes: a deterministic process? Nat Rev Mol Cell Biol (2011) 1.58

Histone variant macroH2A confers resistance to nuclear reprogramming. EMBO J (2011) 1.57

Epigenetic memory of active gene transcription is inherited through somatic cell nuclear transfer. Proc Natl Acad Sci U S A (2005) 1.50

Retracted Differential recruitment of methylated CpG binding domains by the orphan receptor GCNF initiates the repression and silencing of Oct4 expression. Mol Cell Biol (2006) 1.45

Epigenetic control of embryonic stem cell fate. J Exp Med (2010) 1.40

Active tissue-specific DNA demethylation conferred by somatic cell nuclei in stable heterokaryons. Proc Natl Acad Sci U S A (2007) 1.40

Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks. Proc Natl Acad Sci U S A (2006) 1.40

Recent advancements in cloning by somatic cell nuclear transfer. Philos Trans R Soc Lond B Biol Sci (2013) 1.33

DNA glycosylases: in DNA repair and beyond. Chromosoma (2011) 1.29

Cytidine deaminases: AIDing DNA demethylation? Genes Dev (2010) 1.28

Epigenetic regulation in pluripotent stem cells: a key to breaking the epigenetic barrier. Philos Trans R Soc Lond B Biol Sci (2013) 1.26

Lsh participates in DNA methylation and silencing of stem cell genes. Stem Cells (2009) 1.20

Histone deacetylase inhibitors improve in vitro and in vivo developmental competence of somatic cell nuclear transfer porcine embryos. Cell Reprogram (2010) 1.19

Epigenetic factors influencing resistance to nuclear reprogramming. Trends Genet (2011) 1.14

DNA synthesis is required for reprogramming mediated by stem cell fusion. Cell (2013) 1.14

Nuclear transfer to eggs and oocytes. Cold Spring Harb Perspect Biol (2011) 1.13

Injury-dependent Müller glia and ganglion cell reprogramming during tissue regeneration requires Apobec2a and Apobec2b. J Neurosci (2012) 1.04

Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res (2008) 1.03

Epigenetic reprogramming: is deamination key to active DNA demethylation? Reproduction (2011) 1.03

Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Proc Natl Acad Sci U S A (2013) 1.02

Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics (2015) 0.99

Reprogramming of postnatal neurons into induced pluripotent stem cells by defined factors. Stem Cells (2011) 0.96

Epigenetic mechanisms in multiple sclerosis: implications for pathogenesis and treatment. Lancet Neurol (2013) 0.96

Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases. Stem Cells Dev (2011) 0.96

Rapid elimination of the histone variant MacroH2A from somatic cell heterochromatin after nuclear transfer. Cell Reprogram (2010) 0.95

Role of transcription factor Sp1 and CpG methylation on the regulation of the human podocalyxin gene promoter. BMC Mol Biol (2006) 0.94

Differential recruitment of methyl CpG-binding domain factors and DNA methyltransferases by the orphan receptor germ cell nuclear factor initiates the repression and silencing of Oct4. Stem Cells (2011) 0.94

Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: a first step toward a clinical-grade cell source. Stem Cells Transl Med (2014) 0.92

Epigenetic reprogramming of breast cancer cells with oocyte extracts. Mol Cancer (2011) 0.90

Characterization of the human Activin-A receptor type II-like kinase 1 (ACVRL1) promoter and its regulation by Sp1. BMC Mol Biol (2010) 0.88

Gadd45a promotes DNA demethylation through TDG. Nucleic Acids Res (2015) 0.88

Transcriptional regulation and nuclear reprogramming: roles of nuclear actin and actin-binding proteins. Cell Mol Life Sci (2012) 0.87

Epigenetic landscape of pluripotent stem cells. Antioxid Redox Signal (2012) 0.86

Nuclear actin and transcriptional activation. Commun Integr Biol (2011) 0.86

Phosphorylated nucleolin interacts with translationally controlled tumor protein during mitosis and with Oct4 during interphase in ES cells. PLoS One (2010) 0.85

Examination of DNA methyltransferase expression in cloned embryos reveals an essential role for Dnmt1 in bovine development. Mol Reprod Dev (2011) 0.84

Epigenetic stability of repressed states involving the histone variant macroH2A revealed by nuclear transfer to Xenopus oocytes. Nucleus (2011) 0.84

Human amniotic epithelial cell feeder layers maintain iPS cell pluripotency by inhibiting endogenous DNA methyltransferase 1. Exp Ther Med (2013) 0.83

Oxamflatin treatment enhances cloned porcine embryo development and nuclear reprogramming. Cell Reprogram (2014) 0.82

Specificity protein 1 expression contributes to Bcl-w-induced aggressiveness in glioblastoma multiforme. Mol Cells (2014) 0.81

rRNA genes are not fully activated in mouse somatic cell nuclear transfer embryos. J Biol Chem (2012) 0.81

Parallel gateways to pluripotency: open chromatin in stem cells and development. Curr Opin Genet Dev (2010) 0.81

A concise review on epigenetic regulation: insight into molecular mechanisms. Int J Mol Sci (2011) 0.81

SAF-A has a role in transcriptional regulation of Oct4 in ES cells through promoter binding. Cell Reprogram (2011) 0.80

Epigenetic modification of TLR4 promotes activation of NF-κB by regulating methyl-CpG-binding domain protein 2 and Sp1 in gastric cancer. Oncotarget (2016) 0.80

Development to term of cloned cattle derived from donor cells treated with valproic acid. PLoS One (2014) 0.79

Effects of histone deacetylase inhibitor oxamflatin on in vitro porcine somatic cell nuclear transfer embryos. Cell Reprogram (2014) 0.79

Interspecies somatic cell nuclear transfer: advancements and problems. Cell Reprogram (2013) 0.79

Xenopus egg extract treatment reduced global DNA methylation of donor cells and enhanced somatic cell nuclear transfer embryo development in pigs. Biores Open Access (2012) 0.79

A Cell Electrofusion Chip for Somatic Cells Reprogramming. PLoS One (2015) 0.77

Chromatin modifying agents in the in vitro production of bovine embryos. Vet Med Int (2010) 0.77

Constructing a Mouse Oct4 Promoter/EGFP Vector, as a Whole-Cellular Reporter to Monitor the Pluripotent State of Cells. Avicenna J Med Biotechnol (2013) 0.77

Exposure of mouse cumulus cell nuclei to porcine ooplasmic extract eliminates TATA box protein binding to chromatin, but has no effect on DNA methylation. J Assist Reprod Genet (2006) 0.76

Reprogramming cells for brain repair. Brain Sci (2013) 0.76

Looking into the black box: insights into the mechanisms of somatic cell reprogramming. Genes (Basel) (2011) 0.76

Proteomic analysis of early reprogramming events in murine somatic cells incubated with Xenopus laevis oocyte extracts demonstrates network associations with induced pluripotency markers. Cell Reprogram (2013) 0.76

Cell replacement therapy for central nervous system diseases. Neural Regen Res (2015) 0.76

Nuclear transfer: epigenetics pays a visit. Nat Cell Biol (2004) 0.76

Pluripotent state induction in mouse embryonic fibroblast using mRNAs of reprogramming factors. Int J Mol Sci (2014) 0.75

Developmental Competence and Pluripotency Gene Expression of Cattle Cloned Embryos Derived from Donor Cells Treated with 5-aza-2'-deoxycytidine. Int J Fertil Steril (2011) 0.75

The expression of survivin and its related genes in adipocyte-derived stem cell by demethylation. Korean J Anesthesiol (2010) 0.75

Changes in the methylation status of the Oct3/4, Nanog, and Sox2 promoters in stem cells during regeneration of rat tracheal epithelium after injury. Oncotarget (2016) 0.75

The role of hypoxia on the acquisition of epithelial-mesenchymal transition and cancer stemness: a possible link to epigenetic regulation. Korean J Intern Med (2017) 0.75

Epigenetic deregulation of the human Oct4 promoter in mouse cells. Dev Genes Evol (2008) 0.75