Regulation of muscle mass by myostatin.

Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states. Nat Med (2007) 5.25

MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest (2009) 4.39

Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc Natl Acad Sci U S A (2005) 3.52

High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS One (2008) 3.34

MicroRNA regulatory networks in cardiovascular development. Dev Cell (2010) 3.09

Targeted ablation of beta cells in the embryonic zebrafish pancreas using E. coli nitroreductase. Mech Dev (2006) 3.02

Quadrupling muscle mass in mice by targeting TGF-beta signaling pathways. PLoS One (2007) 2.41

Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech (2013) 2.40

A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell (2012) 2.35

A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome. Am J Med Genet A (2013) 2.35

Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors. Proc Natl Acad Sci U S A (2008) 2.31

Lack of myostatin results in excessive muscle growth but impaired force generation. Proc Natl Acad Sci U S A (2007) 2.25

Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation (2010) 2.23

Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22

Follistatin gene delivery enhances muscle growth and strength in nonhuman primates. Sci Transl Med (2009) 2.21

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass. Cell Metab (2011) 2.11

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity. PLoS One (2009) 1.98

Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 1.97

High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo. Am J Physiol Cell Physiol (2009) 1.82

Muscle regeneration in the prolonged absence of myostatin. Proc Natl Acad Sci U S A (2005) 1.81

Regulation of muscle mass by follistatin and activins. Mol Endocrinol (2010) 1.79

Administration of a soluble activin type IIB receptor promotes skeletal muscle growth independent of fiber type. J Appl Physiol (1985) (2010) 1.76

microRNAs and muscle disorders. J Cell Sci (2009) 1.73

An official American Thoracic Society/European Respiratory Society statement: update on limb muscle dysfunction in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2014) 1.73

Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. J Endocrinol (2008) 1.72

Pharmacological inhibition of myostatin suppresses systemic inflammation and muscle atrophy in mice with chronic kidney disease. FASEB J (2011) 1.67

Age-dependent effect of myostatin blockade on disease severity in a murine model of limb-girdle muscular dystrophy. Am J Pathol (2006) 1.64

FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A (2007) 1.55

Immunolocalization of myostatin (GDF-8) following musculoskeletal injury and the effects of exogenous myostatin on muscle and bone healing. J Histochem Cytochem (2012) 1.51

METABOLIC FUNCTIONS OF MYOSTATIN AND GDF11. Immunol Endocr Metab Agents Med Chem (2010) 1.50

Myostatin does not regulate cardiac hypertrophy or fibrosis. Neuromuscul Disord (2007) 1.40

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy. FASEB J (2011) 1.39

The role of myostatin in muscle wasting: an overview. J Cachexia Sarcopenia Muscle (2011) 1.36

Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle Nerve (2009) 1.34

Adverse health consequences of performance-enhancing drugs: an Endocrine Society scientific statement. Endocr Rev (2013) 1.33

Myostatin (GDF-8) as a key factor linking muscle mass and bone structure. J Musculoskelet Neuronal Interact (2010) 1.32

Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy. Dis Model Mech (2015) 1.30

Beyond differential expression: the quest for causal mutations and effector molecules. BMC Genomics (2012) 1.29

Role of TGF-β signaling in inherited and acquired myopathies. Skelet Muscle (2011) 1.28

Novel events in the molecular regulation of muscle mass in critically ill patients. J Physiol (2011) 1.28

Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies. Mamm Genome (2012) 1.28

Smad7 promotes and enhances skeletal muscle differentiation. Mol Cell Biol (2006) 1.27

Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. Endocrinology (2008) 1.27

Genome-wide analysis reveals selection for important traits in domestic horse breeds. PLoS Genet (2013) 1.26

A role for myokines in muscle-bone interactions. Exerc Sport Sci Rev (2011) 1.26

Greater insulin sensitivity in calorie restricted rats occurs with unaltered circulating levels of several important myokines and cytokines. Nutr Metab (Lond) (2012) 1.22

Hydrodynamic limb vein injection of adeno-associated virus serotype 8 vector carrying canine myostatin propeptide gene into normal dogs enhances muscle growth. Hum Gene Ther (2009) 1.21

Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscle. J Nutr (2009) 1.20

Inflammation and cachexia in chronic kidney disease. Pediatr Nephrol (2010) 1.20

Clinical, agricultural, and evolutionary biology of myostatin: a comparative review. Endocr Rev (2008) 1.18

Role of satellite cells versus myofibers in muscle hypertrophy induced by inhibition of the myostatin/activin signaling pathway. Proc Natl Acad Sci U S A (2012) 1.18

Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume. Bone (2008) 1.17

Activin signaling as an emerging target for therapeutic interventions. Cell Commun Signal (2009) 1.16

Blockade of the activin receptor IIb activates functional brown adipogenesis and thermogenesis by inducing mitochondrial oxidative metabolism. Mol Cell Biol (2012) 1.14

The influence of skeletal muscle on systemic aging and lifespan. Aging Cell (2013) 1.13

Extracellular Regulation of Myostatin: A Molecular Rheostat for Muscle Mass. Immunol Endocr Metab Agents Med Chem (2010) 1.13

Growth differentiation factor 11 signals through the transforming growth factor-beta receptor ALK5 to regionalize the anterior-posterior axis. EMBO Rep (2006) 1.13

Intertissue control of the nucleolus via a myokine-dependent longevity pathway. Cell Rep (2014) 1.13

Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS One (2008) 1.10

Extrinsic regulation of satellite cell specification. Stem Cell Res Ther (2010) 1.10

Recombinant myostatin (GDF-8) propeptide enhances the repair and regeneration of both muscle and bone in a model of deep penetrant musculoskeletal injury. J Trauma (2010) 1.10

Inhibition of myostatin does not ameliorate disease features of severe spinal muscular atrophy mice. Hum Mol Genet (2009) 1.09

Mechanisms of muscle growth and atrophy in mammals and Drosophila. Dev Dyn (2013) 1.09

The central role of muscle stem cells in regenerative failure with aging. Nat Med (2015) 1.08

Hindlimb skeletal muscle function in myostatin-deficient mice. Muscle Nerve (2011) 1.07

Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle mass. J Cachexia Sarcopenia Muscle (2012) 1.06

Histone deacetylase inhibitors in the treatment of muscular dystrophies: epigenetic drugs for genetic diseases. Mol Med (2011) 1.06

Normalizing RT-qPCR data: are we getting the right answers? An appraisal of normalization approaches and internal reference genes from a case study in the finfish Lates calcarifer. Mar Biotechnol (NY) (2010) 1.03

Myostatin from the heart: local and systemic actions in cardiac failure and muscle wasting. Am J Physiol Heart Circ Physiol (2011) 1.03

Combination of myostatin pathway interference and dystrophin rescue enhances tetanic and specific force in dystrophic mdx mice. Mol Ther (2010) 1.01

Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids. J Biol Chem (2010) 1.00

Structure of myostatin·follistatin-like 3: N-terminal domains of follistatin-type molecules exhibit alternate modes of binding. J Biol Chem (2011) 1.00

Targeting senescent cells enhances adipogenesis and metabolic function in old age. Elife (2015) 0.99

Altered mRNA expression after long-term soleus electrical stimulation training in humans with paralysis. Muscle Nerve (2011) 0.99

Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2. Proc Natl Acad Sci U S A (2013) 0.99

Regenerative pharmacology in the treatment of genetic diseases: the paradigm of muscular dystrophy. Int J Biochem Cell Biol (2008) 0.98

Regulation of genes affecting body size and innate immunity by the DBL-1/BMP-like pathway in Caenorhabditis elegans. BMC Dev Biol (2010) 0.97

Is functional hypertrophy and specific force coupled with the addition of myonuclei at the single muscle fiber level? FASEB J (2011) 0.97

Sarcopenia and age-related endocrine function. Int J Endocrinol (2012) 0.97

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs. Sci Rep (2015) 0.97

Efficient Generation of Myostatin Knock-Out Sheep Using CRISPR/Cas9 Technology and Microinjection into Zygotes. PLoS One (2015) 0.97

Relation between extent of myostatin depletion and muscle growth in mature mice. Am J Physiol Endocrinol Metab (2009) 0.96

Myotonic dystrophy: therapeutic strategies for the future. Neurotherapeutics (2008) 0.96

Treating cancer cachexia to treat cancer. Skelet Muscle (2011) 0.95

Developmental origins of species-specific muscle pattern. Dev Biol (2009) 0.95

Sparing of the dystrophin-deficient cranial sartorius muscle is associated with classical and novel hypertrophy pathways in GRMD dogs. Am J Pathol (2013) 0.95

The growth hormone-insulin-like growth factor-I axis in chronic kidney disease. Growth Horm IGF Res (2007) 0.95

Deletion of muscle GRP94 impairs both muscle and body growth by inhibiting local IGF production. FASEB J (2012) 0.95

The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy. Genes Dev (2013) 0.94

Functional muscle analysis of the Tcap knockout mouse. Hum Mol Genet (2010) 0.94

Transgenic overexpression of miR-133a in skeletal muscle. BMC Musculoskelet Disord (2011) 0.93

Myostatin and follistatin expression in skeletal muscles of rats with chronic heart failure. Int J Exp Pathol (2009) 0.93

Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes (2009) 0.92

Endurance exercise training in myostatin null mice. Muscle Nerve (2010) 0.92

Myostatin (GDF-8) inhibits chondrogenesis and chondrocyte proliferation in vitro by suppressing Sox-9 expression. Growth Factors (2011) 0.92

Acute resistance exercise activates rapamycin-sensitive and -insensitive mechanisms that control translational activity and capacity in skeletal muscle. J Physiol (2015) 0.91

Myostatin facilitates slow and inhibits fast myosin heavy chain expression during myogenic differentiation. Biochem Biophys Res Commun (2012) 0.91

The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men. Age (Dordr) (2014) 0.90

Muscle wasting in chronic kidney disease: the role of the ubiquitin proteasome system and its clinical impact. Pediatr Nephrol (2007) 0.90

Sex differences in global mRNA content of human skeletal muscle. PLoS One (2009) 0.90