Published in Proc Natl Acad Sci U S A on May 10, 2004
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila. EMBO J (2008) 3.51
Transcriptional profiling of aging in human muscle reveals a common aging signature. PLoS Genet (2006) 3.34
Reactive oxygen species as universal constraints in life-history evolution. Proc Biol Sci (2009) 2.32
Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Genome Biol (2007) 2.12
Drosophila lifespan enhancement by exogenous bacteria. Proc Natl Acad Sci U S A (2004) 2.05
Profiling early infection responses: Pseudomonas aeruginosa eludes host defenses by suppressing antimicrobial peptide gene expression. Proc Natl Acad Sci U S A (2005) 2.02
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Intestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila. Proc Natl Acad Sci U S A (2012) 1.73
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The use of transcriptional profiles to predict adult mosquito age under field conditions. Proc Natl Acad Sci U S A (2006) 1.55
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Genome-wide analysis on inbreeding effects on gene expression in Drosophila melanogaster. Genetics (2005) 1.39
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Mechanisms of suspended animation are revealed by transcript profiling of diapause in the flesh fly. Proc Natl Acad Sci U S A (2010) 1.25
Quantitative image analysis reveals distinct structural transitions during aging in Caenorhabditis elegans tissues. PLoS One (2008) 1.24
Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Genetics (2006) 1.23
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Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY) (2012) 1.21
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Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster. PLoS One (2009) 1.15
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Heat shock proteins and Drosophila aging. Exp Gerontol (2010) 1.05
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Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster. Genetics (2008) 1.03
Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster. PLoS One (2011) 1.02
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Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophys J (2008) 0.99
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Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging Cell (2012) 0.92
Involvement of redox state in the aging of Drosophila melanogaster. Antioxid Redox Signal (2013) 0.91
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Phototransduction genes are up-regulated in a global gene expression study of Drosophila melanogaster selected for heat resistance. Cell Stress Chaperones (2006) 0.90
Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. BMC Genomics (2012) 0.90
The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans. PLoS Genet (2013) 0.90
Drosophila miR-277 controls branched-chain amino acid catabolism and affects lifespan. RNA Biol (2013) 0.89
The transcriptional response to tumorigenic polarity loss in Drosophila. Elife (2015) 0.89
dJun and Vri/dNFIL3 are major regulators of cardiac aging in Drosophila. PLoS Genet (2012) 0.88
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Evolutionary theory and studies of model organisms predict a cautiously positive perspective on the therapeutic use of hormesis for healthy aging in humans. Dose Response (2009) 0.87
Gene expression profiling of three different stressors in the water flea Daphnia magna. Ecotoxicology (2013) 0.87
Antimicrobial peptides increase tolerance to oxidant stress in Drosophila melanogaster. J Biol Chem (2010) 0.86
Mitochondrial maintenance failure in aging and role of sexual dimorphism. Arch Biochem Biophys (2014) 0.86
Lifespan of mice and primates correlates with immunoproteasome expression. J Clin Invest (2015) 0.86
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Microarray methods in Drosophila neurobiology. Invert Neurosci (2005) 0.86
Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia. BMC Genomics (2013) 0.86
Infection-related declines in chill coma recovery and negative geotaxis in Drosophila melanogaster. PLoS One (2012) 0.85
Relationship between heat shock protein 70 expression and life span in Daphnia. Mech Ageing Dev (2014) 0.85
Variegated expression of Hsp22 transgenic reporters indicates cell-specific patterns of aging in Drosophila oenocytes. J Gerontol A Biol Sci Med Sci (2013) 0.85
Divergent transcriptional response to thermal stress by Anopheles gambiae larvae carrying alternative arrangements of inversion 2La. Mol Ecol (2011) 0.84
Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity. Heredity (Edinb) (2012) 0.84
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Chemical profiles of two pheromone glands are differentially regulated by distinct mating factors in honey bee queens (Apis mellifera L.). PLoS One (2013) 0.83
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The effect of peroxiredoxin 4 on fly physiology is a complex interplay of antioxidant and signaling functions. FASEB J (2012) 0.82
Comparison between the effects of aging and hyperoxia on glutathione redox state and protein mixed disulfides in Drosophila melanogaster. Mech Ageing Dev (2006) 0.82
The GATA transcription factor egl-27 delays aging by promoting stress resistance in Caenorhabditis elegans. PLoS Genet (2012) 0.82
Heart-specific Rpd3 downregulation enhances cardiac function and longevity. Aging (Albany NY) (2015) 0.81
Vitellogenin family gene expression does not increase Drosophila lifespan or fecundity. F1000Res (2014) 0.81
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The genetic mechanisms of the influence of the light regime on the lifespan of Drosophila melanogaster. Front Genet (2013) 0.80
alpha- and gamma-Tocopherol prevent age-related transcriptional alterations in the heart and brain of mice. J Nutr (2008) 0.80
Identification of novel modifiers of Aβ toxicity by transcriptomic analysis in the fruitfly. Sci Rep (2013) 0.80
Deciphering life history transcriptomes in different environments. Mol Ecol (2014) 0.79
Activation of the cnidarian oxidative stress response by ultraviolet radiation, polycyclic aromatic hydrocarbons and crude oil. J Exp Biol (2014) 0.79
Genomic response to selection for postponed senescence in Drosophila. Mech Ageing Dev (2012) 0.79
The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress. BMC Genomics (2015) 0.78
Effects of Flight on Gene Expression and Aging in the Honey Bee Brain and Flight Muscle. Insects (2012) 0.78
Endothelial nitric oxide synthase-related mechanotransduction changes in aged porcine angular aqueous plexus cells. Invest Ophthalmol Vis Sci (2014) 0.78
Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process. Front Genet (2015) 0.78
Understanding the role of heat shock protein isoforms in male fertility, aging and apoptosis. World J Mens Health (2014) 0.78
The Genomic Basis of Postponed Senescence in Drosophila melanogaster. PLoS One (2015) 0.78
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The song of the old mother: reproductive senescence in female drosophila. Fly (Austin) (2014) 0.77
Diminished Resistance to Hyperoxia in Brains of Reproductively Senescent Female CBA/H Mice. Med Sci Monit Basic Res (2015) 0.77
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Population-based genetic and evolutionary analysis of Chlamydia trachomatis urogenital strain variation in the United States. J Bacteriol (2004) 1.94
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Genome-wide mapping of ORC and Mcm2p binding sites on tiling arrays and identification of essential ARS consensus sequences in S. cerevisiae. BMC Genomics (2006) 1.83
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CNAseg--a novel framework for identification of copy number changes in cancer from second-generation sequencing data. Bioinformatics (2010) 1.74
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Counting divisions in a human somatic cell tree: how, what and why? Cell Cycle (2006) 1.62
Pretumor progression: clonal evolution of human stem cell populations. Am J Pathol (2004) 1.57
Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell (2013) 1.56
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The pitfalls of platform comparison: DNA copy number array technologies assessed. BMC Genomics (2009) 1.55
Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. Exp Gerontol (2007) 1.51
Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol (2004) 1.51
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Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. Gut (2010) 1.44
Modifier effects between regulatory and protein-coding variation. PLoS Genet (2008) 1.42
Statistical tests of the coalescent model based on the haplotype frequency distribution and the number of segregating sites. Genetics (2005) 1.41
The stem cell population of the human colon crypt: analysis via methylation patterns. PLoS Comput Biol (2007) 1.38
Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. Mech Ageing Dev (2004) 1.33
Spike-in validation of an Illumina-specific variance-stabilizing transformation. BMC Res Notes (2008) 1.28
Single-molecule genomic data delineate patient-specific tumor profiles and cancer stem cell organization. Cancer Res (2012) 1.28
Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci U S A (2005) 1.24
BayesPeak--an R package for analysing ChIP-seq data. Bioinformatics (2011) 1.23
The microRNA miR-124 controls gene expression in the sensory nervous system of Caenorhabditis elegans. Nucleic Acids Res (2010) 1.22
Inferring relative numbers of human leucocyte genome replications. Br J Haematol (2008) 1.22
Non-linear analysis of GeneChip arrays. Nucleic Acids Res (2006) 1.21
Characterisation of microRNA expression in post-natal mouse mammary gland development. BMC Genomics (2009) 1.21
Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY) (2012) 1.21
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany NY) (2009) 1.19
Rad53 regulates replication fork restart after DNA damage in Saccharomyces cerevisiae. Genes Dev (2008) 1.19
Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors. PLoS Comput Biol (2011) 1.18
High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta. BMC Genet (2010) 1.18
Explaining differences in saturation levels for Affymetrix GeneChip arrays. Nucleic Acids Res (2007) 1.16
Genome-wide analysis of a G-quadruplex-specific single-chain antibody that regulates gene expression. Nucleic Acids Res (2009) 1.15
Population-based genetic epidemiologic analysis of Chlamydia trachomatis serotypes and lack of association between ompA polymorphisms and clinical phenotypes. Microbes Infect (2006) 1.15
Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster. PLoS One (2009) 1.15
Estimating a nucleotide substitution rate for maize from polymorphism at a major domestication locus. Mol Biol Evol (2005) 1.14
A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila. Aging (Albany NY) (2009) 1.14
Many colorectal cancers are "flat" clonal expansions. Cell Cycle (2009) 1.10
Conditional inhibition of autophagy genes in adult Drosophila impairs immunity without compromising longevity. Exp Gerontol (2008) 1.10
Expression of hsp22 and hsp70 transgenes is partially predictive of drosophila survival under normal and stress conditions. J Gerontol A Biol Sci Med Sci (2009) 1.10
Cell cycle genes are the evolutionarily conserved targets of the E2F4 transcription factor. PLoS One (2007) 1.07
Age-related human small intestine methylation: evidence for stem cell niches. BMC Med (2005) 1.06
Peroxiredoxins, gerontogenes linking aging to genome instability and cancer. Genes Dev (2012) 1.04
Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging. BMC Med Genet (2007) 1.04
Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes. PLoS Genet (2013) 1.03
Pediatric malignant germ cell tumors show characteristic transcriptome profiles. Cancer Res (2008) 1.03
Simultaneous tracking of fly movement and gene expression using GFP. BMC Biotechnol (2008) 1.02
Three-dimensional tracking and behaviour monitoring of multiple fruit flies. J R Soc Interface (2012) 1.02
Flexible analysis of RNA-seq data using mixed effects models. Bioinformatics (2013) 1.01
Endometrial-peritoneal interactions during endometriotic lesion establishment. Am J Pathol (2008) 1.01
MMASS: an optimized array-based method for assessing CpG island methylation. Nucleic Acids Res (2006) 1.00
The level of origin firing inversely affects the rate of replication fork progression. J Cell Biol (2013) 1.00
High DNA methylation pattern intratumoral diversity implies weak selection in many human colorectal cancers. PLoS One (2011) 0.98