Published in EMBO J on November 30, 2006
Recognition and processing of ubiquitin-protein conjugates by the proteasome. Annu Rev Biochem (2009) 8.83
Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. Annu Rev Biochem (2009) 6.23
Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature (2010) 5.08
Proteasome subunit Rpn13 is a novel ubiquitin receptor. Nature (2008) 4.76
Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol (2009) 4.62
Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction. Nature (2008) 3.11
Molecular mechanisms of proteasome assembly. Nat Rev Mol Cell Biol (2009) 2.82
Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome. Mol Biol Cell (2007) 2.28
Association of C-terminal ubiquitin hydrolase BRCA1-associated protein 1 with cell cycle regulator host cell factor 1. Mol Cell Biol (2009) 2.26
UAF1 is a subunit of multiple deubiquitinating enzyme complexes. J Biol Chem (2008) 2.17
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex. Mol Cell (2008) 1.71
A bis-benzylidine piperidone targeting proteasome ubiquitin receptor RPN13/ADRM1 as a therapy for cancer. Cancer Cell (2013) 1.69
Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol Cell (2009) 1.57
Structural biology of the proteasome. Annu Rev Biophys (2013) 1.42
Regulation of proteolysis by human deubiquitinating enzymes. Biochim Biophys Acta (2013) 1.42
The lysine 48 and lysine 63 ubiquitin conjugates are processed differently by the 26 s proteasome. J Biol Chem (2009) 1.39
Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell (2013) 1.35
Reverse the curse--the role of deubiquitination in cell cycle control. Curr Opin Cell Biol (2008) 1.31
An emerging model for BAP1's role in regulating cell cycle progression. Cell Biochem Biophys (2011) 1.30
Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2. Mol Cell (2010) 1.29
Electron microscopic evidence in support of alpha-solenoid models of proteasomal subunits Rpn1 and Rpn2. J Mol Biol (2009) 1.25
Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. Mol Cell (2015) 1.24
Rpn10-mediated degradation of ubiquitinated proteins is essential for mouse development. Mol Cell Biol (2007) 1.21
Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs. J Biol Chem (2013) 1.20
WDR20 regulates activity of the USP12 x UAF1 deubiquitinating enzyme complex. J Biol Chem (2010) 1.20
Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell (2015) 1.20
Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics (2010) 1.19
Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity. Nat Cell Biol (2014) 1.17
The 6q22.33 locus and breast cancer susceptibility. Cancer Epidemiol Biomarkers Prev (2009) 1.13
Gates, Channels, and Switches: Elements of the Proteasome Machine. Trends Biochem Sci (2015) 1.09
A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. PLoS Biol (2010) 1.08
Multitasking with ubiquitin through multivalent interactions. Trends Biochem Sci (2010) 1.07
Mechanisms for countering oxidative stress and damage in retinal pigment epithelium. Int Rev Cell Mol Biol (2012) 1.05
Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development. PLoS One (2010) 1.02
An optimal ubiquitin-proteasome pathway in the nervous system: the role of deubiquitinating enzymes. Front Mol Neurosci (2014) 1.01
Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13). Proc Natl Acad Sci U S A (2010) 1.00
Chronic ethanol feeding affects proteasome-interacting proteins. Proteomics (2009) 0.98
Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme. FEBS J (2011) 0.96
Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma. Dig Dis Sci (2012) 0.96
Structure characterization of the 26S proteasome. Biochim Biophys Acta (2010) 0.95
Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins. Mol Cell Proteomics (2009) 0.94
Autoregulation of the 26S proteasome by in situ ubiquitination. Mol Biol Cell (2014) 0.91
Functions of the 19S complex in proteasomal degradation. Trends Biochem Sci (2013) 0.90
Stabilization of an unusual salt bridge in ubiquitin by the extra C-terminal domain of the proteasome-associated deubiquitinase UCH37 as a mechanism of its exo specificity. Biochemistry (2013) 0.89
Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer. Int J Mol Sci (2013) 0.89
Structural insights into proteasome activation by the 19S regulatory particle. Biochemistry (2013) 0.87
A novel testis-specific GTPase serves as a link to proteasome biogenesis: functional characterization of RhoS/RSA-14-44 in spermatogenesis. Mol Biol Cell (2010) 0.83
Proteomics reveals a physical and functional link between hepatocyte nuclear factor 4alpha and transcription factor IID. J Biol Chem (2009) 0.83
Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation. Mol Cell Proteomics (2016) 0.83
Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet (2015) 0.82
Adrm1 interacts with Atp6v0d2 and regulates osteoclast differentiation. Biochem Biophys Res Commun (2009) 0.80
Targeting proteasome ubiquitin receptor Rpn13 in multiple myeloma. Leukemia (2016) 0.80
ADRM1 gene amplification is a candidate driver for metastatic gastric cancers. Clin Exp Metastasis (2014) 0.79
Binding of SGTA to Rpn13 selectively modulates protein quality control. J Cell Sci (2015) 0.79
Mechanism of the Rpn13-induced activation of Uch37. Protein Cell (2014) 0.79
The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem (2015) 0.79
Regulation of E2 Promoter Binding Factor 1 (E2F1) Transcriptional Activity through a Deubiquitinating Enzyme, UCH37. J Biol Chem (2015) 0.78
Ubiquitin chain trimming recycles the substrate binding sites of the 26 S proteasome and promotes degradation of lysine 48-linked polyubiquitin conjugates. J Biol Chem (2011) 0.78
Comparison of the neutrophil proteome in trauma patients and normal controls. Protein Pept Lett (2012) 0.78
The Proteasome Ubiquitin Receptor hRpn13 and Its Interacting Deubiquitinating Enzyme Uch37 Are Required for Proper Cell Cycle Progression. J Biol Chem (2016) 0.77
MTMDAT-HADDOCK: high-throughput, protein complex structure modeling based on limited proteolysis and mass spectrometry. BMC Struct Biol (2012) 0.77
Phosphorylated TP63 induces transcription of RPN13, leading to NOS2 protein degradation. J Biol Chem (2010) 0.77
A High Affinity hRpn2-Derived Peptide That Displaces Human Rpn13 from Proteasome in 293T Cells. PLoS One (2015) 0.77
Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome. Structure (2016) 0.76
Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni. Mem Inst Oswaldo Cruz (2013) 0.76
The Logic of the 26S Proteasome. Cell (2017) 0.76
Ubiquitin carboxyl-terminal hydrolase-L5 promotes TGFβ-1 signaling by de-ubiquitinating and stabilizing Smad2/Smad3 in pulmonary fibrosis. Sci Rep (2016) 0.76
Entropic stabilization of a deubiquitinase provides conformational plasticity and slow unfolding kinetics beneficial for functioning on the proteasome. Sci Rep (2017) 0.75
Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases. BMB Rep (2016) 0.75
Purification, crystallization and preliminary X-ray data collection of the N-terminal domain of the 26S proteasome regulatory subunit p27 and its complex with the ATPase domain of Rpt5 from Mus musculus. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Emerging mechanistic insights into AAA complexes regulating proteasomal degradation. Biomolecules (2014) 0.75
Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma. J Ovarian Res (2017) 0.75
Meddling with Fate: The Proteasomal Deubiquitinating Enzymes. J Mol Biol (2017) 0.75
The Ubiquitin Receptor ADRM1 Modulates HAP40-Induced Proteasome Activity. Mol Neurobiol (2016) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiol Rev (2002) 16.10
Protein degradation and protection against misfolded or damaged proteins. Nature (2003) 10.19
The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu Rev Biochem (1999) 8.97
Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (2002) 7.49
A cryptic protease couples deubiquitination and degradation by the proteasome. Nature (2002) 6.21
A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3. Cell (1998) 5.78
Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Mol Biol Cell (2000) 5.19
Short-lived green fluorescent proteins for quantifying ubiquitin/proteasome-dependent proteolysis in living cells. Nat Biotechnol (2000) 5.14
Multiple associated proteins regulate proteasome structure and function. Mol Cell (2002) 4.97
The ubiquitin system. Trends Biochem Sci (1997) 4.67
Proteasome recruitment and activation of the Uch37 deubiquitinating enzyme by Adrm1. Nat Cell Biol (2006) 3.14
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell (2005) 2.82
A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes. EMBO J (2006) 2.69
An integrated mass spectrometry-based proteomic approach: quantitative analysis of tandem affinity-purified in vivo cross-linked protein complexes (QTAX) to decipher the 26 S proteasome-interacting network. Mol Cell Proteomics (2005) 2.62
Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol (2002) 2.17
PA200, a nuclear proteasome activator involved in DNA repair. EMBO J (2002) 2.15
The RING finger of c-Cbl mediates desensitization of the epidermal growth factor receptor. J Biol Chem (1999) 2.13
Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces cerevisiae. J Biol Chem (2004) 1.69
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc Natl Acad Sci U S A (2002) 1.68
The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme. J Cell Biol (2000) 1.66
An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. Proc Natl Acad Sci U S A (2002) 1.52
Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast. Methods Mol Biol (2005) 1.48
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J (2004) 1.46
Analysis of Drosophila 26 S proteasome using RNA interference. J Biol Chem (2001) 1.46
The ATP dependence of the degradation of short- and long-lived proteins in growing fibroblasts. J Biol Chem (1985) 1.38
Deubiquitinating enzymes are IN/(trinsic to proteasome function). Curr Protein Pept Sci (2004) 1.37
Adrm1, a putative cell adhesion regulating protein, is a novel proteasome-associated factor. J Mol Biol (2006) 1.34
Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. J Biol Chem (2002) 1.32
Uch2/Uch37 is the major deubiquitinating enzyme associated with the 26S proteasome in fission yeast. J Mol Biol (2004) 1.28
Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells. Clin Exp Metastasis (1999) 1.03
Adhesion properties of adhesion-regulating molecule 1 protein on endothelial cells. FEBS J (2005) 1.01
Molecular cloning and characterization of the complementary DNA of an M(r) 110,000 antigen expressed by human gastric carcinoma cells and upregulated by gamma-interferon. Cancer Res (1994) 0.95
Xoom is maternally stored and functions as a transmembrane protein for gastrulation movement in Xenopus embryos. Dev Growth Differ (2001) 0.89
Identification of a novel tumor-associated Mr 110,000 gene product in human gastric carcinoma cells that is immunologically related to carcinoembryonic antigen. Cancer Res (1991) 0.87
Rat homologue of the human M(r) 110000 antigen is the protein that expresses widely in various tissues. Biochim Biophys Acta (2000) 0.83
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy (2007) 20.92
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell (2004) 11.33
FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab (2007) 8.90
FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab (2007) 8.05
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression. FASEB J (2004) 7.02
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Reversal of cancer cachexia and muscle wasting by ActRIIB antagonism leads to prolonged survival. Cell (2010) 5.23
Docking of the proteasomal ATPases' carboxyl termini in the 20S proteasome's alpha ring opens the gate for substrate entry. Mol Cell (2007) 4.54
Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet (2011) 4.38
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol (2006) 4.01
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J Biol Chem (2007) 3.68
Mechanism of gate opening in the 20S proteasome by the proteasomal ATPases. Mol Cell (2008) 3.49
The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8-9 residues. Nat Immunol (2002) 3.45
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases. FASEB J (2006) 3.27
An IFN-gamma-induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I-presented peptides. Nat Immunol (2002) 3.22
ATP hydrolysis by the proteasome regulatory complex PAN serves multiple functions in protein degradation. Mol Cell (2003) 3.14
During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation. J Cell Biol (2009) 3.03
Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins. Mol Cell (2004) 2.89
IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab (2004) 2.82
ATP binding to PAN or the 26S ATPases causes association with the 20S proteasome, gate opening, and translocation of unfolded proteins. Mol Cell (2005) 2.82
Importance of the different proteolytic sites of the proteasome and the efficacy of inhibitors varies with the protein substrate. J Biol Chem (2006) 2.59
Monitoring activity and inhibition of 26S proteasomes with fluorogenic peptide substrates. Methods Enzymol (2005) 2.49
The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism. Proc Natl Acad Sci U S A (2005) 2.47
The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem (2005) 2.44
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (2004) 2.42
Patterns of gene expression in atrophying skeletal muscles: response to food deprivation. FASEB J (2002) 2.29
ATP binds to proteasomal ATPases in pairs with distinct functional effects, implying an ordered reaction cycle. Cell (2011) 2.27
Protein degradation and the generation of MHC class I-presented peptides. Adv Immunol (2002) 2.17
Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening. Mol Cell (2009) 2.10
Cancer vulnerabilities unveiled by genomic loss. Cell (2012) 1.95
Trehalose synthesis is induced upon exposure of Escherichia coli to cold and is essential for viability at low temperatures. Proc Natl Acad Sci U S A (2002) 1.85
Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway. Proc Natl Acad Sci U S A (2011) 1.85
Post-proteasomal antigen processing for major histocompatibility complex class I presentation. Nat Immunol (2004) 1.83
TNF-alpha increases ubiquitin-conjugating activity in skeletal muscle by up-regulating UbcH2/E220k. FASEB J (2003) 1.83
Isolation of mammalian 26S proteasomes and p97/VCP complexes using the ubiquitin-like domain from HHR23B reveals novel proteasome-associated proteins. Biochemistry (2009) 1.78
Immuno- and constitutive proteasomes do not differ in their abilities to degrade ubiquitinated proteins. Cell (2013) 1.74
Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins. J Cell Biol (2008) 1.71
ATP-dependent steps in the binding of ubiquitin conjugates to the 26S proteasome that commit to degradation. Mol Cell (2010) 1.68
Properties of the hybrid form of the 26S proteasome containing both 19S and PA28 complexes. EMBO J (2002) 1.68
BMP signaling controls muscle mass. Nat Genet (2013) 1.68
Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. Proc Natl Acad Sci U S A (2002) 1.68
Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy. J Biol Chem (2010) 1.66
Interactions of PAN's C-termini with archaeal 20S proteasome and implications for the eukaryotic proteasome-ATPase interactions. EMBO J (2009) 1.60
Mycobacterium tuberculosis ClpP1 and ClpP2 function together in protein degradation and are required for viability in vitro and during infection. PLoS Pathog (2012) 1.60
Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J (2013) 1.53
Pathway for degradation of peptides generated by proteasomes: a key role for thimet oligopeptidase and other metallopeptidases. J Biol Chem (2004) 1.50
Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor. Autophagy (2008) 1.47
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. J Biol Chem (2003) 1.46
Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. EMBO J (2004) 1.46
CuBr-catalyzed direct indolation of tetrahydroisoquinolines via cross-dehydrogenative coupling between sp3 C-H and sp2 C-H bonds. J Am Chem Soc (2005) 1.44
Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1. Nat Struct Mol Biol (2011) 1.42
Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1. Gastroenterology (2013) 1.38
Yeast adapt to near-freezing temperatures by STRE/Msn2,4-dependent induction of trehalose synthesis and certain molecular chaperones. Mol Cell (2004) 1.37
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity (2003) 1.36
S5a promotes protein degradation by blocking synthesis of nondegradable forked ubiquitin chains. EMBO J (2009) 1.36
Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell (2013) 1.35
Binding of hydrophobic peptides to several non-catalytic sites promotes peptide hydrolysis by all active sites of 20 S proteasomes. Evidence for peptide-induced channel opening in the alpha-rings. J Biol Chem (2002) 1.32
Myostatin/activin pathway antagonism: molecular basis and therapeutic potential. Int J Biochem Cell Biol (2013) 1.32
The active ClpP protease from M. tuberculosis is a complex composed of a heptameric ClpP1 and a ClpP2 ring. EMBO J (2012) 1.31
Cu-catalyzed cross-dehydrogenative coupling: a versatile strategy for C-C bond formations via the oxidative activation of sp(3) C-H bonds. Proc Natl Acad Sci U S A (2006) 1.30
Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. J Biol Chem (2010) 1.28
Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models. Dis Model Mech (2013) 1.28
The cross-dehydrogenative coupling of C(sp3)-H bonds: a versatile strategy for C-C bond formations. Angew Chem Int Ed Engl (2013) 1.26
Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem (2008) 1.23
Reactions of C-H bonds in water. Chem Rev (2007) 1.23
The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1. PLoS One (2008) 1.23
Getting to first base in proteasome assembly. Cell (2009) 1.22
The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9. J Biol Chem (2004) 1.21
Ubiquitinated proteins activate the proteasomal ATPases by binding to Usp14 or Uch37 homologs. J Biol Chem (2013) 1.20
Highly efficient oxidative amidation of aldehydes with amine hydrochloride salts. J Am Chem Soc (2006) 1.19
Characterization of the Brain 26S Proteasome and its Interacting Proteins. Front Mol Neurosci (2010) 1.19
CuBr-catalyzed efficient alkynylation of sp3 C-H bonds adjacent to a nitrogen atom. J Am Chem Soc (2004) 1.18
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy. J Cell Biol (2012) 1.17
Highly efficient copper-catalyzed nitro-Mannich type reaction: cross-dehydrogenative-coupling between sp3 C-H bond and sp3 C-H bond. J Am Chem Soc (2005) 1.17
The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins. EMBO J (2012) 1.15
ATP-induced structural transitions in PAN, the proteasome-regulatory ATPase complex in Archaea. J Biol Chem (2007) 1.15
Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo. Mol Cancer Ther (2005) 1.15
Enantioselective direct-addition of terminal alkynes to imines catalyzed by copper(I)pybox complex in water and in toluene. J Am Chem Soc (2002) 1.14
A highly efficient three-component coupling of aldehyde, alkyne, and amines via C-H activation catalyzed by gold in water. J Am Chem Soc (2003) 1.14
Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. J Immunol (2006) 1.14
The influence of skeletal muscle on systemic aging and lifespan. Aging Cell (2013) 1.13
Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry. EMBO J (2011) 1.13
Not just research tools--proteasome inhibitors offer therapeutic promise. Nat Med (2002) 1.12
Catalytic enantioselective alkynylation of prochiral sp3 C-H bonds adjacent to a nitrogen atom. Org Lett (2004) 1.11
The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. J Biol Chem (2009) 1.10
SIRT1 protein, by blocking the activities of transcription factors FoxO1 and FoxO3, inhibits muscle atrophy and promotes muscle growth. J Biol Chem (2013) 1.09
Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn (2013) 1.09
Bacterial proteolytic complexes as therapeutic targets. Nat Rev Drug Discov (2012) 1.08
Copper-catalyzed oxidative sp3 C-H bond arylation with aryl boronic acids. Org Lett (2008) 1.05
Egr-1 decreases adipocyte insulin sensitivity by tilting PI3K/Akt and MAPK signal balance in mice. EMBO J (2011) 1.05
The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome. J Biol Chem (2013) 1.04
Highly efficient cross-dehydrogenative-coupling between ethers and active methylene compounds. Angew Chem Int Ed Engl (2006) 1.03
Blm10 protein promotes proteasomal substrate turnover by an active gating mechanism. J Biol Chem (2011) 1.01
DDQ-mediated direct cross-dehydrogenative-coupling (CDC) between benzyl ethers and simple ketones. J Am Chem Soc (2006) 1.01
An early response transcription factor, Egr-1, enhances insulin resistance in type 2 diabetes with chronic hyperinsulinism. J Biol Chem (2011) 1.00
A conserved F box regulatory complex controls proteasome activity in Drosophila. Cell (2011) 0.98
Role of myosin light chain kinase in regulation of basal blood pressure and maintenance of salt-induced hypertension. Am J Physiol Heart Circ Physiol (2011) 0.97
Green chemistry oriented organic synthesis in water. Chem Soc Rev (2011) 0.97