Epigenetic programming and reprogramming during development.

Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction? PLoS Biol (2016) 1.49

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region. Immunity (2016) 1.43

Retracted G9a/RelB regulates self-renewal and function of colon-cancer-initiating cells by silencing Let-7b and activating the K-RAS/β-catenin pathway. Nat Cell Biol (2016) 1.40

Transcription factor binding dynamics during human ES cell differentiation. Nature (2015) 1.30

Potential functional roles of DNA demethylation intermediates. Trends Biochem Sci (2013) 1.21

Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer. Cell Stem Cell (2015) 1.13

Genome-wide age-related changes in DNA methylation and gene expression in human PBMCs. Age (Dordr) (2014) 1.12

Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat Rev Cancer (2014) 1.10

A framework for modelling gene regulation which accommodates non-equilibrium mechanisms. BMC Biol (2014) 1.03

Rewiring mesenchymal stem cell lineage specification by switching the biophysical microenvironment. Sci Rep (2014) 1.01

Transcriptional and epigenetic regulation of T-helper lineage specification. Immunol Rev (2014) 0.97

Defending the genome from the enemy within: mechanisms of retrotransposon suppression in the mouse germline. Cell Mol Life Sci (2013) 0.97

Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation. Neuropsychopharmacology (2014) 0.95

A minimal set of tissue-specific hypomethylated CpGs constitute epigenetic signatures of developmental programming. PLoS One (2013) 0.93

Effects of developmental activation of the AhR on CD4+ T-cell responses to influenza virus infection in adult mice. Environ Health Perspect (2014) 0.92

The role of maternal-specific H3K9me3 modification in establishing imprinted X-chromosome inactivation and embryogenesis in mice. Nat Commun (2014) 0.91

HiFive: a tool suite for easy and efficient HiC and 5C data analysis. Genome Biol (2015) 0.91

Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen (2014) 0.89

Transposable elements in the mammalian embryo: pioneers surviving through stealth and service. Genome Biol (2016) 0.86

Polycomb-mediated silencing in neuroendocrine prostate cancer. Clin Epigenetics (2015) 0.86

The tissue is the issue: improved methylome analysis from paraffin-embedded tissues by application of the HOPE technique. Lab Invest (2014) 0.86

microRNA-7 suppresses the invasive potential of breast cancer cells and sensitizes cells to DNA damages by targeting histone methyltransferase SET8. J Biol Chem (2013) 0.85

Increased epigenetic alterations at the promoters of transcriptional regulators following inadequate maternal gestational weight gain. Sci Rep (2015) 0.85

Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes. PLoS One (2014) 0.85

Epigenetic landscape of amphetamine and methamphetamine addiction in rodents. Epigenetics (2015) 0.83

Epigenetic Regulation of Infant Neurobehavioral Outcomes. Med Epigenet (2014) 0.83

Long-term effects of early-life exposure to environmental oestrogens on ovarian function: role of epigenetics. J Neuroendocrinol (2014) 0.82

Epigenetic mechanisms in pubertal brain maturation. Neuroscience (2013) 0.82

DNA methylation markers in the postnatal developing rat brain. Brain Res (2013) 0.82

Reshaping the transcriptional frontier: epigenetics and somatic cell nuclear transfer. Mol Reprod Dev (2013) 0.82

Impact of epigenetic dietary compounds on transgenerational prevention of human diseases. AAPS J (2013) 0.81

Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies. Crit Rev Oncog (2015) 0.81

Epigenetic Modification Agents Improve Gene-Specific Methylation Reprogramming in Porcine Cloned Embryos. PLoS One (2015) 0.81

Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes. Sci Rep (2015) 0.81

Estimation of the methylation pattern distribution from deep sequencing data. BMC Bioinformatics (2015) 0.80

Embryonic stem cell specific "master" replication origins at the heart of the loss of pluripotency. PLoS Comput Biol (2015) 0.80

Gestational hypoxia and epigenetic programming of brain development disorders. Drug Discov Today (2014) 0.80

Environmental Impact on DNA Methylation in the Germline: State of the Art and Gaps of Knowledge. Biomed Res Int (2015) 0.80

Reprogramming of the human intestinal epigenome by surgical tissue transposition. Genome Res (2014) 0.80

A SWI/SNF Chromatin Remodelling Protein Controls Cytokinin Production through the Regulation of Chromatin Architecture. PLoS One (2015) 0.80

Senescence-Inflammatory Regulation of Reparative Cellular Reprogramming in Aging and Cancer. Front Cell Dev Biol (2017) 0.80

Epigenetic Modification of Cloned Embryos Improves Nanog Reprogramming in Pigs. Cell Reprogram (2015) 0.79

Chromatin resetting mechanisms preventing transgenerational inheritance of epigenetic states. Front Plant Sci (2015) 0.79

Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease. Adipocyte (2014) 0.79

Improved development of somatic cell cloned mouse embryos by vitamin C and latrunculin A. PLoS One (2015) 0.79

Epigenetic programming of hypoxic-ischemic encephalopathy in response to fetal hypoxia. Prog Neurobiol (2014) 0.79

Mosquitoes Reset Malaria Parasites. PLoS Pathog (2015) 0.78

The heritability and patterns of DNA methylation in normal human colorectum. Hum Mol Genet (2016) 0.78

Epigenetics in preimplantation mammalian development. Theriogenology (2016) 0.78

Ctr9, a Key Component of the Paf1 Complex, Affects Proliferation and Terminal Differentiation in the Developing Drosophila Nervous System. G3 (Bethesda) (2016) 0.78

Lipid metabolism is associated with developmental epigenetic programming. Sci Rep (2016) 0.77

Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis. Elife (2016) 0.77

Developmental block and programmed cell death in Bos indicus embryos: effects of protein supplementation source and developmental kinetics. PLoS One (2015) 0.77

A Chemical Probe Targets DNA 5-Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. Chem Sci (2014) 0.77

Impact of EZH2 polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic features. PLoS One (2014) 0.77

Challenges and opportunities in developmental integrative physiology. Comp Biochem Physiol A Mol Integr Physiol (2015) 0.77

Epigenetic mechanisms in heart failure pathogenesis. Circ Heart Fail (2014) 0.76

Evolution of an epigenetic gene ensemble within the genus Anopheles. Genome Biol Evol (2015) 0.76

Psammaplin a improves development and quality of somatic cell nuclear transfer mouse embryos. Cell Reprogram (2014) 0.76

Developmental exposure to endocrine disrupting chemicals alters the epigenome: Identification of reprogrammed targets. Gynecol Obstet Res (2016) 0.76

Restitution of gene expression and histone acetylation signatures altered by hepatitis B virus through antiviral microRNA-like molecules in nontransformed murine hepatocytes. Clin Epigenetics (2014) 0.76

A functional N-terminal domain in C/EBPβ-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J Cell Physiol (2014) 0.76

DNA demethylation pathways: recent insights. Genet Epigenet (2013) 0.76

The evolution of the human genome. Curr Opin Genet Dev (2015) 0.76

Perinatal bisphenol A exposure beginning before gestation enhances allergen sensitization, but not pulmonary inflammation, in adult mice. J Dev Orig Health Dis (2014) 0.76

Advances in reprogramming-based study of neurologic disorders. Stem Cells Dev (2015) 0.76

Polycomb group genes are required to maintain a binary fate choice in the Drosophila eye. Neural Dev (2015) 0.76

Age-related epigenetic drift and phenotypic plasticity loss: implications in prevention of age-related human diseases. Epigenomics (2016) 0.76

Evaluation of preprocessing, mapping and postprocessing algorithms for analyzing whole genome bisulfite sequencing data. Brief Bioinform (2015) 0.75

Transmission of Metabolic Dysfunction Across Generations. Physiology (Bethesda) (2017) 0.75

Histone Methyltransferase Enhancer of Zeste Homolog 2-Mediated ABCA1 Promoter DNA Methylation Contributes to the Progression of Atherosclerosis. PLoS One (2016) 0.75

Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition. Elife (2017) 0.75

Epigenetic Research of Neurodegenerative Disorders Using Patient iPSC-Based Models. Stem Cells Int (2015) 0.75

Lineage-specific functions of TET1 in the postimplantation mouse embryo. Nat Genet (2017) 0.75

The epigenome in Alzheimer's disease: current state and approaches for a new path to gene discovery and understanding disease mechanism. Acta Neuropathol (2016) 0.75

Can assisted reproductive technologies cause adult-onset disease? Evidence from human and mouse. Reprod Toxicol (2016) 0.75

The dynamic epigenome. Nat Struct Mol Biol (2013) 0.75

Alteration of the DNA methylation status of donor cells impairs the developmental competence of porcine cloned embryos. J Reprod Dev (2015) 0.75

Epigenetics: A key paradigm in reproductive health. Clin Exp Reprod Med (2016) 0.75

Reduced PRF1 enhancer methylation in children with a history of severe RSV bronchiolitis in infancy: an association study. BMC Pediatr (2017) 0.75

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC Dev Biol (2015) 0.75

Setd5 is essential for mammalian development and co-transcriptional regulation of histone acetylation. Development (2016) 0.75

Integrating evolutionary game theory into epigenetic study of embryonic development: Comment on "Epigenetic game theory: How to compute the epigenetic control of maternal-to-zygotic transition" by Qian Wang et al. Phys Life Rev (2017) 0.75

Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Sci Rep (2016) 0.75

Fetal testis organ culture reproduces the dynamics of epigenetic reprogramming in rat gonocytes. Epigenetics Chromatin (2017) 0.75

A Multistate Toggle Switch Defines Fungal Cell Fates and Is Regulated by Synergistic Genetic Cues. PLoS Genet (2016) 0.75

The Life Span Model of Suicide and Its Neurobiological Foundation. Front Neurosci (2017) 0.75

Late Maternal Folate Supplementation Rescues from Methyl Donor Deficiency-Associated Brain Defects by Restoring Let-7 and miR-34 Pathways. Mol Neurobiol (2016) 0.75

Does the Aryl Hydrocarbon Receptor Regulate Pluripotency? Curr Opin Toxicol (2017) 0.75

A cell culture model for investigation of synapse influenceability: epigenetics, expression and function of gene targets important for synapse formation and preservation in SH-SY5Y neuroblastoma cells differentiated by retinoic acid. J Neural Transm (Vienna) (2017) 0.75

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell (2006) 120.51

An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73

A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell (2006) 48.80

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science (2009) 32.97

The accessible chromatin landscape of the human genome. Nature (2012) 16.86

Dissecting direct reprogramming through integrative genomic analysis. Nature (2008) 16.47

Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science (2011) 14.29

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science (2011) 13.16

Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88

Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell (2008) 12.45

The Polycomb complex PRC2 and its mark in life. Nature (2011) 11.97

Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17

Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat Biotechnol (2008) 10.97

Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell (2011) 9.16

Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev (2002) 8.78

Demethylation of the zygotic paternal genome. Nature (2000) 8.52

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei. Nature (1998) 8.42

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell (2008) 7.79

Role of the murine reprogramming factors in the induction of pluripotency. Cell (2009) 7.46

Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell (2012) 7.17

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome. Cell (2012) 7.09

Active demethylation of the paternal genome in the mouse zygote. Curr Biol (2000) 6.99

Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell (2011) 6.80

The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature (2011) 6.73

A unique regulatory phase of DNA methylation in the early mammalian embryo. Nature (2012) 6.34

Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20

A combined chemical and genetic approach for the generation of induced pluripotent stem cells. Cell Stem Cell (2008) 5.90

Dynamic reprogramming of DNA methylation in the early mouse embryo. Dev Biol (2002) 5.86

Chromatin remodelling during development. Nature (2010) 5.86

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat Commun (2011) 5.66

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev (2005) 5.50

Vitamin C enhances the generation of mouse and human induced pluripotent stem cells. Cell Stem Cell (2009) 5.49

Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc Natl Acad Sci U S A (2011) 5.45

Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr Biol (2001) 5.42

Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse. Genesis (2003) 5.19

Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution. Science (2012) 5.17

Molecular signals of epigenetic states. Science (2010) 4.81

Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature (2008) 4.69

The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol (1962) 4.37

Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science (2010) 4.32

Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4. Proc Natl Acad Sci U S A (1995) 4.26

Chd1 regulates open chromatin and pluripotency of embryonic stem cells. Nature (2009) 4.13

Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science (2011) 4.12

An embryonic stem cell chromatin remodeling complex, esBAF, is an essential component of the core pluripotency transcriptional network. Proc Natl Acad Sci U S A (2009) 4.07

Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04

DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nat Cell Biol (2004) 3.89

In embryonic stem cells, ZFP57/KAP1 recognize a methylated hexanucleotide to affect chromatin and DNA methylation of imprinting control regions. Mol Cell (2011) 3.67

PGC7/Stella protects against DNA demethylation in early embryogenesis. Nat Cell Biol (2006) 3.54

Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells (2010) 3.53

Critical function of Prdm14 for the establishment of the germ cell lineage in mice. Nat Genet (2008) 3.52

A 5' 2-kilobase-pair region of the imprinted mouse H19 gene exhibits exclusive paternal methylation throughout development. Mol Cell Biol (1997) 3.51

Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science (2012) 3.45

De novo DNA methylation promoted by G9a prevents reprogramming of embryonically silenced genes. Nat Struct Mol Biol (2008) 3.33

Reprogramming factor expression initiates widespread targeted chromatin remodeling. Cell Stem Cell (2011) 3.16

G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J (2008) 3.08

Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming. Cell (2010) 3.08

Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev (2008) 2.99

Extensive and orderly reprogramming of genome-wide chromatin modifications associated with specification and early development of germ cells in mice. Dev Biol (2005) 2.94

Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development. Development (2003) 2.91

CpG islands recruit a histone H3 lysine 36 demethylase. Mol Cell (2010) 2.86

A signaling principle for the specification of the germ cell lineage in mice. Cell (2009) 2.81

DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity. EMBO J (2008) 2.81

The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature (2012) 2.80

Asymmetrically modified nucleosomes. Cell (2012) 2.79

Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2. Nature (2012) 2.64

Differential H4 acetylation of paternal and maternal chromatin precedes DNA replication and differential transcriptional activity in pronuclei of 1-cell mouse embryos. Development (1997) 2.63

Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. Development (2002) 2.55

Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. Dev Biol (2005) 2.51

TrxG and PcG proteins but not methylated histones remain associated with DNA through replication. Cell (2012) 2.45

Significant improvement of mouse cloning technique by treatment with trichostatin A after somatic nuclear transfer. Biochem Biophys Res Commun (2005) 2.43

Regulation of transcriptional activity during the first and second cell cycles in the preimplantation mouse embryo. Dev Biol (1997) 2.42

PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature (2012) 2.38

Stella is a maternal effect gene required for normal early development in mice. Curr Biol (2003) 2.38

PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos. Nat Genet (2008) 2.37

Generation and replication-dependent dilution of 5fC and 5caC during mouse preimplantation development. Cell Res (2011) 2.36

Dynamic link of DNA demethylation, DNA strand breaks and repair in mouse zygotes. EMBO J (2010) 2.30

esBAF facilitates pluripotency by conditioning the genome for LIF/STAT3 signalling and by regulating polycomb function. Nat Cell Biol (2011) 2.29

The pre-implantation ontogeny of the H19 methylation imprint. Nat Genet (1997) 2.28

The foundation of two distinct cell lineages within the mouse morula. Cell (1981) 2.24

Complex genome-wide transcription dynamics orchestrated by Blimp1 for the specification of the germ cell lineage in mice. Genes Dev (2008) 2.20

Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet (2008) 2.01

Tet1 controls meiosis by regulating meiotic gene expression. Nature (2012) 2.01

Heterochromatin and tri-methylated lysine 20 of histone H4 in animals. J Cell Sci (2004) 1.98

Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem (2011) 1.88

The structural organization of sperm chromatin. J Biol Chem (2003) 1.86

Trim28 is required for epigenetic stability during mouse oocyte to embryo transition. Science (2012) 1.84

Global profiling of DNA methylation erasure in mouse primordial germ cells. Genome Res (2012) 1.78

G9a and Jhdm2a regulate embryonic stem cell fusion-induced reprogramming of adult neural stem cells. Stem Cells (2008) 1.68

Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev (2011) 1.62

Histone variant macroH2A confers resistance to nuclear reprogramming. EMBO J (2011) 1.57

Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline. Development (2012) 1.55

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol (2012) 1.52

Butyrate promotes induced pluripotent stem cell generation. J Biol Chem (2010) 1.48

Histone variants in metazoan development. Dev Cell (2010) 1.42

Packaging paternal chromosomes with protamine. Nat Genet (2001) 1.42

Histone methylation defines epigenetic asymmetry in the mouse zygote. Int J Dev Biol (2002) 1.41

Sperm-derived histones contribute to zygotic chromatin in humans. BMC Dev Biol (2008) 1.39

X chromosome activity in mouse XX primordial germ cells. PLoS Genet (2008) 1.38

Chromatin signatures of pluripotent cell lines. Nat Cell Biol (2006) 12.88

Cohesins functionally associate with CTCF on mammalian chromosome arms. Cell (2008) 7.80

Ring1-mediated ubiquitination of H2A restrains poised RNA polymerase II at bivalent genes in mouse ES cells. Nat Cell Biol (2007) 6.30

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. Proc Natl Acad Sci U S A (2008) 5.97

Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature (2009) 5.96

A role for Dicer in immune regulation. J Exp Med (2006) 5.81

Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development. Science (2002) 5.47

T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J Exp Med (2005) 5.26

Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell (2010) 4.36

Epigenetic signatures of stem-cell identity. Nat Rev Genet (2007) 3.56

Dynamic assembly of silent chromatin during thymocyte maturation. Nat Genet (2004) 2.68

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity (2007) 2.65

A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. Nature (2011) 2.58

Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nat Cell Biol (2010) 2.55

Neural induction promotes large-scale chromatin reorganisation of the Mash1 locus. J Cell Sci (2006) 2.37

Heritable gene silencing in lymphocytes delays chromatid resolution without affecting the timing of DNA replication. Nat Cell Biol (2003) 2.21

CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. PLoS Genet (2010) 2.20

Different roles for Tet1 and Tet2 proteins in reprogramming-mediated erasure of imprints induced by EGC fusion. Mol Cell (2013) 2.10

Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments. Genome Res (2013) 2.05

Heterokaryon-based reprogramming of human B lymphocytes for pluripotency requires Oct4 but not Sox2. PLoS Genet (2008) 2.01

ESCs require PRC2 to direct the successful reprogramming of differentiated cells toward pluripotency. Cell Stem Cell (2010) 1.98

Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol Cell Biol (2006) 1.81

Nuclear repositioning marks the selective exclusion of lineage-inappropriate transcription factor loci during T helper cell differentiation. Eur J Immunol (2004) 1.76

Chromatin structure and gene regulation in the immune system. Annu Rev Immunol (2001) 1.68

Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev (2009) 1.67

Epigenetic aspects of differentiation. J Cell Sci (2004) 1.64

Chromatin states in pluripotent, differentiated, and reprogrammed cells. Curr Opin Genet Dev (2011) 1.62

Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood (2013) 1.51

Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes. EMBO J (2004) 1.49

The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells. Genome Biol (2007) 1.49

Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation. PLoS One (2007) 1.45

Runx proteins regulate Foxp3 expression. J Exp Med (2009) 1.45

Role of DNA methylation in stable gene repression. J Biol Chem (2007) 1.45

A dynamic switch in the replication timing of key regulator genes in embryonic stem cells upon neural induction. Cell Cycle (2004) 1.39

Is REST required for ESC pluripotency? Nature (2009) 1.34

Stem cells primed for action: polycomb repressive complexes restrain the expression of lineage-specific regulators in embryonic stem cells. Cell Cycle (2006) 1.32

Epigenetic priming of a pre-B cell-specific enhancer through binding of Sox2 and Foxd3 at the ESC stage. Cell Stem Cell (2010) 1.32

REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells. Development (2009) 1.25

Inactive yet indispensable: the tale of Jarid2. Trends Cell Biol (2010) 1.24

Acquisition and extinction of gene expression programs are separable events in heterokaryon reprogramming. J Cell Sci (2006) 1.19

Nuclear organisation and gene expression. Curr Opin Cell Biol (2002) 1.19

The reorganisation of constitutive heterochromatin in differentiating muscle requires HDAC activity. Exp Cell Res (2005) 1.18

DNA synthesis is required for reprogramming mediated by stem cell fusion. Cell (2013) 1.14

The developmentally regulated expression of Twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development. J Exp Med (2002) 1.09

Centromeric repositioning of coreceptor loci predicts their stable silencing and the CD4/CD8 lineage choice. J Exp Med (2004) 0.98

Chromosomes, positions please! Nat Cell Biol (2003) 0.94

IL4 blockade of inducible regulatory T cell differentiation: the role of Th2 cells, Gata3 and PU.1. Immunol Lett (2008) 0.90

Heterokaryon-based reprogramming for pluripotency. Curr Protoc Stem Cell Biol (2009) 0.90

Chromatin organization and differentiation in embryonic stem cell models. Curr Opin Genet Dev (2007) 0.90

Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression. Blood (2010) 0.87

DNA demethylation in pluripotency and reprogramming: the role of tet proteins and cell division. Cell Stem Cell (2013) 0.87

Using heterokaryons to understand pluripotency and reprogramming. Philos Trans R Soc Lond B Biol Sci (2011) 0.87

A reappraisal of evidence for probabilistic models of allelic exclusion. Proc Natl Acad Sci U S A (2008) 0.85

Can controversies be put to REST? Nature (2010) 0.83

Reprogramming somatic cells towards pluripotency by cellular fusion. Curr Opin Genet Dev (2012) 0.82

Reprogramming and the pluripotent stem cell cycle. Curr Top Dev Biol (2013) 0.81

The regulated long-term delivery of therapeutic proteins by using antigen-specific B lymphocytes. Proc Natl Acad Sci U S A (2004) 0.80

Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo. Epigenetics Chromatin (2010) 0.78

Correction of severe anaemia using immuno-regulated gene therapy is achieved by restoring the early erythroblast compartment. Br J Haematol (2006) 0.77

Atypical heterochromatin organization and replication are rapidly acquired by somatic cells following fusion-mediated reprogramming by mouse ESCs. Cell Cycle (2013) 0.77

LOCKing in Cellular Potential. Cell Stem Cell (2009) 0.76

Unraveling epigenetic landscapes: the enigma of enhancers. Cell Stem Cell (2011) 0.76

Chromosomes and expression mechanisms: life on the edge. Curr Opin Genet Dev (2009) 0.76

Maintaining transcriptional states through DNA replication. Cell Cycle (2003) 0.75