Published in J Biol Chem on September 30, 2004
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med (2006) 7.87
TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J Immunol (2008) 3.42
Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum (2007) 3.06
Signal transduction pathways and transcriptional regulation in the control of Th17 differentiation. Semin Immunol (2007) 1.87
Recent advances in the IL-17 cytokine family. Curr Opin Immunol (2011) 1.86
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity. Immunity (2008) 1.73
Interleukin-17 stimulates C-reactive protein expression in hepatocytes and smooth muscle cells via p38 MAPK and ERK1/2-dependent NF-kappaB and C/EBPbeta activation. J Biol Chem (2007) 1.69
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 1.67
Signal transduction pathways and transcriptional regulation in Th17 cell differentiation. Cytokine Growth Factor Rev (2010) 1.61
Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J Exp Med (2008) 1.38
Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol (2006) 1.29
Notch signaling regulates mouse and human Th17 differentiation. J Immunol (2011) 1.21
A genetic variant in the IL-17 promoter is functionally associated with acute graft-versus-host disease after unrelated bone marrow transplantation. PLoS One (2011) 1.20
Low-strength T-cell activation promotes Th17 responses. Blood (2010) 1.15
CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance. J Clin Invest (2014) 1.14
IRF4 and its regulators: evolving insights into the pathogenesis of inflammatory arthritis? Immunol Rev (2010) 1.12
Biology of recently discovered cytokines: interleukin-17--a unique inflammatory cytokine with roles in bone biology and arthritis. Arthritis Res Ther (2004) 1.11
Elucidating the role of interleukin-17F in cutaneous T-cell lymphoma. Blood (2013) 1.09
IL-17 signaling in host defense against Candida albicans. Immunol Res (2011) 1.06
Translational mini-review series on Th17 cells: development of mouse and human T helper 17 cells. Clin Exp Immunol (2009) 1.05
Polymorphism in the interleukin-17A promoter contributes to gastric cancer. World J Gastroenterol (2013) 1.02
Signal transduction and Th17 cell differentiation. Microbes Infect (2009) 0.98
SLAT/Def6 plays a critical role in the development of Th17 cell-mediated experimental autoimmune encephalomyelitis. J Immunol (2009) 0.96
Th17 cells and transplant acceptance. Transplantation (2010) 0.90
Th17 lymphocytes in respiratory syncytial virus infection. Viruses (2013) 0.88
Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women. J Assist Reprod Genet (2014) 0.87
Transcriptional regulatory networks for CD4 T cell differentiation. Curr Top Microbiol Immunol (2014) 0.86
Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter. J Autoimmun (2012) 0.86
SWAP-70-like adapter of T cells: a novel Lck-regulated guanine nucleotide exchange factor coordinating actin cytoskeleton reorganization and Ca2+ signaling in T cells. Immunol Rev (2009) 0.85
Single Nucleotide Polymorphisms in IL17A and IL6 Are Associated with Decreased Risk for Pulmonary Tuberculosis in Southern Brazilian Population. PLoS One (2016) 0.83
Common variants in IL-17A/IL-17RA axis contribute to predisposition to and progression of congestive heart failure. Medicine (Baltimore) (2016) 0.81
IRAK-2 regulates IL-1-mediated pathogenic Th17 cell development in helminthic infection. PLoS Pathog (2011) 0.81
The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients. Mediators Inflamm (2015) 0.80
Role of IL-17A rs2275913 and IL-17F rs763780 polymorphisms in risk of cancer development: an updated meta-analysis. Sci Rep (2016) 0.79
Inhibitory effects of the JAK inhibitor CP690,550 on human CD4(+) T lymphocyte cytokine production. BMC Immunol (2011) 0.78
Interleukin-17A Gene Variability in Patients with Type 1 Diabetes Mellitus and Chronic Periodontitis: Its Correlation with IL-17 Levels and the Occurrence of Periodontopathic Bacteria. Mediators Inflamm (2016) 0.77
Mechanisms of rapid induction of interleukin-22 in activated T cells and its modulation by cyclosporin a. J Biol Chem (2011) 0.77
Association between IL17A and IL17F polymorphisms and risk of Henoch-Schonlein purpura in Chinese children. Rheumatol Int (2016) 0.76
Role of STIM2 in cell function and physiopathology. J Physiol (2017) 0.75
Role of IL-17 Variants in Preeclampsia in Chinese Han Women. PLoS One (2015) 0.75
Analysis of CD95 and CCR7 expression on circulating CD4(+) lymphocytes revealed disparate immunoregulatory potentials in systemic lupus erythematosus. Saudi J Biol Sci (2015) 0.75
Individualized treatment strategies and predictors of virological response for chronic hepatitis C: a multicenter prospective study from China. Int J Clin Exp Med (2015) 0.75
The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina. Sci Rep (2017) 0.75
TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy. J Immunol (2017) 0.75
IL-17A and IL-17F polymorphisms in rheumatoid arthritis and Sjögren's syndrome. Clin Oral Investig (2015) 0.75
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge. Nat Immunol (2007) 10.71
Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. J Exp Med (2009) 5.55
The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science (2009) 4.63
The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol (2006) 3.76
Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology (2010) 3.51
Functional cooperation between interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family members. J Biol Chem (2003) 3.41
A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol (2002) 3.38
Interleukin-17 is required for T helper 1 cell immunity and host resistance to the intracellular pathogen Francisella tularensis. Immunity (2009) 3.33
Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity (2005) 3.14
Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J Leukoc Biol (2004) 2.73
Identification of common transcriptional regulatory elements in interleukin-17 target genes. J Biol Chem (2006) 2.65
Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem (2006) 2.32
Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol (2009) 2.23
Structure-function relationships in the IL-17 receptor: implications for signal transduction and therapy. Cytokine (2008) 2.19
Evaluation of terrestrial carbon cycle models for their response to climate variability and to CO2 trends. Glob Chang Biol (2013) 2.13
Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment. J Leukoc Biol (2004) 2.03
The effect of combined antihypertensive treatment (felodipine with either irbesartan or metoprolol) on erectile function: a randomized controlled trial. Cardiology (2013) 2.02
CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity (2011) 2.00
Th17 cells in immunity to Candida albicans. Cell Host Microbe (2012) 1.97
CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol (2004) 1.96
Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression. Proc Natl Acad Sci U S A (2007) 1.85
IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr Opin Rheumatol (2008) 1.73
IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. J Immunol (2010) 1.69
NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One (2010) 1.69
Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol (2002) 1.68
Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion. Am J Hypertens (2011) 1.67
1,25-dihydroxyvitamin D(3) ameliorates Th17 autoimmunity via transcriptional modulation of interleukin-17A. Mol Cell Biol (2011) 1.67
Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. Front Biosci (2008) 1.60
Evidence of recombination and genetic diversity in human rhinoviruses in children with acute respiratory infection. PLoS One (2009) 1.58
NF-κB signaling pathways regulated by CARMA family of scaffold proteins. Cell Res (2010) 1.58
IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal (2009) 1.57
Genome-wide search for type 2 diabetes/impaired glucose homeostasis susceptibility genes in the Chinese: significant linkage to chromosome 6q21-q23 and chromosome 1q21-q24. Diabetes (2004) 1.54
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J (2007) 1.54
Positive and negative signaling components involved in TNFalpha-induced NF-kappaB activation. Cytokine (2008) 1.50
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J Biol Chem (2008) 1.48
Effect of felodipine with irbesartan or metoprolol on sexual function and oxidative stress in women with essential hypertension. J Hypertens (2012) 1.47
C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity (2013) 1.46
Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A (2006) 1.46
Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep (2012) 1.45
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev (2007) 1.45
CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. Immunol Rev (2009) 1.44
Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A (2006) 1.44
Interleukin-17: a new paradigm in inflammation, autoimmunity, and therapy. J Periodontol (2007) 1.43
The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity (2006) 1.40
Host responses to Candida albicans: Th17 cells and mucosal candidiasis. Microbes Infect (2010) 1.38
Declining snow cover may affect spring phenological trend on the Tibetan Plateau. Proc Natl Acad Sci U S A (2013) 1.38
MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. J Biol Chem (2004) 1.38
Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines. J Immunol (2009) 1.38
Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock (2013) 1.35
The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss. Infect Immun (2008) 1.35
Mucocutaneous candidiasis: the IL-17 pathway and implications for targeted immunotherapy. Arthritis Res Ther (2012) 1.33
The interleukin (IL)-2 family cytokines: survival and proliferation signaling pathways in T lymphocytes. Immunol Invest (2004) 1.31
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity (2010) 1.31
Evidence for ligand-independent multimerization of the IL-17 receptor. J Immunol (2006) 1.29
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem (2005) 1.28
High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. Cancer Epidemiol Biomarkers Prev (2007) 1.27
Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. Biochemistry (2010) 1.27
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol (2009) 1.26
IL-17 in obesity and adipogenesis. Cytokine Growth Factor Rev (2010) 1.23
RGD-modified apoferritin nanoparticles for efficient drug delivery to tumors. ACS Nano (2013) 1.23
Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling. J Clin Invest (2010) 1.22
NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate (2008) 1.21
Cell signalling through thromboxane A2 receptors. Cell Signal (2004) 1.20
Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A (2008) 1.20
Patterns, determinants and models of woody plant diversity in China. Proc Biol Sci (2010) 1.17
C-type lectin receptor-induced NF-κB activation in innate immune and inflammatory responses. Cell Mol Immunol (2012) 1.17
The deubiquitinase A20 mediates feedback inhibition of interleukin-17 receptor signaling. Sci Signal (2013) 1.16
Structure and ion channel activity of the human respiratory syncytial virus (hRSV) small hydrophobic protein transmembrane domain. Protein Sci (2008) 1.15
Study on therapeutic mechanism and clinical effect of mild hypothermia in patients with severe head injury. Surg Neurol (2003) 1.15
Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. J Immunol (2013) 1.15
IL-17RC: a partner in IL-17 signaling and beyond. Semin Immunopathol (2009) 1.14
CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem (2010) 1.14
Model of a putative pore: the pentameric alpha-helical bundle of SARS coronavirus E protein in lipid bilayers. Biophys J (2006) 1.13
Role of TFF in healing of stress-induced gastric lesions. World J Gastroenterol (2003) 1.13
Signaling through the murine T cell receptor induces IL-17 production in the absence of costimulation, IL-23 or dendritic cells. Mol Cells (2005) 1.13
Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis. J Immunol (2014) 1.13
Regulation of NF-κB by the CARD proteins. Immunol Rev (2012) 1.12
HSA coated iron oxide nanoparticles as drug delivery vehicles for cancer therapy. Mol Pharm (2011) 1.11
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J Biol Chem (2007) 1.11
Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. J Biol Chem (2009) 1.10
CARMA3 is crucial for EGFR-Induced activation of NF-κB and tumor progression. Cancer Res (2011) 1.10
Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Clin Cancer Res (2008) 1.09
Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi-isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi-isozizaene metabolite. Microb Biotechnol (2010) 1.07
Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol (2007) 1.06
Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. J Immunol (2007) 1.05
Structure and inhibition of the SARS coronavirus envelope protein ion channel. PLoS Pathog (2009) 1.04
The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe (2012) 1.04
The small hydrophobic protein of the human respiratory syncytial virus forms pentameric ion channels. J Biol Chem (2012) 1.03
Kinematic study of the relation between the instantaneous center of rotation and degenerative changes in the cervical intervertebral disc. Eur Spine J (2014) 1.03
USP18 inhibits NF-κB and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med (2013) 1.02
CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation. J Biol Chem (2007) 1.02
Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. J Trauma Acute Care Surg (2012) 1.02
SEF/IL-17R (SEFIR) is not enough: an extended SEFIR domain is required for il-17RA-mediated signal transduction. J Biol Chem (2010) 1.02
Development of allergen-induced airway inflammation in the absence of T-bet regulation is dependent on IL-17. J Immunol (2009) 1.01
Committed changes in tropical tree cover under the projected 21st century climate change. Sci Rep (2013) 1.01
Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem (2006) 1.00