Published in Cytokine on November 07, 2004
IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates. J Clin Invest (2006) 2.41
Chemical control of protein stability and function in living mice. Nat Med (2008) 2.37
2'-5'-Oligoadenylate synthetase single-nucleotide polymorphisms and haplotypes are associated with variations in immune responses to rubella vaccine. Hum Immunol (2010) 1.30
The control of CD4+CD25+Foxp3+ regulatory T cell survival. Biol Direct (2008) 1.28
STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of Class O Forkhead transcription factors. J Biol Chem (2011) 1.22
Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets. J Transl Med (2006) 1.21
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Cell Immunol (2007) 1.08
Direct inhibition of CDK9 blocks HIV-1 replication without preventing T-cell activation in primary human peripheral blood lymphocytes. Gene (2007) 1.07
The inability to disrupt the immunological synapse between infected human T cells and APCs distinguishes HIV-1 from most other primate lentiviruses. J Clin Invest (2009) 1.07
Progressive multifocal leukoencephalopathy: current treatment options and future perspectives. Ther Adv Neurol Disord (2015) 1.03
Influence of interleukin polymorphisms on development of gastric cancer and peptic ulcer. World J Gastroenterol (2010) 0.97
Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice. Proc Natl Acad Sci U S A (2009) 0.93
IL-2: a two-faced master regulator of autoimmunity. J Autoimmun (2011) 0.93
SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice. Immunol Cell Biol (2011) 0.92
IL-2 and IL-18 attenuation of airway hyperresponsiveness requires STAT4, IFN-gamma, and natural killer cells. Am J Respir Cell Mol Biol (2006) 0.90
Anticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12. Semin Oncol (2015) 0.89
Interleukin-2 inhibits FMS-like tyrosine kinase 3 receptor ligand (flt3L)-dependent development and function of conventional and plasmacytoid dendritic cells. Proc Natl Acad Sci U S A (2011) 0.89
Significantly lower anti-Leishmania IgG responses in Sudanese versus Indian visceral leishmaniasis. PLoS Negl Trop Dis (2014) 0.89
A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice. J Immunol (2012) 0.88
Current status of immunotherapy for the treatment of lung cancer. J Thorac Dis (2010) 0.88
Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice. Immunology (2008) 0.88
In silico identification of opossum cytokine genes suggests the complexity of the marsupial immune system rivals that of eutherian mammals. Immunome Res (2006) 0.87
Promoter hypermethylation in tumour suppressor genes and response to interleukin-2 treatment in bladder cancer: a pilot study. J Cancer Res Clin Oncol (2009) 0.85
Detecting the effects of selection at the population level in six bovine immune genes. BMC Genet (2008) 0.84
Harnessing the immune system to improve cancer therapy. Ann Transl Med (2016) 0.83
Effective modulation of CD4(+)CD25 (+high) regulatory T and NK cells in malignant patients by combination of interferon-α and interleukin-2. Cancer Immunol Immunother (2012) 0.83
Human IL18-IL2 fusion protein as a potential antitumor reagent by enhancing NK cell cytotoxicity and IFN-γ production. J Cancer Res Clin Oncol (2012) 0.83
Comparison of immunodulatory properties of dental pulp stem cells derived from healthy and inflamed teeth. Clin Oral Investig (2014) 0.82
Perioperative immunomodulation with interleukin-2 in patients with renal cell carcinoma: results of a controlled phase II trial. Br J Cancer (2006) 0.82
Exercise training, lymphocyte subsets and their cytokines production: experience of an Italian professional football team and their impact on allergy. Biomed Res Int (2014) 0.80
Phenotypic and Molecular Evidence Suggests That Decrements in Morning and Evening Energy Are Distinct but Related Symptoms. J Pain Symptom Manage (2015) 0.80
Denileukin diftitox for the treatment of cutaneous T-cell lymphoma. Biologics (2008) 0.80
Natural killer cells regulate T-cell proliferation during human parainfluenza virus type 3 infection. J Virol (2008) 0.79
HIV-1 Infection-Induced Suppression of the Let-7i/IL-2 Axis Contributes to CD4(+) T Cell Death. Sci Rep (2016) 0.79
IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents. Am J Clin Nutr (2010) 0.78
Conditions for the generation of cytotoxic CD4(+) Th cells that enhance CD8(+) CTL-mediated tumor regression. Clin Transl Immunology (2016) 0.78
Pharmacokinetic modelling of N-(4-[(18)F]fluorobenzoyl)interleukin-2 binding to activated lymphocytes in an xenograft model of inflammation. Eur J Nucl Med Mol Imaging (2012) 0.78
Key Immune Cell Cytokines Affects the Telomere Activity of Cord Blood Cells In vitro. Adv Pharm Bull (2016) 0.78
Large-Scale Purification of r28M: A Bispecific scFv Antibody Targeting Human Melanoma Produced in Transgenic Cattle. PLoS One (2015) 0.77
Therapeutic efficacy of Bifidobacterium longum-mediated human interleukin-2 with endostatin or TRAIL in transplanted tumors in mice. Exp Ther Med (2011) 0.77
Identification of interleukin genes in Pogona vitticeps using a de novo transcriptome assembly from RNA-seq data. Immunogenetics (2016) 0.76
[Biological switches: the 'all-or-none' principle in T-cell activation]. Z Rheumatol (2009) 0.76
Achieving Remission in Gulf War Illness: A Simulation-Based Approach to Treatment Design. PLoS One (2015) 0.76
Effects of increasing docosahexaenoic acid intake in human healthy volunteers on lymphocyte activation and monocyte apoptosis. Br J Nutr (2008) 0.76
Positive effects of porcine IL-2 and IL-4 on virus-specific immune responses induced by the porcine reproductive and respiratory syndrome virus (PRRSV) ORF5 DNA vaccine in swine. J Vet Sci (2013) 0.76
Defective STAT1 activation associated with impaired IFN-γ production in NK and T lymphocytes from metastatic melanoma patients treated with IL-2. Oncotarget (2016) 0.76
The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling. J Biol Chem (2012) 0.76
Encapsulation of adenovirus serotype 5 in anionic lecithin liposomes using a bead-based immunoprecipitation technique enhances transfection efficiency. Biomaterials (2014) 0.75
Structural basis of GM-CSF and IL-2 sequestration by the viral decoy receptor GIF. Nat Commun (2016) 0.75
Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences. Cancer Gene Ther (2016) 0.75
Pro- and anti-inflammatory cytokines in cutaneous leishmaniasis: a review. Pathog Glob Health (2016) 0.75
Elevated Plasma Levels of sIL-2R in Complex Regional Pain Syndrome: A Pathogenic Role for T-Lymphocytes? Mediators Inflamm (2017) 0.75
The effects of ursolic acid on cytokine production via the MAPK pathways in leukemic T-cells. EXCLI J (2013) 0.75
The Toxicity and Benefit of Various Dosing Strategies for Interleukin-2 in Metastatic Melanoma and Renal Cell Carcinoma. J Adv Pract Oncol (2015) 0.75
A Novel Centrifugation Method Using a Cell Salvage Device Offers an Alternative to the Use of Leukocyte-Depleting Filters for Autologous Blood Transfusions. J Extra Corpor Technol (2016) 0.75
Identification of interleukin-2 for imaging atherosclerotic inflammation. Eur J Nucl Med Mol Imaging (2006) 0.75
Multi-cellular natural killer (NK) cell clusters enhance NK cell activation through localizing IL-2 within the cluster. Sci Rep (2017) 0.75
Modulation of recombinant antigenic constructs containing multi-epitopes towards effective reduction of atherosclerotic lesion in B6;129S-Ldlr(tm1Her)Apob(tm2Sgy)/J mice. PLoS One (2015) 0.75
Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol (2016) 0.75
Autoimmunity and Cytokine Imbalance in Inherited Epidermolysis Bullosa. Int J Mol Sci (2016) 0.75
B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment. Oncoimmunology (2017) 0.75
Decreased level of antibodies and cardiac involvement in patients with chronic Chagas heart disease vaccinated with BCG. Med Microbiol Immunol (2013) 0.75
Terminal Deoxynucleotidyl Transferase (TdT) Inhibiti on of Cord Blood Derived B and T Cells Expansion. Adv Pharm Bull (2017) 0.75
Randomized, placebo-controlled clinical trial of an aerosolized β₂-agonist for treatment of acute lung injury. Am J Respir Crit Care Med (2011) 5.24
Diagnosis, epidemiology and outcomes of acute kidney injury. Clin J Am Soc Nephrol (2008) 3.93
Rosuvastatin for sepsis-associated acute respiratory distress syndrome. N Engl J Med (2014) 3.39
Acute kidney injury: an increasing global concern. Lancet (2013) 2.61
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. Am J Kidney Dis (2013) 2.42
Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. Am J Respir Crit Care Med (2013) 2.17
Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. Crit Care Med (2015) 2.07
Fluid balance, diuretic use, and mortality in acute kidney injury. Clin J Am Soc Nephrol (2011) 2.00
Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clin J Am Soc Nephrol (2012) 1.90
The value of positive end-expiratory pressure and Fio₂ criteria in the definition of the acute respiratory distress syndrome. Crit Care Med (2011) 1.64
The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC Nephrol (2010) 1.63
Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Crit Care Med (2015) 1.55
The incidence and prognostic significance of acute kidney injury. Curr Opin Nephrol Hypertens (2007) 1.49
Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest (2010) 1.44
Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood Purif (2015) 1.41
Ongoing clinical trials in AKI. Clin J Am Soc Nephrol (2012) 1.38
Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Crit Care Med (2010) 1.32
Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Clin J Am Soc Nephrol (2012) 1.20
Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings. Clin J Am Soc Nephrol (2012) 1.13
Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest (2007) 1.10
Protective mechanisms of activated protein C in severe inflammatory disorders. Br J Pharmacol (2009) 1.07
Long-term outcomes after acute kidney injury: where we stand and how we can move forward. Am J Kidney Dis (2009) 1.06
Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. Am J Physiol Lung Cell Mol Physiol (2012) 1.05
Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. Am J Physiol Lung Cell Mol Physiol (2009) 1.04
Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Crit Care Res Pract (2011) 1.03
FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Ann Intensive Care (2011) 1.02
The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology. Clin Toxicol (Phila) (2012) 1.02
The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Chest (2011) 1.02
Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Crit Care Med (2014) 1.01
AKI: a path forward. Clin J Am Soc Nephrol (2013) 0.98
Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med (2015) 0.97
Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia (2014) 0.97
Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. Am J Physiol Renal Physiol (2008) 0.91
Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. Am J Respir Crit Care Med (2011) 0.89
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. J Biol Chem (2008) 0.89
Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation. Biomark Insights (2013) 0.88
Impact of acute kidney injury on lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 0.86
Fluid overload in AKI: epiphenomenon or putative effect on mortality? Curr Opin Crit Care (2012) 0.84
An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. Trials (2014) 0.82
Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Crit Care Med (2015) 0.82
Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup. Clin J Am Soc Nephrol (2012) 0.80
Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Ann Intensive Care (2011) 0.80
Cardiovascular events after AKI: a new dimension. J Am Soc Nephrol (2014) 0.78
Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatr Pulmonol (2009) 0.77
The acute respiratory distress syndrome following isolated severe traumatic brain injury. J Trauma Acute Care Surg (2016) 0.76
Acute renal syndrome/renal angina: a new paradigm for studies of acute kidney injury? Clin J Am Soc Nephrol (2010) 0.76
The authors reply. Kidney Int (2013) 0.76
Acute kidney injury: is acute kidney injury a risk factor for long-term mortality? Nat Rev Nephrol (2010) 0.76
The authors reply. Crit Care Med (2015) 0.75
Rosuvastatin for sepsis-associated ARDS. N Engl J Med (2014) 0.75
Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med (2016) 0.75
Finding the key to dialysis catheter lock. Am J Respir Crit Care Med (2015) 0.75
Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization. J Heart Lung Transplant (2011) 0.75
Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup. Clin Toxicol (Phila) (2015) 0.75
Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families. Crit Care Med (2017) 0.75
Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive Care Med (2015) 0.75
No impact of surviving sepsis campaign care bundles in reducing sepsis-associated acute kidney injury . Clin Nephrol (2017) 0.75
Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Crit Care Med (2017) 0.75
Evolving practices in critical care and their influence on acute kidney injury. Curr Opin Crit Care (2013) 0.75